AEGiS-14IAC: AIDS mortality in a cohort in the HAART era from Sao Paulo city, Brazil.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

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AIDS mortality in a cohort in the HAART era from Sao Paulo city, Brazil.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. C10701)

Casseb J, Almeida A, Veiga AP, Bueno A, Gonsalez C, Araujo F, Brigido LF, Mendonca M, Santos N, Rodrigues R, Rossetti M, Zihlmann K, Duarte AJ
School of Medicine at USP, Sao Paulo, Brazil

Aim: to evaluate AIDS mortality in cohort where HAART is widely available in a South American City.

METHOD: An observational study, with retrospective and prospective components. Patients: A total of 231 adult HIV-1-infected subjects were recruited in the last 10 years at the Secondary Out-Clinic, Dermatology Dept. Hospital das Clinicas da FMUSP. AIDS defining events according to CDC AIDS classification, 1988.

RESULTS: Based on the CDC classification, 159 were asymtomatic, 46 had aids, and 24 had ARC at study entry. 29 (18%) of the asymptomatic subjects developed AIDS during the follow up, with 5 (3%) deaths. The 46 Aids cases at entry, 8 (17%) died during the follow up. Thus, a total of 13 people died of aids in this cohort and 26 people were lost in the mean of 52 months of follow up. 90% of the 218 survivor patients were on combined therapy (82% with 3 or more drugs, 8% with 2 drugs, and 10% without HAART). The most common cause of deaths were not due to the common opportunistic infections, but to HAART complications or neoplasias.

CONCLUSIONS: Overall, we noted a 5.6% mortality rate among our HIV-1-infected patients in the 10 years. As expected, people with AIDS at entry were 5 more likely to die during this period compared to asymptomatic subjects at entry (p=0.006). AIDS incidence among asymptomatic subjects was 20% (29 events/159 patients). These cases progressed to AIDS during the pre-HAART era (before 1996). Only one case progressed to AIDS after 1997 when HAART was widely available in our country. However, AIDS still cause death in our patients, mainly due to non-opportunistic diseases. Support: Fundacao Faculdade de Medicina da FMUSP

Keywords: AEGIS, Antiretroviral Therapy, Highly Active, Acquired Immunodeficiency Syndrome, Incidence, HIV-1, AIDS-Related Complex, Retrospective Studies, Brazil, Adult, Human, mortality, EpidemiologyKWDaegis,antiretroviraltherapy,highlyactive,acquiredimmunodeficiencysyndrome,incidence,hiv-1,aids-relatedcomplex,retrospectivestudies,brazil,adult,human,mortality,epidemiology

020707
C10701

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.