AEGiS-14IAC: Perinatal and pediatric HIV - observations and trends of vertical transmission and clinical features.

14th International AIDS Conference

Barcelona, Spain - July 7-12, 2002

Perinatal and pediatric HIV - observations and trends of vertical transmission and clinical features.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10222)

Raju MS, Vadrevu R, Vadrevu L, Saple DG
Mamatha Children Hospital, Kakinada, India

BACKGROUND: The present study was done over a perid of 4 years in a rural,semi-urban setting in southern part of India. The study focuses on Pediatric disease as a direct result of meternal HIV. The study was conducted in an area with poor hygiene and nutrition. Breast feeding into the 2nd and 3rd years of life is not uncommon. There is a general lack of awareness on MTCT among doctors and the public.

METHODS:24 consecutive children born to HIV +ve mothers were included in the study. Their clinical presentation and course of disease was noted with particular reference to infections. The outcome is compared with that of an ACTG076 cohort. The clinical details, mode of delivery and breast feeding status were particularly noted.

RESULTS: The longest surviving HIV +ve child is more than 10 years old in our study.[table: see text]

CONCLUSIONS: More than 90% of Pediatric infections are due to Materno Fetal Transmission.ACTG076 could effectively save 98% of Children. Respiratory Tract Infections are the commonest presenting feature. Proper vaccine against Resp. Pathogens for these children at risk can substantially reduce the morbidity. Both the prevention capability of ACTG076 and transmitted Percentage from Mother to Child were siginificantly high in our study.

Keywords: AEGIS, Disease Transmission, Vertical, HIV Infections, HIV Seropositivity, Breast Feeding, Parturition, Observation, Delivery, Obstetric, India, Female, Child, Human, trends, transmission, surgery

020707
B10222