AEGiS-15IAC: Microbicidal activity of polyoxidonium in HIV infection prophylactics with discordant partners.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

Microbicidal activity of polyoxidonium in HIV infection prophylactics with discordant partners.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. B10123)

Siziakina L, Kuzina T, Andreeva I, Sokolova J, Kharitonova M, Chumacova E
Medical University , Rostov-on-Don, Russian Federation

BACKGROUND: Polyoxidonium is a high-molecular physiologically active polymer with evident immunotropic action producing powerful stimulating influence over the phagocytic system cells-monocytes and neutrophils - thus leading to an increase of cytokine synthesis and to phagocytosis as well as cytotoxic activity of NK-cells.

METHODS: In order to study its microbicidal activity polyoxidonium was included into complex treatment of HIV-infected women (B stage acc. to CDC), 18 - 35 years of age, in the form of 10 vaginal suppositories (0,006 gr. each) daily. The second group consisted of HIV-seronegative women (15) who had HIV-infected men as their constant sexual partners.

RESULTS: It was discovered that the HIV-infected women demonstrated an increase in the number of resident macrophages in the vaginal mucous membrane expressing FcgammaR- and C3bR-receptors (from 19,2±0,4% to 28,5±0,3% and from 30,3±1,7% to 45,6±1,9% respectively), their phagocytic activity grew up, which fact was accompanied with the increase of oxygen-dependant metabolism and also an increase of the adaptive resources. With those women a decrease of proviral load was registered for the resident mononuclear phagocytes of vaginal mucous membrane and cervical duct (from 645 genc/107 cell to 1607 genc/107 cell) and for cervical mononuclear phagocytes of peripheral blood; viral load of plasma also decreased (from 2027 genc/ml to 548 genc/ml). In the second group of patients who had been under catamnetic observation for half a year no HIV infections of women were detected despite the fact that they had constant sexual contacts with HIV-infected men, who did not use condoms.

CONCLUSIONS: Thus polyoxidonium demonstrates bactericidal and immunotropic activity in cases of local administration.

Keywords: AEGIS, Condoms, HIV Infections, HIV Seropositivity, Sexual Partners, Acquired Immunodeficiency Syndrome, Viral Load, Infection, Humans, Female, Male, therapy

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B10123