AEGiS-14IAC: Epidemiological, clinical and immunological profile of Mexican HIV-infected children.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

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Epidemiological, clinical and immunological profile of Mexican HIV-infected children.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. C10692)

Munoz MR, Gavidia J, Tovar LP, Juarez M, Santos JI, Pavia-Ruz NM
Med. School-UNAM-General Hospital of Mexico, Mexico City, Mexico

BACKGROUND: This study describes epidemiological, clinical and immunological characteristics of Mexican-HIV infected children attending at a referral center for Pediatric-AIDS.

METHODS: Medical records of 54 patients with diagnosis of HIV/AIDS (CDC, 1994) in follow up at the AIDS-Pediatric Clinical (National University of Mexico-General Hospital) since 1997 were reviewed. Demographic, clinical and laboratory information was obtained.

RESULTS: In this report 23 of the cases were males and 31 females,53 of these subjects belonged to a low social-economic status and the majority with parents with antecedents of alcohol or drug addiction. In 30% of these cases one or both parents were already dead. Perinatal transmission occurred in 47(87%) cases,the mean age at the moment of HIV diagnosis was 34.8 months. Severe immunosuppression was present in 19(35%) of the children at the moment of diagnosis with an average of 242 CD4+ and 5 log10 of HIV-RNA. Chronic diarrhea, wasting syndrome, oral candidiasis, pneumonia, recurrent otitis media and parotitis were the commonest clinical presentation. 65.8% were hospitalized before the HIV-diagnosis. All the patients have received anti-retroviral treatment, 66.6% of the cases with protease inhibitors. After the anti-retroviral therapy started 5 patients have been hospitalized; four of these 54 children died. Currently the mean age of these patients is 69.2 months.

CONCLUSIONS: It is important the early identification of HIV infection to provide optimal therapy in infected children. Management of children with HIV/AIDS and their families is complex and requires a multidisciplinary team.

Keywords: AEGIS, HIV Infections, Acquired Immunodeficiency Syndrome, HIV Seropositivity, Candidiasis, Oral, Mexico, Child, Human, Male, Female, immunology, pathogenicityKWDaegis,hivinfections,acquiredimmunodeficiencysyndrome,hivseropositivity,candidiasis,oral,mexico,child,human,male,female,immunology,pathogenicity

020707
C10692

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.