AEGiS-14IAC: Study of the presence of autoantibodies in Cuban HIV-infected patients.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

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Study of the presence of autoantibodies in Cuban HIV-infected patients.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. A10067)

Alvarez AA, Molina RM, Veranes EV, Ponce de Leon OP, Luzardo CL
MINSAP, Habana, Cuba

BACKGROUND: The progression of HIV infection to AIDS is multi-factorial and it includes a great number of immunophatogenics mechanisms that participate exacerbating the immune disregulation. The production of autoantibodies (AAb) could offer significant examples of these mechanisms. In this work, we aim to evaluate the presence of AAb in HIV-infected patients, as well as, its relation with the Infection State and certain infectious and malignant diseases.

METHODS: 118 HIV+ and 100 HIV- individuals (control group) participated in this study. Rheumatoid factors (IgM, IgG, IgA), double-straded (ds) DNA antibodies (Ab), extractable nuclear antigens Ab, neutrophil cytoplasmic Ab, parietal cell Ab, smooth muscle Ab, collagen Ab, absolute CD4+ T lymphocytes count were determinated and data was taken from clinical histories in order to establish the Infection State of the patients.

RESULTS: A significant increase of the AAb frequency, significantly related with progression of HIV infection, was observed in HIV+ patients in comparison to the control group (p<0.005). A direct relation between the presence of AAb and the studied illnesses in HIV+ patients was found.

CONCLUSIONS: The results suggest a possible role for opportunist diseases as positive cofactors involved in AAb development during the course of HIV infection.

Keywords: AEGIS, HIV Infections, Autoantibodies, HIV Seropositivity, Acquired Immunodeficiency Syndrome, Antibodies, Antineutrophil Cytoplasmic, T-Lymphocytes, Human, pathogenicity, immunologyKWDaegis,hivinfections,autoantibodies,hivseropositivity,acquiredimmunodeficiencysyndrome,antibodies,antineutrophilcytoplasmic,t-lymphocytes,human,pathogenicity,immunology

020707
A10067

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.