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13th International AIDS ConferenceDurban, South Africa - July 9-July 14, 2000 |
Int Conf AIDS 2000 Jul 9-14; 13:(abstract no. ThOrB703)
Bernasconi E, Boubaker K, Sudre P, Flepp M, Furrer HJ, Haensel A, Hirschel B, Boggian K, Opravil M, Rickenbach M, Telenti A;;; E. Bernasconi, Regional Hospital Lugano, v. Tesserete 46, CH-6903 Lugano, Switzerland, Tel.: +41-91-805 60 22, Fax: +41-91-805 60 31, E-mail: enbernasconi@tinet.ch
BACKGROUND: To describe the prevalence of fat redistribution and lipid disorders in relation to demographic, virologic, immunologic parameters and to the antiretroviral drugs.
METHODS: One-month prevalence study of adverse events in HIV-infected individuals participating in the SHCS. Data on abnormal body fat distribution reported by the patient, or by the visiting physician, were collected. Serum levels of total cholesterol, HDL-cholesterol and triglycerides were measured at the time of the visit.
RESULTS: Out of 1379 patients treated with antiretroviral drugs, 585 (42.4%) developed signs of fat redistribution. Peripheral fat loss was observed in 386 (28.0%) patients, whereas 416 (30.2%) had signs of fat accumulation. In the analysis by chi2 crosstabulation, AZT, 3TC and the combination AZT + 3TC as part of HAART conferred protection in respect to fat loss, with an OR of 0.5 (0.4-0.6), 0.8 (0.6-1.0), and 0.1 (0.03-0.5), respectively. On the other side D4T and the combination DDI + D4T were associated with an increased risk for peripheral fat loss with an OR of 2.1 (1.6-2.7), and 1.5 (0.4-6.5), respectively. In regard to fat accumulation, a risk increase of 1.4 fold (1.1-1.8) was observed with indinavir, but not with other protease inhibitors. Lipid values were frequently abnormal: hypercholesterolemia (> 6.2 mmol/l) was detected in 28.4% and hypertriglyceridemia (> 2.3 mmol/l) in 37% of patients, with 2.7% of the study population being already treated with lipid-lowering drugs.
CONCLUSIONS: lipoatrophy with fat loss was associated with D4T and/or DDI containing regimens, whereas indinavir conferred an increased risk for fat accumulation disorders.
Copyright © 2000 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.
