11th International AIDS Conference Vancouver, British Columbia — July 7-12, 1996

Int Conf AIDS 1996 Jul 7-12; 11:224 (abstract no. Tu.A.373)
Fay FF, Campodonico M, Taborda M, Janssens W, Heyndrickx L, Fay O; Bios Rosario, Rosario, Argentina. Fax: 54 - 41 - 262913.

OBJECTIVES: To establish the prevalence of the different HIV-1 subtypes in Argentina, and to correlate it with the risk group, time of infection, sex, age and clinical status. Materials and methods: 45 HIV-1 infected patients, with known age, sex, risk group and clinical status, were included. in this study. From blood/EDTA samples, peripheral blood mononuclear cells were isolated, and DNA was extracted. A 700 bp fragment from the env region was amplified by a nested PCR. By means of Heteroduplex Mobility Assay (HMA) all fragments were genetically compared with 9 previously characterized strains belonging to subtypes A through F.

RESULTS: (table: see text)

CONCLUSIONS: The prevalence of genotype B and F are similar to what we have seen in a previous study on Argentinean samples. The same subtypes are seen in Brazil (neighboring country), where subtype C is also present with a low prevalence. No significative differences were seen between the prevalence of genotype B and F in relation to sex, age and clinical status. Although the number of samples is low, genotype F strains seem to be circulating among IDUs, while genotype B strains are more frequent in HETs patients. More extensive studies should be done in order to confirm the rate prevalence of different HIV-1 subtypes in Argentina.

960707
TuA373

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