AEGiS-11IAC: Quantitative RNA levels before and after influenza immunizations in HIV-infected adults.

11th International AIDS Conference


Vancouver, British Columbia — July 7-12, 1996

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Quantitative RNA levels before and after influenza immunizations in HIV-infected adults.

Int Conf AIDS 1996 Jul 7-12; 11:18 (abstract no. We.B.113)
Nelson RP Jr, Ledford D, Vincent A, Zhou L, Bergen-Losee L, Lockey R; University of South Florida, Petersburg, FL. Fax: 813 892 8619. E-mail: rpnelson@coml.med.usf.edu.

OBJECTIVE: To determine the effect of influenza immunization on plasma RNA levels in a cohort of HIV-infected adults.

METHODS: Quantitative plasma RNA levels were determined by RT-PCR (Roche Biomedical, Research Triangle Park, NC) at baseline and from 3-5 wk following immunization with the 1994 trivalent influenza vaccine in 33 HIV-infected subjects (16 females, 17 males; mean age, 35.7 yr). These results were compared to levels drawn at baseline (pre) and 3-5 wk (post) from 19 HIV-infected controls (9 females, 10 males; mean age, 33 yr) who were not immunized. Pre- and post mean log10 RNA copies/mL plasma in subjects and controls were compared using the student's two-tailed t-test. Antiretroviral therapy was not changed or not initiated during the study period.

RESULTS: Ages were similar and males and females were distributed equally between subjects and controls. Pre mean log10 RNA copies/mL were similar in subjects (4.47 plus or minus 0.99) and controls (4.58 plus or minus 0.91). Post mean log10 RNA copies/mL were similar in subjects (4.62 plus or minus 0.88) and controls (4.56 plus or minus 1.03). There was no significant difference between the pre- and post changes in mean log10 RNA copy numbers between the subjects and controls.

CONCLUSION: Influenza immunization does not significantly increase RNA copy number 3-5 wk post-immunization in HIV-infected adults compared to non-immunized controls.

Keywords: AEGIS, HIV, Anti-HIV Agents, HIV Infections, Influenza Vaccine, RNA, RNA, Viral, Reverse Transcriptase Inhibitors, HIV Protease Inhibitors, Immunization, Vaccination, Human, Female, Male, Adult, pathogenicity, ICA11KWDaegis,hiv,anti-hivagents,hivinfections,influenzavaccine,rna,rna,viral,reversetranscriptaseinhibitors,hivproteaseinhibitors,immunization,vaccination,human,female,male,adult,pathogenicity,ica11

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WeB113

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