AEGiS-11IAC: Herpes virus and AIDS related Kaposi's sarcoma.

11th International AIDS Conference


Vancouver, British Columbia — July 7-12, 1996

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Herpes virus and AIDS related Kaposi's sarcoma.

Int Conf AIDS 1996 Jul 7-12; 11:7 (abstract no. We.A.164)
Klaskala W, Sosa C, Benetucci J, Wood C, Baum MK; U of Miami, Dpt. Epidemiology & Public Health, Miami, FL.

OBJECTIVE: To determine whether human herpes virus 8 (HHV-8) sequences are present in AIDS patients diagnosed with Kaposi's sarcoma (KS) in Argentina.

METHODS: Biopsy samples were collected from four HIV+ homosexual men diagnosed with cutaneous KS. PCR was performed to amplify a 233-bp from the KS - 330 Bam fragment sequence of HHV-8. PCR amplified products were directly sequenced.

RESULTS: All four samples were strong positive for the HHV-8 sequences. Two of them, directly sequenced by PCR were found to have a high degree of hemology with the published sequences (94% and 95%) respectively.

CONCLUSIONS: The DNA sequence analysis of the Human Herpes Virus 8 (HHV-8) indicates that this virus is very conserved and one strain can be found in AIDS associated Kaposi's sarcoma patients in Argentina. This result confirms the findings obtained in samples from the United States, France, Africa and Taiwan suggesting that a distinct herpes virus-like agent may be closely associated with Kaposi's sarcoma.

Keywords: AEGIS, Sarcoma, Kaposi, Herpesviridae, Herpesvirus 8, Human, Simplexvirus, Acquired Immunodeficiency Syndrome, Polymerase Chain Reaction, Herpesviridae Infections, Skin Neoplasms, Sequence Analysis, DNA, Homosexuality, Africa, France, United States, Taiwan, Argentina, Human, Male, ICA11

960707
WeA164

Copyright © 1996 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.