AEGiS-14IAC: AIDS transgenic mice treated with a combination of stavudine, lamivudine and indinavir develop cardiomyopathy with increased cardiac mass.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

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AIDS transgenic mice treated with a combination of stavudine, lamivudine and indinavir develop cardiomyopathy with increased cardiac mass.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. A10051)

Lewis W
Emory University, Atlanta, GA, United States

BACKGROUND: Long term side effects of highly active antiretroviral therapy (HAART) are more common because of increased AIDS survival and awareness of mitochondrial toxicity. HAART combinations have been implicated in cardiovascular changes of cardiomyopathy (CM) with increased left ventricle (LV) mass and decreased cardiac performance. This study examined the effects of combined stavudine, lamivudine and indinavir on LV mass and cardiac performance in AIDS transgenic mice (TG).

METHODS: A"2 by 2" protocol was created using 8 week old transgenic AIDS mice (hemizygous NL4-3~ gag/polxC57B/6) and age-matched wild type C57B/6 littermates (WT) with HAART treatment or with vehicle. HAART included 35 day of combined stavudine (~10 mg/kg/d)+lamivudine (0.8mg/kg/d)+indinavir (32 mg/kg/d) or vehicle. Before termination, mice underwent echocardiography as in the past. All values obtained were compared by ANOVA.

RESULTS: CM was found in TGs treated with HAART. LV mass normalized to body weight in TG+HAART was 1.69±0.11 compared to 1.31±0.06 for WT+HAART, 1.36±0.11 for TG+vehicle and 1.12±0.08 for WT+vehicle (p<0.01 for each comparison)

CONCLUSION: This specific HAART regimen administered to transgenic AIDS mice results in CM. Pathophysiological mechanism may relate to altered mitochondrial function as with other HAART regimens. Supported by R01 HL59798, HL63666 and HL65167.

Keywords: AEGIS, Stavudine, Lamivudine, Indinavir, Acquired Immunodeficiency Syndrome, Mice, Transgenic, Myocardial Diseases, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Echocardiography, Heart Ventricle, Case-Control Studies, Mice, Animal, diagnosis, ultrasonography

020707
A10051

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.