AEGiS-11IAC: Efficacy of intermittent doses of atovaquone (ATQ) and trimethoprim-sulfamethoxazole (TMP-SMZ) in the prevention of murine Pneumocystis carinii pneumonia (PCP).

11th International AIDS Conference

Vancouver, British Columbia — July 7-12, 1996

Efficacy of intermittent doses of atovaquone (ATQ) and trimethoprim-sulfamethoxazole (TMP-SMZ) in the prevention of murine Pneumocystis carinii pneumonia (PCP).

Int Conf AIDS 1996 Jul 7-12; 11:230 (abstract no. Tu.B.116)
Hughes WT, Killmar J; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA. Fax: (901) 527-6616.

OBJECTIVE: To determine and compare the prophylactic efficacies of intermittent doses of ATQ and TMP-SMZ for Pneumocystis carinii pneumonitis.

METHODS: Sprague-Dawley rats were immunosuppressed with dexamethasone x 6 weeks to provoke PCP. Groups of 10 or 11 rats received no drug (control) ATQ 100 mg/kg or TMP-SMZ 50/250 mg/kg orally daily, 3 days per week (MTW), weekly or biweekly or no drugs (control). At 6 weeks necropsied lungs were studied for PCP.

RESULTS: Of the 91 animals studied 86 were evaluable at the completion of the experiment. Results are tabulated: (table: see text)

CONCLUSIONS: Both ATQ and TMP-SMZ prevent PCP in 100% of animals when given daily or 3 days per week and in 80% when given once weekly. One dose of ATQ every 2 weeks was ineffective while TMP-SMZ every 2 weeks prevented PCP in 60% compared to only 9% of controls with no PCP.

Keywords: AEGIS, Trimethoprim-Sulfamethoxazole Combination, Pneumonia, Pneumocystis carinii, Naphthoquinones, Pneumocystis carinii, Methylprednisolone Hemisuccinate, Anti-Infective Agents, Antifungal Agents, Lung, atovaquone, 6-methylprednisolone-21-hemisuberate, N,N,N'-triethylenediamine amide, Rats, Animal, prevention & control, ICA11

960707
TuB116