AEGiS-14IAC: Ti: Drug resistance mediated by plasmid in Pseudomonas aeruginosa strains isolated from patients infected with HIV.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

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Ti: Drug resistance mediated by plasmid in Pseudomonas aeruginosa strains isolated from patients infected with HIV.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10232)

Gonzalez A, Salazar D, Palma SV
Instituto de Medicina Tropical Pedro Kouri, La Habana, Cuba

BACKGROUND: The bacteria resistance is a threat for the humanity, it's particularly important in patients because of the high frequency of opportunistic infections . The microorganisms develop many mechanism of resistance to the antibiotics, many of them are mediated by plasmids. We study 63 Pseudomonas aeruginosa strains isolated from patients with HIV infection, and to determinate if the antibiotic resistance were mediated by plasmid.

METHODS: The antibiotic susceptibility testing, determined by minimal inhibitory concentration, to carbenicillin, azlocillin, cefotaxime and ceftazidime and the plasmid analysis were performed to 63 Pseudomonas aeruginosa strains. Transconjugation experiment were executed to all resistant strains with plasmids.

RESULTS: Thirty- two (51%) of the 63 P aeruginosa strains were resistance at least to one of the four tested antibiotic. Sixty-one (97%) of the total strains had plasmids and their profiles were extremely homogeneous ( two plasmid of 1.3 and 1.6 MDa). The transconjugation event of the resistant strains to carbenicillin, azlocillin and ceftazidime was 100% effective, the conjugation to cefotaxime was failed.

CONCLUSIONS: These results suggest that in these strains the resistance to carbenicillin, azlocillin and ceftazidime were mediated by plasmid.

Keywords: AEGIS, Pseudomonas aeruginosa, Plasmids, HIV, Carbenicillin, Anti-Bacterial Agents, Ceftazidime, Drug Resistance, Microbial, Drug Resistance, Azlocillin, Cefotaxime, Drug Resistance, Multiple, Bacterial, Human, geneticsKWDaegis,pseudomonasaeruginosa,plasmids,hiv,carbenicillin,anti-bacterialagents,ceftazidime,drugresistance,microbial,drugresistance,azlocillin,cefotaxime,drugresistance,multiple,bacterial,human,genetics

020707
B10232

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.