|
14th International AIDS ConferenceBarcelona, Spain — July 7-12, 2002 |
Int Conf AIDS. 2002 Jul 7-12;14:Abstract No.
BACKGROUND: The lipodystrophy syndrome (LPDS) is being described in HIV-infected children.It includes clinical and metabolic disorders. Etiology is considered as multifactorial,it could be related with HAART (High Active Antiretroviral Treatment). Lactic acidosis, related to mytocondrial toxicity by antiretroviral treatment (ART), is poorly described in children.
Objectives: To assess the lipodystrophy prevalence and metabolic disorders (lipids, glucose and lactic acid) in a population of HIV-infected children treated. To correlate it with epidemiological parameters, clinical-immune status, viral load and HAART.
METHODS: A cross-sectional study was performed in 56 HIV-infected children.We analysed epidemiological parameters (age, sex, family history), clinical and immune status, viral load, ART and HAART-including protease inhibitors (PI)- lengths. Presence of clinical lipodystrophy and anomalies at lipid, glucose and lactic acid levels were evaluated.
RESULTS: We studied 56 HIV-infected children with ages between 21 mths and 18 yrs (mean 9,5 yrs); 30 (54%) boys and 26 (46%) girls. LPDS was present in 14 patiens (25%): 7 lipohypertrophy, 2 lipoatrophy and 5 mixed pattern. 49 patients (87,5%) followed an ART(mean length 4 yrs), 43 (77%) were treated with HAART (mean length 3,6 yrs). Among patients with clinical LPDS, hypertriglyceridemia (>130 mg/dL) was present in 71,4% and hypercholesterolemia (>180 mg/dL) in 57%. Significant associations between LPDS and age, ART and HAART lengths and hypertriglyceridemia (p=0.000, 0.002, 0.016 and 0.000) were found.
CONCLUSIONS: Our LPDS prevalence was 25%. It was higher in children over 11 years (50%). Lipohypertrophy was the commonest pattern (50%). Presence of LPSD was not related with sex, family history, clinical and immune status, and viral load.Further, ART and HAART lengths or LPDS were not related with lactic acid levels. LPDS presence was significantly associated with higher age, ART and HAART lengths,and hypertriglyceridemia.
Presenting author: Ana Sanchez-Torres
1La Paz Children Hospital, C/ Espronceda, 3. 2°B, 28003, Madrid, Spain.
2La Paz Hospital, Madrid, Spain.
020708
MoOrB1134
Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.
