Exacerbations of clinical symptoms in HIV-1 patients with Multicentric Castelman's Disease are associated with a high increase of KSHV DNA load in PBMCS.
Int Conf AIDS 1996 Jul 7-12; 11:7 (abstract no. We.A.160) Grandadamm, Dupin N, Calvez V, Gorin I, Blum L, Kernbaum S, Sicard D, Buisson Y, Aguth, Jescande JP, Huraux JM; Hopital Tarnier-Cochin, Paris, France. Fax: 33 1 42 34 19 68.
Multicentric Castelman's Disease (MCD) is an atypical lymphoproliferative disorder which has been reported in close association with Kaposi's sarcoma (KS) both in HIV seropositive and seronegative patients. In some cases, MCD is a persistent disease with periodic exacerbations requiring a treatment such as chemotherapy or corticosteroid. Herpesvirus-like DNA sequences were found with a high frequency in Kaposi's sarcoma suggesting the etiological role of a new Herpes virus namely Kaposi's sarcoma-associated Herpesvirus (KSHV) or human Herpesvirus 8 type (HHV-8). Moreover, the same sequences have been described in tumoral tissues in 100% of HIV-infected patients with MCD and in peripheral blood mononuclear cells (PBMCs) of some patients. The epidemiological link between MCD and KS and the high frequency of KSHV detection in both diseases raise the question of a role of this new virus in the pathogenesis of MCD. To explore this hypothesis, we analysed the KSHV DNA load in PBMCs of HIV-infected patients with MCD at different points during the clinical course. We found a correlation between the reemergence of clinical symptoms and increased level of viral load. Our results suggest a strong association between KSHV and MCD in HIV-1 positive patients.
Keywords: AEGIS, Herpesvirus 8, Human, HIV-1, Sarcoma, Kaposi, Sezary Syndrome, Viral Load, Herpesviridae, HIV Infections, DNA, Viral, HIV Seropositivity, Herpesviridae Infections, DNA, HIV, HIV Seronegativity, DNA Primers, Human, immunology, ICA11
