[WeOrC1379] HIV main risk factor for mother-to-child HCV transmission

14th International AIDS Conference

Barcelona, Spain — July 7-12, 2002

[TITLE:] HIV main risk factor for mother-to-child HCV transmission

[AUTHOR(S):] E Mariné Barjoan¹, A Bongain², A Berrebi³, H Haas⁴, J Tricoire⁵, F Monpoux⁶, C Laffont⁷, J Izopet⁸, A Tran⁹, C Pradier¹⁰

Int Conf AIDS. 2002 Jul 7-12;14:Abstract No. WeOrC1379

BACKGROUND: Mother-to-child HCV transmission is the most important mode of infection among children. It is essential to know the factors involved in the transmission in order to implement preventive measures to reduce the risk of contamination for children.

METHODS: Multicenter study in Southern France (Alpes Maritimes, Haute Garonne, Hérault departments) that concerns HCV positive women followed during their pregnancy at one of the public hospitals and who gave their consent to be HCV-tested. Mother-to-child HCV transmission was analysed via questionnaire, laboratory and virological data, in order to determine maternal, child and delivery characteristics.

RESULTS: Among 283 HCV positive women followed during their pregnancy, 261 (92%) have been included. So far, 144 (55%) mother-child pairs have completed six months' follow-up after birth. Main characteristics are : mean age 33 years, first pregnancy for 76%, living with a regular partner 86%, ALAT at delivery 37 UI/ml and PCR positive in 63%; 27% of women are HIV co-infected, 54% have a past history of IVDU and 19% of blood transfusion; 35 (24%) of the women included discovered their HCV status at the time of inclusion. Among them, 14 (40%) were suspected to be contaminated by others routes than IVDU or blood transfusion. Mother-to-child transmission rate at six months' follow-up was 4.9% (95%-CI[1.9%-9.8%] (7 children); 6 of them were born to HIV-infected women (15.4%, 95%-CI [5.9-30.5]) and 1 to a HIV-negative woman (1.0%, 95%-CI[0.03-5.5]). Among the 6 HCV-infected children born to HIV-infected women, 4 (67%) were delivered by elective caesarean before membrane rupture. No child was HIV-infected.

CONCLUSIONS: HIV-infection appears to be the main risk factor for HCV mother-to-child transmission. In HIV-infected mothers, caesarean does not to prevent HCV mother-to-child transmission. Study financed by The National Agency for AIDS Research. France.

Presenting author: E Mariné Barjoan

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1Fédération des Maladies Transmissibles. CHU Nice, Fédération des Maladies Transmissibles, Hôpital de l'Archet, CHU de Nice, BP 3079, 06202 Nice cedex 3, France

2Service de Gynecologie Obstetrique, Hôpital de l'Archet 2, CHU de Nice, Nice, France

3Services de Gynecologie Obstetrique, Hôpital de la Grave, CHU de Toulouse, Toulouse, France

4Service de Pediatrie, Hôpital de l'Archet 2, CHU de Nice, Nice, France

5Service de Pediatrie, Hôpital Purpan, CHU de Toulouse, Toulouse, France

6 Service de Pédiatrie. CHU Nice, Nice, France

7 Laboratoire de Virologie. CHU Nice, Nice, France

8Laboratoire de Virologie.CHU Toulouse, Toulouse, France

9Fédération des Maladies de l'Appareil Digestif. CHU Nice, Nice, France

10Fédération des Maladies Transmissibles.CHU Nice, Nice, France

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