AEGiS-13IAC: Genetic subtypes of HIV-1 based on the ENV/VPU sequences in Republic of Congo-Brazzaville.

13th International AIDS Conference


Durban, South Africa - July 9-July 14, 2000

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Genetic subtypes of HIV-1 based on the ENV/VPU sequences in Republic of Congo-Brazzaville.

Int Conf AIDS 2000 Jul 9-14; 13:33 (abstract no.. LbPeA7008)

Bikandou B, Taniguchi Y, Takehisa J, Mboudjeka I, Harada Y, Nzoukoudi MY, M'Vouenze R, Ido E, Ichimura H, M'Pele P, Parra HJ, Hayami M
Institute For Virus Research, Laboratory of Pathogenic Virus, Kyoto University, Japan. Fax: +81.75.761.9335, E-mail: bbikando@virus.kyoto-u.ac.jp.

BACKGROUND: In order to assess the molecular epidemiology of HIV-1 in Republic of Congo, we investigated 28 HIV-1 isolates obtained from Congolese AIDS patients in 1996 and 1997.

METHODS: A part of the env region including the V3 loop and a part of 5'tat-env C1 region were phylogenetically analyzed.

RESULTS: The genotypes observed were varied : among 28 specimens, 12 (41%) were subtypes A, 1 (4%) was D, 6 (21 %) were G, 5 (18%) were H, 2 (7%) were J and 2 (7%) were unclassified subtype (U) in the env tree. Whereas, in the vpu tree, 1 (4%) was subtype A, 1 (4%) was D, 17 (61%) were G, 5 (18%) were H and 4 (15%) were unclassified. In the env and vpu analyses, 16 (57%) out of 28 isolates did not fall within the same subtype, espacially, 9 out of those 16 were A/G (env/vpu) types. In contrast, neither G/A (env/vpu)-like virus or IbNG-like CRF virus was found in Congo.

CONCLUSION: These data suggested that at least 57% of Congolese HIV-1s had mosaic structures and were derived from independent recombination events in the past. Recombination between subtypes A and G might occurred more frequent than over intersubtypes. The factors responsible for the high prevalence of subtype G-like vpu gene might provide one of the clues to better understand the recombination process and HIV-1 evolution.

Keywords: AEGIS, HIV-1, Genes, vpu, HIV Infections, Acquired Immunodeficiency Syndrome, HIV Envelope Protein gp120, HIV Integrase, HIV Envelope Protein gp41, Congo, HIV Core Protein p24, HIV, HIV Long Terminal Repeat, Human, genetics, immunology, AIDSKWDaegis,hiv-1,genes,vpu,hivinfections,acquiredimmunodeficiencysyndrome,hivenvelopeproteingp120,hivintegrase,hivenvelopeproteingp41,congo,hivcoreproteinp24,hiv,hivlongterminalrepeat,human,genetics,immunology,aids
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LbPeA7008

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