AEGiS-14IAC: Continued benefit from highly active antiretroviral therapy: trends in AIDS-related opportunistic illnesses in a public health care system, 1990-2001.

14th International AIDS Conference

Barcelona, Spain - July 7-12, 2002

Continued benefit from highly active antiretroviral therapy: trends in AIDS-related opportunistic illnesses in a public health care system, 1990-2001.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. ThOrC1443)

Cohn DL, Breese PS, Burman WJ, Lopez DL, Barth BL, Rietmeijer CA, Davidson AJ
Denver Public Health, Denver, United States

BACKGROUND: The use of highly active antiretroviral therapy (HAART) has had a dramatic effect on HIV-related morbidity and mortality, but there are concerns that the benefits of HAART may be waning because of drug resistance, side effects, and nonadherence. We evaluated the incidence of selected opportunistic illnesses (OIs) and mortality in all patients in a public health care system in the pre- and post-HAART era.

METHODS: Since 1990, Denver Health, an integrated public health care system and largest HIV care provider in Colorado, has recorded all HIV-related OIs and mortality using CDC's HIV/AIDS Reporting System (active surveillance) and Adult Spectrum of Disease Study (6-month chart review).

RESULTS: Of 4118 HIV-infected patients, incidence-density of OI-specific first episodes and mortality (per 100 person-years) from 1990 to 2001 was: [table: see text] [table: see text]

CONCLUSIONS: From 1990 to 2001, there was a decrease of 79-97% for selected OIs, and 73% in mortality. These decreases were greatest between 1996 and 1997 (data not shown) and were sustained through 2001. We found no evidence of waning clinical benefit after the implementation of HAART.

Keywords: AEGIS, Antiretroviral Therapy, Highly Active, HIV Infections, Incidence, Delivery of Health Care, Centers for Disease Control and Prevention (U.S.), Acquired Immunodeficiency Syndrome, Colorado, Adult, Human, trends, Economics, Mortality

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