AEGiS-15IAC: Health related quality of life and feeling of control among HIV-infected patients with highly antiretroviral therapy.

15th International AIDS Conference


Bangkok, Thailand - July 11-16, 2004

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Health related quality of life and feeling of control among HIV-infected patients with highly antiretroviral therapy.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. MoOrD1028)

Spire B, Preau M, Vincent E, Trainaud MH, May T, Picard O, Leport C, Morin M
INSERMU379/ORS, Marseille, France

BACKGROUND: This study examined the relations between health related quality of life (HRQL) and the feeling of control using locus of control (LOC) beliefs in 296 HIV-infected patients enrolled in a French cohort, 44 months (M44) after they began HAART.

METHODS: A self-administered questionnaire gathered information about HRQL (MOS-SF36), LOC beliefs and psychosocial and socio-demographic characteristics. LOC beliefs was measured with Levenson's scale that contains 3 independent subscales. The first internal LOC beliefs refers to the belief that one stays or becomes healthy as a result of his/her behaviour. The second scale measures the extent of belief in an external LOC involving powerful others that refers to the expectancy that it is primarily doctors who determine health. The third scale measures the extent of belief in chance. HRQL was measured with the MOS-SF-36. We used the two aggregate scores, physical (PCS) and mental (MCS) component summary of HRQL. Analysis of covariance was used to examine the relations, adjusted for baseline HRQL, between HRQL and LOC beliefs, sociodemographic and psychosocial characteristics.

RESULTS: Mental HRQL and LOC beliefs changed significantly over time during illness. Internal LOC beliefs after more than three years of HAART were associated with both mental and physical HRQL in multivariate analysis. After multiple adjustment, internal LOC beliefs on beginning HAART were not associated with physical and mental HRQL at M44. Self-reported symptoms, patient-provider relationship and social status were always significantly associated with HRQL.

CONCLUSIONS: The dynamics of the mutual influence of control beliefs and treatment experience of treatment were significantly related to HRQL in persons with HIV infection. Our results underline the need of improving the feeling of control and the patient-provider relationship, to take into account to self-reported symptoms and social status for attaining higher HRQL in the long-term.

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, HIV Seropositivity, HIV Infections, Health, Antiretroviral Therapy, Highly Active, Emotions, Quality of Life, Life, Questionnaires, Health Status, Adaptation, Psychological, Health Status Indicators, Activities of Daily Living, Women's Health, Humans, therapy, prevention & control, pathogenicity, rehabilitation, drug therapy

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MoOrD1028

Copyright © 2004 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.