AEGiS-14IAC: Newborns from HIV-positive mothers born at Panait Sarbu Obstetrics and Gynecology Hospital, Bucharest, Romania: prophylaxis of the perinatal HIV infecton; evolution during the newborn period.

14th International AIDS Conference

Barcelona, Spain - July 7-12, 2002

Newborns from HIV-positive mothers born at Panait Sarbu Obstetrics and Gynecology Hospital, Bucharest, Romania: prophylaxis of the perinatal HIV infecton; evolution during the newborn period.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10211)

Puia S, Toma AI, Cristescu C
Panait Sarbu, Obstetris and Gynecology Hospital, Bucharest, Romania

BACKGROUND: to assess the efficiency of the prophylaxis of the HIV transmission from mother to infant, to observe the characteristics of these neonates and their evolution during the newborn period.

METHODS: The population of the study consisted of the neonates born from HIV-positive pregnant women in our unit, between 01.01.1998-31.12.2001. The HIV positive pregnant women received a regime of 2 antiretrovirals (ARV) and were not allowed to breastfeed. The neonates received ARV prophylaxis as follows: Zidovudine(ZDV)( 1998), ZDV and Lamivudine (1999-2001), from birth to 6 weeks of age. There were followed: the HIV status of the mothers, the HIV viral load in the infants at 2 days, 1 month, 6 months, the mode of delivery. There were also noted: birth weight (BW), gestational age (GA), need for resuscitation at birth, death rate. The neonates were assigned to be Small or Appropriate for GA(SGA or AGA)(Lubchenco Charts). The variables were compared to those of the newborn population in our unit.

RESULTS: There were 12 neonates born from HIV positive mothers in the period studied (0.13% of the total of births). Five of them were delivered by cesarean section. Two infants died during the neonatal period. From the 10 survivors 6 were HIV negative (viral load), 4 were HIV positive, 3 of those cases received only ZDV prophylaxis. The incidence of SGA neonates was 50%, significantly greater than in the general newborn population (9,1% - p< 0.001%). 5 newborns needed resuscitation at birth.

CONCLUSIONS: The 2 ARV drugs regime for prophylaxis of HIV transmission decreased the incidence of HIV infection in infants born to HIV positive mothers to 12.5%(1/ 8 cases). The neonates from HIV positive mothers are a group at risk for becoming SGA and needing resucitation at birth, factors that make them candidates for a special surveillance during the newborn period

Keywords: AEGIS, Gynecology, Obstetrics, HIV Infections, Zidovudine, HIV Seropositivity, Mothers, Parturition, Viral Load, Ciprofloxacin, Lamivudine, Organotechnetium Compounds, Incidence, Delivery, Obstetric, Birth Weight, Hospitals, Romania, Technetium Tc 99m ciprofloxacin, Infant, Newborn, Human, Female, Pregnancy, Infant, prevention & control, surgery, therapy

020707
B10211