16th International AIDS Conference Toronto, Canada - August 13 - 18, 2006

RISK FACTORS TO CERVICAL INTRAEPITHELIAL NEOPLASIA RECURRENCE AFTER LOOP ELECTROSURGICAL EXCISION PROCEDURE IN HIV-1-INFECTED AND NON-INFECTED WOMEN

Int Conf AIDS. 2006 Aug 13-18;16 Abstract No. TuAb0304

M.I.M. Lima¹, V.H. Melo², C.P. Tafuri³, A.C.L. Araujo³, L.M. Lima⁴, H.C. Oliveira⁴, I.M. Faria², C.M. Corrêa², F.M. Faria², T.T. Souza², C.T.C. Lodi⁵, N.C.P. Teixeira⁵, M.D.C. Guimaraes², Research Group Women and HIV
¹ Universidade Federal de Minas Gerais, GINECOLOGIA, Belo Horizonte, Brazil, ² Universidade Federal de Minas Gerais, Faculdade de Medicina, Belo Horizonte, Brazil, ³ Prefeitura Municipal, Belo Horizonte, Brazil, ⁴ Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil, ⁵ CTR-DIP Orestes Diniz, Prefeitura Municipal, Belo Horizonte, Brazil

BACKGROUND: cervical intraepithelial neoplasia (CIN) is very common in HIV-1-infected women. The objective of this study was to evaluate risk factors associated with recurrence of CIN after loop electrosurgical excision procedure (LEEP).

METHODS: nested case-control (retrospective) was performed for analysing histopathological results from 201 women that were undergone to LEEP conization. We compared results from two groups of women: 94 HIV-1-infected and 107 non-infected women. All patients had CIN confirmed by biopsy and were followed for a mean period of two years. They were undergone to a colposcopic and cytological evaluation every six months. Event defined was recurrence of CIN after LEEP. Bethesda classification was used to cytological results. Cone biopsy characteristics evaluated were cervical intraepithelial neoplasia grade, margins of lesions, HPV histopathological diagnosis and glandular involvement. Comparative analyses were performed between groups by linear trend qui-square test, with Yates correction, for categorical variables. ANOVA was used for continuous variables comparison. Multivariable analysis was carried out by logistic regression.

RESULTS: CIN recurrence was found in 40 women (cases). The other 161 women were considered as controls. Main factors correlated to CIN recurrence after logistic regression were: glandular involvement (OR=9.11; CI 95%: 3.02 – 27.48); HIV-1-infection (OR=4.6; CI 95%:1.88 – 11.21); compromised margins of lesions (OR=2.59; CI 95%: 1.07 – 6,.7). The most frequent recurrence was found with margins compromised and glandular involvement association (p=000.1). No CIN has progressed to invasive cancer.

CONCLUSIONS: Main risk factors associated to cervical intraepithelial neoplasia recurrence after loop electrosurgical excision procedure were HIV-1-infection, glandular involvement and compromised margins in cone biopsy.

Download PDF of this abstract.

Download Power Point Presentation.

2006-08-13
TuAb0304

Copyright © 2006 - International AIDS Society (IAS). All information and content relating to the abstracts from the 16th International AIDS Conference, such as text, graphics, logos, button icons, images, audio clips, and software is protected by copyright. Permission is hereby granted for the non-commercial use or reproduction of the information on this web site, provided that the use of such information is accompanied by an acknowledgement that IAS is the source of the information and the name of the author of the article.

AEGiS is a 501c(3) not-for-profit organization made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, GlaxoSmithKline, the National Library of Medicine, Roche / Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 2006. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 2006. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. Permission is hereby granted for the non-commercial use or reproduction of the information herein, provided that the use of such information is accompanied by an acknowledgement that IAS is the source of the information and the name of the author of the article.