14th International AIDS Conference


Barcelona, Spain — July 7-12, 2002

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[TITLE:] Perinataly exposed children to antiretrovirals (ARV) in Spain: a multicenter cohort study

[AUTHOR(S):] M.T. Garcia Fructuoso, J. Almeda, J. Casabona1, C. Fortuny2, J.T. Ramos, P. Ferrando, J.M. Hernandez Garcia, J.S. Jimenez, E. Munoz Galligo, F. Pulido, R. Rubio, J. Ruiz Contreras, I. Solis3, I. Bates, M.I. de Jose, J.M. Pena, S. Salas4, J. Beceiro, S. Onate5, J.M. Bertran, L. Garcia6, P. Del Barrio, E. Iglesias, B. Rubio7, C. Garaulet8, A.I. Gonzalez Espinola, F. Regidor9, M.D. Gurbindo, P. Miralles, M.A. Munoz, M.L. Navarro, P. Segovia10 D. Lopez Gay11 M.C. Munoz12 A. Mur13 M.A. Roa14 C. Rodrigo15 N.A. Salcedo, M.J. Santos16 E. Sanchez17

Int Conf AIDS. 2002 Jul 7-12;14:Abstract No. C10694

BACKGROUND: The use of ARV in developed countries have dramatically decrease vertical transmission rates. Nevertheless, some authors have suggested they may also produce side effects and metabolic toxicity. The objectives of this presentation are to describe the perninatally exposed children in Spain and the associated potential side effects.

METHODS: From 1/1/2000 an open multi-center prospective cohort collects data on all HIV+ mothers/newborns from 8 hospitals from Madrid (M) and 4 from Barcelona (BCN). Demographic, obstetrical, clinical and biological data are collected at delivery, at 2, 8, 12, and 24 weeks of follow-up and yearly since after. Until Nov. 2001, 159 and 175 mothers were recruited in M and BCN, contributing with 163 and 181 children (average of 0.22 and 0.71 person-years of follow-up in M and BCN respectively).

RESULTS: Exposure to ARV was as shown as follow:

Pregnancy+delivery+
newborn		 Pregnancy+
delivery		 Pregnancy+
newborn		 Delivery+
newborn		 Only pregnancy Only delivery Only newborn No treatment Unknown
BCN 143 1 10 11  2  1  7  6  0
M 93  0  5 52  0  0  6  0  7

Transmission rates, excluding undetermined, were 0.8% (95%CI=0.01-4.5) and 9% (95% CI=0.2-41.3) respectively for treated and not treated mothers. 38 children were diagnosed with congenital anomalies, either at birth or at follow-up, being most of them genitourinary. At 6 w. 33/213 and 67/146 shown respectively anemia or increase ac. lactic levels.

Conclusion: Although some malformations were identified, the small numbers do not allow for comparisons with the incidence in general population. Rule out an association of ARV exposure with some of the metabolic and clinical findings will require a standard protocol of extraction of samples and a larger follow-up population.

Presenting author: Isabel Solís Villamarzo

1CEESCAT, Hospital Universitai Germans Trias i Pujol, Centre d'Estudis Epidemiològics de la Sida a Catalunya, Hospital Universitari Germans Trias i Pujol, Carretera de Canyet s/n, 08916 Badalona, Spain.

2Hospital Sant Joan de Deu, Esplugues de Llobregat, Spain.

3Hospital Doce de Octubre, Madrid, Spain.

4Hospital La Paz, Madrid, Spain.

5Hospital Principe de Asturias, Alcala de Henares, Spain.

6Hospital U. Materno-Infantil Vall d'Hebron, Barcelona, Spain.

7Hospital de Getafe, Getafe, Spain.

8Hospital de Mostoles, Madrid, Spain.

9Hospital Fundacion de Alcorcon, Alcorcon, Spain.

10Hospital Gregorio Maranon, Madrid, Spain.

11Consejeria Sanidad CAM, Madrid, Spain.

12Hospital Sant Joan de Deu, Barcelona, Spain.

13Hospital del Mar, Barcelona, Spain.

14Hospital de Mostoles, Mostoles, Spain.

15Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

16Hospital Severo Ochoa, Leganes, Spain.

17Agencia d'Avaluacio de Tecnologia Médica. DSSS. Generalitat de Catalunya, Barcelona, Spain.

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C10694

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.