AEGiS-14IAC: Impact of Antiretroviral therapy in the incidence of infectious diseases in a cohort of HIV-Infected children in Mexico.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

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Impact of Antiretroviral therapy in the incidence of infectious diseases in a cohort of HIV-Infected children in Mexico.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. C10712)

Morales-Aguirre JJ, Villalobos-Acosta CP, Cashat-Cruz M, Avila-Figueroa CR, Gomez-Barreto D
Hospital Infantil de Mexico, Mexico city, Mexico

BACKGROUND: To evaluate the impact of antiretroviral (ARV) therapy in the incidence of infectious diseases (ID) in HIV-infected children attending our Pediatric AIDS Clinic.

METHODS: This cohort includes HIV-infected children followed from 1992 to 2000. The analysis include the measure of incidence rates (number of events per 100 patients year -py-) of ID according different ARV regimens (monotherapy, double therapy, three and four drugs regimens) stratified by CD4+ percentage (<15% and >15%) and its impact on hospital admissions during a period of four semesters.

RESULTS: 56 children with monotherapy were followed for a total of 75.9 py with an incidence of 407.02 py of ID. 54 children with double-therapy were followed for a total of 52.9 py with an incidence of ID of 323.14 py. 36 children with triple therapy were followed for a total of 43.5 py with an incidence of ID of 278.16 py. 76 children with a 4-drug regimen were followed for a total of 95.25 py with an incidence of ID of 274 py. The incidence of hospital admissions due to ID was 65.86 py in monotherapy, 43.46 py in double-therapy, 50.57 py in triple therapy and 31.49 py quadruple therapy. On the other hand, an increase on the incidence of hospital admissions was observed with monotherapy from the first to the forth semester (76.5 py to 83.9 py ). However, on the other regimens a substantial decrease was observed (from 74.75 py to zero in double-therapy, 92.3 py to zero in triple-including IP and 55.38 py to zero events in quadruple therapy). In the groups of children with CD4+<15% the incidence of ID were of 455.32 py in monotherapy compare to 472.25 py with quadruple therapy however, for children with CD4+ >15% the incidence of ID was 349.99 py in monotherapy compare to 176.56 py with quadruple therapy.

CONCLUSIONS: The implementation of ARV therapy at our clinic was associated with substantial declines in the rates of ID and hospital admissions.

Keywords: AEGIS, Incidence, HIV Infections, HIV Seropositivity, Communicable Diseases, Antiretroviral Therapy, Highly Active, Drug Therapy, Combination, Hospitalization, Mexico, Child, Human, therapy, epidemiology, pathogenicity, drug therapyKWDaegis,incidence,hivinfections,hivseropositivity,communicablediseases,antiretroviraltherapy,highlyactive,drugtherapy,combination,hospitalization,mexico,child,human,therapy,epidemiology,pathogenicity,drugtherapy

020707
C10712

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.