Involvement of vitamin D receptor gene polymorphisms in Tuberculosis infection of HIV-1 seropositive patients as an AIDS-related illness.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. A10061)
Fibla J, Barber Y, Nieto G, Velasco A, Rubio MC, Rubio M Dep. CMB, University of Lleida, Lleida, Spain
Host genetic factors play a crucial role in the susceptibility to infection and infectious disease progression. Vitamin-D Receptor (VDR) gene polymorphisms have been involved in the susceptibility to Tuberculosis and Leprosy and, recently, in human immunodeficiency virus type 1 (HIV-1) disease progression. We have studied vitamin-D Receptor (VDR) gene polymorphisms as a risk factor for Mycobacterium tuberculosis infection in seropositive HIV-1 (HIV+) patients. From a total cohort of 416 HIV+ patients, 112 developed AIDS (1987-CDC). From these, 66 (59%) developed Tuberculosis (TBC+) as an AIDS-related illness. VDR genotype distribution among TBC+ patients was similar to the distribution observed in the total cohort of HIV+ patients and to the one observed in AIDS patients without TBC. This seems to indicate that susceptibility to TBC infection in HIV+ patients does not correlates with VDR polymorphisms. TBC+ patients were grouped according to their clinical symptoms in two groups. The first group suffered pulmonary TBC (48 patients) and the second one non-pulmonary TBC (18 patients). Comparison of VDR genotype frequencies between these two groups showed statistically significant differences (P=0,001). In patients with pulmonary TBC, VDR genotypes were 6% VDR-BB, 67% VDR-Bb and 27% VDR-bb. In patients with non-pulmonary TBC, VDR genotypes were 39% VDR-BB, 22% VDR-Bb and 39% VDR-bb. In conclusion, VDR-BB genotype seems to be a risk factor for non-pulmonary tuberculosis as an AIDS-related illness.
Keywords: AEGIS, Receptors, Calcitriol, HIV-1, Tuberculosis, Polymorphism (Genetics), Acquired Immunodeficiency Syndrome, Genotype, HIV Infections, HIV Seropositivity, Disease Progression, Human, genetics
