AEGiS-13IAC: Reunion Island: Impact of HAART (Highly Active Anti-Retroviral Therapy) and epidemiological aspects of HIV cohort from 1995 to 1999.

13th International AIDS Conference

Durban, South Africa - July 9-July 14, 2000

Reunion Island: Impact of HAART (Highly Active Anti-Retroviral Therapy) and epidemiological aspects of HIV cohort from 1995 to 1999.

Int Conf AIDS 2000 Jul 9-14; 13:(abstract no. ThOrC744)

Gaud C, Poubeau P, Contant M, Hemery P, Dessart Y, Arvin Berod C, Beral JM
C. Gaud, CISIH de la Reunion, CHD Felix Guyon, Immunologie Clinique, Route de Bellepierre, 97405 ST Denis Cedex, REunion, Tel.: +262 905 560, Fax: +262 907 726, E-mail: immuno@chd-fguyon.fr

BACKGROUND: Reunion Island is an Overseas French Territory in the Indian Ocean (pop: 700.000) who benefits from the French Social Security system and of a full access to treatments registered in France. The first HIV case was registered in 1987. There are 2 types of patients: either locally contaminated or already infected immigrants.

METHOD: Retrospective analysis of the 1995-1999 local database (``DMI2'') who gathers the results from the 2 AIDS hospital units of the Island (St Denis / St Pierre).

RESULTS: - Epidemiological data: Cohort raised from 287 to 445 patients (+55%) with a great stability of the sex-ratio (men 70%, women 30%), the age distribution (average 35 years, 50% between 30 and 40) and the transmission modes (heterosexual 45%, homosexual 35%, injecting drug users 15%). - Clinical status: Total number of death fell from 25 (rate: 8,7%) to 10 (2.2%), while AIDS new declarations has been reduced from 36 (12.5%) to 11 (2.5%). The total number of hospitalizations have also been reduced from 131 (45.6% of the cohort, average length 15.2 days) to 46 (10.3%, average length 17.8 days). - CD4 status: In 1999, 41% of the patients have more than 500 CD4/mm³ (14% in 1995), 43% between 200 and 499 (43% in 1995) and 16% less than 200 (43% in 1995). - HAART treated patients rate raised from 1% in 1995, to 36% in 1996, 60% in 1997, 82% in 1998 and 97% in 1999.

CONCLUSION: During the 5 past years, Reunion Island experienced an increase of its cohort while HAART improved the average CD4 status plus the numbers and rates of death and hospitalization.

Keywords: AEGIS, Antiretroviral Therapy, Highly Active, HIV Infections, HIV Seropositivity, Acquired Immunodeficiency Syndrome, HIV-1, Heterosexuality, Homosexuality, Retroviridae, Retrospective Studies, France, Reunion, Indian Ocean, Human, Female, Male, therapy, Epidemiology, drug therapy
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