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13th International AIDS ConferenceDurban, South Africa - July 9-July 14, 2000 |
Int Conf AIDS 2000 Jul 9-14; 13:(abstract no. ThOrB655)
Soriano V, Kirk O, Antunes F, Johnson M, d'Arminio Monforte A, Teglbjorg LS, Goebel F-D, Lundgren JD
V. Soriano, Service of Infectious Diseases, Hospital Carlos III, Instituto de Salud Carlos III, C/ Sinesio Delgado 10, 28029 Madrid, Spain, Tel.: +34 91 453 25 00, Fax: +34 91 733 66 14, E-mail: vsoriano@dragonet.es
BACKGROUND: Co-infection with HCV may influence the clinical prognosis in HIV-infected patients.
OBJECTIVES: To compare characteristics and mortality among patients testing positive/negative for HCV antibody within the EuroSIDA database, in which data from more than 8500 patients from 60 centres across Europe are recorded.
RESULTS: Results of HCV serology were available for 4034 patients; 1350 (33.5%) HCV positive and 2684 (66.5%) HCV negative. These groups differed in several ways, in particular with respect to: HIV transmission route (74.2% of the seropositive patients were injecting drug users, compared with 3.3% of the seronegative, p>0.001), region of enrolment (47.4% from Southern Europe versus 28.0%, p>0.001), and gender (28.3% female versus 17.9%, p>0.001). A total of 390 patients died (11.9 % versus 8.6%, p>0.001) within a median follow-up time of 2.1 years. In an univariate Cox model, patients who were HCV positive, had a significantly higher risk of dying relative to patients who tested HCV-negative (the relative hazard (RH) = 1.39 (95%-CI:1.14ndash;1.71). In adjusted Cox models including variables such as age, gender, region of enrolment, antiretroviral therapy, CD4 lymphocyte cell count, weight and AIDS diagnosis, the HCV status remained significantly associated with death (RH = 1.51 (1.20ndash;1.89).
CONCLUSIONS: A large proportion of HIV-infected patients in Europe is co-infected with HCV, and differs in several ways from patients who are HCV-negative. Being HCV-positive was associated with an approximately 50% higher risk of dying in respect to HCV negatives.
Copyright © 2000 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.
