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16th International AIDS ConferenceToronto, Canada — August 13-18, 2006 |
Cite as: Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. xx
| Table of Contents Main Monday Tuesday Wednesday Thursday Late-Breakers |
| Oral Abstracts | |
| Track A | |
| MoAa01 | HIV Attachment, Penetration and Tropism |
| MoAa0101 | ATTACHMENT IN HIV ENTRY PROCESS BY ELECTRON MICROSCOPIC TOMOGRAPHY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0101 Goto T.1, Hasegawa T.2, Kajimura N.2, Iwabu Y.3, Yamamoto D.4, Ikuta K.3, Takaoka A.2 At the first contact point, the distance between the virus and the cell membrane corresponds very well to the length of the extended gp41 molecule. Further stages have been investigated and will be discussed. |
| MoAa0102 | CELL-TO-CELL HIV-1 TRANSMISSION THROUGH A CLATHRIN-DEPENDENT ENDOCYTIC PATHWAY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0102 Bosch B.1, Grigorov B.2, Senserrich J.1, Blanco J.1, Clotet B.1, Darlix J.-L.2, Muriaux D.2, Este J.1 Taken together these results suggest that HIV-1 cell-to-cell transmission probably occur through a caveolin-independent but clathrin-dependent endocytic process leading to the formation of endosomal vesicles containing complete HIV-1 particles. |
| MoAa0103 | ROLE OF THE HIGHLY CONSERVED LWYIK MOTIF OF THE TRANSMEMBRANE PROTEIN gp41 OF HIV IN ENV-MEDIATED MEMBRANE FUSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0103 Chen S.S.-L., Chan W.-E. Our study shows that localization of Env in lipid rafts is not sufficient for Env-mediated membrane fusion. The results also demonstrate that the immediate membrane-proximal LWYIK motif is not necessary for Env maturation or incorporation into the virus, but does play a critical role in membrane fusion by promoting formation of a functional fusion pore. |
| MoAa0104 | CXCR4 ANTAGONIST-INDUCED CORECEPTOR SWITCH FROM X4 TO R5 PHENOTYPE IN VITRO DETERMINED BY A SINGLE AMINO ACID SUBSTITUTION IN THE V3 REGION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 gp120 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0104 Maeda Y., Yusa K., Harada S. These results indicated that the coreceptor switch from X4 to R5 phenotype was easily occurred in vitro when intermediate phenotypes of HIV-1 (R5X4 variants) were used. |
| MoAa0105 | THE MECHANISM OF HIV-1 ESCAPE FROM SMALL MOLECULE CCR5 ANTAGONISTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0105 Pugach P., Kuhmann S., Ketas T., Moore J.P. We interpret these findings to indicate that the resistant viruses are utilizing CCR5 receptors to which the small molecule have already bound in a way that blocks PSC-RANTES binding. The appearance of "plateaus" of incomplete resistance suggests that these viruses utilize drug-bound CCR5 less efficiently than drug-free receptors. |
| MoAa02 | Neutralizing Antibodies to HIV |
| MoAa0201 | PROBING THE PROMISCUITY OF THE HIV-1 NEUTRALIZING 2F5 ANTIBODY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0201 Julien J.-P., Bryson S., Pai E.F. The results presented here give new insights in the structure-based design of a peptide-like molecule potentially capable of stimulating 2F5 antibody production and help in the bigger quest of creating a potent vaccine for HIV-1. |
| MoAa0203 | THE E2DISP ANTIGEN DISPLAY SYSTEM: A NOVEL HIV VACCINE APPROACH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0203 Lauman D.N.1, Caivano A.2, Domingo G.3, Meoli L.2, Thomas S.4, Sutton W.F.5, Kaja M.-K.4, Haigwood N.L.5, De Berardinis P.2, Doria-Rose N.5 Both pure and hybrid E2DISP-HIV particles are immunogenic in non-transgenic mice. The successful boosting of HIV-specific antibodies despite the presence of antibodies to the E2DISP backbone suggests that higher titer responses may be elicited with additional immunizations. Future studies will evaluate the immunogenicity of E2Env, E2Nef and E2Rev constructs, and alternative adjuvants will be used to enhance CTL responses. Generation of NAbs will be evaluated following immunizations with E2Env constructs, such as E2Env-gp41EC, which contains a target of broad NAbs, the Membrane Proximal External Region. |
| MoAa0204 | VACCINE-RELEVANT MIMOTOPES SELECTED WITH NEUTRALIZING IGG PRESENT IN PLASMA FROM LONG-TERM NON-PROGRESSORS (LTNP) BY PHAGE DISPLAY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0204 Humbert M.1, Antoni S.1, Landersz M.1, Rodes B.2, Soriano V.2, Knechten H.3, Staszewski S.4, von Laer D.1, Dittmar M.5, Dietrich U.1 The phage display technology was successfully applied to identify HIV-1 specific mimotopes for neutralizing antibodies supposed to have a protective role in LTNP. These mimotopes represent candidates for the derivation of vaccine-relevant immunogens. |
| MoAa0205 | MATERNAL NEUTRALIZING ANTIBODIES TO A CRF01_AE PRIMARY ISOLATE ARE ASSOCIATED WITH LOW INTRA-PARTUM TRANSMISSION OF HIV-1 IN THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0205 Samleerat T.1, Jourdain G.2, Braibant M.3, Ngo-Giang-Huong N.2, Lallement M.2, Leechanachai P.4, Sirithadthamrong S.5, Surasaerneewongse V.6, Warachit B.7, Hotrawarikarn S.8, Barin F.3 Our analysis confirmed our previous observation that high levels of NAb to MBA were associated with low risk of MTCT, and this was mainly due to a lower risk of intra-partum transmission. Such data support the hypothesis that passive immunization could be efficient in preventing MTCT. Further studies are needed to understand why levels of Nab to MBA are more relevant to MTCT than other Nab. |
| MoAa0206 | LOOP DELETIONS IN gp120 EXPOSE THE CD4 BINDING SITE FOR IMPROVED BINDING OF 1b12 AND F105 ANTIBODIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAa0206 Berkower I., Ni Y., Patel C., Spadaccini A. These results suggest that naturally occurring features of the gp120 structure may inhibit antibody binding and reduce the induction of antibodies to the CD4 binding site. These structures can be removed without upsetting the overall conformation. Exposure of the CD4 binding site could occur by reducing steric hindrance or through an allosteric effect on the excursion between open and closed forms of the protein, as occurs during CD4 binding. Open forms of gp120 bearing an exposed CD4 binding site may favor the induction of broadly cross-reactive neutralizing antibodies. |
| Track B | |
| MoAb01 | Challenges in Tuberculosis |
| MoAb0101 | ELISPOTs IN THE DETECTION OF MYCOBACTERIUM TUBERCULOSIS INFECTION IN A POPULATION WITH HIGH PREVALENCE OF HIV AND HIGH EXPOSURE TO BCG AND ENVIRONMENTAL MYCOBACTERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAB0101 Mutsvangwa J.1, Corbett E.L.2, Chaka-Boyd K.3, Vundla R.4, Muzangwa J.4, Mavhudzi T.4, Cheung Y.5, Mason P.R.6, Millington K.7, Ewer K.7, Lalvani A.7, Butterworth A.E.8 A proportion of positive TSTs and PPD responses may be attributable to exposure to organisms other than MTB. Both TSTs and PPD ELISPOTs are substantially reduced in HIV-infected individuals, whereas RD1 ELISPOTs are unaffected. Thus, this study supports that the RD1 ELISPOT is a useful marker of MTB infection in individuals from areas with a high prevalence of HIV infection and high exposure to BCG or cross-reactive environmental mycobacteria. |
| MoAb0102 | CHARACTERISTICS OF PEOPLE LIVING WITH HIV-1 (PLWH) SCREENED FOR ISONIAZID PREVENTIVE THERAPY (IPT) - BOTSWANA, 2004-2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0102 Samandari T.1, Mosimaneotsile B.2, Nyirenda S.3, Agizew T.2, Motsamai O.4, Kilmarx P.H.5, Talbot E.A.6, Wells C.D.6 Many PLWH seeking IPT in Botswana have advanced HIV disease, and were ineligible for IPT due to current illness at first-round screening or an abnormal CXR in second-round screening. As these exclusions were most likely related to advanced HIV disease, national IPT programs may best target candidates for IPT by targeting HIV screening to healthier individuals. |
| MoAb0103 | FACTORS ASSOCIATED WITH MULTIDRUG-RESISTANT TUBERCULOSIS IN HIV-INFECTED PATIENTS, PERU Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0103 Vargas D.1, Bernabé A.2, Gilman R.H.3, Kawai V.1, Soto G.1, Moore D.A.1, Caviedes L.4, Bautista C.T.5, Tovar M.1, Chávez V.6, Huaroto L.6, Ticona E.6, Evans C.A.1 Amongst this population of HIV-positive subjects, the risk factors associated with MDR-TB were previous antituberculosis chemoprophylaxis with isoniazid, recent hospital admission and the close contact witn another tuberculosis patient. These results emphasize the importance of ruling-out active tuberculosis before administering isoniazid preventive therapy and optimizing infection control practices to prevent nosocomial and domiciliary dissemination of MDR-TB. |
| MoAb0104 | TUBERCULOSIS INCIDENCE AND RISK FACTORS AMONG ADULT PATIENTS RECEIVING HAART IN SENEGAL: A 7-YEAR COHORT STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0104 Diouf A.1, Etard J.-F.2, Ndiaye I.3, Ngom Guèye N.F.4, Guèye P.M.5, Ba Fall K.5, Thierry-Mieg M.2, Dieng A.B.1, Cilote V.6, Lanièce I.6, Christian L.2, Sow P.S.3, Ndoye I.6, Delaporte E.2, ANRS 1290 This study provides the first estimates of tuberculosis incidence following HAART initiation in Senegal. |
| MoAb0105 | UNMASKING OF MYCOBACTERIA TUBERCULOSIS IN PATIENTS INITIATING FREE ARVS IN AN URBAN HIV CLINIC IN KAMPALA UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0105 Wandera B.1, Kigonya C.2, Kambugu A.3, Thomas D.4, Kamya M.R.5 There is an appreciable risk of unmasking of TB in patients starting ARVs in this urban HIV clinic and therefore TB and HIV treatment programs in sub Saharan Africa need to be designed in partnership. Innovative interventions are needed to control TB in HIV-infected populations. Detailed analyses and results will be discussed. |
| MoAb0106 | BLOOD BASED METHODS OF IDENTIFYING TUBERCULOSIS INFECTIONS IN HIGH HIV/TB INCIDENCE AREAS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0106 Rangaka M.1, Wilkinson K.1, Shey M.2, Seldon R.1, Mouton P.2, van Cutsem G.3, Goemare E.3, Meintjes G.4, Maartens G.5, Wilkinson R.6, Mycobacterial Immunology Group Compared to HIV uninfected, the recall response to PPD in HIV-infected people is impaired. By contrast, the responses to antigens secreted by dividing M. tuberculosis are well preserved. This has implications for immunodiagnosis: There is a role for RD1 assays in the HIV context and these tests may identify more people for TB prophylaxis. HIV may not quite be the Achilles’ heel of T cell based assays! |
| MoAb02 | Scaling Up ART for Children - Negotiating the Access Gap |
| MoAb0201 | CHILDREN ENROLLED IN A PUBLIC HIV CARE AND TREATMENT PROGRAM IN LUSAKA, ZAMBIA: RAPID SCALE-UP AND FIRST-YEAR CLINICAL OUTCOMES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0201 Mbewe M.1, Bolton C.1, Levy J.1, Sinkala M.2, Bulterys M.3, Chi B.1, Wilfert C.4, Stringer J.1, Dumas A.1, Chintu N.1, Stringer E.1 In this population without full access to infant HIV diagnostics, more than two-thirds of HIV-infected children presenting for care were eligible for ART. Providing quality HIV care and treatment to children on a large scale in a resource-limited setting is feasible but requires a strong commitment to pediatric care. |
| MoAb0202 | IMPACT OF FREE AND UNIVERSAL ACCESS TO ANTIRETROVIRAL TREATMENT ON THE SURVIVAL AMONG BRAZILIAN CHILDREN WITH AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0202 Matida L.H.1, Novaes A.2, Moncau J.E.C.3, Marcopito L.F.3, Marques H.H.S.4, Succi R.C.M.3, Della Negra M.5, Hearst N.6, Brazilian Group of Survival Study in Children with HIV A free and universal access to ART, even in a country that lacks an ideal health infrastructure, can make a substantial difference in survival. These results argue strongly for making such treatment available to children elsewhere in the developing world. |
| MoAb0203 | OUTCOMES OF CHILDREN, STRATIFIED BY IMMUNE STATUS, RECEIVING ANTI-RETROVIRAL THERAPY (ART) IN MÉDECINS SANS FRONTIÈRES (MSF)-SUPPORTED PROJECTS IN RESOURCE-POOR COUNTRIES (RPCS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0203 Olson D.1, Sauvageot D.2, Ferradini L.2, O' Brien D.3, Humblet P.4, The MSF AIDS Working Group Young children can be successfully treated with ART in RPCs, as measured by treatment continuation and immunologic criteria. Extent of baseline IS does not appear to impact on treatment outcome by month 12. |
| MoAb0204 | ANTI-RETROVIRAL THERAPY (ART) OUTCOMES IN CHILDREN < 13 YEARS OF AGE IN RESOURCE-POOR COUNTRIES (RPCS): A MÉDECINS SANS FRONTIÈRES (MSF) COHORT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0204 Olson D.1, Sauvageot D.2, Ferradini L.2, Humblet P.3, the MSF AIDS Working Group In RPCs, children < 13 years of age appear to do well on ART, based on survival and immunologic criteria, with a low incidence of significant adverse side effects. Continuing efforts at treatment scale-up should include increased attention on ART for children. |
| MoAb0205 | FORECASTING HIV TREATMENT NEEDS IN CHILDREN TO GUIDE POLICY, PLANNING AND SCALE UP: A MULTI-COUNTRY EXPERIENCE FROM INDIA, MALAWI, CAMEROON, RWANDA AND COTE D'IVOIRE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0205 Ngashi N.1, Luo C.1, Mulenga D.2, Little K.3, Gass R.1 National programs have started using this information to revise national policies on pediatric care and to define realistic population-based targets, scale up plans and strategies for achieving these targets. The estimation of country-specific burden of disease and treatment needs is a powerful tool for advocacy and scale up planning and should be roll out. |
| MoAb03 | Complications of HIV-Infections |
| MoAb0301 | Neurodevelopmental functioning in HIV-infected children before and after the introduction of highly active antiretroviral therapy (HAART) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0301 Lindsey J.1, Malee K.2, Brouwers P.3, Hughes M.1 Suppression of HIV-1 RNA levels and subsequent benefits in survival and immunologic status brought about by HAART have been followed by decreasing differences in developmental functioning between HIV+ and HIV- children during the first three years of life. |
| MoAb0302 | NEUROCOGNITIVE IMPAIRMENT, SYMPTOMATIC PERIPHERAL NEUROPATHY AND DEPRESSION ARE HIGHLY PREVALENT IN HIV INFECTED OUTPATIENTS WITHIN THE ASIA PACIFIC REGION: FINDINGS OF THE ASIA PACIFIC NeuroAIDS CONSORTIUM (APNAC) STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0302 Wright E.1, Brew B.2, Kongsaengdao S.3, Arayawithchanont A.4, Samintarapunya K.5, Imran D.6, Lun W.7, Kamarulzaman A.8, Li P.9, Tau G.10, Vonthanak S.11, Sarim C.11, Huffam S.11, Kishore K.12, Ali S.T.13, Robertson K.14, Lal L.15, Lim M.15, Devadson D.15, Bain P.2, Dwyer R.16, McCormack G.1, Scholten C.1, Cherry C.15, McArthur J.17, Wesselingh S.15 HIV-related NCI, symptomatic PN and depression are common under-diagnosed conditions in HIV-infected outpatients at sites in Thailand, Indonesia, China and Malaysia and require further study. |
| MoAb0303 | TRENDS AND RISK FACTORS FOR COMMUNITY-ACQUIRED PNEUMONIA AMONG HIV-INFECTED AND HIV-UNINFECTED INTRAVENOUS DRUG USERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0303 Stein K.1, Astemborski J.2, Mehta S.2, Vlahov D.3, Galai N.2, Kirk G.2 CAP incidence is declining among IDUs. Among HIV-infected IDUs, CAP risk from lifestyle-related factors has diminished while effects of HIV disease status predominate. HAART greatly reduces CAP risk, but HIV-infected IDUs remain at high risk even with relatively intact immune function. |
| MoAb0304 | INCREASING RATES OF COMMUNITY-ACQUIRED MRSA INFECTIONS AMONG HIV-INFECTED PERSONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0304 Crum-Cianflone N.1, Hale B.2, Burgi A.1, Utz G.2, Truett A.2, Chun H.2, Bavaro M.2, TriService AIDS Clinical Consortium Community-acquired MRSA infections are rapidly increasing among HIV-infected patients. HIV patients have a 18-fold higher risk for CA-MRSA than the general population. Risk factors for CA-MRSA include recent use of B-lactam antibiotics and high-risk sexual activity as demonstrated by syphilis infection. |
| MoAb0305 | STUDY OF IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME (IRIS) IN RESOURCE LIMITED SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0305 Bhrushundi M., Mishra P. After initiating ART in individuals with low CD4+T-helper cells, meticulous follow up and patients awareness can detect the IRIS early. TB IRIS tops too followed by PCP. IRIS increases cost of the treatment especially with CMV, Hepatitis C and Cryptococcal meningitis IRIS. IRIS can have fetal outcome also. |
| MoAb04 | Nutrition and HIV |
| MoAb0401 | A PILOT RANDOMIZED TRIAL OF NUTRITIONAL SUPPLEMENTATION IN FOOD INSECURE PATIENTS RECEIVING ANTIRETROVIRAL THERAPY (ART) IN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0401 Megazzini K.1, Washington S.1, Sinkala M.2, Lawson-Marriott S.3, Stringer E.1, Krebs D.1, Levy J.1, Chi B.1, Cantrell R.1, Zulu I.4, Mulenga L.1, Stringer J.1 In this pilot study, a monthly household food ration for food insecure patients commencing ART improved adherence by 40% and resulted in a better CD4+ response at 12 months of therapy. Further study is warranted of food supplementation as an adjunct to ART in food insecure patients. |
| MoAb0402 | MICRONUTRIENT SUPPLEMENTATION INCREASES CD4 COUNT IN HIV-INFECTED INDIVIDUALS ON HAART: A PROSPECTIVE, DOUBLE-BLINDED, PLACEBO-CONTROLLED TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0402 Kaiser J.1, Baum M.2, Campa A.2, Ondercin J.3, Leoung G.4, Pless R.5 Micronutrient supplementation can significantly improve CD4 cell count reconstitution in HIV-infected patients taking HAART. The micronutrient supplement tested was well-tolerated and may hold promise as an adjuvant therapy in the treatment of HIV. Further investigation is warranted. |
| MoAb0403 | THE ROLE OF SELENIUM AS ADJUNCT TO HAART AMONG HIV INFECTED INDIVIDUALS WHO ARE ADVANCED IN THEIR DISEASE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0403 Odunukwe N.N.1, Onwujekwe D.1, Ezechi O.O.1, Ezobi P.1, Gbajabiamila T.1, Anyanwu R.1, Iloka E.1, Adu R.1, Nwogbe O.1, Audu R.1, Herbertson E.1, Idigbe E.O.1, Kanki P.2 Selenium supplementation resulted in higher CD4. This supports Selenium supplement as an adjunct to HAART in HIV positive individuals with severe immune suppression. |
| MoAb0404 | GROWTH AND BODY COMPOSITION IN CHILDREN BEGINNING OR CHANGING ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0404 Chantry C.1, Hughes M.2, Alvero C.2, Cervia J.3, Hodge J.4, Borum P.5, Moye J.6, PACTG 1010 HIV+ children beginning or changing ART demonstrate greater gains in weight, height and lean mass than age/sex/race-adjusted norms. Baseline characteristics, but not virologic response to therapy, immune reconstitution nor specific ART class(es) in the new regimen are associated with growth or body composition changes. IGF-1 increases and IGFBP-1 decreases in these children may relate physiologically to growth and body composition changes. |
| MoAb0405 | IMPACT OF HIV STATUS ON PATTERNS OF MORTALITY IN HIV INFECTED SEVERELY MALNOURISHED CHILDREN, ADMITTED TO 3 NUTRITION REHABILITATION UNITS IN THE CENTRAL REGION OF MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAb0405 Chinkhumba J.1, Fergusson P.2, Thurstans S.3, Nyirenda G.1, Mafupa H.1, Tomkins A.4 HIV positive severely malnourished children have a greater risk of dying in early rehabilitation and the average admission in the NRU is nearly twice as long in HIV positive children than HIV negative. There is need for prompt referral of malnourished children to NRUs and need for early identification of HIV status in children and caretakers for essential access to HIV treatment. More effective treatment regimes for HIV positive children in early rehabilitation need to be developed and tested. |
| Track C | |
| MoAc01 | What is Working (or not) for HIV Prevention Among MSM? |
| MoAc0101 | SURVEILLANCE OF HIV PREVALENCE AMONG POPULATIONS OF MEN WHO HAVE SEX WITH MEN IN THAILAND, 2003-2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0101 van Griensven F.1, Varangrat A.2, Naorat S.2, Sinthuwattanawibool C.2, McNicholl J.M.1, Mock P.A.2, Siraprapasiri T.2, Jommaroeng R.3, Phanuphak P.4, Tappero J.W.5, the Thailand MSM Study Group Data show that by 2005, HIV was widespread in Thai populations of men who have sex with men. Among MSM in Bangkok, HIV prevalence increased over 50% between 2003 and 2005. In 2005, more than 20% of Bangkok MSM ≤22 years old were HIV-infected, suggesting high underlying HIV incidence. Thai populations of men who have sex with men should be considered for the implementation and evaluation of preventive interventions. |
| MoAc0102 | BEING POSITIVE ABOUT STAYING NEGATIVE; THE POWER OF FIRST PERSON NARRATIVE IN HIV PREVENTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0102 Grierson J.1, Batrouney C.2, Mclean M.3, Kennedy M.4 This approach will continue informing our thinking in relation to the work of the program while allowing us a ‘snapshot’ of current issues facing homosexually active men (both HIV positive and negative) living in the midst of an ongoing epidemic. |
| MoAc0103 | EVALUATION OF A COMMUNITY-LEVEL PEER-BASED HIV PREVENTION INTERVENTION ADAPTED FOR YOUNG BLACK MEN WHO HAVE SEX WITH MEN (MSM) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0103 Jones K.1, Gray P.2, Wang T.1, Johnson W.1, Foust E.2, Dunbar E.1, The North Carolina Men's Health Initiative We observed significant decreases after implementing the adapted intervention. We concluded that adapting evidence-based interventions is a key step in increasing the number interventions for black MSM. |
| MoAc0104 | A THEORY-BASED, TAILORED, INTERACTIVE INTERVENTION DIRECTED AT MSM WHO MEET SEXUAL PARTNERS THROUGH INTERNET CHAT SITES: EFFECTIVE FOR MSM WHO PRACTICE UAI WITH CASUAL PARTNERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0104 Harterink P.1, Hospers H.2, Vriens P.1, Kok G.2, De Zwart O.1 Interactive tailored interventions linked to chat sites can be an effective instrument in HIV prevention for MSM who practice unprotected anal intercourse (UAI) with casual partners. |
| MoAc0105 | HIV SEROSORTING? INCREASES IN SEXUALLY TRANSMITTED INFECTIONS AND RISK BEHAVIOR WITHOUT CONCURRENT INCREASE IN HIV INCIDENCE AMONG MEN WHO HAVE SEX WITH MEN IN SAN FRANCISCO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0105 Truong H.M.1, Kellogg T.2, Klausner J.2, Katz M.2, Dilley J.2, Knapper K.3, Chen S.2, Prabhu R.2, Grant R.4, Louie B.2, Mc Farland W.2 HIV incidence among MSM appears to have stabilized at a plateau following several years of resurgence. Increases in the selection of sexual partners of concordant HIV serostatus may be contributing to the stabilization of the epidemic. However, current incidence rates of STI and HIV remain high. Moreover, a strategy of risk reduction by HIV serosorting can be severely limited by imperfect knowledge of one´s own and one´s partners´ serostatus. |
| MoAc02 | Prevention Works: What's the Evidence? |
| MoAc0201 | ASSESSING A NATIONAL HIV BEHAVIOR CHANGE CAMPAIGN FOCUSING ON MULTIPLE CONCURRENT PARTNERSHIPS IN SWAZILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0201 Halperin D.1, Andersson N.2, Mavuso M.3, George B.4 The study ended up helping guide the development of the government BCC campaign, and could also help inform similar such behavior change interventions carried out elsewhere in the region. |
| MoAc0202 | EXPOSURE TO A COMMUNITY-MOBILIZATION INTERVENTION AND HIV-RELATED KNOWLEDGE, ATTITUDES, AND PRACTICES - BOTSWANA, 2003 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0202 Koppenhaver T.1, Fleming D.2, Meyerson B.3, Robbins A.3, Kebonang G.S.4, Roels T.H.1, Kilmarx P.H.5 These findings suggest that TCM has helped to improve HIV-prevention knowledge, reduce stigma, and encourage testing in Botswana. The lack of association between TCM exposure and targeted sexual behaviors indicates that important behavior-change challenges remain. |
| MoAc0203 | AN EVALUATION OF A QUASI-EXPERIMENTAL COMMUNITY LEVEL HIV INTERVENTION AMONG OUT-OF-SCHOOL YOUTH IN 26 COMMUNITIES IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0203 Anyanti J., Omoregie G., Ankomah A., Adebayo S., Buba-Vaganda A. For both males and females, the PEP interventions were effective in increasing condom use at the intervention but not the control sites. The model is therefore recommended as an effective tool and can be scaled up at similar sites throughout Nigeria and elsewhere. |
| MoAc0204 | CHANGES IN SEXUAL BEHAVIOR AND RISK OF HIV TRANSMISSION AFTER TWO YEARS OF ANTIRETROVIRAL THERAPY AND PREVENTION INTERVENTIONS IN RURAL UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0204 Bunnell R.1, Wamai N.2, Ekwaru J.P.1, Moore D.2, Were W.2, Bechange S.1, Coutinho A.3, Madraa E.4, Mermin J.1 Providing ART and on-going prevention interventions was associated with a reduced estimated risk of HIV transmission among HIV-infected Ugandan adults after two years of therapy, despite an increase in overall sexual activity. Integrated ART and prevention programs may reduce HIV transmission in Africa. |
| MoAc0205 | LIFE IN THE FASTLANE: TESTING THE EFFICACY OF A BEHAVIORAL INTERVENTION TO REDUCE HIGH RISK SEXUAL BEHAVIORS AMONG HIV-NEGATIVE, HETEROSEXUAL METHAMPHETAMINE USERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0205 Patterson T.L.1, Mausbach B.1, Semple S.J.1, Zians J.1, Strathdee S.2 Our behavioral intervention was associated with significant increases in intentions for safer sex and the percentage of total sex acts that were protected, indicating that heterosexual methamphetamine users can learn to engage in safer sex behaviors in the context of methamphetamine use. |
| MoAc03 | People on the Move: HIV in Migrant and Mobile Populations |
| MoAc0301 | EXPERIENCES AND REFLECTIONS ON DELIVERING AN HIV/AIDS PROGRAMME WITH, AND FOR, IMMIGRANTS AND MOBILE POPULATIONS IN AUSTRALIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0301 Katsaros E., Eisenberg M., Sabri W., McMahon T., Paljor S., Yaman R., Luisi B., Kerr L. The programme experience points towards a pragmatic and sustainable response to HIV/AIDS among multiple immigrant populations, working within the constraints of (comparatively) limited resources to deliver on the rhetoric of a "cultural and linguistic appropriate" response to HIV/AIDS. This experience may be particularly relevant to delivering HIV/AIDS responses in national programmes among immigrants and mobile populations. |
| MoAc0302 | TRUCKING AGAINST AIDS: A UNIQUE AND SUSTAINABLE RESPONSE TO HIV/AIDS BY THE SOUTH AFRICAN ROAD FREIGHT INDUSTRY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0302 Matthew P., Watson B. Recommendations: (1) Services expanded to include treatment. (2) Scale up network of Roadside Wellness Centre and Mobile Wellness Centres. (3) Continual staff training. |
| MoAc0303 | THE IMPACT OF HIV/AIDS PROGRAMMING FOR TRUCKDRIVERS IN CAMEROON FROM 1997 TO 2004 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0303 Onana Ekembene J.-A.1, Dillow A.2, Cissé B.3, Beauchamp M.C.4 CARE’s experience working for STI and HIV prevention among mobile populations was applied recently when CARE designed a scale-up project intended to target truckdrivers and roadside communities across the country. In addition to the aforementioned strategies, this new project, to be implemented from 2005-2009 with CIDA and CARE funding, will focus on community mobilization and VCT promotion. It will work in line with updated national AIDS policies and will support recent improvements in VCT and ART availabilty. |
| MoAc0304 | SEXUAL NETWORKING AND HIV RISK IN MIGRANT WORKERS IN INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0304 Gelmon L.1, Singh K.2, Singh P.2, Bhattacharjee P.3, Moses S.4, Costigan A.2, Blanchard J.5 Migration intensifies risk for contracting HIV/STIs, but the key finding is that the determinant of risk for migrant workers is prior behaviour. Migrating does not change sexual behavior, migrants take their established behavior into an environment where there is a higher rate of HIV/STIs. This is different from the commonly-accepted wisdom that being a migrant leads one to assume high-risk behaviour. Therefore migration programming has to address both the points of origin as well as the points of destination. |
| MoAc0305 | HIV-RELATED RISK BEHAVIORS AND HISTORY OF SEXUALLY TRANSMITTED DISEASES AMONG MALE MIGRANTS WHO PATRONIZE COMMERCIAL SEX IN CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAc0305 Wang B.1, Li X.1, Stanton B.1, Fang X.2, Lin D.2, Mao R.3 Male migrants who paid for sex in China were vulnerable to HIV/STDs. HIV prevention efforts should target young migrant men who work at factory and construction sectors. STD clinics may be important sites for outreach and intervention efforts among male clients. |
| Track D | |
| MoAd01 | Disclose or disappear: the impact of disclosure |
| MoAd0101 | A qualitative study into the impact of HIV disease progression on initial HIV-serostatus disclosure to significant others Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0101 Almeleh C. The results suggest that the unique and changing biophysical nature of HIV/AIDS lends itself to possible social and individual confusion which in-turn facilitates false popular perceptions of HIV/AIDS. HIV-positive individuals have to negotiate through the disclosure process in this particular social context. Consequently, the motivations for disclosure and the choice of recipients are based on a complex and subjective combination of countering false popular perceptions of HIV/AIDS, and accessing appropriate treatment, care and support. Further research on HIV-status disclosure in Africa needs to be conducted and theoretical models developed, where HIV/AIDS is viewed as a dynamic and changing bio-psychosocial experience in which the HIV-positive person simultaneously negotiates their way through and reproduces their individual and social contexts. |
| MoAd0102 | GETTING AROUND DISCLOSURE: SOCIAL STATUS AND SUPPORT OF PATIENTS ENROLLED IN AN ART PROGRAMME IN RURAL SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0102 Fitzgerald M.1, Collumbien M.1, Gumede Z.2, Hosegood V.2 What we know about disclosure and adherence in government ART programmes in South Africa comes from early initiators. Such people are expected to have strong material or social capital, or be skilful in securing support and avoiding social approbation. Programs and policies need to be cognizant of, and responsive to, the pervasive social inequalities that strongly restrict the lives of the majority of people who have not yet sought treatment and those having difficulty with adherence. |
| MoAd0103 | DISCLOSING YOUR HIV STATUS: THE ROLE OF ETHNICITY AMONG PEOPLE LIVING WITH HIV IN LONDON Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0103 Elford J.1, Anderson J.2, Bukutu C.1, Ibrahim F.1 In London, there were striking differences, by ethnicity, in the extent to which people told their family, friends and partners that they have HIV. African men and women in particular may require support in disclosing their HIV status. |
| MoAd0104 | CALCULATED STRATEGIES ON HOW CLIENTS DECIDE TO DISCLOSE HIV TEST RESULTS: EXPLORING GENDER DIMENSIONS IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0104 Nsabagasani X.1, Orobaton N.1, Kironde S.1, Yoder S.2, Kateebire L.1, Nakamatte N.1 The pattern of disclosure discussed above raises important gender implications for couple communication. There is a need to pay program attention on gender dimensions to communication to better address timely and effective disclosure among couples. |
| MoAd0105 | THE RELATIONAL CONTEXT OF NON-DISCLOSURE OF HIV+ SEROSTATUS TO MAIN SEXUAL PARTNER AMONG WOMEN LIVING WITH HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0105 Peterson S.H., DiClemente R.J., Wingood G.M., Lang D. Women who chose not to disclose were more likely to report unsupportive and threatening sexual relationships. These factors may impede their ability to safely disclose their serostatus, and may negatively effect their health and that of their sexual partners. It is important that clinicians, counselors, and health educators engage women in the process of identifying healthy relationships as well as safe alternatives to unhealthy relationships. |
| MoAd02 | Ethics and Community involvment in Research |
| MoAd0201 | ENHANCING THE PROCESS OF INFORMED CONSENT IN CROSS-LINGUISTIC RESEARCH TRIALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0201 Penn C. A series of recommendations are offered with regard to facilitating aspects of communication and ensuring true informed consent in the multilingual health care setting. A culturally attuned model for effective health communication will be proposed for the development and implementation of appropriate guidelines for training health professionals who work in cross-cultural and cross-linguistic contexts. |
| MoAd0202 | EXPLORING COMMUNICATION IN THE INFORMED CONSENT PROCESS OF AN HIV/AIDS VACCINE TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0202 Watermeyer J. The study highlights the need for monitoring and review of informed consent protocols currently utilized in clinical trials, and implementation of measures to ensure thorough understanding of information by patients and trial participants. Such protocols need to be culturally and linguistically modified for the target population, and health professionals need to receive communication skills training in obtaining informed consent from trial participants and patients. |
| MoAd0203 | WEB-BASED COMMUNITY RESEARCH ON SEXUAL VENUES IN MEXICO CITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0203 Feliciano O.1, Montiel V.2, Lopez M.2 The recognition of the principal trends in the cruising scene allows to design site-specific interventions or to address specific users. The cruising scene is a network woven by the sexual scripts, interactions and homophobia. The more risky activities happened in the limited anal sex and in the private sex interactions among no calculated risk takers. Anal sex in the subway and the sex-shops cabins are an example. |
| MoAd0204 | PERSPECTIVES OF MINORS AND CAREGIVERS ON THE RIGHTS OF MINORS TO BE INVOLVED IN DECISION MAKING ABOUT RESEARCH PARTICIPATION: FINDINGS FROM FORMATIVE RESEARCH ON ASSENT AND DISCLOSURE FOR HIV-POSITIVE CHILDREN IN KINSHASA, DEMOCRATIC REPUBLIC OF THE CONGO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0204 Corneli A.1, Rennie S.2, Vaz L.1, Dulyx J.1, Omba S.3, Kayumba Baye J.4, Badinga T.4, Kutumbakana N.4, Daiku O.4, Ilaka M.4, Kalengi Kukemfuka J.-S.4, Callens S.3, Van Rie A.1, Behets F.1 Involving minors in discussions about research participation and obtaining their assent is considered acceptable; however, in this context, caregiver decisions are regarded as final. Understanding minors' and caregivers' perspectives can inform the development of guidelines on assent in this setting. |
| MoAd0205 | INCREASING ACCESS TO VOLUNTARY COUNSELLING AND TESTING (VCT) THROUGH MOBILE VCT SERVICES; CASE STUDY OF 6 COMMUNITIES IN OYO STATE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0205 Okeke U.R.1, Ogungbenro T.2, Faloye A.2 Mobile VCT services should be encourage in reducing access barriers and stigmatization. Community Based Initiatives should be encouraged and funded to create linkages for service providers. |
| MoAd03 | Gender, Violence and Sexuality |
| MoAd0301 | GENDER DISCRIMINATORY BELIEFS ARE ASSOCIATED WITH VULNERABILITY TO HIV AMONG WOMEN AND MEN IN BOTSWANA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0301 Leiter K.S.1, Weiser S.2, Heisler M.3, Percy-de Korte F.1, DeMonner S.1, Tlou S.4, Phaladze N.4, Dandu M.3, Iacopino V.1 For women in Botswana, risk-taking sexual behavior is often not chosen but compelled by social and economic inequality. In order for HIV/AIDS interventions to be effective for women, not only individual behaviors but attitudes that perpetuate socially-sanctioned discrimination must be addressed through policies that promote women’s equality and protect human rights. |
| MoAd0302 | SOCIAL SILENCE AND THE TRANSPORT SECTOR, CONSPIRE IN-SCHOOL GIRLS' VULNERABILITY TO HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0302 Bulawo N.D.1, Zulu K.2, Zulu W.3, Daka M.4 The analysis of data suggests that the transport sector is at the core of the vicious circle of STIs and HIV transmission from adults to children below the age of 17. Data further suggest unreported child defilement and molestation which constitute a moral and child health crisis in Zambia if not in Africa. Social conspiracy of silence is undoing achievements in children’s rights, health and welfare in the past decade. On the flip side of child defilement and molestation is the local transport industry and its staff who have been left unattended to by HIV prevention programs. |
| MoAd0303 | SEXUAL RISK BEHAVIOR AND HIV PREVALENCE AMONG MALE-TO-FEMALE TRANSGENDERED PEOPLE SEEKING VOLUNTARY COUNSELING AND TESTING SERVICES IN MUMBAI, INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0303 Kumta S.1, Lurie M.1, Gogate A.2, Jerajani H.3, Weitzen S.4, Row Kavi A.5, Anand V.5, Makadon H.6, Mayer K.7 Transgendered people accessing VCT services in Mumbai, India have high rates of STIs and HIV. They are in urgent need of HIV education, risk reduction counseling and culturally sensitive behavioral interventions to prevent HIV acquisition. |
| MoAd0304 | RAPE, VIOLENCE AND HIV TRANSMISSION AMONG MEN WHO HAVE SEX WITH MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0304 Reynolds P.1, Aspin C.2 This study raises serious concerns about the HIV risk of men who are raped by other men. The risk of HIV transmission is significant given that condoms were not used. This paper calls for ongoing research in order to ascertain the extent of the problem so that it can be factored into HIV health promotion campaigns for MSM. As well, it is vital that the silence around this issue be eliminated so that appropriate support services can be provided. Recommendations from this study will contribute towards reducing the risk of HIV among MSM. |
| MoAd0305 | CORRELATES OF SEXUAL COERCION AMONG POPULATIONS OF MEN WHO HAVE SEX WITH MEN IN THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAd0305 Guadamuz T.E.1, Naorat S.1, Varangrat A.1, Phanuphak P.2, Jommaroeng R.3, Mock P.A.1, Tappero J.W.4, van Griensven F.5, Siraprapasiri T.1, Thailand MSM Study Group Sexual coercion was common in Thai populations of men who have sex with men. Risk factors associated with sexual coercion as documented in our analysis may help identify those at higher risk and inform preventive interventions for them. |
| Track E | |
| MoAe01 | Not Your Typical Session on HIV/AIDS and the Workplace |
| MoAe0102 | THE DEBSWANA ANTI-RETROVIRAL THERAPY PROGRAMME Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0102 Mbakile B., Johnson O. All businesses should have a workplace programme that facilitates access to treatment, care and support as a way of minimising the negative impact of the epidemic on the business. |
| MoAe0103 | BUILDING A SUSTAINED PRIVATE-PUBLIC PARTNERSHIP TO ADDRESS HIV/AIDS AND REDUCE STIGMA AND DISCRIMINATION IN THE WORKPLACE: THE CASE OF MEXICO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0103 Negroni Belen M.J.1, Hoadley E.1, Kincaid M.2, Moody J.3 The next challenge is to bring this approach to a local level so as to build better private-public partnerships at a state and municipal level. |
| MoAe0104 | AN INNOVATIVE PRIVATE SECTOR LED RESPONSE TO HIV/AIDS, TARGETING SEASONAL AND PERMANENT FARM WORKERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0104 Hill-Mlati J.1, Craviolatti P.2 Although this is work-in-progress it is hoped that it will be replicated in the Southern Africa Region. |
| MoAe0105 | SEXUAL HARASSMENT AND HIV/AIDS AT THE WORKPLACE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0105 Bakaki L. There was rampant workplace sexual harassment including forced sex with minimal policies to deal with the problems of sexual harassment and HIV/AIDS. Employers should develop policies to address the problems of HIV and sexual harassment at the workplace. |
| MoAe0106 | AIDS EDUCATION FOR MEDICAL PERSONNEL: DOES IT MAKE A DIFFERENCE? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0106 Malek A., Sallam S., Hassab A., Mahfouz A. Yes, AIDS education program could make a difference, by allaying medical personnel anxiety, alleviating attitudinal barriers and improving their practice. It is strongly recomended to be incuded as an essential component in medical personnel in-service training program. |
| MoAe02 | Moving the Agenda Forward: Women's Rights and HIV |
| MoAe0201 | THE PERPETUAL BATTLE OF THE BETTER HALF Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0201 Singh S., Prathibha S. The gap between law and social context is breached only by re-conceptualising our interpretations of legal definitions. Use of the Act should be monitored to see if it can address HIV issues. |
| MoAe0202 | GENDER VIOLENCE & HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0202 Sorley D. With the high demand for this service, a better follow up system needs to be put in place to monitor the 80% of clients who did not return for follow up HIV testing. We recognize that our program is 5 years old and at first we did not have an adequate data collection system to follow our clients. That system is now in place. |
| MoAe0203 | RESEARCH ON REPRODUCTIVE RIGHTS OF WOMEN LIVING WITH HIV IN RUSSIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0203 Rukavishnikov M. To increase awareness among health professionals, legal professionals and PLWHA, especially WLWHA, of medical and legal aspects of PLWHA reproductive health issues. To promote public monitoring and control of the implementation of legal instruments in HIV context. To inform the general public about legal rights related to HIV. To reduce stigma and discrimination both within the general public and medical personnel through work with the mass media. |
| MoAe0204 | THE NEED FOR AIDS FEMINISM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0204 Mthathi S.1, Richter M.2 AIDS feminism emphasizes women’s empowerment and agency, while focusing on the root causes of gender inequality that ultimately give rise to the increased vulnerability of women to the epidemic. It proposes a number of strategies that will make feminism more relevant and appropriate to the lives of women with HIV/AIDS. |
| MoAe0205 | HIV TREATMENT FOR WOMEN IN UGANDA: INCREASING ACCESS THROUGH INTEGRATED SERVICE PROVISION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAe0205 McGrath J.1, Rundall S.1, Kaawa-Mafigiri D.1, Kakande N.2 These data demonstrate the urgent need to create integrated programs to deliver HIV care. Because women are driven by symptoms to seek care, integrating HIV care into other health care will increase the likelihood women receive appropriate treatment earlier in the disease process. |
| Cross-Track | |
| MoAx01 | Host Response in Acute Infection, Setting the Stage for Disease Outcome |
| MoAx0102 | CLINICAL CORRELATIONS OF INFLAMMATORY CYTOKINES IN THE FEMALE GENITAL TRACT DURING ACUTE HIV-1 INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0102 Bebell L.1, Passmore J.-A.2, Williamson C.3, Mlisana K.4, Iriogbe I.4, Abdool Karim Q.4, Karim S.A.4, and the CAPRISA Acute Infection Study Team Elevated CVL cytokines in acute HIV may be associated with rapid disease progression. Women co-infected with acute HIV and BV also have higher cytokine levels. Further research will focus on defining the relationship of CVL cytokines to local genital tract pathogenesis. |
| MoAx0103 | INTERFERON REGULATORY FACTOR 1: A NOVEL DETERMINANT OF RESISTANCE TO INFECTION BY HIV-1 IN HIGHLY EXPOSED UNINFECTED SEX-WORKERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0103 Ji H.1, Ball T.1, Kimani J.2, McLaren P.1, Marlin C.1, Hill A.3, Plummer F.4 IRF-1 is a host immune regulator and a potential transcriptional activator of HIV-1 replication. We conclude that IRF-1 is an important determinant of host susceptibility to HIV-1 infection. Lowered IRF-1 expression or response at early stage may be crucial in disrupting the establishment of HIV-1 infection and allow for the generation of an adaptive immune response which may contribute to resistance to HIV-1 infection. |
| MoAx0104 | CLINICAL AND IMMUNOLOGICAL IMPACT OF HAART DURING ACUTE HIV-1 INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0104 Streeck H.1, Jessen H.2, Alter G.1, Teigen N.1, Waring M.1, Jessen A.2, Stahmer I.3, v.Lunzen J.3, Gao X.4, Lichterfeld M.1, Allen T.1, Carrington M.4, Walker B.1, Altfeld M.1, Rockstroh J.5 Our data suggest that despite a boosting of immunological functions and T cell maturation following 6 months of therapy in acute HIV-1 infection, this intervention had no impact on immunological control of HIV-1 replication. |
| MoAx0105 | COMPREHENSIVE ANALYSIS OF HIV-SPECIFIC IL-2 AND IFN- IMMUNE RESPONSES IN TREATMENT-NAÏVE INDIVIDUALS IN ACUTE INFECTION EARLY DISEASE (AIED) VERSUS LONG TERM NON PROGRESSORS (LTNP) AND INDIVIDUALS WITH PROGRESSIVE DISEASE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0105 Lubaki N.1, Peretz Y.1, Boisvert M.P.2, Boulassel R.1, Tremblay C.3, LeBlanc R.4, Rouleau D.5, Tsoukas C.1, Routy J.P.1, Bernard N.1 The specificity and hierarchy of HIV recognition in AIED differs from that of subjects with chronic infection. Both LTNP and subjects in AIED have HIV-specific IL-2 responses and these are associated with VL control. |
| MoAx02 | Crossing boundaries: migration and HIV |
| MoAx0201 | INTERSECTING SEXUALITY, GENDER, RACE AND CITIZENSHIP: MENTAL HEALTH ISSUES FACED BY IMMIGRANTS AND REFUGEES LIVING WITH HIV/AIDS IN TORONTO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0201 Wong J.P.1, Li A.2, Chen Y.B.3, Kanagaratnam P.3, Yee S.3, Fung K.4, Roy Sen A.3 Service coordination, research on the mental health needs of I&R-PHAs, and policy analysis of HIV/AIDS in the contexts of migration, employment, health care access and systemic discrimination are critical to promoting health and reducing health disparity in this PHA subpopulation. |
| MoAx0202 | THE SILENT BULLET, THE UNFOUGHT WAR: HIV/AIDS AMONGST YOUNG PEOPLE IN CONFLICT SITUATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0202 Ochan W.1, Mugumya E.2, Nambooze R.2 Despite high level of awareness on HIV/AIDS, young people in conflict situations are constrained in practicing safer sex methods. Material and security needs, coupled with lack of HIV/AIDS services make them engage in involuntary, unprotected early sexual intercourse with soldiers, camp leaders, etc. Places were rapes take place are water points & night clubs. HIVAIDS intervention should be made part of emergency response, and mechanisms of dealing with child sex abuse in conflict situations should be instituted and/or enforced. |
| MoAx0203 | INTERNATIONAL MIGRATION AND HIV RISK AMONG MEXICAN GAY MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0203 Carrillo H., Fontdevila J., Brown J. To fully understand HIV risk and safety among gay immigrant populations (particularly among those individuals whose motivations for migration are primarily sexual) and design appropriate interventions, we must pay close attention to their situations and sexual histories before relocation, their paths of international migration, and their processes of incorporation into gay life in host countries. |
| MoAx0204 | PARTICIPATORY RESEARCH INTO HIV/AIDS WITH AFRICAN COMMUNITIES IN AUSTRALIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0204 Lemoh C.1, Hellard M.2, Street A.3, Biggs B.4 Social and epidemiological research into HIV/AIDS in immigrant or culturally diverse communities should involve members of the communities in order to improve the quality of the studies and the relevance of their findings. |
| MoAx0205 | OPTIMIZING HEALTH OUTCOMES IN HIV+ REFUGEES FROM SUB-SAHARAN AFRICA PRESENTING TO URBAN MEDICAL SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0205 Cyr J.1, Thompson D.1, Gilmore N.1, Duchesneau C.1, Ankouad A.2 A multidisciplinary team with a collaborative, skillful and culturally sensitive approach will intervene most effectively with this vulnerable population. Rapid assessment of psychosocial stressors and emotional adjustment via the involvement of medical, social work, mental health and pastoral services can help to enhance patients´ coping resources and optimal health outcomes. |
| MoAx03 | High Time to Deliver on Stigma and Discrimination |
| MoAx0301 | IMPACT OF UNIVERSAL ACCESS TO ANTIRETROVIRAL THERAPY ON HIV STIGMA IN BOTSWANA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0301 Wolfe W.1, Weiser S.2, Leiter K.3, Steward W.2, Percy-de Korte F.3, Phaladze N.4, Iacopino V.3, Heisler M.5 Our findings support the hypothesis that ART access may be a key factor in reducing HIV stigma. Nevertheless, evidence of significant projected stigma suggests that HIV discrimination remains a significant concern despite expanded access and requires ongoing programmatic attention. |
| MoAx0302 | TIME TO MAKE HEALTH SERVICES SAFE FROM STIGMA: VOICES OF CANADIAN ABORIGINAL PEOPLE LIVING WITH HIV/AIDS AND HEALTH CARE PROVIDERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0302 Jackson R.1, MacLean L.2, Leonard L.2, Mill J.3, Reintjes F.3, Austin W.3, Edwards N.2, Dumont-Smith C.4 HIV-related stigma continues to influence access and use of health services for APHAs. Recommendations are made for improving access/use of health services in a safe, trusting and culturally competent manner. |
| MoAx0303 | QUALITATIVE STUDY OF THE CHALLENGES TO SEEKING HEALTH CARE AMONG HIV-POSITIVE PREGNANT WOMEN IN HO CHI MINH CITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0303 Bain Brickley D.1, Hanh D.L.D.2, Nguyet L.T.3, Giang L.T.4, Sohn A.5 Pregnant women with HIV in HCMC report fear of discrimination as a primary factor influencing the peripartum experience. Identifying infections earlier in pregnancy would help address fear of disclosure and facilitate access to medical interventions. Additional research should be conducted on the role of non-medical hospital staff in stigma and discrimination; in the meantime, HIV-related educational training should be provided to non-medical staff to promote acceptance and sensitivity. |
| MoAx0304 | ALL BECAUSE I AM POSITIVE – VIDEO DOCUMENTARY ON HIV-RELATED STIGMATIZATION OF PLWH IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0304 Oladapo O.1, Musa E.2, Garba S.3, Olotu B.4 Using audio-visual AIDS helps in facilitating better understanding of HIV/AIDS-related issues and problems by workshops and seminars participants. Video documentaries also help in portraying PLWH leaders as role models for others just learning about their HIV-positive status while demand for voluntary counseling and testing. |
| MoAx04 | Immune Based Therapies |
| MoAx0402 | A SINGLE DOSE OF GLYCOSYLATED RECOMBINANT SIMIAN IL-7 INDUCES TRANSIENT T CELL HOMING INTO LYMPH NODES, INCREASES PERIPHERAL NAÏVE AND MEMORY T CELL NUMBERS AND STIMULATES THYMIC FUNCTION IN HEALTHY RHESUS MACAQUES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0402 Beq S.1, Schilte C.1, Gautier D.1, Assouline B.2, Lavedan P.3, Montagutelli X.3, Brahic M.1, Cheynier R.1 The administration of a single dose of r-sIL-7gly both stimulates thymic function leading to enhanced RTE frequency and induces an increase of peripheral naïve and memory subset numbers in healthy Rhesus macaques, suggesting that r-humanIL-7gly might be used to help patient to recover from lymphopenia. |
| MoAx0403 | TREATMENT WITH RECOMBINANT HUMAN GROWTH HORMONE (R-HGH) LEADS TO INCREASED THYMIC OUTPUT IN HIV-INFECTED SUBJECTS WITH INCOMPLETE IMMUNE rRECONSTITUTION ON HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0403 Smith K.1, Zheng L.2, Bosch R.2, Margolis D.3, Tenorio A.1, Napolitano L.4, Pollard R.5, Connick E.6, Gross B.7, Frances I.7, Wang R.2, Muurahainen N.8, Stocker V.9, ACTG 5174 Protocol Team Treatment with r-hGH is associated with improved thymic output as measured by increases in naïve CD4 cells, thymus size and recent thymic emigrants. |
| MoAx0404 | COMPARING CD4+ T-CELL DECLINE DURING TREATMENT INTERRUPTION IN HIV-1-INFECTED PATIENTS WHO DID OR DID NOT RECEIVE THE CANDIDATE IMMUNOTHERAPY VACC-4X Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0404 Sommerfelt M.A.1, Wit F.W.N.M.2, Nyhus J.1, Kran A.-M.B.3, Baksaas I.4, Lange J.M.A.2, Sorensen B.1, Kvale D.3 This study suggests a significant benefit of the Vacc-4x immunotherapy intervention in terms of CD4+ T cell decline following CART interruption. However, these findings should be verified through a randomised prospective placebo-controlled clinical trial. These results nevertheless support the potential for immune-based strategies to sustain immunological fitness during prolonged treatment interruptions – in line with CD4-guided therapy - to reduce exposure to CART and its associated adverse side effects. |
| MoAx0405 | SAFETY OF VSSP AS IMMUNOPOTENTIATOR IN CUBAN HIV/AIDS PATIENTS TREATED WITH ANTIRETROVIRAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0405 Trujillo A.1, Abreu D.2, Diaz R.1, Rittoles A.1, Godinez M.C.1, Molina R.1, Borrero Y.1, Bebelagua Y.3, Garrido D.1, Rojas T.1, Urbino A.1, Serrano T.1, Cofat D.1, Calderon O.1, Nuñez F.1, Leal M.1, Gonzalez A.1, Trueba M.2, Carr A.3, Perez R.4, Fernandez L.E.3, Perez J.5 Our findings support the safety of VSSP + antiretroviral treatment in HIV/AIDS patients. |
| MoAx05 | Youth and HIV: What's Sex Got to Do With It? |
| MoAx0501 | GYP EGYPT; YOUTH-DRIVEN ADVOCACY-BASED SUCCESS STORY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0501 Shawer S. Young people should be allowed to plan for advocacy projects tackling their own issues. Financial support should be invested in youth-driven and youth designed advocacy plans. |
| MoAx0502 | USING HUMAN RIGHTS STANDARDS TO ASSESS HIV-PREVENTION PROGRAMS FOR CHILDREN AND YOUTH: A CASE STUDY OF UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0502 Cohen J.1, Tate T.2 HIV-prevention policies for young people should comply with international standards on the right to health information, which include the right to be informed of all effective methods of HIV prevention, including condoms. International human rights bodies should hold governments to account for restricting young people’s access to potentially life-saving information about condoms and safer sex. |
| MoAx0503 | HOW WELL DO KENYAN YOUTH UNDERSTAND ABC MESSAGES FOR HIV PREVENTION? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0503 Pulerwitz J.1, Lillie T.2, Apicella L.3, McCauley A.4, Nelson T.5, Ochieng S.6, Mwarogo P.6, Kunyanga E.7 HIV prevention programs incorporating ABC messages must clarify the ABC behaviors, particularly being faithful in the context of HIV prevention and consistent condom use. Terminology that is locally appropriate and clear should be used, and negative perceptions of condom use addressed. ABC messages should be combined with other interventions that address barriers to the behaviors, such as gender-based violence prevention. |
| MoAx0504 | EFFICACY OF AN ABSTINENCE-ONLY INTERVENTION OVER 24 MONTHS: A RANDOMIZED CONTROLLED TRIAL WITH YOUNG ADOLESCENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0504 Jemmott III J.B.1, Jemmott L.S.2, Fong G.T.3 Theory-based abstinence-only interventions have the potential to reduce sexual activity or delay sexual debut among young adolescents, without having adverse effects on condom use when adolescents initiate sexual activity. |
| MoAx0505 | CHALLENGES IN DIAGNOSIS DISCLOSURE TO HIV POSITIVE TEENAGERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoAx0505 Manescu N., Bobolea B.C. The young people living with HIV/AIDS and must be directly involved in programs regarding their peers. Their messages transmitted directly to other HIV/AIDS affected families are highly credible and have a strong impact on the parents who refuse diagnosis disclosure to their children. |
| Poster Discussions | |
| Track A | |
| MoPdA | siRNA Gene Therapy for HIV |
| MoPdA01 | USE OF MODIFIED U1snRNAs TO INHIBIT HIV-1 REPLICATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdA01 Sajic R., Lee K., Asai K., Cochrane A. We have identified several modified U1snRNA that are able to inhibit viral structural protein expression by as much as 95%. Maximal antiviral activity is dependent upon binding of U1 70K and Sm proteins, while loss of U1A binding to the U1snRNAs only reduced activity. The potential activity of this new strategy suggests that it may be possible to render cells expressing these constructs unable to support HIV replication. |
| MoPdA02 | POST-TRANSCRIPTIONAL INHIBITION OF HIV-1 SUBTYPE C BY EXPRESSED LONG HAIRPIN RNAs TARGETED TO THE R AND U5 REGIONS OF THE LTR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdA02 Barichievy S.1, Carmona S.1, Crowther C.1, Saayman S.1, Morris K.2, Arbuthnot P.1, Weinberg M.1 As an index of the activation of interferon inducible genes, none of the lhRNAs induced expression of OAS1, MxA and IFN-ß mRNA concentrations. These data indicate that expressed lhRNAs are capable of inhibiting HIV-1 gene expression without eliciting an unwanted interferon response, and may have potential therapeutic application to counter viral escape. |
| MoPdA04 | siRNA RESTRICTION OF HIV-1 REPLICATION IS PRIMARILY DUE TO mRNA RATHER THAN GENOMIC RNA DEGRADATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdA04 Gao Y.1, Lobritz M.1, Roth J.2, Abreha M.1, Nankya I.1, Moore D.1, Abraha A.1, Nelson K.1, Gerson S.2, Arts E.1 HIV-1 genomic RNA is protected from siRNA degradation and the dominant effect of siRNA knockdown occurs at the level of mRNA. |
| MoPdA05 | PHASE II CLINICAL TRIAL DEMONSTRATES THE SAFETY AND TOLERABILITY OF MULTIPLE DOSES OF AUTOLOGOUS CD4+ T-CELLS TRANSDUCED WITH VRX496, A LENTIVIRAL VECTOR DELIVERING ANTI-HIV ANTISENSE IN PATIENTS FAILING 1 OR MORE HAART TREATMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdA05 Rebello T.1, Afable C.1, Callahan S.1, Humeau L.1, Chopra A.1, Lu X.1, Slepushkin V.1, Stein D.2, Steinhart C.3, Greenberg R.N.4, Zolopa A.5 Multiple doses of autolougous CD4+ T-cells transduced with a lentiviral vector appear to be safe and well tolerated. The clinical utility of lentiviral vector technology as an alternative for treatment of HIV infection continues to be explored. |
| MoPdA06 | SAFE AND SUSTAINABLE ANTI-HIV HEMATOPOIETIC PROGENITOR CELL-DELIVERED ANTISENSE: FOLLOWUP THROUGH MONTH 60 FROM PHASE I TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdA06 Liu D.1, Dunn E.2, Unemori P.2, Eden C.2, Conant M.A.2, Cowan M.J.2 These results are an example of the survival at low levels of transduced CD34+ stem cells in nonablated subjects with sustainable transgene activity as well as the long term presence of engineered cells in the circulating progeny, i.e., CD34+ and CD4+ cells. |
| MoPdA07 | INHIBITION OF HIV-1 REPLICATION IN HUMAN T CELLS BY RNA INTERFERENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdA07 Meshcheryakova Y.1, Gashnikova N.1, Plyasunova O.1, Pokrovskaya N.1, Pokrovsky A.1, Petyovka N.2, Tchurikov N.2 Our experiments demonstrated significant inhibition of HIV-1 reproduction in cells containing expression vector constructions compared to relevant controls. The obtained results showed the potential ability of using these HIV-1 specific shRNA expression constructs for AIDS gene therapy. |
| MoPdA08 | INHIBITING HIV-1 BY AUGMENTING CELLULAR ANTIVIRAL PATHWAYS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdA08 Christensen H.1, Ong C.1, Chung S.1, Frankel L.2, Daher A.2, Laine S.2, Bannwarth S.2, Gatignol A.2, Purcell D.1 The vector-derived TRBP dsRNA yielded insufficient RNAi and did not reduce TRBP levels sufficiently to augment the PKR response to a degree that reduced HIV-1 expression. However, jointly targeting HIV Tat and TRBP with RNAi greatly enhanced the inhibition of HIV-1NL4.3 expression. Poor silencing activity of vectors targeting TRBP in HIV-1 infected cells appears to be linked to the silencing-suppressor activity of HIV-1 Tat. |
| Track B | |
| MoPdB | Morbility/Mortality in the HAART Era |
| MoPdB01 | RISK OF CLINICAL PROGRESSION OVER LONG TERM FOLLOW-UP IN A WIDE COHORT OF PATIENTS BY DIFFERENT PATTERNS OF VIRO-IMMUNOLOGICAL RESPONSE ASSESSED AT MONTH 18. RESULTS OF THE ITALIAN MASTER COHORT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdB01 Torti C.1, Paraninfo G.1, Casari S.1, Quiros Roldan E.1, Suter F.2, Maggiolo F.2, Quirino T.3, Migliorino G.3, Minoli L.4, Maserati R.4, Ghinelli F.5, Sighinolfi L.5, Mazzotta F.6, Lo Caputo S.6, Antinori A.7, Antonucci F.8, Pastore G.9, Ladisa N.9, Castelnuovo F.10, Tinelli C.11, De Silvestri A.11, Carosi G.1 Diagnosis of HIV infection, treatment before ADE and maintenance of high CD4+ T cell count induced by HAART remain important priorities protecting from AIDS morbidity and mortality over a long-term follow-up even in this cohort of patients who followed a first line HAART for at least 18 months. Viro-immunological trends over this initial period did not appear to influence subsequent clinical progression. |
| MoPdB02 | CAUSES OF SEVERE MORBIDITY IN HIV-INFECTED PATIENTS. AQUITAINE COHORT 2000-2004: THE IMPORTANCE OF BACTERIAL INFECTIONS, CARDIO-VASCULAR, DIGESTIVE, AND PSYCHIATRIC MORBIDITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdB02 Bonnet F.1, Chêne G.2, Lawson-Ayayi S.2, Dupon M.3, Pellegrin J.-L.4, Thiébaut R.2, Morlat P.1, Groupe d'Epidemiologie Clinique du SIDA en Aquitaine Severe morbidity has shifted from AIDS-related to non AIDS-related causes. Ageing, co-morbidities (hepatitis, addictive behaviours) might explain this evolving distribution. Immunodepression, even moderate may also have a role in the development of non-AIDS morbidity. Limiting endpoints to AIDS events and death could be misleading in the interpretation of prognostic and therapeutic studies. |
| MoPdB03 | ATTRIBUTES TO DEATH OF HIV/AIDS PATIENTS IN THE ERA OF HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdB03 Ho C.F., Cheng K.L.S., Wong K.H., Chan K.C.W. Only one-fourth of deaths in the HAART era resulted from AIDS. Beyond biomedical factors, one-fourth of deceased patients were late presenter of HIV diagnosis and half had poor adherence to medical follow-up and HAART. Both groups deserve special attention as their death may be avoidable. Interventions should be formulated to encourage early diagnosis, modify unfavourable behaviour and address psychosocial needs of HIV-infected persons. |
| MoPdB04 | PREDICTORS OF MORTALITY IN HIV-INFECTED ADULT AFRICAN PATIENTS RECEIVING HIGHLY ACTIVE ANTI-RETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdB04 Siika A.M.1, Wools-Kaloustian K.2, Kimaiyo S.N.1, Mwangi A.3, Diero L.O.1, Ayuo P.O.1, Owino-Ong'or W.D.1, Sidle J.E.4, Einterz R.M.4, Yiannoutsos C.5, Musick B.5, Tierney W.M.4 Patients on HAART who died were in poor health based on CD4 cell count and WHO Stage and often did so soon after initiation of therapy. |
| MoPdB05 | PREDICTORS OF MORTALITY IN PATIENTS INITIATING ANTIRETROVIRAL THERAPY IN DURBAN, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdB05 Ojikutu B.1, Zheng H.2, Walensky R.2, Lu Z.2, Losina E.2, Giddy J.3, Freedberg K.2 History of oral candidiasis and CD4 count <50/mm3 are independent predictors of mortality in patients initiating ART in Durban, South Africa. Further interventions to reduce mortality associated with these clinical markers should be developed and urgently implemented. |
| MoPdB06 | VERY LOW CD4 T CELL COUNTS AND LOW TOTAL LYMPHOCYTE COUNTS AT INITIATION OF HAART ARE ASSOCIATED WITH A POOR OUTCOME IN THE FIRST 6 MONTHS OF ANTIRETROVIRAL TREATMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdB06 Mayanja-Kizza H.1, Lutwama F.2, Kamya M.3, Kikawa C.2, Spacek L.4, Quinn T.4 High mortality on HAART may be associated with late commencement of treatment at very low CD4 counts, where despite adequate treatment immune recovery lags behind virological suppression. Commencing HAART at earlier CD4 counts should be considered, even in resource limited countries to improve outcome. |
| Track C | |
| MoPdC | Women: Choosing When There is No Choice |
| MoPdC01 | DO ECONOMIC DEVELOPEMENT PROGRAMMES REDUCE VULNERABILITY TO HIV AND INTIMATE PARTNER VIOLENCE (IPV): QUALITATIVE PERSPECTIVES FROM A PROSPECTIVE CLUSTER-RANDOMIZED TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdC01 Phetla G.1, Busza J.2, Pronyk P.3, Kim J.2, Euripidou R.4, Hargreaves J.2, Morison L.2, Watts C.2, Porter J.2 Qualitative data suggests the intervention enhances self-sufficiency, self-confidence, and critical-thinking around issues including gender-based violence, gender roles and HIV/AIDS. There is evidence to support wider changes at the household and community level. Quantitative results will also be presented at the conference. |
| MoPdC02 | SEXUAL ASSAULT, SEXUAL RISKS, AND GENDER ATTITUDES AMONG SOUTH AFRICAN MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdC02 Cain D.1, Simbayi L.C.2, Cherry C.1, Henda N.2, Kalichman S.1 These findings extend previous research to show that men who have a history of sexual assault also exhibit elevated risks for HIV/AIDS and that both sexual violence and HIV risk can be addressed in a single integrated intervention model. |
| MoPdC03 | POST-EXPOSURE PROPHYLAXIS FOLLOWING SEXUAL ASSAULT IN CAPE TOWN: ADHERENCE AND HIV RISK BEHAVIOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdC03 Roland M.1, Myer L.2, Chuunga R.3, Martin L.2, Maw A.2, Coates T.4, Denny L.2 Although overall PEP completion rates were high, adherence was often incomplete. Ongoing HIV risk behavior was common and probably resulted in new HIV acquisition. To improve HIV prevention services for sexual assault survivors, universal adherence interventions and targeted intensified HIV risk reduction counseling should be provided. |
| MoPdC04 | A PROSPECTIVE COHORT STUDY OF UNIVERSAL OFFERING OF HIV-1 POST-EXPOSURE PROPHYLAXIS IN SEXUAL ASSAULT VICTIMS/SURVIVORS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdC04 Loutfy M.1, MacDonald S.2, Myhr T.3, Humphries H.3, Du Mont J.3, Leeke T.3, Rachlis A.1 Since the universal counselling and offering of PEP to sexual assault victims/survivors in our study appears feasible and warranted, all jurisdictions should consider developing guidelines for this topic. Since we found that although high-risk clients accepted PEP at a greater rate than those at unknown-risk, equal numbers completed the course, a universal strategy for offering PEP should be considered. Since our completion rate was three times that reported in earlier studies, more rigorous follow-up should be considered by all programs. |
| MoPdC05 | MOTHERS´ PROTECTIVE VARIABLES AGAINST DAUGHTERS´ HIV RISK Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdC05 Dancy B.1, Crittenden K.2, Bowman M.1, Huang Z.1, Kennedy A.1, Spencer B.1, Starks A.1, HIV Risk Reduction The results suggest that mothers can be protective factors against daughters’ HIV risk. Health care providers should provide mothers with comprehensive, accurate information about HIV and help mothers to increase their own safer sex self-efficacy and intention to encourage daughters to avoid HIV risks. |
| MoPdC06 | DISTRIBUTING BARRIER METHODS FOR WOMEN: DETERMINANTS OF WILLINGNESS TO PAY FOR MICROBICIDES, THE DIAPHRAGM AND THE FEMALE CONDOM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdC06 Terris-prestholt F.1, Kumaranayake L.1, Macphail C.2, Rees H.2, Watts C.1 Interest in the diaphragm and microbicides, which are likely to be less effective but more discrete than condoms, is higher among cohabitating women, a group known to lack long-term prevention options. This is reassuring for policymakers fearing condom migration. With careful price setting, it should be feasible to recover some of the costs of these products from women of higher SES. To reach lower income women, subsidised distribution is likely to be necessary. |
| Track D | |
| MoPdD | Enriching Community Mobilization: Not For But With People |
| MoPdD01 | PROMOTING GREATER INVOLVEMENT OF PEOPLE LIVING WITH HIV/AIDS (GIPA) IN MYANMAR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdD01 Naing Z.Z.1, Wah N.S.2, Lwin T.M.1, Eh D.1, Thida A.M.1 There are an estimated 339,000 to 832,000 PLHA in Myanmar. There are few projects addressing PLHA issues and PLHA involvement is low. A number of PLHA support groups have been formed but these are managed by international or local NGOs and networking among them is weak. |
| MoPdD02 | HIV YOUTH AMBASSADOR PROGRAMME - A COMMUNITY-LED RESPONSE TO HIV & AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdD02 Gurney L., MADaboutART Youth Ambassadors Young people have the capacity to input and should be involved in all stages of development and delivery of youth educational programmes. |
| MoPdD03 | INTERNATIONAL COOPERATION, SOCIAL MOBILIZATION AND ACCESS TO TREATMENT OF HIV/AIDS IN LATIN-AMERICAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdD03 Kamel L., Maksud I., Raxach J.C., Pimenta C., Terto Jr. V., Molnar R. The Brazilian Interdisciplinary AIDS Association has been acting in the fight against the HIV/AIDS epidemic in the areas of prevention, advocacy, social mobilization, adherence to treatment and support to people living with HIV/AIDS, and monitoring of health policies. During 2004 and 2005, ABIA conducted case studies of Bolivia and Paraguay where most of the first line ARV medication is made available through donations under cooperation agreements of the Brazilian government. |
| MoPdD04 | VOLUNTARY SUPPORT GROUPS IMPROVE THE QUALITY OF LIVE OF PEOPLE LIVING WITH HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdD04 Mello J.H. Voluntary support groups formed and directed by PLWHIV/AIDS appear to be an extremely cost-effective method to facilitate information exchange, enhance of knowledge, and promote self-steem, as well as foster and expand better social relationships. We intend to implant these support groups in our branches in order to inhance quality of life of PLWHA. |
| MoPdD05 | LESOTHO AND SWAZILAND: A TRADE UNION (CIVIL SOCIETY) RESPONSE TO THE WORKPLACE AND AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdD05 Ndlovu V.1, Mariel C.2 Unions must be lead actors in workplace AIDS to leverage workers’ trust and participation, to protect workers’ rights, and to build coalitions that stretch globally and reach across business, government, nongovernmental organizations, and communities. The lessons learned, relevant to all AIDS stakeholders, implementers, and decision-makers, are replicable in workplaces throughout the world. |
| MoPdD06 | MOBILIZING COMMUNITIES FOR THE CARE AND SUPPORT OF HIV/AIDS AFFECTED CHILDREN AND FAMILIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdD06 Tesfaye A. The CAC model of community mobilization, if replicated to other areas with some adaptation, can bring the same outcomes that would ensure sustainability of response. |
| Track E | |
| MoPdE | Double Jeopardy: Vulnerable Populations and HIV |
| MoPdE01 | HIV/AIDS AMONG DISPLACED POPULATIONS IN NORTH-WEST ZIMBABWE: AWARENESS, KNOWLEDGE AND BEHAVIOURAL PATTERNS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdE01 Araujo de Carvalho I.1, Stigter E.2, Voetem H.3, Haliman L.1 The study provides evidence of significant high risk sex, and the high impact of AIDS within the community. The findings indicate that food insecurity brought by displacement seems to be fuelling risky behaviours such as early marriages for women and intergenerational sex. The surveyed IDP group do not access government programmes within the context of addressing the persisting complex emergency in Zimbabwe. |
| MoPdE02 | USING A RIGHTS-BASED APPROACH TO PROMOTING THE ACCESS OF URBAN REFUGEES TO NATIONAL HIV/AIDS PROGRAMMES IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. MoPdE02 Bruns L.1, Groot F.J.2 |