AEGiS-14IAC: A multi-centre comparison of HIV-relevant data to establish a basis for a virological quality management.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

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A multi-centre comparison of HIV-relevant data to establish a basis for a virological quality management.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. E11424)

Knechten H, hn C, Yun-Kremer MO, Ehret R, Braun P, Knickmann M
PZB, Aachen, Germany

BACKGROUND: No data-supported basis for general practitioners exists on virological control and antiretroviral therapy (ART) efficacy. We compared ART regimens and successes in HIV-1 positive patients (pts) in order to build such a data-supported basis.

METHODS: This multi-centre (14 HIV-specialised medical centres) evaluation analyzed HIV therapy relevant data obtained in the first three month of 2000/2001, retrospectively. Following parameters were ascertained: the lowest HIV-1 viral load (vL), CD4+ cell count, number and composition of different ART. A successful therapy was defined as a vL ≤ 50 cps/ml.

RESULTS: Data from 13 centres from the first quarter of 2000 and the complete data from the first quarter of 2001 were available. Mean HIV-RNA (±SD) was 4.3 log ±5.1 log and 4.2 log ±4.8 log in the first quarters of 2000/2001, respectively; mean CD4+ cell count was 520 and 534 cells/ é l. [table: see text] 1 calculated from total absolute patients 2calculated from total absolute ART 3calculated from total absolute corresponding regimen 4 no data of ART were available by 52 pts with a vL≤ 50cps/ml *Pts receiving 1 PI + Ritonavir as a booster are included

CONCLUSIONS: There were changes in the ART-regimens during the time of evaluation. In 2000, most pts were treated with a PI regimen. 2001, most patients were more successfully treated with a combination of NRTI + NNRTI. This best achievement may be due to the relative short availability of this substance-class. No adequate virological response could be seen in some pts who began a new regimen recently before the blood sampling. This data could improve quality management for Medical centres.

Keywords: AEGIS, HIV, HIV Infections, CD4 Lymphocyte Count, Viral Load, HIV-1, Antiretroviral Therapy, Highly Active, HIV Protease Inhibitors, Anti-HIV Agents, Ritonavir, HIV Seropositivity, Human, virology, organization & administrationKWDaegis,hiv,hivinfections,cd4lymphocytecount,viralload,hiv-1,antiretroviraltherapy,highlyactive,hivproteaseinhibitors,anti-hivagents,ritonavir,hivseropositivity,human,virology,organization&administration

020707
E11424

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.