AEGiS-15IAC: Anal papilloma and human immunodeficiency virus: Incidence and involved serotypes.

15th International AIDS Conference


Bangkok, Thailand - July 11-16, 2004

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Anal papilloma and human immunodeficiency virus: Incidence and involved serotypes.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. ThOrA1406)

Alfonzo R, Garcia NA, Weidenfeld J, Ochoa R, La Cruz MJ
Hospital de Clinicas Caracas, Caracas, Venezuela

Infection by Human Immunodeficiency Virus (HIV) has been considered pandemic since the 1980's, in part due to the multiple forms of transmission of which one of the most important is anal sex. Several studies have demonstrated an increased incidence of coinfection with Human Papilloma Virus (HPV). There is a progressive increase of anal HPV probably according to genetic or immunological susceptibility. Objectives: The aim of this study is to determine the incidence and to identify the HPV type in patients who have had anal sex, followed in an outpatient coloproctology consult at the Hospital de Clinicas Caracas between July 1999 and December 2003.

METHODS: This is a cross sectional study of all patients with HIV who underwent anal cytology (n= 402) and Polymerase Chain Reaction (PCR) (n= 396) to obtain the serotype of virus involved and to classify them as high risk (types 16, 61) and low risk (types 6,11), mixed or absence of infection.

RESULTS: We found that 74% of HIV (+) patients where coinfected with HPV, 44% belonged in the high risk group, 12% in low risk and 18% had both high and low risk serotypes. Anal cytology showed: low grade intraepithelial lesions in 17%, high grade 39%, Carcinoma 4% and normal cytology in 35%, while 5% of the cytologies where unclassifiable. Conclusion We conclude that anal cytology and PCR are complementary studies in the diagnosis of anal VPH infection in HIV (+) patients, and recommend the use of both methods for the purpose of classifying the patients' risks.

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, Incidence, Papillomavirus, Human, HIV Seropositivity, Anus Diseases, Sexual Behavior, Anus, Cross-Sectional Studies, Humans, epidemiology

040711
ThOrA1406

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