[WePeB5831] Factors related to adherence to HAART in patients in usual clinical follow-up

14th International AIDS Conference

Barcelona, Spain — July 7-12, 2002

[TITLE:] Factors related to adherence to HAART in patients in usual clinical follow-up

[AUTHOR(S):] A Tuldra, C R Fumaz, M J Ferrer, A Ballesteros, A Bonjoch, A Jou, E Negredo, J Romeu, G Sirera, C Tural, B Clotet¹, R Bayes²

Int Conf AIDS. 2002 Jul 7-12;14:Abstract No. WePeB5831

BACKGROUND: Correct adherence (ADH) to antiretroviral treatments (HAART) depends from a lot of factors. Some of them have been described in controlled studies but information about this issue in patients in usual clinical follow-up is scarce.

METHODS: In a retrospective observational descriptive study, information contained in 1713 follow-up visits about ADH was analyzed: % of self-reported ADH, intake conditions ADH, week of treatment, effort to follow HAART, self-perceived capability to follow treatment (SC), health status believes, confidence in current HAART, satisfaction with physician attention, lipodystrophy presence and worries related to it, work state, current partner existence, family or near-people informed about HIV status, worry about viral load (VL) changes, quality of life, support to follow HAART, adverse events (AE), AE duration, CD4, VL, opportunistic infections, emotional status (POMS questionnaire). A logistic regression analysis was performed to determine variables related to good ADH (³95%).

RESULTS: In the univariate analysis, ADH was related to intake conditions ADH (p<0.001), less effort to follow HAART, (p= 0.009), less SC (p<0.001), higher confidence in HAART (p=0.02), lipodystrophy (p=0.0013), to have a job (p=0.024), family (p=0.057) or near-people (p=0.03) informed, AE duration (p=0.02), higher CD4 recount (p=0.03), less VL (p=0.004), and better emotional status (p<0.001). In the multivariate analysis, variables related to ADH were: intake conditions ADH (p<0.001), less SC (p<0.001), less VL (p=0.017), and better emotional status (p<0.05).

CONCLUSIONS: As observed in previous studies, the relation between ADH and VL is confirmed. Personal variables as SC and emotional status might be specially useful to monitor ADH in clinical practice.

Presenting author: A Tuldra

1 Fundació Lluita SIDA-Univ Hosp Germans Trias i Pujol, Badalona, Spain.

2 Psychology Dept. Universitat Autònoma de Barcelona, Bellaterra, Spain.

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