AEGiS-14IAC: Impact of antiretroviral therapy in the natural history of HIV infection in children.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

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Impact of antiretroviral therapy in the natural history of HIV infection in children.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. C10722)

Marques HH, Aquino MZ, Sato HK, Hamamoto LA
Sao Paulo University Medical School, Sao Paulo, Brazil

BACKGROUND: Since the introduction of antiretroviral therapy mortality and morbidity rates have been decreasing among adults with HIV infection. The aim of this study is to provide information relating therapeutics and outcome issues in a cohort of Brazilian HIV-infected children followed since 1985 to 2000.

METHODS: Patient-based, longitudinal study with data collected by the Register for HIV Infection in Children at Sao Paulo State University Center. Data was assessed according to time of HIV-related death (survival analysis) and grouped by predominant type of antiretroviral therapy in sequential periods: A) no specific treatment (1986-1990) B) monotherapy (1991-1995), C) double or triple therapy (after 1996). The variables analyzed were hospitalization/patient-year and lethality/patient-year in the groups described.

RESULTS: A total of 226 perinatally HIV-infected children admitted between 1985 and 2000 were included for evaluation. Hospitalization/patient-year rate decreased from 22/27 (81,5%), 174/232 (75%) and 145/679 (21,3%) from the group A to C respectively. Most prominent changes were observed in lethality/patient-year rate varying from 9/27 (33,3%), 38/232 (16,3%) and 26/679 (3,8%) in the same sequential period considered above, respectively. Kaplan-Meyer curves were used to estimate survival time according to type of therapy. Data are described bellow: [table: see text]

CONCLUSIONS: Survival and morbidity of perinatally HIV-infected children are affected and improved as a result of the introduction of antiretroviral therapy.

Keywords: AEGIS, HIV Infections, Antiretroviral Therapy, Highly Active, HIV Seropositivity, Drug Therapy, Combination, Survival Analysis, Longitudinal Studies, Brazil, Child, Human, Adult, therapy, drug therapyKWDaegis,hivinfections,antiretroviraltherapy,highlyactive,hivseropositivity,drugtherapy,combination,survivalanalysis,longitudinalstudies,brazil,child,human,adult,therapy,drugtherapy

020707
C10722

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