AEGiS-15IAC: Effects of single nucleotide polymorphism in the RANTES promoter region on HIV infection and disease progression in indigenous Chinese.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

Effects of single nucleotide polymorphism in the RANTES promoter region on HIV infection and disease progression in indigenous Chinese.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. TuOrA1105)

Zheng BJ, Zhao XY, Lee SS, Wong KH, Chan KC, Ma S, Ng MH
The University of Hong Kong, Hong Kong, China

BACKGROUND: Previous studies showed that single nucleotide polymorphism (SNPs) at coordinates -403 and -28 in the promoter region of RANTES, ie. -403A/G and -28 C/G, exhibit distinct ethnic distribution. Their apparent impact on the course of HIV infection also seems to differ for different ethnic groups.

METHODS: We determined the occurrence of these SNPs in 1,082 Chinese blood donors and 249 HIV patients, and related the distribution to HIV infection and plasma level of RANTE.

RESULTS: We showed that the frequency of these SNPs is the same for Northern and Southern Chinese, and is also similar to that of Japanese. The frequency of the -403G (62.7%) is higher than in indigenous Africans and lower than in Caucasians, Hispanics, Asians and in American Africans. The -28G mutant allele has a comparable frequency (12%) in Chinese and Japanese, but is rare among the other ethnic groups. Compared with blood donors, AIDS patients have a significantly higher frequency of the -403G allele and the haplotypeI, -403G/-28C, and a lower frequency of the -403A/A genotype (p<0.05). Symptomatic patients have higher frequency of -28G allele and lower frequency of the -28C/C (p≤0.01. Plasma RANTES level was significantly lower in blood donors homozygous for haplotype I than in those who are homozygous for haplotype II or III (p<0.05).

CONCLUSIONS: SNP -403G was associated with increased susceptibility to HIV infection, whereas -28G was associated with rapid disease progression. The impact on the course of HIV infection appears to be distinct for Chinese.

Keywords: AEGIS, Disease Progression, RANTES, Polymorphism, Single Nucleotide, HIV Infections, Promoter Regions (Genetics), Acquired Immunodeficiency Syndrome, Haplotypes, Genotype, Asian Continental Ancestry Group, HIV Seropositivity, Alleles, Ethnic Groups, Humans, genetics

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TuOrA1105