AEGiS-14IAC: Characteristics of patients who died since the use of highly active antiretroviral therapy (HAART) at Lyon University Hospitals, France.

14th International AIDS Conference

Barcelona, Spain - July 7-12, 2002

Characteristics of patients who died since the use of highly active antiretroviral therapy (HAART) at Lyon University Hospitals, France.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. C10679)

Baratin D, Marceillac E, Gayet A, Ritter J, Touraine JL, Trepo C, Chidiac C, Peyramond D, Fabry J, Vanhems P
Service d'Hygiene hospitaliere, Epidemiologie et Sante Publique, Lyon, France

BACKGROUND: The objective was to compared the characteristics of HIV infected patients who deceased at the hospital before and after the use of HAART.

METHODS: Data were collected prospectively with similar methodology between 1985 and December 31, 2000 in the Lyon University Hospitals. The data were recorded at the time of death or shortly after. HAART was prescribed after 1996. Multiple logistic regression was used to identify the variables associated to death <1996 compared to =<1996 based on their odd-ratio (OR) and their 95% confidence interval (95% CI).

RESULTS: A total of 1,171 deaths occurred before and 154 after the use of HAART. The decrease of deaths between 1993-96 and 1997-2000 was of -76%. After univariate analysis, the gender distribution was similar in the 2 periods (p=0.17), an AIDS event as cause of death (OR 0.6, [95% CI 0.3-1.0]), living in Lyon area (OR 2.6 [95% CI 1.6-4.1]) and the risk of being heterosexual among deceased persons compared to men who had sex with men (OR 3.1 [95% CI 2.1-4.7]) were associated with a death >1996. Deceased individuals were older after 1996 (mean: 45 years old) compared to before 1996 (mean: 39 years old, p<0.001). After adjustment for the infection duration and for age at HIV infection diagnosis, age at death (per 1 year increased) (OR 1.9 [95% CI 1.6-2.3]), the risk of being heterosexual among deceased persons compared to men who had sex with men (OR 3.7 [95% CI 2.3-6.1]) and living in Lyon area (OR 2.7 [95% CI 1.5-4.1]) were associated with the occurrence of death >1996. Conclusion After checking for recruitment and detection bias, the number of patients who died decreased dramatically since 1996. The proportion of heterosexual persons who died >1996 are greater compared to other populations. This result needs to be confirmed and explored. The higher age at death after 1996 after adjustment for the duration of HIV infection confirmed a longer survival since the use of HAART.

Keywords: AEGIS, Antiretroviral Therapy, Highly Active, HIV Infections, Acquired Immunodeficiency Syndrome, HIV Seropositivity, Heterosexuality, Death, France, Human, Male, utilization

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