AEGiS-11IAC: Prevalence of oral manifestations in a cohort of HIV-positive children and its correlation with the T4/T8 ratio.

11th International AIDS Conference


Vancouver, British Columbia — July 7-12, 1996

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Prevalence of oral manifestations in a cohort of HIV-positive children and its correlation with the T4/T8 ratio.

Int Conf AIDS 1996 Jul 7-12; 11:449 (abstract no. Pub.B.1070)
Fonseca R, Cardoso A, Teles G, Souza I; Federal University of Rio de Janeiro, Brazil.

OBJECTIVE: To investigate the frequency of oral manifestations and to correlate the presence of oral lesions with the T4/T8 ratio in a cohort of HIV+ children of both sexes, with AIDS.

METHODS: Fifty one (22 male and 29 female) HIV+ children, age ranging from 1.8 to 11.6 years with AIDS were followed for two years and examined weekly to investigate the presence of oral lesions. Oral lesions were studied according to the classification and diagnostic criteria proposed by the EC Clearinghouse on Oral Problems Related to HIV Infection and WHO Collaborating Centre on Oral Manifestations of the Immunodeficiency Virus in 1992. A questionnaire used in this investigation was based on the children's classification proposed by CDC in 1987.

RESULTS: Oral lesions were observed in 26 children (50.98%). Pseudomembranous candidiasis was observed in 21.57% of the children. Salivary gland disease was seen in 19.61% of the patients. Erythematous candidiasis was observed in 5.88% and linear gengival erythema and hairy leukoplakia were seen in 1.96% of the children. Twenty four of the children with lesions (47.05%) had T4/T8 less than 0.5; only two of the children with lesions (3.92%) had T4/T8 greater than 0.5. Among the children without oral lesions, 16 (31.37%) had T4/T8 greater than 0.5 and 9 (17.65%) had T4/T8 less than 0.5.

CONCLUSIONS: Pseudomembranous candidiasis was the most common type of oral lesion found in this study, being observed in 21.57% of the children. Salivary gland disease (19.61%), erythematous candidiasis (5.88%), linear gengival erythema (1.96%) and hairy leukoplakia (1.96%) were also observed. A relationship was found between the frequency of oral manifestations and the T4/T8 ratio. Children with T4/T8 ratios less than 0.5 were more prone to develop pseudomembranous candidiasis and other oral lesions.

Keywords: AEGIS, HIV Infections, Prevalence, Candidiasis, Oral, Leukoplakia, Hairy, HIV Seropositivity, Mouth Diseases, Acquired Immunodeficiency Syndrome, Salivary Gland Diseases, Erythema, Child, Human, Female, Male, epidemiology, ICA11KWDaegis,hivinfections,prevalence,candidiasis,oral,leukoplakia,hairy,hivseropositivity,mouthdiseases,acquiredimmunodeficiencysyndrome,salivaryglanddiseases,erythema,child,human,female,male,epidemiology,ica11

960707
PubB1070

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