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13th International AIDS ConferenceDurban, South Africa - July 9-July 14, 2000 |
Int Conf AIDS 2000 Jul 9-14; 13:41 (abstract no.. LbPeB7038)
Agarwal SK, Singh A, Baveja UK, Subramanian A, Kapoor AK, Agarwal K, Singh NP, Prakash A
Maulana Azad Medical College, Dept of Medicine, Delhi, India. Fax: +91-11-3236437, E-mail: drashok@del3.vsnl.net.in.
BACKGROUND: The present study was conducted to assess and compare the cytokine profiles in HIV +ve patients with and without Pulmonary Tuberculosis(PTB).
METHODS: 20 HIV +ve patients and 20 controls were divided into 4 groups of 10 each- group 1-HIV +ve patients without PTB, group 2-HIV +ve patients with PTB, group 3- healthy adults,and group 4- HIV -ve patients with PTB. The CD4 cell counts, and cytokine profile- Interieukin(IL)-2,4, 6,10,12,Interferon(IFN) gamma and Tumour Necrosis Factor(TNF) alpha were evaluated in all the subjects at the start and after 3 months of study initiation.
RESULTS: The CD4 counts were significantly lower in groups 1 and 2 compared to group 3(P<0.01). The Counts in group 2 were significantly lower in group 2 over group I at the start (p=0.0076) and at 3 months(p=0.0089). The levels of the Type 1 cytokines (IL-2,12 and IFN Gamma) were significantly lower in groups I and 2 compared to group 3(p< 0.001 for both),more so in group 2 over 1 (p<0.001).The type 2 cytokines(IL-4,6, 10 and TNF alpha) were higher in groups 1 and 2 compared to group 3, though significant only for IL6 in group 1 and for IL4,6 and TNF Alpha in group 2. A highly significant (p<0.0001 for both) positive correlation between CD4 counts and type 1 cytokines and negative correlation between CD4 counts and type 2 cytokines was observed.
CONCLUSIONS: HIV +ve patients with pulmonary tuberculosis had the lowest CD4 cell counts,type 1 cytokines and highest type 2 cytokines denoting maximum immunosuppression.
Copyright © 2000 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.
