14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

Cite as: Int Conf AIDS. 2002 Jul 7-12;14:Abstract No. xx

Track B: Clinical Sciences and Care
Abstract Numbering & Table of Contents

The abstracts have been given reference numbers as follows:

  • MoOrA1001
  • TuPpB2001
  • WePeC3001
  • ThOr245
  • LbOr17

Mo = Monday, Tu = Tuesday, We = Wednesday, Th = Thursday, Lb = Late-Breaker
Or = Oral Abstract Presentation
Pp = Poster Presentation
Pe = Poster Exhibition

Print only abstracts.

The 2,807 printed only abstracts are identified by their special numbering, which begins with a letter A-G (signifying the track) and is followed by a 5 digit number.

Tracks

Track A: Basic Sciences

This track will highlight all aspects related to HIV structure and replication and its regulation as well as host immune responses. Drug discovery, research on vaccines and development of animal models will also be addressed. This track will be of particular interest to laboratory researchers and clinicians involved in basic principles of HIV.

Track B: Clinical Sciences and Care

This track will highlight the characteristics and clinical course of HIV infection and related diseases, the evaluation of diagnostic and therapeutic tools, including resistance tests, and the clinical trials and cohort studies which provide the scientific basis for therapeutic interventions and care. This track will be of particular interest to investigators and clinicians participating in clinical research related to HIV-1 infection.

Track C: Epidemiology

This track will highlight the description and dynamics of the evolving HIV/AIDS epidemic, the natural history and the burden and impact of HIV infection in the world. Presentations in this track will be based on both observational and experimental studies, as well as on surveillance methods. This track will be of particular interest to public health professionals, academic researchers in epidemiology or related areas, and people using epidemiologic parameters in support of HIV/AIDS programs and policies.

Track D: Prevention Science

This track will highlight the design, testing and evaluation of HIV preventive interventions for both HIV- and HIV+ persons, including those interventions addressing early diagnosis, co-factors, and risk and harm reduction. This track will also address methodological and ethical issues in HIV prevention research. This track will be of particular interest to those involved in advancing multidisciplinary (biomedical, behavioral, and social sciences) investigations of HIV prevention.

Track E: Social Sciences

This track will highlight the scientific investigation of behavioral, social, economic, political and cultural mechanisms underlying risk of, and protection from, HIV infection and AIDS, access to and continuity of care and treatment, and will assess the psychological and social impact of the epidemic on individuals, communities and society as a whole. This track will be of particular interest to people concerned with the social and economic dimensions of the epidemic who are using concepts, approaches, and frameworks derived from the well-established body of knowledge of social sciences and the methodological tools of scientific research.

Interventions, Program Implementation and Policy

Tracks in the Interventions, Program Implementation and Policy component (Tracks F and G) will present, discuss, and share lessons learned about programs, activities, and policies related to HIV/AIDS prevention, care, treatment, support, and impact mitigation. Component key aims are to improve understanding of factors contributing to successful and unsuccessful outcomes, to identify approaches to overcome barriers to implementing, sustaining, and scaling up effective responses to HIV/AIDS, and to develop and strengthen effective strategies for action.

Track F: Interventions and Program Implementation

This track will highlight planning, implementation, monitoring and evaluation of activities/programs for HIV/AIDS prevention; treatment, care and support; and impact mitigation. Sessions will focus on sharing lessons learned.

Track G: Advocacy and Policy

This track will highlight description, analysis and lessons learned in HIV/AIDS-related advocacy and policy. The track will address both HIV/AIDS specific advocacy and policy, and related areas such as gender, human rights, economic development, and trade and patents.


Many individuals would use instant home HIV tests if approved in the U.S.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10165)
Phillips KA, Chen J;;; University of California, San Francisco, San Francisco, United States
BACKGROUND: Home collection tests, which allow users to obtain results 3-7 days after sending samples to a laboratory, are currently available in the U.S. However, home tests that would provide instant results are not available and are not under consideration for FDA approval. We examined willingness to use instant hom


HIV seroprevalence study among women pregnancy in Sao Paulo city, Brazil.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10166)
BiancoRosana RD, DantasStella SB, KenjiGreicy GK, CremonesiGinalda GC, BismarckZulmira ZA, CismottoOdomeria OC, MesquitaFabio FB;;; Municipal Institution, Sao Paulo, Brazil
Background - The HIV seroprevalence in women in Sao Paulo is one of the highest in Brazil and HIV testing is recommended for all pregnant women. In order to control the mother-to-child transmission, the Brazilian Ministry of health estabillished in july 1996 a special program to reduce vertical transmission. Training p


Projecting performance measures and costs of alternative HIV rapid test strategies.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10167)
Shields JM, Mwinga AZ, Nelson DB;;; CDC/GAP - Zambia, Lusaka, Zambia
BACKGROUND: Increasing numbers of HIV Rapid Tests present testing protocol optimization challenges to researchers and program specialists. The number of possible protocols exceeds even the combinations of the available tests. The many calculations required to evaluate alternatives mitigate against making analytically b


Performance of the HIV-1 +O/HIV-2 assay on the Bayer ADVIA Centaur®.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10168)
Freeman J, Patel M, Baker L;;; Bayer Corporation, Tarrytown, United States
A new assay is under development for anti-HIV types 1, 2 and subtype O has been developed for the ADVIA Centaur®, a fully random access immunoassay analyzer. The assay utilizes a two step, two wash protocol in which patient specimen IgG and/or IgM is HIV antigen linked to paramagnetic microparticles in the first ste


Detection of cytomegalovirus in HIV-1 infected cases.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10169)
Siritantikorn S, Tanterdtam J, Anekthananont T, Techasathit W, Ratanasuwan W, Puthavathana P;;; Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
BACKGROUND: Human cytomegalovirus ( CMV ) is an important opportunistic infection in HIV infected persons. CMV viremia and CMV load in HIV 1-infected cases and in acquired immunodeficiency syndrome (AIDS) patients will be investigated. METHODS: EDTA-blood samples used for detection of CMV were collected from 31 asympto


Putting in place blood algorithm based on a speedy tests for aids screening.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10170)
Kouette Epouse Lontouo AC, Nerrienet, Ngassam A, NKamse P;;; Bafoussam, Cameroon
ISSUE: in 1998, a report from West Cameroon health centres said that a dozen of speedy tests have been performed. Prices of those tests varied from one centres to other. No guarantee for wholesome blood transfusion. This conduct us to carry a study aiming at identifying 2 speedy tests ( sensitive, trustworthy, easy to


Low technology predictors of mortality for resource-poor settings: association of total lymphocyte count (TLC) and white blood cell count (WBC) with mortality in HIV-1-infected children.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10171)
Mofenson LM, Harris DR, Moye J, Bethel J, Korelitz J, Nugent RN, Meyer W;;; PAMA/NICHD/NIH, Rockville, MD, United States
BACKGROUND: CD4 count and HIV RNA are useful for prognosis and to evaluate antiretroviral (ARV) response in resource-rich settings, but too complex and expensive for many resource-poor settings. We evaluated predictors of mortality applicable to such settings in HIV-infected children in the NICHD IVIG Clinical Trial, a


Mean cell volume changes in hiv positive patients taking nucleoside reverse trascritase inhibitors: A surrogate marker for adherence.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10172)
Steele RH, Keogh GL, Quin JW, Fernando SL, Stojkova V;;; Bigge Park Centre, Liverpool, Australia
BACKGROUND: Poor adherence is an important factor in drug treatment failure. Monitoring adherence in a clinical setting is practically difficult. This study assessed the utility of changes in mean red cell volume (MCV)as a surrogate marker of adherence to nucleoside analogues in combination antiretroviral therapy. METH


Utility of Cerebrospinal fluid (CSF) examination as an essential aid in the diagnosis of CNS-HIV disease in a resource -- limited setting.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10173)
Prabhu VA;;; Institute of STD.Madras Medical College, Chennai, India
BACKGROUND: Increasing frequency of neurological complications leads to devastating neurologic disease. In a resource-limited setting with scarce access to specific tests and non invasive radiological services-CT scan/MRI,CSF examination provides the diagnostic inputs and guides therapy in HIV seropositive patients wit


Monitoring and diagnostic tools for the management of antiretroviral therapy in resource-poor settings.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10174)
Gonsalves GS, Cheng B;;; Gay Men's Health Crisis, New York, United States
BACKGROUND: In November 2001, Gay Men s Health Crisis and Project Inform sponsored a scientific workshop to identify: the role of laboratory vs. clinical monitoring in the management of antiretroviral therapy (ART) in the developing world; the role of current tools in use or in development, in the diagnosis of HIV infe


Comparison of CD4 levels with absolute lymphocyte counts in clients with HIV at JCRC - Uganda.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10175)
Okiror J, Otim T, Segonga P;;; Medical Technologist, Kampala, Uganda
BACKGROUND: To determine correlation between CD4 levels with absolute lymphocyte counts in clients who were seen for the first time at JCRC. In third world countries such as Uganda where flowcytometry is not readily available, it is advocated that a white cell count of less than 1000/cm predicts CD4 levels of less than


Hemi-nested PCR by using TGR1E sequence for detection of Toxoplasma gondii in blood samples from HIV-infected patients in the city of Sao Paulo, Brazil.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10176)
Gomes VM, Hirata RD, Hirata MH, Yamamoto YI, Soares CL, Kanashiro CK, Daher MA, Souza AM, Yokio S;;; Clinic and Toxicology Analysis Department of The School of Pharmaceutical Sciences of The University of Sao Paulo, Sao Paulo, Brazil
Introduction: The reactivation of latent T. gondii cysts is one of the most common opportunistic infection in patients with AIDS. METHOD: In this study, we have developed a hemi-nested PCR (Henes-PCR) procedure for detection of T. gondii in blood samples of 38 seropositive and 21 seronegative individuals. DNA was extra


Outcome of baseline viral resistance testing in newly diagnosed human immunodeficiency virus infected patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10177)
Harry TC, Karas A, Elumogo NT, Loveday C;;; Bure Clinic, James Paget Hospital, Great Yarmouth, United Kingdom
BACKGROUND: Benefit has been shown in the utility of viral resistance testing in virological failure. Primary resistance to most classes of antiretroviral drugs is now increasingly reported. The aim of this study was to evaluate the outcome of viral resistance testing in newly diagnosed HIV/AIDS patients seen from 1/1/


GART Rounds: a model for group interpretation of genotypic resistance test results.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10178)
MacVeigh MS, Parrish DA;;; Multnomah County Health Dept, Portland, OR, United States
BACKGROUND: Interpretation of GART assay results is believed affected by experience, expertise and opinions of the care provider. To help gain experience and share opinions, a system of group reviews of GART results was established at our county HIV clinic, where 600 patients are managed by 4 providers. The initial goa


Genotype testing practices in a HIV clinic in New York City.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10179)
Suh JS, Ristau PE, Warford R, Sharp V;;; St. Luke's-Roosevelt Hospital, The Center for Comprehensive Care, New York City, New York 10025, United States
Backgound: Testing for HIV drug resistance has become an important adjunct to guide antiretroviral management. Current guidelines (Department of Health and Human Services and IAS-USA) recommend incorporating resistance tests for management of patients (pts) experiencing failure on antiretroviral (ARV) therapy. Despite


Prevalence of HIV-1 resistant to antiretroviral drugs in Thailand.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10180)
Jenwitheesuk E, Watitpun C, Pongthanapisith V, Vibhagool A, Sungkanuparph S, Chantratita W;;; Ramathibodi Hospital, Bangkok, Thailand
BACKGROUND: Prolonged treatment with antiretroviral drugs results in the selection of HIV-1 variants with mutations conferring resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTI and NNRTI) or to protease inhibitors (PI). METHODS: This study report on the frequency of genetic mutation ass


Performance of the TRUGENE HIV-1 genotyping assay in global clinical trials.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10181)
Tau KR, Romack JC, Crose GA, Gilonske KD, Kapke GF;;; Covance CLS, Indianapolis, United States
With increasing emerging resistance to antiretroviral therapies, HIV-1 genotyping is a powerful new technology for use in drug development and clinical trials. The performance of the TRUGENE HIV-1 genotyping assay in a central laboratory was determined. The bi-directional sequence of the protease and reverse transcript


Antiretroviral resistance profile in HIV1 infected pregnant women: a french prospective study in 93 patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10182)
Ciraru-Vigneron N, Mazeron MC, Lefevre V, Colonna R, Chaix ML, Burgard M, Rouzioux MC;;; CHU - Lariboisiere-Saint Louis, Necker - Universities of Paris VII &V, PARIS, France
To prevent materno fetal transmission (MFT) HIV1 infected pregnant women (HIPW) of developed countries received antiretroviral treatment (ART) and MFT rate is 1% to 2% although most ART are still given on a probable effective basis. In HIPW few data are available on HIV1 drug resistance profile, therefore the aim of ou


Clinical impact of HIV genotypic resistance testing: comparison between two methods.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10183)
Setti M, Bruzzone B, Murdaca G, Gota F, Marasso P, Bacilieri S, Icardi G;;; University of Genoa, Genoa, Italy
OBJECTIVE: to assess the difference of impact on clinical outcome between two methods of testing genotypic drug resistance in a cohort of HIV+ subjects undergoing HAART. METHODS: 32 HIV+ naive (12) or treatment-failed (20) compliant individuals sequenced (TruGene-Visible Genetics) before starting a three-drug protocol


Phenotypic resistance testing for RT inhibitors with a biochemical method - problems and potential solutions.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10184)
Obermeier MJ, Opgen-Rhein MH, Huber C, Eberle J;;; Max von Pettenkofer Institut LMU Muenchen, Munich, Germany
BACKGROUND: Viral resistance to ART is a common cause for therapy failure. Different types of assays have been developed to prove susceptibility of HIV strains to various drugs: Genotypic, phenotypic cell culture based, and biochemical resistance tests. METHODS: The ultra-sensitive RT assay of H. Pyra et al. (PNAS 91:


Prevalence and pattern of genotypic drug resistance among HIV Patients in Hong Kong.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10185)
Yam WC, Wong KH, Lee SS;;; Queen Mary Hospital / The University of Hong Kong, Hong Kong, China
BACKGROUND: Presence of genotypic mutations that promote drug resistance has been associated with failure of anti-retroviral therapy. We examined the prevalence of mutations associated with resistance among patients enrolled in a clinical cohort in Hong Kong . METHODS: Plasma of patients were collected for HIV genot


HIV genotyping drug resistance virco vs visible genetics methods evaluation.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10186)
Swantee C, Fearon M, Sandstrom P, Choi KW, Major C;;; Ontario Ministry of Health and Long-Term Care, Toronto, Canada
BACKGROUND: To compare the results of HIV genotyping drug resistance testing using the Virco Virtual Phenotype method and the Visible Genetics TRUGENE HIV-1 Genotyping Systems. METHODS: Thirty-one plasma specimens were selected from naive (17) and ART experienced(14) patients. HIV viral load ranged from 1000 - >500,000


HIV-1 resistance testing using a commercial kit can be performed reliably without prior sequencing experience.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10187)
Debaisieux L, Laethem KV, Vandamme AM, Schrooten Y, Delforge ML, Liesnard C;;; Hopital Erasme-Universite Libre de Bruxelles, Bruxelles, Belgium
OBJECTIVE: To compare 1) sequencing results obtained with a commercial kit in a lab without experience in sequencing (Lab A) with those of an experienced lab (Lab B), 2) the drug resistance reports generated. METHODS: 16 plasma samples already analyzed by Lab B were retrospectively tested by Lab A. Lab A used the TRUGE


Building up a national network for HIV genotyping test in Brazil.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10188)
Dantas MC, Lima JN, Vitoria MA, Teixeira PR, Costa-Filho RB, Grangeiro AL;;; STD/AIDS Program - Ministry of Health (MOH), Brasilia, Brazil
ISSUES: PLWA in Brazil have been an universal access to ART since 96 and 113000 HIV+ individuals was on treatment in the Public Health System in Dec. 2001. However, as have been occurred in developed countries, the wide use of the ART promotes the emergence of HIV resistant strains that can commits the effectiveness of


Simple Culture Assay for isolation and resistance assessment of clinical HIV-1 isolates.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10189)
Mukadi BK, Delferiere N, Bodeus M, Goubau P;;; Universite Catholique de Louvain, Brussels, Belgium
We developed a simple method giving a high isolation rate of patient HIV-1 strains and an antiviral drug susceptibility assay for clinical isolates. The two-step procedure consists in either the culture of plasma HIV-1 virus or co-cultivation of infected PBMC with PHA-stimulated CD4 from blood donors. Patients sample a


Long-term CD4+Tcell response in HIV-1infected patients continuing on combination antiretroviral therapy despite high-level viremia and drug resistance.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10190)
Dionisio D, Vivarelli A, Zazzi M, Esperti F, Uberti M, Fabbri C;;; Pistoia General Hospital, Pistoia, Italy
The benefit of highly active antiretroviral therapy (HAART) in HIV-1 infection has been linked to its complete suppression of viral replication, though durable HIV treatment benefit despite low-level viremia has been reported. HAART often leads to increases in CD4+ T cell count of 100-200 cells/ml or more, even though


Drug susceptibility assay using peripheral blood mononuclear cells as target cells.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10191)
Tanaka R, Saito Y, Hanabusa H, Kato S;;; Keio University, Tokyo, Japan
BACKGROUND: To develop a clinically applicable phenotypic assay using peripheral blood mononuclear cells (PBMC) as target cells to assess HIV-1 susceptibility to numerous drugs. METHODS: PBMC were prepared by Percoll centrifugation and depleted of CD8 cells with anti-CD8 antibody-coated magnetic beads (Dynabeads, DYNAL


Retrospective analysis of nelfinavir containing antiretroviral combinations in treatment experienced patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10192)
Weiss SE, Cervia JS, Dali P, Freeman K;;; Long Island Jewish Medical Center, New Hyde Park, United States
BACKGROUND: Prior studies have reported the impact of Nelfinavir containing antiretroviral combinations in profoundly suppressing HIV replication. There is little data however, involving treatment experienced individuals with advanced disease. METHODS: We retrospectively analyzed the records of 24 HIV infected, antiret


The impact of hiv infection on maternal morbidity and mortality at Queen Elizabeth Central Hospital, Blantyre, Malawi.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10193)
Kanyenda JT, Kumwenda NI, Lema VM;;; Johns Hopkins Project, Blantyre, Malawi
BACKGROUND: Aimed at determining the possible impact of HIV infection on maternal morbidity and mortality. METHODS: Subjects wer enrolled upon admission in the labour ward or soon after delivery, and followed up till discharge from hodspital and for six weeks postpartum. Demographic, reproductive profiles, history of h


Successful management of gastrointestinal (GI) adverse events (AEs) in a prospective trial of ritonavir boosted saquinavir/lopinavir in heavily PI experienced patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10194)
Gordon DM, Foy K, Morris AB, Hellinger J, de Caprariis PJ, Jackson-Pope L, Cohen CJ;;; Community Research Initiative of New England, Springfield and Boston, MA, United States
OBJECTIVES: Ritonavir boosted levels of PIs provide greater antiviral suppression as well as associated AEs. Strategies must be identified to minimize intolerance and achieve optimal adherence. METHODS: AEs were evaluated & managed in a prospective, open label pilot of high dose (1000mg bid) saquinavir-sgc in combi


HIV-1 genetic diversity: impact on the performance of three commercial viral load assays.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10195)
Swanson P, de Mendoza C, Bodelle P, Yamaguchi J, Golden A, Brennan C, Soriano V, Devare SG, Schochetman G, Hackett J;;; Abbott Laboratories, Abbott Park, IL, United States
BACKGROUND: The evolution and ever-changing distribution of HIV-1 strains challenge the performance of nucleic acid-based tests. Reliable patient monitoring requires that viral load assays have the ability to detect and accurately quantify genetically diverse HIV-1. In this study, three commercially available quantitat


The impact of HAART in HIV+ hemophilic patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10196)
Villafane Fioti MF;;; Argentine Hemophilic Foundation, Buenos Aires, Argentina
BACKGROUND: The response to highly active antiretroviral therapy (HAART) was evaluated in a group of hemophilic patients infected with HIV for more than 18 years. METHODS: Twenty seven HIV+ hemophilc patients were included in this study. All had been infected prior to 1985 and received assistance at the Argentine Hemop


~32/wt CCR5 genotype, viral load and previous nucleoside analogue (NRTI) experience do not effect the viral outcome after five years in an unselected cohort of advanced HIV-1 patients who started Protease Inhibitor based antiretroviral treatment (PI-ART) in 1996.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10198)
Karlsson A, Bratt G, Koppel K, Nilsson A, Hejdeman B, Hedman P, Ingmar S, Grutzmeier S, Fredriksson EL, Sandstrom E;;; Venhalsan, Stockholm Soder hospital, Stockholm, Sweden
BACKGROUND: The efficacy of PI-ART in HIV-1 disease is well established, although there are few reports on long-term follow-ups from clinical practice. METHOD: 202 unselected patients with known HIV-1 infection for 80 +/-44 months who, in 1996, started PI-ART with at least two NRTI in combination with either


Multicenter performance evaluation of a real-time HIV-1 viral load assay, NucliSens EasyQ HIV-1.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10199)
Cuypers H, Soriano V, Segondy M, Oosterlaken T, Koppelman M, de Mendoza C, Montes B, van de Wiel P;;; Sanguin Div. CLB, Amsterdam, The Netherlands
BACKGROUND: A HIV-1 viral load assay (NucliSens EasyQ HIV-1) was developed based on NASBA amplification and real time detection with molecular beacon probes. The performance of this assay was evaluated in routine settings at three different sites. METHODS: HIV-1 RNA is isolated from plasma using the NucliSens Extractor


Virologic and clinical outcomes in pretreated patients receiving regimen containing a protease inhibitor or a non nucleoside analogue as first HAART.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10200)
Grabar S, Arvieux C, Lang JM, Pradier C, Reliquet V, Simon A, Costagliola D;;; Inserm SC4, Paris, France
BACKGROUND: Clinical prognosis of patients treated with non-nucleoside analogues (NNRTI) is poorly studied. We studied virologic and clinical outcomes of patients who started a triple regimen with 2 nucleoside analogues (NRTI) and either one protease inhibitor (PI) or NNRTI.METHODS:879 pretreated patients who started a


Benefit effects of capsular pneumococcal polysaccharides immunization on hiv type 1 and type 2 infected individuals in Senegal.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10201)
Dieye TN, Sow PS, Simonart T, Gueye A, Delforge ML, Popper SJ, Crusiaux A, Devleeschouwer M, Diakhate L, Kanki P, Mboup S, Farber CM;;; Immunodeficiency unit, Erasme university hospital, ULB, Brussels, Belgium
OBJECTIVE: Comparative evaluation of plasma HIV-RNA levels, humoral and cellular responses on HIV-1 and HIV-2 individuals after immunization with non T dependent 23 valent pneumococcal polysaccharides antigens (PPS). METHODS: 12 HIV-1, 9 HIV-2 and 8 HIV negative subjects received PPS. Blood was collected on day 0, 7 an


Study of the gastrointestinal tract diseases in hiv-patients in Lima-Peru.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10202)
Cisneros PC, Miyagui J, Liechty C, Gilman R;;; Dos de Mayo Hospital, Lima, Peru
BACKGROUND: Determine the ethiology of the syntomatic disease of the upper gastrointestinal tract in HIV-infected patients to guide the selection of a most appropriate empiric therapy. METHODS: The prospective and analytical study includes HIV infected-patients between 18 and 70 years old (100) that were sent to upper


Prevalence of HIV-1 genotypic mutations in the protease and reverse transcriptase genes from infected individuals in Taiwan: Treatment challenges.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10203)
Elbeik T, Lan YC, Dileanis J, Marlowe N, Ng V, Chen YM;;; University of California, San Francisco and San Francisco General Hospital, San Francisco, United States
BACKGROUND: Increasing prevalence of HIV-1 genotypic resistant strains in newly infected presents a challenge to treatment strategies. We investigate the prevalence of HIV-1 genotypic mutations in retrospective samples collected between 1996-2000 from cohorts of recently infected subjects in


Polymorphism of protease in protease inhibitor (PI)-naive patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10204)
Cho Y, Ahn S, Kang M, Sung H;;; University of Ulsan College of Medicine, SEOUL, Republic of Korea
BACKGROUND: There is no report on natural polymorphism of protease (PRO) from PI-naive patients in Korea although we have reported on the frequency of resistance mutation to reverse transcriptase inhibitors (J Clin. Microbiolol, in press) and natural polymorphism (AIDS Res & Hum Retroviruses. 16:1549-, 2001). The d


The prognostic significance of basal CD4 cell counts on immunologic and virologic responses to antiretroviral therapy (ART) in AIDS patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10205)
Ranin JT, Salemovic D, Zerjav S, Jevtovic DJ;;; Institute for Infectious and Tropical Diseases, KCS, Belgrade, Yugoslavia
BACKGROUND: The majority of HIV infected patients in Yugoslavia have severe immunodeficiency on presentation. We examined the possibility to achieve complete suppression of viral replication and immune reconstitution in these patients after ART. METHODS: Using an electronic database, a study of a cohort of 195 patients


Predicting the HIV set point: comparison of sampling times and methods of set point calculation.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10206)
Langan SJ, Sabundayo BP, Bollinger RC, McArthur JH, Quinn TC, Margolick JB;;; Johns Hopkins University, Baltimore, United States
BACKGROUND: Set point of plasma HIV RNA achieved after primary HIV infection is an important predictor of future disease progression. However, the optimal methods for calculating this set point have not been defined. METHODS: Participants in the Baltimore site of the Acute HIV Infection and Early Disease Research Progr


Greater prevalence of anemia in women and Blacks with HIV/AIDS in the HAART era.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10207)
Mildvan D, Creagh T; Beth Israel Medical Center, New York, United States
BACKGROUND: Data on anemia frequency among HIV/AIDS patients (pts) in the HAART era are sparse. This study describes anemia prevalence and associated risk factors among US pts receiving HAART. METHODS: A survey of medical records with prospective hemoglobin (Hb) assessment of approximately 10,000 HIV/AIDS pts >18yrs, s


Are there clinical/laboratorial differences between HIV positive men and women at first medical visit? A prospective study.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10208)
Almeida VC, Monteiro MM, Melo EV, Figueiredo NE, Temponi PF, Pierri MH, Lupatelli S;;; University of Sao Paulo, Araraquara, Brazil
BACKGROUND: Since the introduction of antiretroviral therapy in Brazil , there has been a decrease in mortality among HIV patients. However, despite universal use of specific therapy for all patients, mortality sharply decreased in men, but not as much in women. Factors that may contribute to these findings are not yet


HIV-1 subtype C infected children who have survived beyond five years of age have high levels of neutralizing antibodies.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10209)
Taylor NA, Morris L, Meyers TM;;; National Institute for Communicable Diseases, Johannesburg, South Africa
BACKGROUND: Perinatal HIV-1 infection remains a major route of transmission in developing countries with few children surviving beyond five years of age. Neutralizing antibodies (NAb) are considered an important immune control mechanism and in this study we aimed to examine levels of NAb in children who have survived b


Late breastmilk transmission of HIV-1 and infant disease progression.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10210)
Richardson BA, John-Stewart GC, Nduati R, Mbori-Ngacha D, Reiner M, Overbaugh J, Emery S, Kreiss JK;;; University of Washington, Seattle, United States
BACKGROUND: Previous studies among HIV-infected children have shown more rapid disease progression among infants infected in-utero versus intrapartum. Little is known regarding disease progression in children infected through late postnatal breastmilk transmission. METHODS: Data are from antiretroviral naive HIV-infect


Newborns from HIV-positive mothers born at Panait Sarbu Obstetrics and Gynecology Hospital, Bucharest, Romania: prophylaxis of the perinatal HIV infecton; evolution during the newborn period.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10211)
Puia S, Toma AI, Cristescu C;;; Panait Sarbu, Obstetris and Gynecology Hospital, Bucharest, Romania
BACKGROUND: to assess the efficiency of the prophylaxis of the HIV transmission from mother to infant, to observe the characteristics of these neonates and their evolution during the newborn period. METHODS: The population of the study consisted of the neonates born from HIV-positive pregnant women in our unit, between


CD4 cell counts in children born to HIV infected women in Europe.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10212)
Gray L, European Collaborative Study TH;;; Institute of Child Health, London, United Kingdom
BACKGROUND: Little is known about the pattern of CD4 cell count in HIV infected children over age, but the commonly used CDC immune categories based on CD4 counts are not reliably associated with clinical progression. There is a lack of data of the development of immune system in uninfected children. METHODS: Serial in


Impact of chloroquine on viral load in breast milk.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10213)
Semrau K, Kasonde P, Vwalika C, Ghosh M, Sinkala M, Kankasa C, Thea DM, Kuhn L, Aldrovandi G;;; University of Alabama, Department of Pediatrics, Birmingham, United States
BACKGROUND: Chloroquine (CQ) has in-vitro and in-vivo antiviral effect, and accumulates in mammary epithelial cells. Maternal CQ administration during breastfeeding may decrease milk viral load (VL), and therefore lower the risk of breastmilk (BM) associated mother-to-child transmission. METHODS: The Zam


Ocular lesions in HIV-infected children.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10214)
Oswal JS;;; Bharati Vidyapeeth Medical College, Pune, India
BACKGROUND: Opportunistic infections of the eye in HIV-infected children is rarely studied in India . METHODS: Ten HIV-infected children below 12 years of age were examined for ophthalmic lesions. All the children acquired infection by vertical mode. Six children were from CDC clinical category B and four from catego


Survival of Ugandan infants with subtype A and D HIV-1 infection (HIVNET 012).
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10215)
Eshleman SH, Guay LA, Fleming T, Mwatha A, Mracna M, Becker-Pergola G, Musoke P, Mmiro F, Jackson JB;;; The Johns Hopkins Medical Institutions, Baltimore, MD, United States
BACKGROUND: Virologic factors may influence survival of HIV-1 infected infants. We compared the survival of Ugandan infants with subtype A and D HIV-1 infection. This study was performed in the context of the Ugandan clinical trial, HIVNET 012, which compared the efficacy of single dose


Prevalence of HIV antibodies in children in rural Tanzania and association with anaemia.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10217)
Nabwera HM, Hills E;;; Nottingham University, Nottingham, United Kingdom
BACKGROUND: Teule hospital is a district designated hospital situated in the north eastern part of Tanzania , in East Africa. In addition to other health services, it provides extensive Paediatric services with over 20 admissions per day to the children s wards. The number of malaria deaths in children admitted to the


Incorporation of the Nuclisens HIV RNA qualitative (QL) assay in the early diagnosis of pediatric HIV infection.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10218)
Canizal AM, Fernandez Giuliano S, Zapiola I, Multare S, Bouzas MB;;; Hospital Francisco Javier Muniz, Ciudad de Buenos Aires, Argentina
BACKGROUND: Previous reports have demonstrated that high viral RNA levels are detected in plasma inmediately after infection both in adults and infants. The sensitivity of the Roche Amplicor HIV-1 DNA assay has been reported to be 54.5% for infants younger than 48hs and 95% for those older than 1 month. The objective o


Evaluation of the sensitivity an specificity of IgA immunoblot assay and PCR for diagnosing perinatal HIV infection in children younger than 24 months born to seropositive women.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10219)
Basualdo MC, Moran K, Alcantara P, Puentes E, Soler C;;; UNAM, Mexico D.F., Mexico
OBJECTIVE:-To evaluate sensitivity and specificity of IgA immunoblot assay and PCR in order to use as confident and efficiently auxiliary diagnosis of HIV perinatal infection using as reference viral isolation. Samples:90 infected an 153 non-infected children less than 24 months born form HIV infected women were analyz


Growth hormone deficiency in children with perinatally acquired human immunodeficiency virus infection.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10220)
Ezeanolue EE, Hardy SL, Nunlee-Bland G, Frederick WR;;; Department of Pediatrics, Howard University Hospital, Washington, D.C., United States
BACKGROUND: Reports of growth hormone (GH) deficiency in HIV+ children are rare. HIV+ children with growth failure were found to have opportunistic infections (OI) and low CD4+ cell counts but normal GH and insulin like growth factor 1 (ILGF-1) serum concentrations. We herein report three African-American male children


Immune-reconstitution in HIV-1 vertically infected children.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10221)
Salvini F, Cucchi C, Tonella M, Zuccotti GV;;; Clinica Pediatrica Ospedale San Paolo, Milano, Italy
In HIV infected children, CD45RA+ CD4+ T lymph. reconstitution has been related to efficient thymopoiesis. Because human thymus undergoes spontaneous involution at a relatively young age, institution of antiretroviral therapy early in the course of infection has been recommended. 12 HIV vertically infected children age


Perinatal and pediatric HIV - observations and trends of vertical transmission and clinical features.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10222)
Raju MS, Vadrevu R, Vadrevu L, Saple DG;;; Mamatha Children Hospital, Kakinada, India
BACKGROUND: The present study was done over a perid of 4 years in a rural,semi-urban setting in southern part of India . The study focuses on Pediatric disease as a direct result of meternal HIV. The study was conducted in an area with poor hygiene and nutrition. Breast feeding into the 2nd and 3rd years of life is not


Disseminated bacille calmette guerin (BCG) infection in Argentine AIDS children.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10223)
Sardi FM, Casanueva EV, Moreno R, Barboni G, Gregorio G, Gazpio M;;; Argentine pediatric asociation, Buenos Aires, Argentina
BACKGROUND: In Argentina BCG vaccination is obligatory at birth. In other colaborative study presented in this Congress, we found disseminated BCG infection in 6 / 656 aids children. METHODS: We present 6 patients with disseminated BCG and aids, who received the vaccine before HIV diagnosis. RESULTS: The average age wa


Pneumocisis carinii pneumonia treated with surfactant.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10224)
Bernardi S, Palma P, Perrotta D, Marano M, Cursi L, Pirozzi N, Rossi P, Castelli-Gattinara G;;; Bambino Gesu Hospital, Rome, Italy
BACKGROUND: Pneumocistis carinii pneumonia is one of the most serious diseases in children with HIV. It can represent the first sign of infection in children under one year of age and, in this cases, it is related to a poor prognosis. Several supportive treatments as steroids and surfactant can improve the outcome. MET


Management of maternal hiv diagnosed late in pregnancy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10225)
Lyons F, Hopkins S, Butler K, Mulcahy F;;; St. James's Hospital, Dublin, Ireland
BACKGROUND: Late diagnosis of maternal HIV in pregnancy presents multiple challenges. There has been a dramatic rise in the numbers of pregnant women presenting, particularly in those diagnosed late in pregnancy. The mean gestation for antenatal HIV diagnosis from January to December 2001 was 26 weeks (w). A protocol f


A rapid procedure to detect a single copy of HIV-1 virion RNA.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10226)
Saito Y, Tanaka R, Hanabusa H, Kato S;;; Keio University, Tokyo, Japan
BACKGROUND: It is often required in clinical settings to judge the presence of HIV-1 in materials to avoid the risk of infection completely. Thus, we established a rapid procedure by assessing minimal requirement in whole steps from RNA isolation to detection of PCR-amplified products that was able to detect a single c


Bacillary Angiomatosis (BA) as Initial Manifestations of AIDS.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10227)
Gulotta H, Fumagalli J, Espinosa G, Toller M, Brezzo C, Troncoso A;;; Infectious Diseases Francisco Muniz Hospital, Buenos Aires, Argentina
BACKGROUND: BA is an unusual cutaneous complication in AIDS patient. Also, BA is a marker of advanced HIV infection. So far, it is a scarcely reported condition in Argentina . METHODS: We report a case of BA in a 40 year-old man with unknown HIV infection and chronic, disseminated, erythematous purplish vascular nodule


Bacterial chest infections in HIV-1 positive and negative individuals in rural Uganda; aetiology and antibiotic sensitivity.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10228)
Mayanja B, Van der Paal LV, Kigozi B, Eotu H, Whitworth JA;;; Medical Research Council Programme on AIDS-Uganda Virus Research Institute, Entebbe, Uganda
Background Recurrent chest infections are associated with severe HIV disease. Knowledge of the aetiology and antibiotic sensitivity in resource poor countries with limited laboratory facilities is essential to formulate appropriate treatment protocols. Methods Adult participants in a clinical cohort study presenting wi


Chlamydia pneumoniae prevalence by antibody, PCR and a novel gamma interferon release assay in HIV infected and uninfected persons.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10229)
Woolley IJ, Jones S, Gahan ME, Jasenko I, Johnsen SP, Wesselingh S, Fuller A, Birkelund S, Christiansen G, Ostergaard L;;; Alfred Hospital/ Monash University, Prahran, Australia
BACKGROUND: There has been increasing interest in potential risk factors for cardiovascular disease in persons with HIV. One association identified in HIV negative individuals is Chlamydia pneumoniae. Previous studies have shown increased rates of C pneumoniae infection in AIDS patients however they have used predomina


Recurrent tricuspid endocarditis sustained by Streptococcus agalactiae and Enterococcus faecalis in an HIV-infected intravenous drug abuser patient.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10230)
Calza L, Manfredi R, Marinacci G, Fortunato L, Chiodo F;;; Infectious Diseases, University of Bologna, Bologna, Italy
Introduction. Infective endocarditis associated with HIV infection occurs almost exclusively in i.v. drug users and is rarely reported in other HIV-infected patients. Case report. A 33-year-old i.v. drug abuser male patient, with advanced HIV infection was first hospitalized owing to persisting hyperpyrexia, chills, as


Prevalence of Helicobacter pylori infection in HIV patients in Spain.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10231)
Gutierrez CD, Quijada SG, Saez CG, Ezquerro AM, Ibanez AF, Gonzalez JF;;; Internal medicine, Burgos, Spain
BACKGROUND: Conflicting results have been reported by european authors in patients with human immunodeficiency virus infection and the acquired immunodeficiency syndrome. The aim of this study is to evaluate the prevalence of Helicobacter pylori (HP) infection in HIV-infected patients in Spain , which is the major


Ti: Drug resistance mediated by plasmid in Pseudomonas aeruginosa strains isolated from patients infected with HIV.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10232)
Gonzalez A, Salazar D, Palma SV;;; Instituto de Medicina Tropical Pedro Kouri, La Habana, Cuba
BACKGROUND: The bacteria resistance is a threat for the humanity, it s particularly important in patients because of the high frequency of opportunistic infections . The microorganisms develop many mechanism of resistance to the antibiotics, many of them are mediated by plasmids. We study 63 Pseudomonas aeruginosa stra


Root caries and oral conditions in people with HIV.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10233)
Matsumoto H, Sunakawa M, Iwamoto A, Suda H;;; Clean Room, Hospital, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
BACKGROUND: This presentation is aimed to investigate oral conditions of homosexual males with HIV / AIDS in Japan , especially focused on the early root caries. METHODS: In twenty-five Japanese males infected with HIV-1 by homosexual intercourse, oral conditions were assessed by using CRT, Dentobuff Strip, Dentocult C


Cavitary pulmonary lesions associated with Flavimonas oryzihabitans in a patient with HIV Infection.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10234)
Newell L, Natarajan U, Curtis S, Churchill DR;;; Elton John Centre, Brighton General Hospital, Brighton, United Kingdom
Case report: A 33 year old HIV-positive gay man presented with a 3 week history of productive cough, fever and pleuritic chest pain. He was on no medication. On examination, he was febrile, had a tachycardia, oral thrush and had signs of left-sided pulmonary consolidation. His CD4+ lymphocyte count was 230/mm3, and his


Severe pulmonary infections in HIV-positive patients in the HAART era.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10235)
Narciso P, Tozzi V, Antinori A, Bellagamba R, Topino S, Sampaolesi A, Lorenzini P, Ghirga P, Antonucci F, Petrosillo N, Girardi E, Navarra A, Alba L, Palmieri F, Usro R, Ippolito G;;; INMI L Spallanzani, Rome, Italy
BACKGROUND: To analyze the characteristics of severe pulmonary infections. To evaluate physician s adherence to a diagnostic algorithm, approved during an internal Consensus Conference in 1999. METHODS: All HIV-infected subjects admitted to our clinic for acute respiratory symptoms between January 2000 and June 2001 we


Self reported testing and treatment in an infected population: results from an interview project in Uganda.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10236)
Katumba KM, Ruth RR, Francis KM;;; TASO(U)Ltd, Kampala, Uganda
BACKGROUND: Persons living With HIV/AIDS are at risk of being infected with tuberculosis (TB) co-infection can affect ther clinical outcomes of both diseases. in 1994, the Uganda National TB control programme recommended that all persons infected with HIB be tested for TB with appropriate therapy for those


On the complexity of TB / AIDS association.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10237)
Jidy MD, Nunez IG, Avila JP;;; Instituto Pedro Kouri, Ciudad Habana, Cuba
BACKGROUND: The complexity of both diagnosis and treatment of tuberculosis associated with AIDS is a challenge for any physician. METHODS: Data were collected from the medical records of 197 AIDS/TB patients hospitalized at Pedro Kouri Institute, the national reference center for diagnosis and treatment of AIDS complic


Tuberculous pancreatic mass as initial manifestations of AIDS.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10238)
Wainstein C, Gulotta H, Bava J, Fumagalli J, Troncoso A, Bernardini E;;; Infectious Diseases Francisco Muniz Hospital, Buenos Aires, Argentina
BACKGROUND: TB of the pancreas in HIV infected patient is very uncommon. It is usually associated with a delay in starting antituberculosis therapy since cultures may take up to 8 weeks. METHODS: We report two cases of HIV+ patients, who were diagnosed as having a pancreatic mass on CT scans. Patient RM: clinical prese


Dyslipidaemia in HIV infection with or without Tuberculosis.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10239)
Das PK, Das PC;;; Ross Clinical Laboratory, Kolkata, India
BACKGROUND: Though minor controversy exists lipid alterations do occur in cases of HIV infection. Of various types of infection tuberculosis is a very common accompaniment in such cases. Thus we were interested to find out the lipid alteration in cases of HIV infection with or without tuberculosis. METHOD: A total of 6


Radiological response to anti-tuberculosis treatment in HIV - TB dual infection.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10240)
Dholakia Y, Hira SK;;; ARCON, Mumbai, India
The HIV/AIDS pandemic has been responsible for changing the trends of tuberculosis . There is not only an increase in the incidence of tuberculosis but, due to the immunocompromised state, the clinical presentation and radiological response to therapy are also altered. This retrospective study was designed to assess th


Hepatotoxicity due to latent tuberculous infection treatment as a marker for hepatopathy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10241)
Aldamiz M, Portu J, Martin MJ, Almaraz MJ, Pinedo A, Salazar A, Barroso J;;; Hospital Txagorritxu, Vitoria, Spain
BACKGROUND: The interruption of latent tuberculous infection (ITLB) due to hepatotoxicity is a frequent fact in patients with HIV infection. Our objective is to check if the interruption of the treatment due to hepatotoxicity represents a marker for hepatopathy. Patients and methods: 438 patients with HIV infection sta


Mycobacterium tuberculosis associated immune reconstitution syndrome and HAART in South Africa.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10242)
Conradie FM, Van der Horst C, Venter WD, Ive PD, Jentsch U, Sanne IM;;; University of the Witwatersrand, Johannesburg, South Africa
BACKGROUND: Guidelines for HAART in resource poor areas need to consider high tuberculosis rates. In South Africa with a high HIV and TB incidence (600 per 100 000) many patients are co-infected. Fulminant and potentially fatal inflammatory reactions to TB may occur when starting HAART.


Tuberculosis and HIV/AIDS in a reference center for HIV treatment in Niteroi, state of Rio de Janeiro, Brazil 1995-2000.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10243)
Brito RC, Selig L, Cunha M, Palombo C;;; FMS - Niteroi/State Health Department RJ/Fundacao Educacional Serra dos Orgaos, Niteroi, Brazil
BACKGROUND: Tuberculosis (TB) and AIDS are great problems of public health in Brazil . The state of Rio de Janeiro has high prevalence of both disease. Here we describe the patterns of co-infection in a reference center for HIV treatment (Centro Previdenciario de Niteroi) wich is located in metropolitan region of State


Feasibility of tuberculosis preventive therapy and cotrimoxazole prophylaxis in South African TB/HIV pilot districts.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10244)
Hausler HP, Naidoo P, Karpakis B, Pronyk P, Campbell L, Colvin M, Sallet J, Sheard C, Matji R, Simelela N, Godfrey-Faussett P;;; Chief Directorate: HIV/AIDS & Tuberculosis, Department of Health and London School of Hygiene and Tropical Medicine, Pretoria, South Africa
BACKGROUND: The convergence of HIV and tuberculosis has led to a rapid increase in TB incidence in South Africa . The Department of Health established 4 TB/HIV Pilot Districts in 1999 to address the dual TB/HIV epidemic by implementing and evaluating a comprehensive package of TB/HIV/STI prevention, care an


Clinical and laboratory characteristics of tuberculosis associated with AIDS in the HAART era in Rio de Janeiro.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10245)
Sant'Anna FM, Vieira A, Lourenco MC, Carvalho SS, Donnel M, Morgado M, Rolla V;;; Centro de Pesquisa Hospital Evandro Chagas/FIOCRUZ, Rio de Janeiro, Brazil
Introduction: Tuberculosis (TB) is the most important opportunistic infection associated with HIV in our country. METHODS: All patients diagnosed with TB and AIDS from 07/ 2000 to 09/2001 in CPqHEC - FIOCRUZ were prospectivelly evaluated, in order to describe clinical and laboratory characteristics of TB in HIV+ patien


Continued increase of HIV-related tuberculosis and impact of the improved TB control program on prevalence of drug resistant TB, Chiang Rai, Thailand.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10246)
Yanai H, Supawitkul S, Uthaivoravit W, Rienthong D, Yoshiyama T, Khuptarat R, Sawanpanyalert P;;; TB/HIV Research Project, Chiang Rai, Thailand
BACKGROUND: There is limited information about the epidemiological trend and impact of tuberculosis (TB) control program improvement in the HIV epidemic area in Asia. METHODS: A population-based surveillance study was set up. Provincial TB registry data since 1987 together with 6-month treatment results was computerize


In vitro IFN- [gamma] production in whole blood culture in response to mycobacterial antigens in HIV/AIDS Bulgarian patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10247)
Markova R, Kostov K, Stefanova D, Terzieva V, Todorova Y, Taskov H, Valkova I;;; National Center of Infectious and Parasitic Diseases, Sofia 1504, Bulgaria
BACKGROUND: During last decades mycobacterial infections have been increasing in pts with advanced HIV-1 disease and their poor detection is a great problem. Tuberculin skin anergy as a manifestation of severe immune deficiency in AIDS pts is the main cause for false negative TST results. The aim of this study was by u


Epidemiology of difficult to diagnose pneumonia in HIV/AIDS positive patients in Maputo, Mozambic.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10248)
Bure M, Bergoin C, Viget N, Sidat A, Nunes E;;; CHG Bethune service de pneumologie, Bethune, France
BACKGROUND: In Mozambic Tuberculosis (TB) and AIDS are two diseases whose frequency and interaction set an acute public health problem. Management of difficult to diagnose pneumonia in HIV positive patients is difficult because of lack of sharp diagnosis means and epidemiology knowledge. The aim of this study was to de


Pneumocystes carini pneumonia in aids cases in Mumbai, India.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10249)
Kolambkar SR, Bhave GG;;; Seth G.S. medical college, Mumbai, India
BACKGROUND:- Number. of HIV infected individuals progressing to AIDS with apportunistic infections is incrising in Mumbai, India . This report discribs uncommonly reported Pneumocystis carini, pneumonia, in AIDS cases in Mumbai. METHODS:- induced sputum samples and braonchoalveolar lavage (BAL) samples from 214 clinica


Pneumocystis carinii pneumonia in the highly active antiretroviral era: increased prevalence in people of color.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10250)
O'Brien JG, Gooze L, Lee SA, Nix D;;; Santa Clara Valley Health and Hospital System, University of California, San Francisco, University of Pacific, San Jose, CA, United States
BACKGROUND: In the past few years, patients unaware of their HIV status have presented with moderate to severe pneumocystis carinii pneumonia ( PCP ). Of interest PCP cases seemed to cluster at certain times of the year.


Pneumocystis carinii Pneumonia: A major cause of infections among AAFB sputum smear negative patients admitted to Mulago Hospital, Kampala, Uganda.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10251)
Worodria WW, Okot-Nwang MO, Yoo SD, Aisu AT;;; Makerere University, Kampala, Uganda
BACKGROUND: Up to 60% of HIV infected patients develop pulmonary complications during their illness. Tuberculosis (TB) is a common cause of such infections. Sputum smear negative TB is common in advanced AIDS disease. African studies have found varied rates of pulmonary infections in HIV patients. This study was conduc


Histoplasmosis of the Larynx in HIV Woman Patient.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10252)
Gulotta H, Olenchuk A, Dure R, Bava J, Troncoso A;;; Infectious Diseases Francisco Muniz Hospital, Buenos Aires, Argentina
BACKGROUND: Laryngeal Histoplasmosis was first described in 1952. Since then, fewer than 100 cases had been reported. METHODS: We report a 30-year-old woman, IDU, with prolonged fever > 102 F persisting > 6 weeks, weight loss, disphagia, upper respiratory symptoms who developed laryngitis with dyspnoea, dysnea, cough a


Oral lesions associated to human immunodeficiency virus infection or acquired immunodeficiency syndrome in individuals without antiretroviral treatment in Bogota (Colombia).
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10253)
Montoya JH;;; Universidad Nacional de Colombia, Bogota, Colombia
BACKGROUND. Oral disease may represent the first sign of the disease in HIV-infected individuals and have been shown to be highly predictive marker of severe immunosuppression and disease progression. A review of the literature shows that there is hardly any published data on oral manifestations of HIV infection or AID


The treatment of cryptococcal meningitis at Centre de Traitement Ambulatoire de Pointe-Noire.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10254)
Tchissambou TT;;; Doctor of medecine, Pointe-Noire, Congo
BACKGROUND: Among the factus that decrease the situation of HIV patients, we can find at a good place cryptococcal infection mainly when located in meningitis. In Africa, mainly at Pointe-Noire, HAART are not available and protocols against cryptococcal meningitis are not easy to conduct. We will share the experience o


Epidemiological and clinical features of Cutaneous Mycoses in HIV-positive patients in Sao Paulo, Brazil.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10255)
Silva BC, Paula CR, Yoshioka MC, Nunes RS, Castro LG, Santos JI, Gambale W;;; USP, Sao Paulo, Brazil
Individuals infected with the human immunodeficiency virus (HIV) are prone to opportunistic infections. In addition, numerous HIV-positive patients also present cutaneous mycoses caused by filamentous fungi or yeasts, particularly dermatophytes and species of Candida genus. In these patients, the clinical and diagnosti


Comparative treatment and prophylaxis of P.marneffei in HIV infectived patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10256)
Natpratan C;;; CDC Region10, Chiangmai, Thailand
BACKGROUND: Primary treatment of P.marneffei infection, Secondary prophylaxis with oral Itraconazole is well tolerated and prevents relapse of this opportunistic infection but still high cost than ketoconazole . METHOD: Multi Center prospective cohort study in 20 hospital in Upper Northern part of Thailan


Comparative initial treatment and prophylaxis of P.marneffei in HIV infectived patients : Northern part of Thailand.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10257)
Natpratan C, Kunawararak P, Piyakul S, Suwanbongkot P, Chanmangkang S, Sirisanthana T, Suppraratpinyo K;;; CDC region 10, Chiangmai, Thailand
BACKGROUND: Primary treatment of P.marneffei infection, Secondary prophylaxis with oral Itraconazole is well tolerated and prevents relapse of this opportunistic infection but still high cost . METHOD: Multi Center prospective cohort study was conduct in 20 hospitals in Upper Northern part of Thailand . Sys


Oral Candida colonization in perinatal HIV-exposed children.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10258)
Hornke L, Colombo A, Machado DM, Barros A, Succi RC;;; UNIFESP, Sao Paulo, Brazil
BACKGROUND: Candida spp infections are usually a consequence of endogenous colonization and are one of the most frequent opportunistic infection in HIV-infected children. The objective of this study was to evaluate oral Candida spp colonization in HIV-exposed children during the first year of life. METHODS: 108 HIV-exp


Cryptococcus neoformans infections in persons living with HIV/AIDS that attend to urban hospitalary clinic.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10259)
Brol CG, Cotton L, Samayoa B, Paz L, Samayoa CA, Quattrini E, Gonzalez M, Velasquez-Porta T, Arathoon E;;; Asociacion de Salud Integral ASI, Guatemala, Guatemala
BACKGROUND: Cryptococcosis is an infection caused by the yestlike intracelular facultative encapsulated fungus Cryptococcus neoformans, a highly virulent organism. Before the introduction of highly active antiretroviral therapy (HAART) in 1996, C. neoformans had a prevalence among the AIDS patients group between 8 to 1


Renal abscess by Aspergillus fumigatus in HIV-infected patient.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10260)
Mesquida J, Sala M, Navarro M, Jimenez R, Font B, Serrate G, Segura F;;; Corporacio Parc Tauli, Sabadell, Spain
BACKGROUND. Infection by Aspergillus is very infrequent in HIV-infected patients. We present the case of a patient with isolated renal abscess by Aspergillus fumigatus. PATIENT. 46 y. Male, HIV+ (stage C3), hepatic cirrhosis by CHV. Admitted due to fever and left lumbar pain. Imaging explorations (US/CT) showed a 15 cm


Disseminated histoplasmosis: scondary prophylaxis suspension in patients under haart.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10261)
Pugliese DV, Galache V, Helou S, Negroni R;;; Hospital de infecciosas F.J.Muniz, Buenos Aires, Argentina
OBJECTIVES: To assess the evolution of patients under highly active antiretroviral therapy (HAART) that were suspended Itraconazol as a secondary prophylaxis (SP) for Histoplasmosis METHOD: Retrospective observation of 3 patients with the antecedent of disseminated Histoplasmosis (DH) who received Itraconazol as SP. We


A comparative study of amphotericin B, fluconazole and caspofungin for out patient antibiotic therapy (OPAT) of infections caused by Candida sp in people living with AIDS (PLWA).
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10262)
Arathoon E, Rivera BE, Samayoa B;;; Clinica Familiar Luis Angel Garcia Asociacion de Salud Integral, Guatemala, Guatemala
BACKGROUND: With the AIDS epidemic in countries where HAART treatment is not available, PLWA frequently present with severe esophagic and oropharyngeal candidosis, their treatment requires hospitalization which is costly and inconvenient. OPAT could be a cost-effective mode of IV therapy in PLWA. Amphotericin B (AmB) a


Paracoccidioidomycosis and AIDS. Is it an oportunistic infection?
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10263)
Schwarzbold AV, Fauci D;;; complexo hospitalar santa casa, porto alegre, Brazil
The paracoccidiodomycosis (PCM) is one of the most important systemic mycoses in Latin America. The etiologic agent is Paracoccidiodes brasiliensis. It is usually manifested as a chronic, progressive disease of adult men. It has the ability to remain dormant for long period of time until the resistant host becomes immu


Correlates of malaria parasitemia among HIV-infected pregnant women.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10264)
Msamanga GI, Villamor E, Habib N, Kapiga S, Antelman G, Fawzi WW;;; Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
BACKGROUND. Malaria and HIV infection are major causes of morbidity and mortality in sub-Saharan Africa. The prevalence and correlates of malaria among HIV infected pregnant women are unknown. METHODS. Among 1075 HIV positive, pregnant women participating in a clinical trial of vitamin supplementation in


Frecuency of visceral leishmaniasis relapses in HIV infected patients undergoing highly active antiretroviral therapy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10265)
Mira JA, Corzo JE, Rivero A, de la Torre J, Macias J, Lozano F, Jurado R, Kindelan JM, Pineda JA;;; Servicio de Medicina Interna, Hospital Universitario de Valme, Seville, Spain
BACKGROUND: The introduction of highly active antiretroviral therapy (HAART) has decreased the incidence of visceral leishmaniasis (VL) in HIV infected patients. However, in some studies it have shown that HAART is not effective to prevent the relapses in patients with a previous VL. The aim of this study was to assess


Simultaneous visceral and cutaneous Leishmaniasis in HIV infected patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10266)
Marques S, Aldomiro F, Camoes AC, Pereira J, Filho D, Baptista AM, Pacheco MH, Malhado JA;;; Hospital de Curry Cabral, Lisboa, Portugal
Introduction: Over the last decade various authors have presented cases in which Leishmaniasis is associated with human imunodeficiency virus (HIV) infection. In this context, visceral leishmaniasis continues to be the most frequently described, although cutaneous forms have also been found. The simultaneous presentati


Visceral leishmaniasis (VL) in an adolescent presenting early after highly active antiretroviral therapy: another immunoreconstitution syndrome?
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10267)
Ramos JT, Gonzalez-Tome MI, Sanchez-Granados JM, Carreno MP, Rojo P, Ruiz-Contreras J;;; Hospital 12 Octubre, Madrid, Spain
BACKGROUND:.Visceral leishmaniasis (VL) is common in HIV-1 infected individuals in Southern Europe. Although the incidence appears to have declined in the era of HAART, VL may occur in patients with good virological response. Nevertheless, VL has seldom been reported in children and adolescents and rarely early after t


Atypical Molluscum Contagiosum (MC) Infection in an HIV-Infected Patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10268)
Braunstein S, Rodriguez Rios E, Gulotta H, Bisione F, Troncoso A, Santucho E;;; Infectious Diseases Francisco Muniz Hospital, Buenos Aires, Argentina
BACKGROUND: MC, affects about 5-10% of patient with HIV infection, often showing extensive, confluent and atypical lesions. METHODS: Our objective was to present on the clinical aspect of two HIV-infected patients with atypical and severe MC. Patient 1: A 35-year-old patients was admitted with confluent masses of up to


Topical cidofovir for the treatment of Human papilloma virus, Poxvirus and Herpes simplex virus infections in HIV+ patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10269)
Toutous-Trellu L, Saurat JH, Hirschel B, Pechere M;;; Geneva University Hospital, Geneva, Switzerland
BACKGROUND: Cidofovir (Vistide®) is a nucleoside analogue approved for Cytomegalovirus retinitis treatment. Its wide antiviral spectrum includes Poxvirus involved in Molluscum contagiosum lesions, HPV producing verruca and condylomata and Herpes simplex virus.


The effect of cytomegalovirus retinitis on quality of life of patients with AIDS in the HAART era.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10270)
Wu AW, Kempen J, Martin BK, Jabs DA;;; John Hopkins University, Baltimore, United States
BACKGROUND: To evaluate the effect of cytomegalovirus ( CMV ) retinitis on quality of life (QOL) in AIDS. METHODS: Multi-center, cross-sectional study of patients with AIDS age >13 years enrolled at 19 US centers between 9/98 and 3/01. Patients were in three groups: Newly diagnosed CMV retinitis (median months since di


Seroprevalence of Hepatitis B in pregnant women.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10271)
Owusu-Boateng J, Adu-Sarkodie Y;;; Public Health Laboratory, Ministry of Health, Kumasi, Ghana
BACKGROUND: Hepatitis B virus can be transmitted from mother to child in utero. The sequela of infection in children can be phenomenal. This study was undertaken to assess the prevalence of Hepatitis B surface antigen (HBsAg) in pregnant women attending an ante natal clinic in Ghana . The results will better inform our


Histology and clinical behavior of lung cancer in patients with AIDS.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10272)
Cone LA, Wilson J;;; Eisenhower Med Center, Rancho Mirage, CA, United States
BACKGROUND: Lung cancer is the most common malignant neoplasm in the United States , being diagnosed in about 99,000 men and 78,000 women annually. Eighty-six percent of patients die within 5 years of diagnosis. More than 40% of patients with HIV-infection develop cancer during their illness, and Kaposi s sarcoma, inte


Prolonged remission of PEL with anti-HHV8 therapy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10273)
Wallace MR, Johnson KB, Looney DJ;;; San Diego Medical Center San Diego, San Diego, CA, United States
BACKGROUND: Primary effusion lymphoma is an HHV8 associated malignancy. Standard chemotherapy often produces a brief remission, but long term survival is rare. The role of anti-HHV8 agents in PEL therapy is unknown; a single care of long-term remission utilizing cidofovir and interferon therapy has b


Cervical intraepithelial neoplasia (CIN) in HIV-infected women.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10274)
Ferrero S, Cristoforoni P, Biasotti B, Fulcheri E, Bentivoglio G;;; Department of Obstetrics and Gynecology University of Genova, Genova, Italy
BACKGROUND: to determine: 1) whether the pathology correlates with the degree of immunosuppression, 2) whether there is a relation between pathology and antiretroviral therapies, 3) whether Papanicolau smears correlate with colposcopic and histological findings, 4) whether there is rapid genital disease progression aft


Lung Cancer and HIV Infection.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10275)
Bachs MR, Guitart R, Deig E, Soler A, Hernandez-Bronchud M, Barbeta E, Pedrol E;;; Internal Medicine, Hospital General de Granollers, Granollers. Barcelona, Spain
BACKGROUND: Although it is known that there is an increase risk of non-Hodgkin lymphoma and Kaposi s sarcoma in HIV-infected patients, other malignant tumours could be associated with HIV infection. Some cases of lung cancer have been described in these patients, however the clinical-epidemiological relevance of this r


Characteristics of immune reconstitution syndrome in a community clinical setting.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10276)
GatheJr. JC, Schrader S, Mayberry C, Stool E, Piot D;;; Therapeutic Concepts, Donald R. Watkins Memorial Foundation, Houston, United States
BACKGROUND: Immune Reconstitution Syndrome (IRS) has been described in the early weeks of HAART therapy. Characteristics have not been well described in community setting pts. METHODS: From 1999 -2001 33 pts. developed severe infections and/or neoplasia within a few weeks of HAART therapy. All were identified and follo


Visceral Kaposi's Sarcoma as an AIDS presenting diagnosis during pregnancy - rapid progression despite antiretroviral therapy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10277)
Hurtado RM, Theisen W, Goldberg J, Bryant A, Chen K, Genc M, Kaye K, Yawetz S;;; Brigham and Women's Hospital, Boston MA, United States
BACKGROUND: Little is known about the course of Kaposi s sarcoma (KS) during pregnancy or its response to antiretroviral therapy in women. We report a case of visceral KS presenting during pregnancy with an aggressive course despite combination antiretroviral therapy. Case description: 26 year old Cape Verdean woman wa


Inasive cervical cancer and HIV infection in Kenya.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10278)
Gichangi P, de Vuyst H, Estambale B, Bwayo J, Rogo K, Abwao HO, Temmerman M;;; University of Nairobi, Nairobi, Kenya
BACKGROUND: Invasive cervical cancer (ICC) is one of the commonest cancers affecting women worldwide. HIV infection is a risk factor for premalignant cervical lesions and rapid progression of HPV related lesions. HIV seroprevalence among women with ICC in Kenya is unknown.


HIV-associated multicentric castleman`s disease (MCD) managed by intermittent - oral etoposide on request.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10279)
Jaegel-Guedes E, Bogner JR, Hoffmann C, Jaeger H;;; KIS-Curatorium for Immunedeficiency, Munich, Germany
BACKGROUND: Multicentric Castleman`s disease (MCD) is a rare lymphoproliferative disorder of unknown etiology. In HIV-infected individuals it is associated with HHV8 and the development of Kaposi`s sarcoma. Clinical features comprise periodical fever, generalized lymphadenopathy, hepatosplenomegaly, pancytopenia and pe


Cutaneous plasmacytoma in a HIV patient.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10280)
Laurido MF, Civitilo C, Rovo A, Cassetti LI;;; Helios Salud, Buenos Aires, Argentina
Introduction: HIV infection is a risk factor to develop several neoplasms. However, some tumors are observed more frequently in AIDS patients but their association with HIV is not well established. We present the case of a HIV infected man receiving HAART who develop a cutaneous plasmacytoma. Case presentation: This is


Pneumocystis treatment in AIDS: from atovaquone (AVQ) to other less toxic ubiquinone (UQ) (= co-enzyme Q) (CoQ) analogs : artemisinin and beta-resorcylic acid, 2 active drugs against plasmodium.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10281)
Richert A, Caprani A, Kirkiacharian S, Nguyen DX, Tran MK, Maurrisson G;;; Association Positifs, Paris, France
BACKGROUND: AVQ (hydroxy-1,4-naphtoquinone ; 566C80), an anti-Pneumocystis carinii pneumonia ( PCP ) agent in HIV infection, is an anti-protozoal analog of UQ or CoQ. In Plasmodium, AVQ site of action appears to be the mitochondrial cytochrome bc1 complex (complex III). Inhibition of electron transport by AVQ results i


Squamous Intraepitelial Lesion (SIL) prevalence and risk of relapsing after treatment in HIV positive women.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10282)
Barelli A, Bergamin L, Panese S, Rocchetto P, Raise E;;; Infectious Disease Dpt Umberto I Hospital - SS Giovanni e Paolo Hospital, Mestre - VE, Italy
BACKGROUND: SIL is an increasingly common problem in HIV-infected individuals and there is evidence that human Papilloma virus( HPV )-related anogenital SIL are more common in HIV-positive individuals than in HIV-negative. METHODS: In our clinic for Sexually Transmitted Disease(STD), twice a year HIV infected women are


Abnormal cervical findings in HIV-positive women: a role for colposcopy?
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10283)
Pavia C, Peroni M, Migliore G, Piselli P, Orchi N, Calcaterra S, Serraino D, Ippolito G;;; National Institute for Infectious Disease L. Spallanzani IRCCS, Rome, Italy
BACKGROUND: Evidence of colposcopic findings in HIV infected women are scanty, though colposcopy may be useful in improving the diagnostic accuracy of sexually transmitted diseases (STD). The purpose of this study was to compare the colposcopic and cytological findings in HIV-positive women METHODS: 178 HIV-positive wo


Castleman's Disease in HIV positive patients; a Presentation of five cases.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10284)
Schrage D, Goelkel L, Mueller M, Heise W, Neudeck H, Weiss R, Arasteh K;;; II. Department of Internal Medicine, Infectiology, Auguste-Viktoria-Klinikum, Berlin, Germany
BACKGROUND: Castleman s Disease describes a heterogeneous group of lymphoproliferative disorders, the etiology of which has never clearly explained. The multicentric Castleman s Disease (MCD) is a systemic disease with various outcomes. It is associated with a human herpes virus 8 (HHV 8) infection. Histologically MCD


Arterial hypertension in HIV patients on HAART.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10285)
Gomez F, Cousinou M, Trouillhet I, Herran M, Escobar M, Fernandez FJ, Orihuela FM;;; Department of Medicine. Hospital Universitario Puerto Real/SAS. University of Cadiz, School of Medicine, Cadiz, Spain
BACKGROUND: HAART-induced metabolic alterations (insulin resistance and dyslipemia), are similar to those frequently found in patients with essential arterial hypertension (AHT). OBJECTIVES: We have prospectively followed a cohort of HIV patients on HAART to assess the prevalence of AHT and its potential relationship t


Breast masses in HIV infected men: a case series.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10286)
Aronson NE, Hawkes CA, Bernstein WB;;; Uniformed Services University of the Health Sciences, Bethesda, MD, United States
BACKGROUND: Little guidance exists to assist the clinician with the management of a unilateral breast mass in a HIV infected man. Gynecomastia has been described in men treated with efavirenz and protease inhibitors less commonly than in women. METHODS: This is a description of seven men,


A randomized, open label, controlled study on the use of anabolic steroids, nutritional supplementation and exercise for HIV-positive males.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10287)
Schrader S, Vergel N;;; Montrose Clinic / Body Positive, Houston, United States
BACKGROUND: The study evaluated the efficacy of exercise and nutritional counseling/supplementation (NSC) +/- anabolic steroids in HIV-positive males with unintentional weight loss of greater than 5%. METHODS: Thirty HIV-Positive males on stable anti-retroviral therapy were randomized to one of two treatment arms for 1


Abacavir induced diabetes mellitus due to severe beta cell dysfunction and insulin resistance.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10288)
Woerle HJ, Jaeger H, Sovric M, Lueddeke H, Renner R, Gerich J;;; Diabetes Center Bogenhausen, Munich, Germany
Introduction: This is a case of a Abacavir induced diabetes mellitus in a 34 years old male african subject. HIV infection has been known for nine years and been treated with Efavirenz , AZT


Comparison of cardiovascular risk factors between HIV-infected patients and non-infected general population.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10290)
Benito R, Pinilla J, Labarga P, Anton F, Ramalle-Gomara E, Ramalle-Gomara E, Mosquera D, mez-Alamillo C, Brea A;;; CH San Millan San pedro, Logrono, Spain
BACKGROUND: The purpose of this study is to assess the prevalence of cardiovascular risk factors in HIV-infected patients on highly active antiretroviral tretament (HAART) and to compare it to non-infected general population. Also, to ascertain if patients receiving protease inhibitors (PI) have a higher prevalence


Development of a simple questionnaire to assess changes in body appearance among antiretroviral (ar) naive hiv-infected patients (pts).
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10291)
Shlay JC, El-Sadr WM, Bartsch G, Mullin C, Gilbert C, Visnegarwala F, Carr A, Rappoport C, Raghavan S;;; Denver Public Health, Denver, United States
BACKGROUND: Body appearance changes have been reported among HIV-infected pts. Various methods have been used to assess changes, (questionnaires, body measurements, CT/DEXA scans), the latter limited by cost and complexity. There is a need for a simple and validated questionnaire. METHODS: A 10-item questionnaire was a


The effect of HIV disease and demographic factors on lipid parameters in a large antiretroviral naive cohort.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10292)
El-Sadr WM, Bartsch G, Mullin C, Carr A, Visnegarwala F, Rappoport C, Gibert C, Raghavan S;;; Terry Beirn Community Program for Clinical Research on AIDS, New York, United States
BACKGROUND: Studies of lipids changes among HIV-infected patients (pts) are limited by the variability of antiretroviral therapy (ART) history, limited demographic diversity and non-fasting specimens. The impact of HIV disease markers on lipid levels was assessed in heterogeneous population of ART naive pts. METHODS: S


Chlamydia Pneumoniae infection and lipid abnormalities in HIV-positive patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10293)
Tositti G, Rassu M, Fabris P, Scagnelli M, Giordani MT, Cazzavillan S, Zoppelletto M, de Lalla F;;; Departments Of Infectious Disease, Vicenza, Italy
Lipid abnormalities are relatively common in HIV-positive patients, particularly after the introduction of HAART. Chlamydia pneumoniae (CP) is considered an important co-factor in the pathogenesis of atherosclerosis and seems per se responsable of lipid abnormalities. The prevalence of CP infection and its role in indu


Intradermal polylactic acid for severe HIV associated facial lipoatrophy: preliminary results.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10294)
Day JN, Raabe A, Shiner AM, Wilkins EG;;; Monsall Unit, North Manchester General Hospital, Manchester, United Kingdom
BACKGROUND: HIV associated facial lipoatrophy (FLA) is an increasing problem in patients receiving antiretroviral therapy (ART), and has marked effects on self-esteem and social functioning. Patient concerns about FLA may lead to reduced adherence and limit treatment choices with impacts on overall health. Intradermal


Lipodystrophy classifications: a comparative approach.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10295)
Orlando G, Guaraldi G, Murri R, Nardini G, Beghetto B, Wu A, Sterrantino GK, Borderi M, Cattelan AM, Antinori A, Sbaragli S, Grosso C, Erba C, Talo S, Esposito R;;; Universita di Modena, Modena, Italy
BACKGROUND: No consensus exists in lipodystrophy diagnosis. Three major classification have been proposed: Marrakech, MACS, HOPS. The aim of this study is to compare the three classifications on the basis of relationship to physician evaluations and patient self-estimate and concordance between physician and patient. M


Efficacy and safety of lipid-lowering agents in HIV-infected patients on HAART.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10296)
Moreno JN, Gutierrez LF, Scerpella EG, Ferron P, Boulanger C;;; University of Miami School of Medicine, Miami, United States
BACKGROUND: Metabolic complications, including dyslipidemias and lipodystrophy (LD), are described in HIV patients on HAART. While the etiology remains obscure, medications are commonly prescribed to treat these abnormalities. Drug interactions and the potential for toxicities may limit the success of lipid-lowering th


Dislipidemia and lipodystrophy associated to ARV treatment based in Abacavir, Nevirapine and Efavirenz.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10297)
Alvarado-Diez Rocio AD, Feregrino-Goyos FG, Ruiz-Campos Omar. RC, Mireles- Vyera Maria MV, Gomez-Caro Humberto GC;;; CITAID, SC. Centro de Investigacion y Terapeutica Avanzada en Inmunodeficiencias, SC., Mexico, City, D.F., Mexico
BACKGROUND. Lipodystrophy and hyperlipidemia are metabolic complications less frequent been see in HIV patients treated with abacavir, nevirapine or efavirenz plus 2NIRT. OBJECTIVES.Looking for the incidence of lipodystrophy and hyperlipidemia in HIV patients treated with ARV combined based in ABACAVIR, NEVIRAPINE or E


HCV infection influences lipid abnormalities in HIV/HCV co-infected patients ungergoing HAART.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10298)
Patroni A, Torti C, Castelli F, Tomasoni L, Puoti M, Cadeo GP, Vangi D, Tinelli C;;; Institute of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy
Introduction: Lipid abnormalities are among the most frequent metabolic disorders in HIV pts under HAART. HCV co-infection has been suggested to influence cholesterol and triglycerides plasma levels in HIV patients in across-sectional study. OBJECTIVES: to assess prospectively the influence of HCV co-infection on treat


Report of breast enlargement in eleven HIV patients treated with HAART.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10299)
Ribas MA, Delibes C, Riera M, Leyes M, Salas A, Villalonga C;;; Hospital Son Dureta, Palma, Spain
OBJECTIVE: To report eleven cases of gynecomastia in HIV-infected patients, detected in the last twenty months in a HIV clinical who attends 1.162 HIV patients. METHODS: Is a descriptive study based on the dates collected from the clinical chart of the HIV patients which consulted for painful breast enlargement. RESULT


The effect of a liquid nutritional supplement containing omega (n)-3 fatty acids on HIV-related hypertriglyceridemia.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10300)
Ionescu G, He Q, Luty B, Engelson ES, Albu JB, Kotler DP;;; St.Luke's-Roosevelt Hospital Center, New York City, NY 10025, United States
BACKGROUND: Metabolic alterations among HIV+ patients treated with HAART include dyslipidemia, which suggests increased risk of heart disease. Studies in non-HIV show these metabolic alterations and by extension the atherogenic process may be modified by n-3 fatty acids, through reduction of circulating triglycerides (


Factors associated with abnormal glucose tolerance tests in HIV -- infected persons receiving HAART.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10301)
Falutz J, Gardiner R, Frouah F;;; Montreal General Hospital, Montreal, Canada
BACKGROUND: HAART is associated with body shape and metabolic changes, including insulin resistance (IR), known as the Lipodystrophy (LIPO) syndrome. Screening for IR, a risk factor for atherosclerosis, includes: lengthly tests (oral glucose tolerance test [OGTT]); derived results (homeostasis model assessment [HOMA]);


Lack of significant changes in blood pressure of HIV+ subjects, even after long -term use of PI therapy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10302)
Yao LK, O'Riordan M, Lederman MM, Valdez H, Gripshover B, Rodriguez B, Salata R, McComsey GA;;; Rainbow Babies and Children's Hospital, Cleveland, United States
BACKGROUND: Hypertension (HTN) has been linked to indinavir treatment and to lipodystrophy in HIV-infected subjects. We assess here changes in BP in HIV-infected patients receiving their first HAART regimen. METHODS: Retrospective chart review of 81 HIV+ patients receiving their first HAART regimen for > 3 months.


Long-term use of recombinant human growth hormone.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10303)
Corales RB, Fine SM, Valenti WM, Mang KM, Christie ML;;; Community Health Network, Rochester, United States
BACKGROUND: Very few data exist concerning recombinant human growth hormone (rhGH) in the treatment of patients with AIDS wasting syndrome (AWS); even fewer data exist for HIV-associated adipose redistribution syndrome (HARS). Moreover, no data exist with long-term use of rhGH beyond 12 to 24 weeks. METHODS: We describ


Evaluation of metabolic status and incidence of lipodistrophy under different HAART regimens in patientes with AIDS coinfected with multi-drug resistant mycobacterium Tuberculosis.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10304)
Waisman JL, Gurtubay JL, Rizzone MR, Palmero DJ, Alberti FA, Francos JL;;; Hospital F. J. Muniz, Buenos Aires, Argentina
BACKGROUND: The mortality of TBMR-associated AIDS had diminished substantialy with the use of second-line anti-TB drugs and the rapid administration of HAART. The toxity and appareance of HAART-associated lipodistrophy conspires against efficacy and adherence to treatment. OBJECTIVES: Describe the prevalence and incide


Lipidic alterations in AIDS patients in use of antiretroviral therapy regimen containing lopinavir/ritonavir.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10305)
Ribeiro JE, Santos NA, Pilotto JH, Roy LO, Moreno AM, Pires ML;;; DST/AIDS-Hospital Geral de Nova Iguacu(HGNI), Rio de Janeiro, Brazil
BACKGROUND: Among the most frequent metabolic alteration associated to the use of antiretroviral(ARV) are the dislipideousnes(DL). This study evaluate, in AIDS patients(pts) in use of ARV therapy rescue regimen containing lopinavir/ ritonavir (lopinavir/r), the changing of triglyceridics(TG), total cholesterol(COL), HD


Reducing visceral fat accumulation, and blood lipid disorders in HIV-infected patients with lipodystrophy by an aerobic training program.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10306)
Thoni GJ, Fedou C, Renard E, Mercier J, Reynes J, Varray A;;; University of Sports Sciences, Montpellier, France
BACKGROUND: Few efficient therapies are available to reduce central fat and dyslipidemia in HIV1-lipodystrophic patients. This study tried to assess the effects of an aerobic training program on these disorders. METHODS: 24 lipodystrophic or dyslipidemic infected adults were studied before and after 18 weeks of a light


Prevalence of silent myocardial ischemia in asymptomatic HIV patients with dyslipidemia detecting with dobutamine stress echography.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10307)
Riveline JP, Habis M, Lardoux H, Mourgeon B, Kousignian P, Toledano I, Devidas A;;; Hopital Sud-Francilien, Service d'Endocrinologie, Corbeil Essonnes, France
BACKGROUND: HIV infection is associated with, compound-specific dyslipidemia. The risk of premature atherosclerosis due to HIV infection remains to be establish. The five specific cases we observed in young patients and some examples found in litterature let us to evaluate the risk of silent myocardial ischemia (SMI) i


Lipodystrophy in an HIV negative patient treated with antiretrovirals.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10308)
Ward DJ;;; Dupont Circle Physicians Group, Washington, DC, United States
BACKGROUND: Lipodystrophy is a syndrome of fat redistribution and associated metabolic changes. The cause of this syndrome is uncertain; while there is evidence that antiretroviral medications are causative, there is also evidence that immune or demographic factors may be more important. This is a case report of a pati


Body composition in men and women with HIV-associated adipose redistribution syndrome (HARS).
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10309)
Thompson M, Moe A, Kotler DP, Engleson EF, Grunfeld C, Gertner J, Muurahainen N;;; AIDS Research Consortiumof Atlanta, Atlanta, GA, United States
BACKGROUND: It is unclear how fat maldistribution varies in male (F) and female (F) patients (pts) with HARS. In this analysis, HARS pts selected by waist circum-ference (WC) and waist/hip ratio (WHR) criteria (Chang, 2000, 2001) were compared by gender to healthy controls from SLRHC. METHODS: In a multicenter trial, a


Prevalence of body fat redistribution and metabolic alterations in a cohort of African Americans and Latinos.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10310)
Chowdhury N, Raghavan S, Levine K, Iqbal S, Im A, El-Sadr W;;; Columbia University/ Harlem Hospital Center, New York, United States
BACKGROUND: Limited data are available on the prevalence of body fat redistribution and metabolic alterations in HIV+ African Americans (AA) and Latinos. METHODS: 179 males & 126 females were recruited from Harlem Hospital between 1998 and 2001. Self-reported changes including fat accumulation at the abdominal, bre


Clinical Characteristics of HIV -1 peruvians patients in the National Hospital Hipolito Unanue-Lima- Peru.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10311)
Callacna MC, Sanchez E;;; Infectology Unit HospitaL National Hipolito UnanueATIONALp, Lima, Peru
BACKGROUND: Nearly of 70,000 peruvians are infected with Human Inmunodeficiency virus. Most of them developed inmunosuppression resulting in opportunistic infections and less frequent tumors. METHODS: We describe the clinical characteristics of HIV-1 patients in the outpatient Clinic in the Infectology Unit at the Nati


Primary central nervous system lymphomas in AIDS patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10312)
Corti ME, Villafane Fioti MF, Schtirbu RB, Yampolsky CG;;; F.J.Muniz Infectious Diseases Hospital, Buenos Aires, Argentina
BACKGROUND: Primary central nervous system lymphomas (PCNSL) occurs frequently in patients with AIDS and is the most common neoplasm in these patients. METHODS: We reviewed the clinical manifestations, neuroimaging findings, diagnosis methods, histologic characteristics, detection of DNA-EBV by PCR and outcome of 14 HI


The utility of neuropsychological and functional outcome measures for HIV+ Spanish-speakers: A pilot study.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10313)
Mindt MR, Cherner M, Bentley H, Esquivel MM, Heaton RK, Marcotte TD, McCutchan JA, Grant I;;; University of California, San Diego Department of Psychiatry, HIV Neurobehavioral Research Center (HNRC), San Diego, United States
BACKGROUND: HIV-associated neuropsychological (NP) impairment is related to declines in employment and independence. In the U.S., Latinos account for a disproportionate rate of AIDS cases, and many are primarily Spanish-speaking. Anticipating the inclusion of Spanish-speakers in clinical trials, linguistically/cultural


Neuro-surveillance in HIV cohort from Indore, India.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10314)
Khare KC, Raman P, Vaish N, Pathak S, Galwankar S, Persad A, Naik E, Sinnott J;;; MGM Medical College, Indore, India
BACKGROUND: HIV has a complicated patho-physiology, and although detectable during the course of the disease, are often diagnosed post-mortem. The presence of these neurological changes may be an important symptom to indicate the necessity of testing for HIV. The study was conducted at the Center for Health, HIV/AIDS,


Psychological assessment in the first 100 patients of the indore HIV cohort.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10315)
Pathak S, Tripathi S, Mathew V, Raman P, Vaish N, Khare K, Galwankar S, Persad A, Naik E, Sinnott J;;; University of South Florida, Tampa, Florida, United States
BACKGROUND: Psychiatric manifestations are found in many HIV patients due to the stressors associated with living with a terminal disease, i.e. economic status, stigmatization, and fear of death. The treatment of these mental illnesses is often needed but secondary to the treatment of HIV itself. The study was conducte


CNS infections in AIDS patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10316)
Salam J, Chugh S, Yadav P, Shrivastava D, Bharat B, Sethi A, Verma U;;; Dr. Ram Manohar Lohia Hospital, New Delhi, India
BACKGROUND: CNS infection is a fatal infection among AIDS patients. The aim of the study was to find out its etiology, characteristics and frequency among HIV infected patients. METHODS: A perspective study was conducted at Dr. Ram Manohar Lohia Hospital, New Delhi, India of all cases of CNS infectio


Impact of cognitive impairment on quality of life in HIV-infected patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10317)
Tozzi V, Balestra P, Murri R, Galgani S, Bellagamba R, Narciso P, Antinori A, Giulianelli M, Tosi G, Fantoni M, Noto P, Ippolito G, Wu AW;;; INMI L Spallanzani, Rome, Italy
BACKGROUND: To examine the impact of HIV-related cognitive impairment (CI) on health-related quality of life (QoL). METHODS: Cross-sectional study. Subjects completed a neuropsychological (NP) test battery and the MOS-HIV QoL questionnaire. CI was defined as performance > one standard deviation (SD) below the normative


Effect of vitamin supplementation on the neuropsychological development over the first 2 years of life of children born to HIV infected women in Dar es Salaam, Tanzania.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10318)
McGrath NM, Msamanga G, Hertzmark E, Manji K, Hunter D, Fawzi WW;;; Harvard School of Public Health, Boston, MA, United States
BACKGROUND: As the number of children born to HIV infected mothers in developing countries increases, it is imperative to understand the neuropsychological development in these children. Maternal vitamin supplementation may be expected to improve child development. METHODS: As part of a clinical trial to study vitamin


Use of computed tomography scan in the diagnosis of HIV-1 related treatable central nervous system opportunistic infections in Uganda.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10319)
Mayanja-Kizza H, Kabugo C, Mugerwa R;;; Makerere University, Kampala, Uganda
BACKGROUND: HIV-1 related central nervous system (CNS) opportunistic infections (OIs) are common causes of morbidity and mortality in Africa, especially where antiretroviral treatment is not widely available. Meningitis may easily be diagnosed by cerebrospinal fluid (CSF) examination. However, CNS OIs presenting with f


Oral pathologies observed in HIV-positive children in Venezuela.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10320)
Guerra ME, Albornoz E, Tovar V, Rodriguez AI;;; Universidad Central de Venezuela, Servicio Enfermedades Infectocontagiosas, Caracas, Venezuela
The first experience of our department with HIV-positive children occurred in 1998. treatment was performed under general anesthetic in the operating room of our College. To date the Department has treated 41 HIV-positive children. The objective of this study is to present the oral pathologies most frequently observed


Clinical manifestation of leishmaniasis in HIV/AIDS - a study of six cases at Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10321)
Salam J, Chugh S, Shrivastava D;;; Dr. Ram Manohar Lohia Hospital, New Delhi, India
BACKGROUND: There are a large number of kala azar cases in certain endemic areas of India , however its association with HIV/AIDS has not been reported in substantial number of cases. METHOD: 427 HIV infected (397 adults and 30 children) were seen over a period of two years in the medical out/in patient department of D


Comphrensive dental service to the patients with HIV / AIDS.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10322)
Guerra ME, Albornoz E, Tovar VC;;; Profesora, Caracas, Venezuela
The Department of Attention Services to the patients with infecto or contagious diseases,of the Dental School of The Central University of Venezuela , was created for the specific task to render specialized services to the patients with infecto or contagious diseases; HIV/AIDS;simple herpes; zoster herpes


Importance of the protesic rehabilitation in HIV/AIDS patients.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10323)
Lambertini A, Tovar V;;; Sapei, Caracas, Venezuela
The total or partial loss of the teeth affects the human beings from the psychological, social and functional perspective. In the positive patients this loss becomes more important since they are already psychologically depressed and not accepted socially, as a consequence they must maintain or recover good nutritional


Idiopathic Trombocytopenic Purpura as a form of presentation of HIV Infection.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10324)
Agostini M, Trape L, Suarez C, Careno E, Lupo S;;; CAICI, Rosario, Argentina
BACKGROUND: Idiopathic Trombocytopenic Purpura (ITP) is an unusual complication related to HIV. Our objective was to show three patients with ITP as a form of presentation of HIV infection. METHODS: We analyzed 600 medical record of patients HIV+ and found hematological abnormalities. RESULTS: three patients, 2 women a


No Hodgkin Lymphoma in the era of HAART.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10325)
Somenzini C, Cerana S, Oberto D, Lupo S;;; CAICI, Rosario, Argentina
BACKGROUND: The incidence of NHL in HIV+ patients is 100 times > than in the general population, without changing its incidence with HAART. To describe the clinical characteristics and the response to treatment in a cohort of patients with NHL in the era of HAART. METHODS: there were checked 830 medical records from pa


Lung Nocardosis in women with AIDS.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10326)
Mantello D, Arbulu MM, Neuman M, Beraudo N, Amigot S;;; Infectology Service - Carrasco Hospital, Rosario, Argentina
Introduction: The infection caused by Nocardia as complication in aids patients is not very frecuent in our country. The main localizations of this infection are: lung, brain and skin. The mortality rate is bigger in aids inmunocompetent patients. METHOD: We describe one patient, female, 29 years old, diagnosed VIH (+)


Macrocytosis in patients under TAAE.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10327)
Radeliffe S, Careno E, Gilardoni N, Lupo S;;; Laboratorio Central Facultad de Bioquimica, Rosario, Argentina
BACKGROUND: Alterations in hemacytometric indexes are common in HIV+ patients, especially in advanced stages. Taking as highest maximum point an Average Corpuscular Volume 3 97fl., macrocytosis is associated with multiple modification, folie acid and vitamin B12 deficiency, and hepatopathologics. To assess the presence


The voice of HIV positive primary health care service users in South Africa.
Int conf AIDS 2002 Jul 7-12; 14:(abstract no. B10328)
[No authors listed];;;
BACKGROUND: The research was developed to inform the implementation of primary health care clinical guidelines. As part of a bigger process of identifying barriers and opprtunities in implementing this guidelines - HIV positive people were interveiwed on their experiences of using and not using public primary health ca


Are you HIV prejudiced? - an integrated media approach to tackling stigma and discrimination associated with HIV and AIDS.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10329)
Winestein K;;; Charity, London, United Kingdom
ISSUES: Over the last two decades HIV and AIDS has emerged as one of the most challenging public health problems in the UK. The HIV epidemic has been accompanied by intensely negative public reaction to people presumed to be living with or indeed affected by HIV and AIDS. Today, the stigma and discrimination associated


Long term efficacy of nevirapine based triple therapy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10330)
Greene RE, Ward DJ;;; Dupont Circle Physicians Group, Washington, DC, United States
BACKGROUND: Nevirapine (NVP) is a potent non-nucleoside RT Inhibitor that can be a convenient and well tolerated backbone for HAART therapy. Concerns remain, however, about the long term efficacy of a NVP based regimen. METHODS: Retrospective chart-review analysis of NVP based triple-drug therapy (NVP plus 2 nucleoside


Incidence of AIDS-related opportunistic infections in patients with and without HAART in Morocco.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10331)
Himmich H, Maaroufi A, Marih L, Chakib A;;; hospital, casablanca, Morocco
OBJECTIVES: To assess the impact of Highly Active Antiretroviral Therapy ( HAART) on the incidence of opportunistic infections (IOs) in a limited resource country, over a 30 months period. METHODS: Retrospective cohort study. Eligible patients were 216 HIV-1 positive patients attended in the infectious disease unit of


Infection with Mycobacterium tuberculosis among HIV infected patients in Morocco.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10332)
Sodqi M, Marih L, Marhoum El Filali K, Himmich H;;; Hospital, Casablanca, Morocco
OBJECTIVES: To describe the characteristics of HIV/TB co-infection and to show the impact of HAART on this co-infection in Morocco , country with limited resource, low prevalence of HIV and high prevalence of TB ( TB incidence = 30000 new case/ year ). METHODS: Retrospective cohort study. Eligible patients were 966 HIV


Renal failure in HIV/AIDS - clinical experience at Jodhpur, India.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10333)
Mathur A, Contractor T, Mathur A, Kishoria N, Kotru S, Baweja S;;; S N Medical College, Jodhpur, India
ISSUES: Renal failure is observed in patients infected with the human immunodeficiency virus (HIV). Underlying glomerular disease and disturbances in renal tubular function predispose them to a number of hemodynamic and nephrotoxic insults. Prerenal azotemia due to depletion of intravascular volume is the most common c


Eosinophilia in patients with HIV infection in Singapore.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10334)
Lim MY, Chan SP, Leo YS;;; Communicable disease centre, Singapore, Singapore
BACKGROUND: To assess i)frequency of eosinophilia in patients infected with HIV in Singapore ii)relation of eosinophilia with itching skin conditions iii)relation of CD4 cells with eosinophil level iv)relation of eosinophilia with both itching skin conditions and CD4 cells METHODS: This study was conducted at Communica


Hypogonadism &HIV wasting -- An Indian Scenario.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10335)
Kelkar D, Deshpande AK;;; Grant Medical College &Sir J J Hospital, Mumbai, Mumbai, India
BACKGROUND: Wasting syndrome is an AIDS defining condition. Wasting significantly affects the quality of life, causes accelerated disease progression and decreases survival. Nutritional insults, chronic infections, malabsorption and hormonal abnormalities compound wasting. Testosterone being an anabolic hormone, we dec


The consultation of nursing with focus in the adherence.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10336)
Muller C, Preussler GM, Wacthholz NI, Piazza MG, Krilow I;;; SAE, Porto Alegre, Brazil
SUBJECT:The advent of antiretrovirais medicines,provided an increace of the life expectancy of the people who living with HIV/AIDS and one better quality of life. However for attimment of the waited results na adherence of 95% of prescribed medicines is necessary. The factors are innumerable that make it difficult this


Cardiac manifestations in patients infected with the human immunodeficiency virus in Yucatan, Mexico.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10337)
Castro-Sansores Carlos CS, ngora-Biachi Renan Alberto GB, Gonzalez-Martinez Pedro GM, Aguilar-Romero Rafael AR, Guerrero-Flores Alejandro GF, Yza-Villanueva Ruben YV, Quintal-Flores Alvaro QF, Fernandez-Gonzalez Armando FG, Saldivar-Armenta Carmen SA;;; Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico
BACKGROUND. Cardiac irregularities caused by the human immunodeficiency virus (HIV) have not been described in detail and tend to be subclinical. They are usually produced by opportunist agents in patients with lymphocites T CD4


Frequency of bucal pathologies in HIV-infected patients in Venezuela.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no.. B10338)
Tovar V, Lambertini A, Bravo IM;;; UCV, Caracas, Venezuela
The propouse of this study was to investigate the prevalence of bucal manifestation in HIV-infected patientes. The study populstion consisted of 384 patients (examined betwen january 1999 and may 2001) aged 35 +/- years who had been diagnosed with HIV-infection and who were attending the service of attention to patient


Long term HIV-infected survivors following GSPH-1 therapy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10339)
Amar MB, Morisset R, Ghadirian P;;; University of Montreal, Montreal, Canada
BACKGROUND: Assess the efficacy and safety of GSPH-1, in a pilot study of HIV-infected subjects. METHODS: In march 1993, GSPH-1 was administered to 10 HIV-infected patients with CD4 counts ranging from 76 to 422 cells/mm3 at onset of treatment. During the first 3 years, GSPH-1 was used as a monotherapy. Then, it was co


Long-term safety and efficacy of nevirapine, stavudine and lamivudine in a real-world setting.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10340)
Farrell PC, Shalit P;;; University of Washington, Seattle, Washington, United States
BACKGROUND - Recent studies have demonstrated the efficacy of protease-sparing regimens including NNRTIs in treatment-naive patients. Long-term side-effects of PIs, including lipodystrophy and hyperlipidemia, have led to consideravble interest in the use of the NNRTI as a first-line therapy. To date, however, only limi


Predictors of virological outcome to Highly Active Antiretroviral Therapy (HAART) in 340 naive patients with HIV-1 infection, Medellin - Colombia, 1997-2000.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10341)
Nagles J, Lopera A, Donado J, Arbelaez MP, Betancur J, Velez J, Jaramillo C, Ocasionez D;;; MD MSc Programa VIH/SIDA Seguro Social, Medellin, Colombia
BACKGROUND: To measure the effectiveness of HAART and to identify predictors associated with the virological response at six months of therapy, in patients with HIV-1 infection who had no prior experience with antiretroviral agents (naive), in an urban cohort of a developing country. METHODS: Historical cohort. We stud


A Prospective Study of Sequencing Strategies of Protease Inhibitor Based HAART: Salvagability of Amprenavir (APV) with Nelfinavir (NLF) based therapies among antiretroviral naive HIV-infected patients initiating therapy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10342)
Schrader SR, Rohde P, Musser J, Pottage J;;; Southampton Medical Group, Houston, United States
BACKGROUND: The sequencing of PIs is unknown. Both APV&NLF s unique resistance profiles may allow for salvage upon tx failure. The objectives of this study are to evaluate the activity of APV when used as initial tx & its salvagability w/ NLF. This study is designed to evaluate sequential PI therapies. METHODS:


Triple versus quadruple therapy with non-nucleoside reverse transcriptase inhibitors in drug naive HIV-1 infected individuals with high baseline viral load.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10343)
Bucher HC, Taffe P, Mandalia S, Flepp M, Furrer HJ, Telenti A, Hirschel B, Bernasconi E, Vernazza G, Gazzard B, Battegay M;;; Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
OBJECTIVES: We investigated in a longitudinal analysis the impact of quadruple therapy (3 class regimen) in antiretroviral drug naive patients with high plasma HIV-1 viral load (> 100 000 copies per ml). Data from the Swiss HIV Cohort (SHCS) and the British London Cohort Study (BLCS) were used. METHODS: To assess wheth


Efficacy and affordability of 2 NRTI &1 NNRTI in India --an open study.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10344)
Pandey VP, Saple DG, Vaidya S;;; Associate Professor Medicine,Incharge-HIV/AIDS Physician for M.P.,MGMMedical College,and MY Group of Hospitals,, Indore, India
BACKGROUND: In South -East Asia, India is having one of the worlds largest population of patients living with the HIV. Treatment offered to them in HAART is Zidovudine ,( AZT )


The igestion of aspirin and micronutrients by HIV ifected, ARV naive patients increses the CD4 count, IL-4 and IL-6 but reduces TNF-alpha and IL-2.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10345)
Sibanda EN, Stanczuk GA, Thompsen M, Sorenson AM;;; Medical School, University of Zimbabwe, Harare, Zimbabwe
BACKGROUND: The rates of infection with the HIV have reached epidemic levels in Zimbabwe . Management is constrained by the costs of the medicines and the costs of monitoring. We have investigated the purported role for aspirin in the management of HIV diseases. METHODS: We randomised20 anti-retroviral naive HIV+ mena


Tuberculosis disease in human immunodeficiency viruses infection following effective antiretroviral therapy : the senegalese Initiative to access to ARVs experience.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10346)
Diakhate ND, Sow Papa Salif PS, Ngom Gueye Ndeye Fatou NF, Diouf Louis Martin LM, Bara BN, Adama AN, Sofiatou ST, Gueye Papa Mandoumbe PM, Toure Kane Ndeye Coumba NC;;; Fann Hospital, Dakar, Senegal
BACKGROUND: Effective antiretroviral therapy leads to rapid decrease in plasma HIV-1 RNA, frequently followed by an increase in CD4 T-helper cell counts. The improvement of immune function during highly active antiretroviral therapy has important impact on natural history of AIDS-related opportunistic infections. METHO


A pilot study of saquinavir-SGC (Fortovase, SQV) 1000mg and lopinavir /ritonavir (LPV/r) twice daily in protease inhibitor naive (PIN) HIV+ individuals.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10347)
Hellinger J, Cohen CJ, Morris AB, Hall SS, Jackson-Pope L, de Caprariis PJ;;; Community Research Initiative of New England, Boston and Springfield, MA, United States
BACKGROUND: Four yr followup of the RTV/SQV study (ABT 462) showed sustained viral suppression in 39 PI naive subjects with NRTI intensification and in 44 with no intensification. Lipoatrophy was significantly more prevalent in subjects on NRTIs. OBJECTIVES: To evaluate the Cmin, safety & antiviral activity in PI n


A pilot study of adherence and efficacy of abacavir and combivir in an HIV patient cohort selected to represent diversity - 48 week data.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10348)
Pao D, Erwin J, Kulasegaram R, Peters B;;; St. Thomas' Hospital, London, United Kingdom
BACKGROUND: Efficacy of antiretroviral regimens depends on high levels of adherence, including required dose intervals. Clinical trials tend to exclude people with identified adherence issues, therefore under-representing diverse patient groups. Our study included a high proportion of patients with adherence issues or


Is it safe to switch to Tenofovir when individuals are virologically controlled on antiretroviral therapy.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10349)
Nelson M, Bell C, Bower M, Pozniak A, Gazzard BG, Nelson M;;; Chelsea &Westminster Hospital, London, United Kingdom
Aim To assess the virological safety of switching a successful antiviral regimen to a tenofovir containing regime when viral load is undetectable (


Long term efficacy of treatment in HIV-1 experienced patients with lopinavir and ritonavir.
Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. B10350)
Raise E, Bechi P, Narne E, Bechi M, Rocchetto P;;; Infectious Disease Dpt. SS. Giovanni e Paolo, Umberto 1° Hospital, Venice, Italy
BACKGROUND: potent antiretroviral therapy (HAART) has shown encouraging results in HIV 1 infected patients (pts) but emergence of resistence is frequent. Lopinavir (LPV) and Ritonavir (RTV) ( Kaletra ) are known to cause benefit in experienced pts.


A multicenter, open-label, 24-week study with a 24-week extension to evaluate the efficacy and safety of indinavir sulfate (IDV/CRIXIVAN) 800 mg and ritonavir (RTV) 200 mg b.i.d. Plus 2 NRTIs b.i.d. in HIV-1 infected individual