AEGiS-15IAC: Mother-to-child transmission of hepatitis C virus in babies born to co-infected both HIV and HCV women.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

Mother-to-child transmission of hepatitis C virus in babies born to co-infected both HIV and HCV women.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. B10442)

Zverev SY, Alikina YI, Novikova OV, Zemskova EA
Regional AIDS Centre, Perm, Russian Federation

BACKGROUND: Of 4,915 HIV-infected persons registered on the 1-st of January, 2004, in Perm region, 29,5% were women of fertile age and co-infected with HIV-1 and HCV. To evaluate risk of HCV maternal transmission to babies exposed to both viruses we have investigated all cases of childbirth among these women.

METHODS: Plasma samples from children were analysed for HCV and HIV-1 RNA and antibodies to HCV using PCR and ELISA.

RESULTS: There were 91 children under our observation. Mode of delivery was by vaginal route for all infants, none of them were breast-fed. Ten babies had HCV RNA in plasma in the age of 1 - 2 month, but three of them became negative both RNA-PCR and antibodies -ELISA HCV tests after nine month from birth. All 10 children were none HIV-infected.

CONCLUSIONS: Performing of adequate diagnostics of both infections for babies born to women co-infected both HIV and HCV is necessary. Final diagnosis of HCV- infection among such children may be determine no earlier one-year age.

Keywords: AEGIS, HIV, HIV Seropositivity, Hepacivirus, Acquired Immunodeficiency Syndrome, HIV Infections, Mothers, Pregnancy Complications, Infectious, HIV Seronegativity, Infection, Polymerase Chain Reaction, Viremia, HIV-1, Delivery, Obstetric, Infant, Child, Infant, Newborn, Humans, Female, transmission, immunology, surgery

040711
B10442