AEGiS-14IAC: Determination of survival period from aids diagnosis to the time of death in patients from Evandro Chagas Hospital Research Center / Fiocruz. Rio de Janeiro - Brazil. 1986/2000.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

DonateNow
Print this article

Determination of survival period from aids diagnosis to the time of death in patients from Evandro Chagas Hospital Research Center / Fiocruz. Rio de Janeiro - Brazil. 1986/2000.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. C10668)

Gadelha AM, Campos DP, Grinsztejn BG, Veloso VG, Ribeiro SR, Bandeira TS, Valente JG
National School of Health Public-ENSP-FIOCRUZ, Rio de Janeiro, Brazil

OBJECTIVE: To compare the elapsed time starting from aids diagnosis to the occurence of death of patients from Evandro Chagas Hospital Research Center applying the definitions of case of aids according to CDC87, CDC93 and Brazilian Health Ministry -98's criteria.

METHODS: Of 1591 individuals HIV positive, registered during 1986/1999, a systematic aleatory sample of 392 individuals was selected. The length of survival was considered as the elapsed time from the date of aids diagnosis to the the time of death (failure). Censorship was established for the patients with following loss or that stayed alive until December of 2000 with censorship referred to last attendance date. The duration of the survival was determined by the procedure of Kaplan-Meier.

RESULTS: Of the 193 patients with aids, 92 (47,7%) died, 21 (10,9%) abandoned treatment, and 80 (41,4%) stayed alive until the end of the study. The median time of general survival varied according to the criteria adopted for definition of case of aids from 32 months [IC95%: 23; 40], for CDC-87; 41 months [IC95%: 28; 54], for CDC-93, and 85 months [IC95%: 49; 121] for MS/BR-98.

CONCLUSIONS: The relatively high survival observed in the three evaluated approaches of case definition can be explained, partly, by the fact that this cohort has been followed in a clinical research hospital, with high level of expertise in HIV/AIDS management and care. It was shown that the choice of the criteria for case definition interferes directly in the results obtained in the description of the survival of a cohort of individuals infected by HIV. The approach adopted by Brazil in 1998 (MS98), with larger sensibility, detects the cases in an earlier period and consequently presents better survival prognostic. Similar results of better prognostic for the most recent approaches were observed by authors who compared survival functions using different approaches for case definition (VELLA et al., 1994; LEMP et al., 1992).

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, Death, HIV Infections, Time, Centers for Disease Control and Prevention (U.S.), CD4 Lymphocyte Count, HIV Seropositivity, Survival, Survival Analysis, Survival Rate, Brazil, Human, Diagnosis, mortalityKWDaegis,acquiredimmunodeficiencysyndrome,death,hivinfections,time,centersfordiseasecontrolandprevention(uKWDsKWD),cd4lymphocytecount,hivseropositivity,survival,survivalanalysis,survivalrate,brazil,human,diagnosis,mortality

020707
C10668

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.