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16th International AIDS ConferenceToronto, Canada — August 13-18, 2006 |
Cite as: Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. xx
| Table of Contents Main Monday Tuesday Wednesday Thursday Late-Breakers |
| Thursday | Oral Abstracts |
| ThAa01 | Preclinical Vaccine Development |
| ThAa0101 | ENHANCED HIV/SIV SPECIFIC CELLULAR IMMUNITY IN MACAQUES FOLLOWING A NOVEL PEPTIDE IMMUNOTHERAPY (OPAL) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0101 Kent S., Chea S., De Rose R., Batten C.J. CTL responses can be monitored in vivo by infusing peptide-pulsed autologous cells. The infusion of Overlapping Peptide-pulsed Autologous cells (OPAL) sharply enhances broad SHIV-specific CD4+ and CD8+ T cell responses. This simple technique holds promise for the immunotherapy of HIV. |
| ThAa0102 | NON-INFECTIOUS PAPILLOMA VIRUS - LIKE PARTICLES (VLPS) INHIBIT HIV REPLICATION: IMPLICATIONS FOR IMMUNE CONTROL OF HIV REPLICATION BY IL-27 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0102 Fakruddin J.M.1, Lempicki R.2, Yang J.2, Adelsberger J.3, Pineres A.4, Pinto L.4, Lane H.C.5, Imamichi T.1 The identification of IL-27 as a novel anti-HIV-1 cytokine along with a better understanding of the molecular mechanism of action of IL-27 may lead to the rational design of a new immune-based therapy against HIV-1 infection. |
| ThAa0103 | PRIME-BOOST VACCINATION WITH PLASMID DNA AND A CHIMERIC ADENOVIRUS TYPE 5 VECTOR WITH TYPE 35 FIBER INDUCES PROTECTIVE IMMUNITY AGAINST HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0103 Xin K.-Q.1, Someya K.2, Yoshida A.1, Honda M.2, Okuda K.1 These findings indicate that an Ad5/35 vector-based HIV vaccine may be of considerable value for clinical use. |
| ThAa0104 | COMPARATIVE EVALUATION OF CD70, LIGHT AND 4-1BBL, AS COSTIMULATORS OF HUMAN ANTI-VIRAL MEMORY CD8 T CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0104 Wang C., Wen T., Watts T. Thus, three costimulatory molecules from the same gene cluster have different impact on anti-viral memory CD8 response in human and CD70 and 4-1BBL represent a promising adjuvant combination for expanding CD8 effector cells. This work was funded by the Canadian Institutes of Health Research and by CANVAC, the Canadian Network for Vaccines and Immunotherapeutics. |
| ThAa0105 | CHIMERIC CD40L/SHIV VIRUS-LIKE PARTICLES ENHANCED DENDRITIC CELLS ACTIVATION AND BOOSTED IMMUNE RESPONSES AGAINST HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0105 Zhang R., Li M., Chen C., Yao Q. These data demonstrate that chimeric CD40L/SHIV VLPs are able to potently induce DC maturation and activation, mainly through CD40 and CD40L interaction. CD40L/VLPs can enhance both humoral and cellular immune responses to the SIV Gag and HIV Env protein in a mouse model. The results indicate that incorporation of CD40L into VLPs may be highly effective in enhancing immunogenicity of HIV vaccines. |
| ThAa02 | HIV-1 Mediated Pathogenesis |
| ThAa0201 | CXCR4-SPECIFIC VIRAL LOAD PREDICTS CLINICAL HIV-1 DISEASE PROGRESSION DURING HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0201 Philpott S.1, Ledergerber B.2, Klimkait T.3, Burger H.1, Kitchen C.4, Bürgisser P.5, Gorgievski M.6, Joller H.7, Perrin L.8, Piffaretti J.-C.9, Schmid P.10, Gormley A.1, Schroeder T.1, Weiser B.1, Swiss HIV Cohort Study QXR and X4-specific viral loads were strong predictors of disease progression during HAART, independent of and in addition to CD4 count or total viral load. They promise to be useful for clinical management of HIV-1 infection. |
| ThAa0202 | HIV-1 VPR EXERTS NEUROPATHOGENIC EFFECTS CAUSING NEURONAL APOPTOSIS AND GLIAL CELL TYPE-DEPENDENT NEUROINFLAMMATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0202 Barsby N.1, Jones G.2, Jhamandas J.3, Dickie P.3, Cohen E.4, Power C.5 Vpr-induced neuronal apoptosis occurs by both direct and indirect mechanisms. Direct application of soluble Vpr causes apoptosis involving Akt suppression and caspase-9 activation while the indirect effects may be mediated by excitation of glial cells. |
| ThAa0203 | HIV-1 TAT PROTEIN INDUCES COX-2 THROUGH A NFAT/AP-1 MEDIATED MECHANISM IN ASTROCYTOMA CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0203 Blanco A.1, Alvarez S.1, Suñé C.2, Fresno M.3, Muñoz-Fernández M.A.1 COX-2 regulation by extracellular Tat in human U-87 astrocytoma cells is highly induced in a NFAT/AP-1 dependent way. |
| ThAa0204 | MICROARRAY BASED STUDY OF EARLY INTERACTIONS BETWEEN HIV-1 AND A PBMC POPULATION HIGHLY ENRICHED IN CD4+ T CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0204 Imbeault M., Tremblay M.J. We conclude that HIV-1 rapidly influences the transcriptional profile of primary CD4+ T lymphocytes and sensitizes bystanders CD4+ T lymphocytes to apoptosis, primarily via p53 upregulation. |
| ThAa0205 | THE NEF-TCR INTERACTION: POTENTIAL ROLE IN AUGMENTATION OF T-CELL SIGNALING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0205 Kim W.M., Sigalov A.B., Stern L.J. By binding specifically to the cytoplasmic domain of TCRζ, Nef may function as a biological crosslinker capable of clustering multiple TCR complexes from within the intracellular compartment. The potential for Nef to augment T cell activation through the formation of TCR clusters presents a novel mechanism of Nef function and T cell signaling. |
| ThAa03 | HIV Drug Development |
| ThAa0301 | THE LEDGF-INTEGRASE INTERACTION AS A NEW TARGET FOR ART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0301 Vandekerckhove L., De Rijck J., Gijsbers R., Christ F. Witvrouw M., Debyser Z., Molecular Medicine The highly potent inhibition of HIV-1 replication by the IBD of LEDGF/p75 provides a proof-of-principle for a novel antiviral therapeutic strategy targeting the interaction of LEDGF/p75 with HIV-1 IN. By binding to HIV-1 IN, the IBD likely competes with the binding of native LEDGF/p75 that is required to dock the preintegration complex to the chromosomes. DKA resistant strains remain susceptible to inhibition by IBD. Peptides and small molecules targeting LEDGF/IN interaction offer great potential as future antiviral agents. |
| ThAa0302 | BIOCHEMICAL AND ANTIVIRAL ACTIVITY OF MK-0518, A POTENT HIV INTEGRASE INHIBITOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0302 Miller M.1, Witmer M.1, Stillmock K.1, Felock P.1, Ecto L.2, Flynn J.2, Schleif W.2, Dornadula G.1, Danovich R.1, Hazuda D.1 MK-0518 is a potent HIV integrase inhibitor that displays broad antiviral activity against HIV isolates, including isolates resistant to other classes of HIV drugs. The virological profile of MK-0518 support its use in combination with all other classes of antiretroviral agent. |
| ThAa0303 | NEXT GENERATION FUSION INHIBITOR CANDIDATES TRI-1144 AND TRI-999 HAVE IMPROVED PHARMACOKINETICS: PROGRESS TOWARDS ONCE/WEEK DOSING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0303 Delmedico M.1, Bray B.1, Cammack N.2, Di J.1, Heilman D.1, Silinski P.1, Webb S.1, Wring S.1, Greenberg M.1 Enfuvirtide (ENF, Fuzeon™), the first approved HIV entry inhibitor, is administered by SC injection twice/day and is an important therapeutic option for treatment-experienced patients. The Next Generation Fusion Inhibitor (NGFI) goal is to improve upon ENF efficacy while decreasing injection frequency to once/week. Two NGFI peptide candidates, TRI-1144 and TRI-999, demonstrate substantial improvements in potency, genetic barrier to resistance and pharmacokinetics. These peptides have been evaluated in sustained-release formulations. |
| ThAa0304 | PL-100, A NOVEL PROTEASE INHIBITOR WITH A HIGH GENETIC BARRIER Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0304 Dandache S.1, Wainberg M.A.2, Panchal C.1, Wu J.J.1 PL-100 is a promising new PI that forces HIV into a unique mutational pathway that conferred only a mild resistance to our drug and that proved detrimental to its replication capacity. No cross-resistance to other PIs was observed. The mutational pathway made the virus more sensitive to a few other PIs that could potentially be applied in combination with PPL-100, a phosphorylated form of PL-100 currently in Clinical Phase I trials in Canada, in a more potent HAART regime. |
| ThAa0305 | COOPERATIVE INTERACTION BETWEEN A CCR5 ANTAGONIST, APLAVIROC(873140/ONO-4128), AND HUMAN CCR5 WITH ALLOSTERIC MECHANISM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0305 Shibayama S.1, Tanihiro T.1, Takeda K.1, Watanabe N.1, Hayashi T.1, Sagawa K.1, Demarest J.2, Mcdanal C.2, Sparks S.2, Takaoka Y.3, Fukushima D.1 [3H]aplaviroc showed persistent binding to human CCR5 both in vivo and in vitro, but was dissociated 10-times faster from the huCCR5 (Ile198Met) mutant despite a similar kon value in both CCR5s. Ile198 in transmembrane region-5 is a key residue to confer the property. The binding of aplaviroc does not appear to follow the law of mass-action simply according to the analysis of Scatchard plot and Hill plot. The results imply that involvement of positive co-operativity and CCR5 dimerization in the binding mechanism of aplaviroc is associated to persistent RO. |
| ThAb01 | HIV-1 Mediated Pathogenesis |
| ThAb0101 | LONG-TERM CHANGES IN LIPIDS AND GLUCOSE/INSULIN LEVELS AMONG HIV-INFECTED ANTIRETROVIRAL NAÏVE PERSONS RANDOMIZED TO PI VS. NNRTI VS. PI + NNRTI-BASED ANTIRETROVIRAL REGIMENS: RESULTS OF THE CPCRA 061 METABOLIC STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0101 Shlay J.1, Bartsch G.2, Peng G.2, Wang J.3, Gibert C.4, Visnegarwala F.5, Raghavan S.S.6, Xiang Y.2, Farrough M.7, Perry H.8, Kotler D.3, Grunfeld C.9, El-Sadr W.6 In this prospective trial, all ART strategies had impact on lipid and glucose metabolism. Highest increase in TG and LDL was noted in PI+NNRTI containing regimens. HDL increased the least on PI. Significant increases in insulin were seen with all strategies. These findings necessitate close monitoring of patients. |
| ThAb0102 | NUMBER AND MIGRATORY ACTIVITY OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN HIV-INFECTED PATIENTS RECEIVING HIGHLY ACTIVE ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0102 O. Korzh, S. Krasnokutskiy, G. Kotchuev EPC biology, which is critical for neovascularization and the maintenance of vascular function, is altered in HIVinfected patients receiving HAART. Our data strongly suggest that dysfunction of circulating EPC has a role in the progression of cardiovascular disease in these patients. |
| ThAb0103 | IN UTERO NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR EXPOSURE AND SIGNS OF POSSIBLE MITOCHONDRIAL DYSFUNCTION IN HIV-UNINFECTED CHILDREN IN THE PEDIATRIC AIDS CLINICAL TRIALS GROUP PROTOCOLS 219 & 219C Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0103 Brogly S.1, Ylitalo N.2, Mofenson L.3, Oleske J.4, Van Dyke R.5, Crain M.6, Abzug M.7, Brady M.8, Patrick J.-P.9, Hughes M.10, Seage III G.R.2 There was no association between overall in utero NRTI exposure and possible MD. The association with first in utero exposure to 3TC and to ZDV/3TC in the 3rd trimester warrants investigation in studies that rigorously assess MD and achieve better control of confounding. |
| ThAb0104 | RISK OF DISCONTINUATION OF NEVIRAPINE DUE TO TOXCITIES IN ANTIRETROVIRAL NAIVE AND EXPERIENCED PATIENTS WITH HIGH AND LOW CD4 COUNTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0104 Mocroft A.1, Lacombe K.2, Rockstroh J.3, Gasiorowski J.4, Antunes F.5, Panos G.6, d'Arminio Monforte A.7, Rakhmanova A.8, Phillips A.N.1, Lundgren J.D.9, for the EuroSIDA study group Patients in the HE group had a reduced risk of discontinuation due to TOXPC compared to patients from the HN group. Patients in this study were not randomised to treatment, and the results should be interpreted with caution. While NVPc is not recommended for antiretroviral-naïve patients with high CD4 counts due to the risk of TOXPC, results from this analysis suggest it may be safer for use in antiretroviral experienced-patients starting NVPc. |
| ThAb0105 | GLOMERULAR DYSFUNCTION AND ASSOCIATED RISK FACTORS FOLLOWING INITIATION OF ART IN ADULTS WITH HIV INFECTION IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0105 Reid A.1, Stöhr W.2, Walker S.2, Ssali F.3, Munderi P.4, Gilks C.5, on behalf of the DART Trial Severe GFR impairments were infrequent on all regimens, and patients with baseline renal impairment showed greatest improvements, suggesting that renal benefits outweigh risks over the short-to-mid-term. Differences between regimens in changes from baseline were small, statistically significant but clinically insignificant. Investigating the potential for longer-term nephrotoxicity requires further follow-up. |
| ThAb0106 | CHANGES IN ADIPOSE TISSUE MITOCHONDRIAL DNA QUALITY AND QUANTITY - RELATION TO HIV DISEASE, LIPOATROPHY AND EXPOSURE TO STAVUDINE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0106 P. Mallon1, R. Sedwell1, N. Duarte2, A. Kelleher1, D. Cooper1, A. Carr3 Decreases in SAT mtDNA quantity and quality occur with HIV-infection. Greater mtDNA depletion in lipoatrophic patients (especially those on d4t), with no changes in mtDNA quality, regardless of ongoing d4t exposure, suggests that this further mtDNA depletion may arise through mechanisms other than inhibition of DNA pol-γ. |
| ThAb02 | Scaling Up ART: Time to Deliver |
| ThAb0201 | PROJECT HEART: INITIATING CARE AND ARV TREATMENT FOR OVER 45,000 PEOPLE IN 22 MONTHS IN FOUR AFRICAN COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0201 Marlink R.1, Adjorlolo-Johnson G.1, Anglaret X.2, Bolton C.3, Boni-Ouattara E.4, Bulterys M.5, Buono N.6, Dabis F.2, Ellerbrock T.7, Essombo J.4, Fullem A.8, Gavitt C.9, Giddy J.10, Ginsburg A.1, Giphart A.9, Grundmann C.11, Havlir D.12, Hawkins S.11, Hirschhorn L.8, Holst H.10, Hurkchand H.6, Kline M.13, Lyons C.12, Maharaj S.6, McCullough R.11, Neluheni T.6, Nolan M.14, Nwanyanwu O.15, Oguda L.11, Reid S.3, Schimana W.9, Seyler C.16, Sinkala M.17, Spensley A.11, Stringer E.18, Stringer J.18, Swai M.19, Tanoh A.4, Tindyebwa D.9, Toure S.20, Wahl A.1, Wiktor S.21, Wilfert C.1, Project HEART Implementation Teams The number on treatment is high, despite many challenges across settings, including uptake of pediatric patients; patient follow-up; management of toxicities/OIs and providing basic HIV care to the large number of patients either on treatment or not yet eligible for treatment. The number of children on ART needs to increase to meet existing needs. Many treatment sites have reached capacity, emphasizing the need to train both primary care facilities and non-physicians for management of HIV/AIDS C&T. |
| ThAb0202 | REACHING THE WHO/UNAIDS 3×5 INITIATIVE TARGET IN NAMIBIA – WHAT DID IT TAKE? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0202 Katjitae I.1, Mugala-Mukungu F.1, Goraseb M.2, Damesyn M.3, Matroos E.4, Hamineme N.2, Kaura H.5, Gaeseb J.6, Stevens L.7, Shihepo E.2, Forster N.8, Kenyon T.3 Next steps include decentralizing ART from hospitals to health centers and transferring more tasks from doctors to nurses; increasing emphasis on quality; and development of a human resource plan to meet Namibia's needs for sustaining ART in the future. |
| ThAb0203 | OUTCOMES OF HAART IN HIV-1 INFECTED INDIVIDUALS IN BUENOS AIRES, ARGENTINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0203 Zala C.1, Hogg R.2, Salomon H.3, Chan K.2, Ceriotto M.4, Beltran M.5, Burgos M.6, Montaner J.S.2, Cahn P.1, and the PUMA study team We report data on the effect of HAART within a population-based cohort in Argentina. Initiation of HAART was associated with an advanced HIV disease. Urgent efforts are needed to optimize timing of initiation of antiretroviral therapy in our setting. |
| ThAb0204 | KNOWLEDGE, ATTITUDES, AND PRACTICES OF HIV CARE AND ANTIRETROVIRAL THERAPY AMONG HIV-INFECTED ADULTS ATTENDING PRIVATE AND PUBLIC CLINICS IN INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0204 Vaidya S.B.1, Ramchandani S.R.2, Saple D.G.3, Mehta S.H.4, Pandey V.P.5, Vadrevu R.6, Rajasekaran S.7, Bhatia V.P.8, Chowdhary A.8, Bollinger R.C.9, Gupta A.9 Knowledge and access to ART were greater for patients attending private clinics, but overall levels were low in both private and public settings. Further educational and programmatic efforts are needed to improve treatment awareness and access for HIV-infected persons in both public and private settings in India. |
| ThAb0205 | INSTITUTIONAL CHALLENGES IN ACCESS TO DRUGS IN DEVELOPING COUNTRIES: AN ANALYSIS OF DRUG FORECASTING AND DRUG CONSUMPTION CAPACITY IN AFRICAN HEALTH CARE INSTITUTIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0205 Arnold C.1, K¨rzinger M.L.1, Besson M.-H.1, Sembatya Y.2, Ladner J.3, Saba J.1 Forecasting challenges are frequent. Adequate forecasts should be projected on drug demand consistent with capacity limitations and not on epidemiological indicators. Uptake of VDP and DPP programs appears to be limited by institutional capacity. Analytical data on institutional capacity will be presented. |
| ThAc01 | PMTCT: Meeting the Needs of Moms and Babies |
| ThAc0101 | 18-MONTH EFFECTIVENESS OF SHORT-COURSE PERINATAL ANTIRETROVIRAL REGIMENS COMBINED TO INFANT-FEEDING INTERVENTIONS FOR PMTCT IN ABIDJAN, CÔTE D'IVOIRE. DITRAME PLUS ANRS 1201/1202 2001 – 2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0101 Leroy V.1, Ekouévi D.K.2, Dequae-Merchadou L.1, Viho I.2, Becquet R.1, Tonwe-Gold B.2, Rouet F.3, Horo A.4, Sakarovitch C.1, Timité-Konan M.5, Dabis F.1, Toni T.3, DITRAME PLUS ANRS 1201/1202 Study Group A combination of perinatal ZDV+3TC+sdNVP associated to infant-feeding interventions reduces significantly MTCT of HIV with long-term benefit until age 18 months. |
| ThAc0102 | ILLNESS DURING PREGNANCY IS ASSOCIATED WITH IN UTERO HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) TRANSMISSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0102 Farquhar C.1, Mbori-Ngacha D.2, Harris J.3, Wamalwa D.2, Bosire R.4, Redman M.5, Gichuhi C.2, Obimbo E.2, Overbaugh J.5, John-Stewart G.1 Illness during pregnancy was an independent risk factor for in utero HIV-1 transmission in this cohort. Prevention and treatment of co-infections should be considered as potential interventions to reduce HIV-1 transmission during the antenatal period. |
| ThAc0103 | VIRAL SAFETY OF FLASH-HEATED BREASTMILK AS AN INFANT FEEDING OPTION FOR HIV POSITIVE MOTHERS IN DEVELOPING COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0103 Israel-Ballard K.1, Donovan R.2, Chantry C.3, Coutsoudis A.4, Sheppard H.2, Sibeko L.5, Abrams B.1 Breastmilk viral loads were relatively low in this population of women without advanced disease. FH is capable of inactivating HIV in naturally infected breast milk from HIV positive mothers. FH may be a practical infant feeding method for mothers in developing countries who need safe alternatives. |
| ThAc0104 | HIV PREVALENCE RATES AMONGST 6 WEEK OLD INFANTS IN SOUTH AFRICA: THE CASE FOR UNIVERSAL SCREENING AT IMMUNIZATION CLINICS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0104 Rollins N.1, Mzolo S.1, Little K.2, Horwood C.3, Newell M.-L.4 Screening of all infants at immunisation clinics using this method is an effective and feasible method to monitor the overall impact of PMTCT programmes. In settings where longitudinal follow-up of HIV-infected mother and their children has proven to be difficult universal informed screening of infants at 6 week immunisation visits could serve as an additional opportunity for women to learn their HIV status, identify exposed and infected children early and to increase referrals to the HIV care programmes including ART programmes. |
| ThAc0105 | HOW WELL DO PMTCT PROGRAMS IN INDIA FACILITATE ACCESS TO HIV CARE AND SEXUAL AND REPRODUCTIVE HEALTH (SRH) SERVICES FOR HIV-POSITIVE WOMEN? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0105 Sharma Mahendra V.1, Sarna A.1, Rutenberg N.2, Rau A.3, Singh L.B.4, Mudoi R.3, Oinam A.4, Pakkela V.5, Panda S.6 Interim analysis indicates that linkages between PMTCT programs and HIV care and SRH services are weak. Failure to address the SRH needs of women and to connect them to HIV care is a shortcoming of the PMTCT program. Study results will be used to strengthen linkages between PMTCT and other services vital to meeting the needs of HIV-positive women. |
| ThAc02 | Are We Living Longer, Better Lives? Trends in Morbidity and Mortality |
| ThAc0201 | PERSISTENT CONTRIBUTION OF SUBSTANCE ABUSE TO EXCESS MORTALITY AMONG PERSONS WITH AIDS IN NEW YORK CITY, 1999 – 2003 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0201 Pfeiffer M.R., Hanna D.B., Begier E.M., Sepkowitz K.A., Torian L.V., Sackoff J.E. IDU constitute a disproportionate share of deaths among persons with AIDS in NYC. Excess deaths were mainly due to substance abuse-related causes including overdose, HCV and other liver diseases. Mortality could be cut substantially by addressing these causes through substance abuse treatment, HCV treatment, and promotion of harm reduction strategies such as syringe exchange programs and naloxone distribution to treat accidental overdose. |
| ThAc0202 | TRENDS IN MORTALITY AND CAUSES OF DEATH AMONG HIV-INFECTED INDIVIDUALS DIAGNOSED IN THE UK: 1993 – 2004 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0202 Ciancio B.C.1, Forde J.2, Dougan S.2, Chadborn T.2, Delpech V.2 Early diagnosis and treatment could prevent some AIDS-related deaths, particularly among black African heterosexuals. For MSM public health intervention should also consider the prevention of deaths due to cardiovascular and hepatic disease. |
| ThAc0203 | CHILD MORTALITY ACCORDING TO MATERNAL AND INFANT HIV STATUS IN ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0203 Marinda E.1, Humphrey J.H.2, Iliff P.J.3, Mutasa K.3, Piwoz E.G.4, Moulton L.H.2, Nathoo K.J.5, Ward B.J.6, Salama P.7, ZVITAMBO Study Group Mortality is exceedingly high among HIV-infected children. The earlier children are infected, the faster they die. Respiratory infection is by far the major cause of their deaths. These data highlight the need for timely antiretroviral treatment and cotrimoxazole prophylaxis for HIV-infected children. |
| ThAc0204 | RETROSPECTIVE COHORT STUDY OF SURVIVAL RATES IN A SEROCONVERTER COHORT OF NEARLY 2000 SOUTH AFRICAN GOLD-MINERS OVER 10 YEARS OF FOLLOW-UP Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0204 Glynn J.1, Sonnenberg P.2, Nelson G.3, Bester A.4, Shearer S.4, Murray J.5 This study is much the largest cohort of individuals with known dates of seroconversion available in Africa, HIV infection sharply increased mortality rates to high levels. Mortality rates in the HIV positive men were slightly higher than those in the West before ARVs, but the median survival is slightly longer than that reported in Uganda. |
| ThAc0205 | ANEMIA IN EARLY STAGES OF HIV-1 INFECTION IN ADULTS IN BOTSWANA, AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0205 Sales S.1, Campa A.1, Essex M.2, Wester W.3, Redd A.2, Burns P.2, Duan R.1, Xue L.1, Bussman H.3, Arimi P.3, Widenfelt E.3, Thior I.3, Makhema J.3, Marlink R.2, Baum M.K.1, Micronutrient Study Team Anemia was prevalent in this African cohort in early stages of HIV-1C disease. Since anemia has been found independently related to HIV mortality, efforts to better monitor, diagnose and treat are needed in the region. Additional studies on types of anemia among patients with early HIV-1C infection and its association to viral characteristics are needed. |
| ThAd01 | Strategies for equity and efficiency in HIV/AIDS assistance |
| ThAd0101 | MODELING THE POTENTIAL IMPACT OF HIV CHEMOPROPHYLAXIS STRATEGIES AMONG MEN WHO HAVE SEX WITH MEN IN THE UNITED STATES: HIV INFECTIONS PREVENTED AND COST-EFFECTIVENESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0101 Desai K.1, McGreevey W.P.2, Ackers M.L.3, Hall H.I.3, Hu D.J.3, Sanders R.2, Sansom S.L.3, Scotton C.R.3, Soorapanth S.3, Stewart S.R.4, Boily M.C.1, Garnett G.P.1, McElroy P.D.3 Even with modest levels of efficacy, HIV chemoprophylaxis among high-risk MSM in a major US city could prevent a significant number of HIV infections and be cost effective. |
| ThAd0102 | PRIVATE-PUBLIC PARTNERSHIP TO SCALE UP RESPONSE IN THE TRANSPORT SECTOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0102 Jenkin J.1, Landis R.2, Matthew P.3 In southern Africa, where humanitarian crises result in huge quantities of food being transported by road, saving lives and risking lives oddly intertwine. Sexual networks flourish along transport routes placing long distance truck drivers, including those moving food aid for the World Food Programme (WFP), at the heart of the action. TNT, the global transport/logistics company, recognized that industry practices can endanger drivers and fuel the epidemic. With core business of each linked to both problem and solution, WFP and TNT overcame different corporate cultures and objectives to work together to increase industry accountability and protect the lives of drivers and their sexual partners. |
| ThAd0103 | MONITORING HIV/AIDS FINANCIAL FLOWS FROM GLOBAL INITIATIVES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0103 Dmytraczenko T., De S. As HIV/AIDS funds increasingly flow from external sources to NGOs, the ability of government to exercise stewardship over prevention and care is challenged. As demonstrated by the experiences of the governments of Kenya, Malawi, Rwanda, Ukraine, Vietnam, Zambia and Zimbabwe, developing systems to track the flow of resources against program objectives can be a powerful tool in guiding HIV/AIDS policy. |
| ThAd0104 | PROTECTING AFRICA'S WILDLIFE AND PARKS: THE IMPACT OF AIDS ON THE ZAMBIA WILDLIFE AUTHORITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0104 Rosen S.1, Hamazakaza P.2, Long L.3 AIDS is constraining ZAWA's ability to protect Zambia's wildlife and parks. Despite the logistical challenges of treating patients in remote locations, even at a cost of $1,000/patient/year, antiretroviral therapy would result in net budgetary savings to the organization and greatly increase its patrol capacity. |
| ThAd0105 | LINKING MDGS AND HIV PREVENTION: UTILIZING POSITIVE EXTERNALITIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0105 Stillwaggon E. Transmission models for HIV and other diseases must incorporate multiple factors that increase risk. Achievement of MDGs requires concerted effort to recognize and exploit the numerous interactions among the goals. Overall costs of achieving MDGs are reduced by integrating programs for interrelated diseases. |
| ThAd02 | Strategies for equity and efficiency in HIV/AIDS assistanceMethodological and Conceptual advances in social research |
| ThAd0201 | METHODOLOGICAL ISSUES AND CHALLENGES IN RESEARCHING WITH CHILD-HEADED HOUSEHOLDS IN RURAL ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0201 Francis-Chizororo M. The fact that children are heading households calls for a need to develop sensitive and appropriate research approaches and methods that place children's voices at the centre of research. |
| ThAd0202 | IMPACT OF LEVEL OF RESEARCHER SUPPORT ON COITAL DIARY RESULTS AND ACCEPTABILITY AMONG WOMEN AT HIGH RISK OF HIV IN THE MICROBICIDES DEVELOPMENT PROGRAMME FEASIBILITY STUDY IN MWANZA, TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0202 Allen C.F.1, Lees S.S.2, Desmond N.1, Der G.1, Chiduo B.3, Vallely A.2, Hayes R.2, Ross D.A.2 CDs result in higher reporting of socially stigmatised activities than FFIs, and are less sensitive to level of support. Convergence with interview results at higher levels of support also shows the relative validity of diaries. Intensive support improved the acceptability of the research process. |
| ThAd0203 | HIV/AIDS RISK RESEARCH AMONG YOUNG PEOPLE: A METHODOLOGICAL STUDY OF THE REPORTING OF SENSITIVE ISSUES AMONG ADOLESCENTS IN THE BIRTH TO TWENTY STUDY, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0203 Norris S.A.1, Richter L.M.2 Interviewer-based questioning is not recommended for collecting sensitive data from adolescents. Even though ACASI was appealing to these urban adolescents, intensive tutorial-based and supportive procedures need to be in place to overcome the technical difficulties associated with the technique. |
| ThAd0204 | RETHINKING THE COMPLEXITIES OF AIDS IMPACT: A CALL FOR INTERDISCIPLINARITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0204 Chazan M.1, Brklacich M.1, Whiteside A.2 Social vulnerability provides valuable new ways of thinking about generalized epidemics. It facilitates a reframing of AIDS as a long-wave societal stressor, which interacts with a myriad of other processes to augment differential vulnerabilities. This study illustrates that it is time to move AIDS research beyond the crisis-oriented "impact model" to a comprehensive vulnerability framework, probing the complex socio-political processes underpinning the epidemic's tragic and uneven effects. |
| ThAd0205 | MEASUREMENT AIDS: IMPROVING MEASUREMENT OF CULTURE IN HIV/AIDS RESEARCH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0205 McDonnell T.E., Gazley J.L. Drawing from advances in social science research, we offer alternative measures of culture, attitudes and practices for use in assessing prevention interventions and analyzing drivers of the HIV epidemic. |
| ThAd03 | Understanding and reaching marginalised groups |
| ThAd0301 | BUILDING REFERRAL NETWORKS BETWEEN TRADITIONAL HEALTH PRACTITIONERS AND BIOMEDICAL HEALTH SYSTEM - A STRATEGY TO REACH THE UNDERSERVED COMMUNITIES WITH COMPREHENSIVE HIV SERVICES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0301 Balaba D.1, Kyeyune P.1, Lutalo I.2, Semafumu E.3 If universal access to comprehensive HIV/AIDS care in sub-Saharan Africa is to be achieved, there is an urgent need to build functional community referral networks. |
| ThAd0302 | HOW THE OBJECT OF RESEARCH TRANSFORMED INTO RESEARCHER: A DURBAR EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0302 Pal S.1, Jana S.2, Roy G.1, Saha A.1 Given the opportunity, even illiterate or less literate sexworkers can prove their worth as researcher and can guide in helping articulating research question and framework for research. Replication of this experience is recommended to provide sexworkers a voice in setting research agendas that are "aimed at them." |
| ThAd0303 | THE DIAGNOSIS AND CARE OF HIV INFECTION IN CANADIAN ABORIGINAL YOUTH: ENGAGING THE COMMUNITY IN RESEARCH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0303 Wong T.1, Prentice T.2, Mill J.3, Jackson R.2, Sommerfeldt S.3, Worthington C.4, Archibald C.1, Myers T.5 To prevent the spread of HIV in Aboriginal communities, Aboriginal peoples must play key roles in all aspects of HIV research, including study design, implementation, result dissemination and knowledge translation. Actions taken have to address the health disparities and needs of the Aboriginal people. |
| ThAd0304 | INTENSIVE ETHNOGRAPHIC TRAINING PROGRAM FOR JUNIOR HIV/AIDS RESEARCHERS IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0304 Sember R.1, Preston-Whyte E.2, Parker R.1 The curriculum for the course be made available to social science educators across the continent and elsewhere in the world. Proficiency in ethnographic research be greatly expanded in order to foster a deeper historical and contextual understanding of the how the epdidemic is shaped and interpreted locally. With adequate supervision, junior researchers are able to undertake longitudinal ethnograph research that provides data of significant value to researchers and providers alike. |
| ThAd0305 | ABORIGINAL PERSPECTIVES ON KNOWLEDGE TRANSLATION IN COMMUNITY-BASED HIV/AIDS RESEARCH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0305 R. Masching1, Y. Allard2, T. Prentice1, R. Jackson1, J. Mill3, K. Barlow4 Identifying effective KT strategies that meet community need is an exciting and challenging process. This presentation seeks to continue a dialogue with Indigenous researchers from around the world regarding the application of KT strategies that effectively support research uptake at the grassroots level and beyond. |
| ThAe01 | Money Makes a Difference: Monitoring and Accountability of Global AIDS Funding |
| ThAe0101 | AN ETHICAL ANALYSIS CONTRASTING INTERNATIONAL HIV/AIDS RELIEF EFFORTS WITH RELIEF EFFORTS FOR OTHER DISEASES AND DISASTERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0101 T. Christie1, G. Asrat1, F. Koning2, J. Montaner3 The international response to disasters is fundamentally irrational. The consequences are the resultant funding disparities that violate the principle of justice with no conceivable ethical justification. |
| ThAe0102 | PEPFAR: PROMISES AND PITFALLS AND THE NEED FOR CHANGE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0102 S.A. Lynch1, D.R. Palmer2, T.R. Corcoran3 Community review is needed of PEPFAR´s policies and impact. A new paradigm for international assistance for HIV/AIDS is long overdue as are local and global programs that revolutionize the public health sector and the way aid is delivered, that ensures equity and empowers local groups by addressing the underlying socioeconomic issues that intensify the HIV/AIDS pandemic. |
| ThAe0103 | FROM POLICIES TO PEOPLE: AN ANALYSIS OF THE MECHANISMS IN PLACE TO RESOURCE COMMUNITY RESPONSES TO HIV AND AIDS IN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0103 E. Wachira1, B. Kanina2, P. Niuguna3, S. Nyokabi4, r. Weaver5, L. Webster5, P. Okaalet6 International donors have rapidly increased aid for Kenya's response to HIV and AIDS in recent years. The plans and strategies being put into place at a national level use convincing language. Yet there is concern that they are not making a real difference to the people most affected. |
| ThAe0104 | GETTING RESOURCES TO THE BASE: A COMMUNITY BASED M&E OF GOVERNMENT UTILIZATION OF FUNDS FOR HIV/AIDS AFFECTED AND INFECTED CHILDREN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0104 R. Okoh Fraud and impropriety in the use of funds provided by international donor organization for HIV/AIDS related programmes and projects are rife in Africa and many developing countries including Nigeria. HIV/AIDS Affected and Infected Children(HAIC) are in particular vulnerable to budgetary cuts and diversions during periods of lean resources because they are voiceless and lack political power. A community based Participatory Monitoring and Evaluation(PM&E) process for government spending on HIV/AIDS with special focus on budgetary allocations for HAIC programmes is absolutely imperative. |
| ThAe02 | Time to Deliver: Influencing Policy and Law |
 ThAe0200 |
INTRODUCTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0200 Jonathan Cohen, United States This is a Power Point presentation. There is no abstract available. |
| ThAe0201 | THE LIBERIAN SIGNATORY CAMPAIGN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0201 A. Attah1, D. Wallace1, J. Cooper2, M. Sheriff1 That organizations begin to advocate for stringent laws that ensure good health. |
| ThAe0202 | A POLICY ANALYSIS FOR INTERVENTIONS TO BRIDGE THE GAP BETWEEN TRADITIONAL HEALERS AND THE PUBLIC SECTOR FOR HIV/AIDS CONTROL IN UGANDA AND ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0202 R. Brugha1, M. Oliff2, R. Vongo3, D. Balaba Byansi4, P. Ndubani5, F. Ssengooba6, B.B. Kaboru7, R. King4, B.G. Team8, Bridging Gaps Implementation of a policy tracking component, in parallel to designing, implementing and evaluating a new HIV intervention, is comparatively simple and should be routine in major intervention research. Findings from the Bridging Gaps intervention will encounter greatly changed global and national policy environments, since its 2002 inception, with opportunities from new global funds but also residual policy-level obstacles to overcome. |
| ThAe0203 | FROM SCIENCE TO POLICY TO LAW IN CHINESE RESPONSE TO AIDS MOVING FROM PILOT TO SCALE-UP Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0203 Z. Wu1, S. Sullivan1, Y. Wang1, M.J. Rotheram2, R. Detels3 The China experience provides a model of positive action that should be shared with the international community, and in particular with other developing nations. |
| ThAe0204 | IT'S NOT THAT IT'S A BOTTOM, IT'S WHAT THE BOTTOM HAS BEEN DOING THAT WILL CAUSE THE PROBLEM - POLICY CONFLICTS IN HIV PREVENTION CAMPAIGN APPROVALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0204 M. Kennedy1, C. Batrouney2 Policy conflicts in this area are predictable and approval guidelines for HIV prevention resources should establish mechanisms for early identification and resolution. Approval processes should provide for input from external health promotion experts. |
| ThAe0205 | REMOVING REQUIREMENT FOR SELF-DISCLOSURE OF HIV STATUS FROM CANADA'S TEMPORARY RESIDENT VISA APPLICATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0205 L. Stoltz1, J. Anderson2, G. Flintoft2, R. Elliott3, L. Samson4, L. Binder5, M. Battista6, R. Shahin7 Candidate countries for the Conference should continue to be evaluated on the basis of their ability to assure freedom of entry for people living with HIV/AIDS, consistent with a minimally intrusive approach to the infringement of human rights. |
| ThAe03 | Law, Human Rights and HIV: Broadening the Agenda |
| ThAe0300 |
INTRODUCTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0300 Richard Elliott, Canada This is a Power Point presentation. There is no abstract available. |
| ThAe0301 | PUBLIC SERVICE FOR HUMAN RIGHTS OF PLWHA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0301 N. Panchenko Improving Russian legislation with the goal to provide access to information about HIV/AIDS, to prevention and treatment; raising public awareness about HIV/AIDS by disseminating truthful information about HIV/AIDS; inclusion people living with HIV/AIDS related policymaking process at both the regional and federal levels. |
| ThAe0302 | RHETORIC AND RISK: HUMAN RIGHTS ABUSES IMPEDING UKRAINE'S FIGHT AGAINST HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0302 R. Schleifer1, P. Skala2, K. Lezhentsev3, J. Amon1 Ukraine's obligation to ensure the human right to health require it to take urgent action to stop abuses impeding access to HIV/AIDS information and services. Drug users, people living with HIV/AIDS, and nongovernmental organizations working with them, whose efforts have been instrumental in providing HIV/AIDS information and services to marginalized groups, should be an integral part of government efforts. |
| ThAe0303 | EXAGGERATED CONTAGIOUSNESS: DELINEATING THE BOUNDARIES IN THE EVERYDAY LIVES OF CHINESE PEOPLE WITH HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0303 Y.R. Zhou The findings of this study illustrate the conflicts existing between people's mastery of HIV/AIDS knowledge and their over-carefulness towards HIV-infected bodies in practice. It suggests that AIDS education should not be limited to the dissemination of knowledge per se, and that the interactive or interpersonal dimensions of discrimination/anti-discrimination must also be taken into account. |
| ThAe0304 | ACCESSING MORPHINE FOR HIV/AIDS PAIN MANAGEMENT IN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0304 S. Nkhoma, M. Reynolds, N. Khan, P. Bhatt, G. Kombe Simplified legislation is needed to address the legal constraints to access, and medical education and training on morphine prescription and implications must be implemented. Civil society should recognize the importance of pain relief in the broader scope of palliative care and integrate it into other HIV/AIDS interventions to address comprehensive treatment and care needs of PLWHA. |
| ThAe0305 | HIV/AIDS AND HUMAN RIGHTS IN THE CARIBBEAN - THE CASE OF THE DOMINICAN REPUBLIC AND GUYANA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0305 J. Hanefeld1, J. Welsh2, G. Ducos1 For the response to HIV/AIDS to be successful human rights need to be at the centre of all policy and programming. The research shows the need for states to fulfil, protect and guarantee the human rights of their citizens in order to successfully address the challenge of HIV/AIDS. Amnesty International will campaign around the recommendations that have emerged from the research. The findings add to an evidence base highlighting the importance of a rights-based approach to HIV/AIDS. |
| ThAe0306 |
CONCLUSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0306 Richard Elliott, Canada This is a Power Point presentation. There is no abstract available. |
| ThAe04 | GIPA: Participate, Engage, Empower |
| ThAe0401 | EMPOWERMENT: WHAT DOES THIS CONCEPT MEAN FOR PLWAS? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0401 C.R. Murguía Pardo Training for PLWAs has focused on antiretrovirals, HIV/AIDS and emotional support, but not focused on issues that they consider priorities, such as human rights and advocacy. Empowerment involves providing them with information about the epidemic and support for dealing with being HIV-positive, but ignores systematic, sustained enhancement of skills to enable them taking an active, leading role in the national response to the epidemic. Few organizations are interested in empowering PLWAs because they do not understand their needs or how to meet their high expectations. PLWAs don't want a complementary role in HIV/AIDS response, they want to play a main role in the same condiitons as other civil sociaty actors. |
| ThAe0402 | CONSUMER INVOLVEMENT IN A GOVERNMENT-SPONSORED HIV QUALITY IMPROVEMENT (QI) PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0402 V. Johnson1, M. Lopez2, C. Steinbock3, D. Tietz3, J. Perou3, B. Agins3 Consumer advisory groups should be included in QI programs of governmental HIV agencies which should lead to improved consumer satisfaction with care, thereby facilitating adherence with care and treatment. Consumers should have the opportunity to participate in the selection and development of indicators to measure the quality of care and contribute to the continuous improvement activities in HIV care in the United States. |
| ThAe0403 | TOWARDS MEANINGFUL INVOLVEMENT: BUILDING FUNCTIONAL COMMUNITIES OF PEOPLE LIVING WITH HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0403 D. Walker1, E. Kamunvi2, J. Ntale Nkurunziza3 The greater involvement of PLWHA should not stop at integration into the healthcare system, but must aim at equipping PLWHA with the skills for mobiling and organizing themselves into strong action groups. It has been our experience that mature networks of PLWHA are most effective at reaching marginalized populations, both for the delivery of care-services and the introduction of prevention modalities that are culturally-appropriate. |
| ThAe0404 | LIVING AGAIN: SUPPORTING PLHA TO LEAD THE RESPONSE TO HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0404 B. Nheok1, S. Bou2, M. Dunbar3, C. Francis4, C. Natpratan4 Full participation of people living with HIV (both men and women) in the production of the video is key to ensuring the video addresses their priority information needs. PLHA have strong and motivational experiences of coping and adapting to living with HIV. It is builds their knowledge and skills and promotes ownership of the educational tool. Monitoring and follow-up support is important to provide feedback and on-the-job skills building support. |
| ThAe05 | Treatment Access, TRIPS and Trip-ups |
| ThAe0501 | HIV/AIDS AND SOUTH AFRICA'S WAR ON SCIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0501 J. Berger AIDS denialism and the associated attack on evidence-based medicine in South Africa provide a unique "opportunity" for civil society to transform the way in which lay people relate to health care services and systems. The study indicates the need for a broad civil society-lead public education campaign on evidence-based medicine that builds on - and helps to expand - HIV treatment literacy programmes. |
| ThAe0502 | MEASURING PUBLIC HEALTH - SENSITIVE DEGREE OF IPR LEGISLATION IN THE CONTEXT OF THE WTO TRIPS AGREEMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0502 G.C. Chaves, M.A. Oliveira The instrument was accurate in measuring the health-sensitive degree of IPR legislation of the countries studied. It was also possible to propose a new concept for health-sensitive IPR legislation, which includes all TRIPS flexibilities and do not includes TRIPS-Plus provisions. |
| ThAe0503 | TAKING THE FIGHT TO THEIR REALM: THE ROLE OF PATENT OPPOSITIONS IN THE STRUGGLE FOR ACCESS TO MEDICINES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0503 P. Radhakrishnan, C. Park Educate and empower civil society throughout the Global South on TRIPs-related issues; build capacity in patent law and basic pharmaceutical science. Build network for sharing of information and resources. |
| ThAe0504 | IMPROVING THE AVAILABILITY OF ARVS IN NAMIBIA BY USING POLICY CHANGE TO STREAMLINE THE DRUG REGISTRATION PROCESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0504 D. Pereko, J. Nwokike Barriers to accessing ARVs can come at different levels in the pharmaceutical system. In Namibia, an administrative backlog was keeping ARVs and other medicines off the market; a combination of policy and managerial interventions streamlined the drug registration process and made way for vital additions to HIV/AIDS treatment. Countries should monitor and evaluate all aspects their pharmaceutical policies and procedures to find "hidden" obstacles to access. |
| ThAe0505 | BENCHMARKING RESEARCH-BASED PHARMACEUTICAL COMPANY RESPONSES TO AIDS, TB, & MALARIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0505 D. Rosan1, B. Aires2, C. Rowan3, L. Compere4, J. Byron5, K. Hartsough6, S. Finn7 Companies should institute internal benchmarking programs to evaluate social performance versus their peers. Advocates can be more effective by taking an industry-wide approach and using competitive dynamics between companies to improve performance. |
| ThAx01 | Resistance - Before you Start HAART |
| ThAx0101 | PRIMARY HIV-1 DRUG RESISTANCE IN CANADA: UPDATED RESULTS FROM THE CANADIAN HIV STRAIN AND DRUG RESISTANCE SURVEILLANCE PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0101 N. Goedhuis, G.C. Jayaraman, J. Brooks, R. Pilon, P. Sandstrom, C.P. Archibald, Canadian HIV Strain and Drug Resistance Surveillance Program Mutations associated with antiretroviral drug resistance were found in both male and female cases, across all reported ethnic categories, and within all risk groups. Drug resistance has also been consistently noted in both recently infected and prevalent cases. These results support the need for continued surveillance of HIV diversity to inform our understanding of the changing nature of the HIV epidemic in Canada, in order to guide treatment and care strategies across the country. |
| ThAx0102 | ANALYSIS OF DRUG RESISTANCE TRANSMISSION OF ACUTELY NON-B INFECTED HIV PATIENTS IN CAMEROON Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0102 N. Ndembi1, D. Mbanya1, A. Abraha2, L. Kaptue1, R. Salata2, E.J. Arts2 The emergence of ARV resistance, particularly to nevirapine (NVP) may have a grave consequence to the success of future treatment strategies (Triomune) as well as most perinatal prevention programs utilizing NVP. |
| ThAx0103 | HIV-1 DRUG RESISTANCE GENOTYPING IN TREATMENT NAÏVE SUBJECTS USING DRIED WHOLE BLOOD SPOTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0103 S. Bertagnolio1, L. Soto-Ramirez2, R. Pilon3, R. Harrigan4, R. Rodriguez2, M. Viveros2, L. Fuentes2, T. Mo4, D. Sutherland1, P. Sandstrom3 The results suggest that DBS are a promising public health tool for HIVDR surveillance of treatment-naïve subjects, especially in regions where specimens are likely to be subjected to severe environmental conditions and where logistical difficulties for specimens handling could prevent timely blood processing. Additional investigations are needed to validate DBS as an alternative to plasma for patient monitoring. |
| ThAx0104 | A SOUTH-SOUTH COLLABORATIVE NETWORK FOR HAART RESISTANCE SURVEILLANCE AND MONITORING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0104 C. De Schacht1, M. van Vugt1, T.F. Rinke de Wit1, K. Frost2, P. van Rooijen3, R. Hamers1 Timely building of capacity for measuring HIVDR in Asia and Africa is of importance, in light of the massive scale-up of HAART in those continents. The coordination of Asian and African efforts will provide unique and complementary insights in the development of HIVDR. |
| ThAx0105 | ANTIRETROVIRAL RESISTANCE IS NOT AN IMPORTANT RISK OF THE ORAL TENOFOVIR PROPHYLAXIS TRIAL IN BOTSWANA: A SIMPLE MATHEMATICAL MODELLING APPROACH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0105 D. Smith1, P. Kebaabetswe1, K. Disasi2, D. Fleming3, L. Paxton4, M. Davis3 The oral tenofovir trial will likely result in less than 1/500th of the persons in Botswana with the K65R mutation. Most resistance will be generated within the treatment program. Patients with K65R may still be phenotypically sensitive, so TDF treatment regimens are likely to continue remain effective in Botswana despite genotypic resistance mutations among those in the treatment program and the very few who seroconvert in the trial. |
| ThAx02 | Vaccine Research |
| ThAx0201 | KNOWLEDGE AND ATTITUDES ABOUT HIV VACCINE RESEARCH AMONG HEALTH WORKERS IN TWO PROVINCES IN KENYA: BASELINE SURVEY CONDUCTED FEB-APR 2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0201 S. Kalibala1, F. Manguyu1, J. Ndinya-Achola2, S. Wakasiaka2, J.Bwayo2, W. Jaoko2, O. Anzala2 While the majority was knowledgeable in some aspects significant knowledge gaps remained and there were serious misconceptions regarding what candidate HIV vaccines were made of with some suggesting live attenuated HIV. This seems to have resulted in a lack of confidence in the safety of AIDS vaccines as shown in the lack of clear supportive attitudes on this issue. |
| ThAx0202 | USE OF CONJOINT ANALYSIS METHODS TO ASSESS HIV VACCINE ACCEPTABILITY IN THREE POPULATIONS: AN INNOVATION IN THE ASSESSMENT OF CONSUMER HEALTHCARE PREFERENCES (PROJECT VIBE) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0202 S.-J. Lee1, P. Newman2, W. Cunningham3, D. Seiden1, N. Duan1 CA methods enabled direct assessment of HIV vaccine preferences. Acceptability varied widely depending on hypothetical HIV vaccine characteristics. CA methods identified efficacy as the most important attribute across groups; preferences for other attributes varied across demographic subgroups. CA methodology may support empirically-based, population-specific interventions to increase HIV vaccine acceptability. |
| ThAx0203 | SEVEN POINTS OF ENTRY FOR ACTION - MICROBICIDES, VACCINES AND TREATMENT (MTV) ADVOCATES AGENDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0203 S. Mellors, D. Cavanagh Developing collaborative agendas requires commitment - financial and human, as well as clear action plans that can be followed up, implemented and sustained |
| ThAx0204 | SAFE ADMINISTRATION OF DNA (PTHR.HIVA) AND MVA.HIVA TO 169 HIV-1 UNINFECTED VOLUNTEERS ENROLLED IN PHASE I/II TRIALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0204 A. Guimaraes-Walker1, I. Cebere1, N. Mackie2, T. Hanke1, P. Fast3, L. Dally4, J. Weber2, A. McMichael1 Both DNA and MVA.HIVA were safe and well tolerated. The most common event post vaccination was mild local reaction at the injection site. Escalation of dose did not correlate with increased severity of reactions. There were no SAEs caused by the vaccines. When evaluating a candidate vaccine, it is vital to ensure consistency in the grading criteria within a programme consisting of overlapping trials. |
| ThAx0205 | DIFFERENCES IN WILLINGNESS TO PAY FOR SELF AND FAMILY MEMBERS AN AIDS VACCINE IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0205 P. Patil1, D. Bishai2 In a high prevalence developing country where clinical trials of experimental vaccines have been conducted, adults are willing to undertake significant expense to purchase a vaccine against HIV/AIDS particularly for themselves. Some evidence suggests that women are also more likely to spend on spouses than men. |
| ThAx03 | ABC in Africa - What is the Evidence? |
| ThAx0301 | SYSTEMATIC REVIEW OF THE IMPACT OF ABSTINENCE-ONLY PROGRAMMES ON RISK BEHAVIOR IN DEVELOPING COUNTRIES (1990 – 2005) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0301 K. O'Reilly1, A. Medley2, J. Dennison2, M. Sweat2 Even with the inclusion of new studies since our last synthesis, little evidence of the effectiveness of abstinence-only programmes in developing countries was found, either because of weak study designs or the difficulty in measuring outcomes of interest. Most evidence of effectiveness related to changes in beliefs. However encouraging changes in beliefs may be, they cannot be assumed to result in complete abstinence or other safer sexual behaviour. |
| ThAx0302 | A COW DIES WITH GRASS IN IT'S MOUTH" – FISHERMEN'S RESPONSE TO "ZERO GRAZING" IN KISUMU, KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0302 A. Sharma1, E. Bukusi1, Z. Kwena1, A. Buffardi2, B. Agot1, C. Muga1, K. Holmes2 Resources are needed for STI/HIV risk reduction through changes in the structures that influence highly localized sexual behavior. Changes in how business is transacted and provision of livelihood programmes and basic health and social services, particularly for widows and single mothers, could prevent new infections and may eventually, save on funds required for treatment and comprehensive care. |
| ThAx0303 | LIKE MOTHER LIKE DAUGHTER: THE INFLUENCE OF PERCEIVED MOTHERS' VALUES ON DAUGHTERS' ATTITUDES TOWARDS SEXUAL ABSTINENCE IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0303 O. Adeleke, A. Ankomah Mothers play an enormous role in shaping the attitudes of their daughters towards sexual abstinence. Values and belief orientation are easily imbibed through effective mother-daughter communication. Prevention of HIV/AIDS, STIs, and unintended pregnancies can be achieved through effective intra-family communication. Daughters who are properly mentored by their mothers are likely to pass across such values on to their daughters. |
| ThAx0304 | ABC - ABSTAIN, BE FAITHFUL, CONDOMISE - AFRICA'S NON-SOLUTIONS. SO WHAT WILL WORK? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0304 B.A. Kenyon HIV/AIDS prevalence is increasing among children. Current prevention programs, whose core theme is "ABC", are making no difference. This presentation will explore the need for "DEFs" that are more effective and relevant in preventing sexual assault and HIV/AIDS transmission among children and youth. |
| Poster Discussions | |
| Track A | |
| ThPdA | HIV Molecular Pathogenesis |
| ThPdA01 | HIV-1 ENVELOPE GLYCOPROTEIN 120 INDUCES CYCLOOXYGENASE-2 EXPRESSION IN ASTROCYTOMA CELLS THROUGH A NUCLEAR FACTOR-κB DEPENDENT MECHANISM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA01 S. Álvarez1, M.J. Serramía1, M. Fresno2, M.A. Muñoz-Fernández1 HIV-1 gp120 alters astroglial function which compromises the function of the nearby of neuronal cells contributing to the cognitive impairment in HIV-1 infection. Cyclooxygenase-2 (COX-2) has been involved in this process, although the intracellular pathways and second messengers involved are yet unknown. |
| ThPdA02 | PERIPHERAL T CELL POPULATION OF HIV-INFECTED PATIENTS SHOWS DIFFUSED BIOCHEMICAL AND ULTRA-STRUCTURAL LESIONS TYPICAL OF THE LATE STAGES OF APOPTOSIS: CONSEQUENCES FOR CLINICAL BIOCHEMISTRY AND PATHOLOGY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA02 M. Paiardini1, B. Cervasi1, A. Favaloro2, G. Pellicanò3, C. Chirico2, G. Visalli2, I. Picerno2, G.P. Anastasi2, G. Piedimonte2 Peripheral T cells from HIV-infected patients show biochemical and ultra-structural anomalies typical of the late stages of apoptosis. These anomalies are found in a high percentage of lymphocytes in naïve or both immunological responders and non-responders treated patients. These data suggest that peripheral T cell population represents only the apoptotic fraction continuously released from lymph nodes, and may give misleading information on immune reconstitution after ART. |
| ThPdA03 | GENETIC CHARACTERISTICS OF GP160 IN ACUTE HIV-1 SUBTYPE C INFECTION: IMPACT ON DISEASE PROGRESSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA03 G.P. Bandawe1, F. Treurnicht1, Z. Woodman1, K. Mlisana2, F. van Loggerenberg2, S.S. Abdool Karim2, C. Williamson1, CAPRISA Acute Infection Study Team Early control of the infection determines viral set point and disease progression. Preliminary data suggests that individuals with rapid disease progression had higher viral diversity following transmission. Furthermore, our results suggest that in HIV-1 subtype C acute infection, transmitted viruses with longer, more glycosylated V1/V2 loops, may be associated with rapid disease progression. |
| ThPdA04 | LOCALIZATION AND CONFIGURATION OF NUCLEIC ACID IN VIRUS PARTICLE BY ELECTRON MICROSCOPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA04 T. Goto1, T. Kido1, T. Fukui2, K. Sano2 We established a method to reveal the nucleic acids in the core and to clarify their configuration in the particles. This method may play an important roles in the elucidation of viral packaging. After isolation and dissection of core from the whole virions, the relationship between nucleic acids and RT and/or NC proteins will be resolved in more detail. |
| ThPdA05 | CELL LINES HARBORING REVERSE TRANSCRIPTASE MUTATIONS IN DEFECTIVE PROVIRAL HIV-1 CAN PRODUCE INFECTIOUS VIRUSES AFTER INFECTION OF A SECOND DEFECTIVE VARIANT OF HIV-1 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA05 Y. Quan, C. Liang, M. Wainberg RNA viruses including HIV-1 generate swarms of similar but genetically distinct variants, called quasispecies. A large proportion of HIV-1 infection is defective. However, the significance of defective infection has not been well explored. We asked whether defective viruses can play any role in HIV drug resistance or HIV-1 persistent infection. |
| ThPdA06 | EVALUATING CIS- AND TRANS-MODULATORS OF HIV-1 RNA PROCESSING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA06 C. Platt1, J. Nemet2, A. Cochrane2 Control of HIV-1 RNA processing plays an important role in regulating viral protein production. Upon synthesis, the 9 kb viral transcript is converted into over 30 mRNAs by alternative splicing, regulated by both cis- and trans-acting factors. Evaluating how these factors interact and how their modulation alters HIV-1 gene expression may identify new means of disrupting viral RNA processing and of controlling the infection. |
| Track B | |
| ThPdB | Can We Deliver? HIV and Hard to Reach Populations |
| ThPdB01 | PROGRESS OF CHINA'S METHADONE MAINTENANCE TREATMENT PROGRAMME Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB01 L. Pang, G. Mi, W. Luo, Z. Wu, National MMT Working Group The principle source of HIV transmission in China is through injecting drug use (IDU). In 2004, China opened it's first eight methadone maintenance treatment (MMT) clinics. By the end of 2005, 128 clinics had been approved and 58 were operational. This paper provides an update on the progress of those first eight clinics and their impact on controlling drug use and HIV transmission in China. |
| ThPdB02 | ACCESSING HIV/AIDS CARE AND SUPPORT SERVICES IN INTERNALLY DISPLACED PEOPLE CAMPS [IDP CAMPS] Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB02 I. Omagor, Persons living with HIV/AIDS in Internally Displaced People Camps AIDS service agencies in war affected areas should design and implement outreach clinics to enable PLWHAs access care and support services for better quality of life. Strengthening collaboration and networking is very important when applying such a model becuase various services will be offered to economically poor PLWHAs. |
| ThPdB03 | RISK FACTORS FOR FAILURE TO INITIATE PRIMARY CARE AFTER DIAGNOSIS OF HIV, NEW YORK CITY: IMPACT OF TRANSMISSION RISK AND SITE OF INITIAL DIAGNOSIS ON SUCCESSFUL TRANSITION TO CARE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB03 L. Torian, E. Wiewel, D. Hanna, J. Sackoff The majority (83%) of patients who initiate care do so within 3 months of diagnosis, suggesting that there is a window of opportunity during which the transition can most effectively be facilitated. IDU, blacks, and persons of non-US origin are at risk for delayed presentation; persons diagnosed at public and community-based testing sites are at risk for failure to present. New strategies are needed to facilitate linkage and to ensure timely presentation for care. Non-medical settings should develop more effective referral procedures so that patients transition successfully from diagnosis to care. |
| ThPdB04 | THE IMPACT OF INCARCERATION ON HIV INFECTION AMONG INJECTION DRUG USERS (IDUS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB04 K.A. Phillips1, N. Galai2, J. Astemborski2, D. Vlahov3, G.D. Kirk2, S.H. Mehta2 Correctional settings need to improve HIV care and treatment within detention/jail settings where persons stay for brief periods and further maintain continuity of care after longer periods of time spent in prison. |
| ThPdB05 | CULTURAL DIFFERENCES IN PREDICTORS OF DEPRESSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB05 L. Sanzero Eller1, Y.-F. Tsai2, M. Rivero3, G. Canaval4, C. Valencia4, E.H. Bunch5, J. Kemppainen6, F.Y. Chou7, P.J. Dole8, I. Corless9, M.J. Hamilton10, C. Coleman11, D.J. Wantland12, K.M. Kirksey13, E. Sefcik10, P. Nicholas9, K.M. Nokes14, W.L. Holzemer12, N.R. Reynolds15, C.J. Portillo12 The prevalence of depression was high in each country sampled. Predictors suggest the need for culturally-based interventions. Predictors of depression can inform interventions that vary by country. Targeted interventions may improve treatment adherence, reduce risky behaviors and improve health outcomes in people living with HIV. |
| ThPdB06 | RECRUITING THE UNREACHABLE AND THE SLIPPERY: CRACK USING WOMEN AND STREET SEX WORKERS AS SUBJECTS FOR A VACCINE PREPAREDNESS STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB06 C. Zorrilla1, L. Santiago2, G. Estronza3, J. Perez3, G. Djomand4, S. Buchbinder5, C. Beyrer6, HVTN 903 PR Site Reported risk behaviors decreased among the women during the first year of the study. Retention rates were low and characteristic of the population: homelessness, drug use, violent neighborhoods and chaotic lifestyles. The observation time (12 months) may have been insufficient to capture HIV seroconversions or the eventual return to the original high risk behaviors. |
| Track C | |
| ThPdC | HIV Prevention in Cyberspace |
| ThPdC01 | FUN & GAMES': REACHING CANADIAN HIV-POSITIVE YOUTH ONLINE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC01 S. Flicker1, A. Buchan2, E. Goldberg3, A. McClelland4, H. Skinner5, T. Smith6, D. Taylor7, T. Veinot8, S. Read9 Health and social service providers may benefit from using www.livepositive.ca as an adjunct to their work with HIV-positive youth. This project also showed the benefits of youth involvement in creating audience-appropriate resources. Finally, it demonstrates the viability of using the Internet to reach HIV-positive youth. |
| ThPdC02 | ACCEPTABILITY AND UTILITY OF A PARTNER NOTIFICATION SYSTEM FOR SEXUALLY TRANSMITTED INFECTION EXPOSURE USING AN INTERNET-BASED, PARTNER-SEEKING WEBSITE FOR MEN WHO HAVE SEX WITH MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC02 M.J. Mimiaga1, A. Tetu2, D. Novak3, S. Adelson4, R. Vanderwarker2, K.H. Mayer5 High-risk and HIV-infected MSM reported high-levels of willingness to use electronic-media in conjunction with public-health specialists for PN if they were infected-with/exposed-to an STI. |
| ThPdC03 | THE DEVELOPMENT OF CYBER-BASED EDUCATION AND REFERRAL/MEN FOR MEN (CYBER/M4M): A CHAT ROOM-BASED INTERVENTION TO PREVENT HIV INFECTION AMONG GAY MEN AND MSM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC03 S. Rhodes1, K. Hergenrather2, B. Ramsey3, L. Yee4, A. Wilkin5 Further research on the efficacy of CyBER/M4M and similar interventions is needed. CBPR is feasible within this population, which is often considered to be "harder-to-reach," and should be considered when planning future interventions. |
| ThPdC04 | MYSEXYCITY.COM: A WEB BASED HIV PREVENTION INTERVENTION FOR MSM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC04 G. Ayala1, L. Templeton Horwitz2 This presentation will highlight the importance of community engagement in projects at their genesis. It will also model one way of tapping into the Internet as a tool for HIV prevention with young MSM. |
| ThPdC05 | NEXT GENERATION HIV PREVENTION: BUILDING HIGHLY INTERACTIVE WEB-BASED HIV INTERVENTIONS FOR MEN WHO USE THE INTERNET TO SEEK SEX WITH OTHER MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC05 B.R.S. Rosser1, S. Hooper2, C. Naumann1, J. Konstan3, T. Manning4, D. Bratland4, M. Allen4, Men's INTernet Sex II (MINTS-II) Team Entirely new approaches to HIV prevention are being developed based on technological advances and developments in the fields of computer science, virtual reality, and e-learning. This presentation will showcase what HIV prevention in the future may well look like while addressing the strengths and limitations of online interventions. |
| ThPdC06 | COMPULSIVE SEXUAL BEHAVIOR AND RISK FOR UNSAFE SEX IN ONLINE LIAISONS FOR MEN WHO USE THE INTERNET TO SEEK SEX WITH MEN: RESULTS OF THE MEN'S INTERNET SEX (MINTS-II) STUDY II Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC06 E. Coleman1, K.J. Horvath2, M. Miner1, M. Ross3, M. Oakes4, B.R.S. Rosser1, Men's INTernet Sex II (MINTS-II) Team MISM who are sexually compulsive appear to be at greater risk for transmitting HIV to other men. HIV+ individuals may be at more risk for spreading the infection as a function of their compulsive sexual behavior and unsafe sex. Addressing CSB as part of Internet based HIV prevention efforts is a critical strategy to address safer sex behavior. |
| Track D | |
| ThPdD | Choices and Challenges of Living with ART |
| ThPdD01 | THE SOCIAL CONSEQUENCES OF ANTIRETROVIRALS: PREPARING FOR THE UNEXPECTED FUTURES OF HIV-POSITIVE CHILDREN IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD01 G. Domek In conclusion, the provision of antiretrovirals must be accompanied by a number of medical, psychological, educational, and social services that help prepare HIV-positive children for futures they only recently have been able to expect. |
| ThPdD02 | LIVING AND WORKING WITH HIV IN FRANCE IN 2003: RESULTS OF THE ANRS-EN12-VESPA STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD02 R. Dray-Spira, F. Lert, VESPA Study Group Employment status of PLWHA is associated with HIV characteristics additionally to sociodemographic/occupational situation. Management of HIV infection at work is still a challenge in 2003. |
| ThPdD03 | QUALITY OF LIFE ASSOCIATED WITH CHANGES IN WEIGHT AND BODY APPEARANCE AMONG PEOPLE LIVING WITH HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD03 A. Bayoumi Weight and body changes are common and bothersome symptoms among people with HIV and have significant and measurable quality of life effects. TTO scores indicate that participants are willing to forego 10 to 15% of future life expectancy to alleviate these symptoms. |
| ThPdD04 | CULTURAL FACTORS INFLUENCING ACCESS TO AND ADHERENCE WITH ANTIRETROVIRAL THERAPY (ART) IN AN URBAN ZAMBIAN COMMUNITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD04 E. Grant1, A. Patching2, D. Gorman3, D. Logie4, J. Mulwanda5, S. Murray6, Lothian Zambia Partnership Powerful cultural and economic factors hinder ART treatment and adherence, despite its local availability. Community based interventions aimed at deconstructing male sexual roles and behaviour, empowering women and promoting early testing are needed. Training of "treatment support workers" to help explain the role of ART and support and encourage people on ART might change poor adherence to better concordance with therapy. |
| ThPdD05 | ADVERSE CONSEQUENCES OF USER FEES FOR PATIENTS STARTED ON ANTIRETROVIRAL THERAPY (ART) IN THE GOVERNMENTAL HIV-PROGRAMS IN NIGERIA. ANALYZED IN THE INTEGRATED FREE OF CHARGE ART-PROGRAM OF MÉDECINS SANS FRONTIÈRES (MSF) IN LAGOS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD05 J. Wenkel1, W. van den Boogaard2, D. O'brien3, E. Botha Standaert4, K. Braker5, M.A. Olaiya6, B.A. Olomo4, P. Orji1, C. Mills7 The user fees charged in the Nigerian ART programs are not affordable for the vast majority of patients. Consequences can be treatment interruptions and sharing ARVs, potentially causing antiretroviral resistance and ART failure. User fees are detrimental to the long term outcome of patients and may expedite the need to provide more expensive second line ARVs. |
| ThPdD06 | IMPROVED SOCIO-ECONOMIC STATUS AND QUALITY OF LIFE AND DECREASED HOSPITALIZATION RATES AMONG PATIENTS IN THAILAND ONE YEAR AFTER INITIATING HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD06 S. Chariyalertsak1, P. Oberdopher2, D. Thapinta3, J. Suwanteerangkul2, A. Sarna4, P. Guest5, A. Wu6 HAART dramatically improves quality of life of people living with AIDS. Increases in incomes and employment and a decrease in hospitalization suggest that HAART programs also contribute to reducing health care costs and increasing economic productivity. A national policy of providing free access to HAART for HIV-infected patients provides benefits to both the patients and society and may be a sound investment for other developing countries. |
| Track E | |
| ThPdE | Care Counts: Investing in Quality of Life |
| ThPdE01 | FUNDING CIVIL SOCIETY ORGANIZATIONS TO SCALE-UP HIV/AIDS SERVICES IN LOW RESOURCE SETTINGS; THE AIM-JSI UGANDA EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE01 D. Mabirizi The bulk of the burden against HIV/AIDS is carried by the household. It's from this unit that many community initiatives have emerged in an attempt to share the burden. Uganda is facing high demand for care and treatment services. Civil Society Organisations (CSOs) access to resourcess is below expectation yet they are vital actors in the fight against HIV/AIDS. In an effort to increase service delivery, a grants programme was designed within the national guidelines. |
| ThPdE02 | DEVELOPING MINIMUM STANDARDS FOR HOME BASED CARE IN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE02 N. Drost1, S. Glyde1, A. Munalula2, M. Mubanga1, G. Mwale3, M. Sepiso4, W. Wakunuma5 Once a set of draft standards have been developed, a country-wide process for reviewing minimum standards will take place through consultations at community, district and national levels. Standards will be redrafted according to the input received from these different stakeholders and subsequently taken to an expert review panel for further refining. A national consensus building workshop will be held towards the end of the year to advocate for the adoption of CHBC standards by the Ministry of Health and the National AIDS Council. |
| ThPdE03 | ASSESSING PALLIATIVE CARE NEEDS IN VIET NAM: A RAPID SITUATION ANALYSIS IN 5 PROVINCES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE03 K. Luong Ngoc1, K. Green2, K. Le Van1, V.N. Son2, N. Nguyen Thi Minh3, E. Krakauer4, T. Nguyen Minh5, M. Coughlan6 The prevalence of pain among PLHA and people with cancer is high while access to opiate analgesics is extremely limited. Health care workers are not adequately trained in palliative care. National palliative care guidelines, training in palliative care for healthcare workers, and palliative care services are badly needed. |
| ThPdE04 | THE CHANGING ROLE OF HOME-BASED CARE IN CAMBODIA IN THE ERA OF ART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE04 S. Samreth1, C.V. Mean1, C. Kaoeun1, B. Gnov1, N. Seguy2 With the increasing availability of health facility-based care providing antiretroviral treatment (ART) to more than half of the people in need in 2005, the National Center for HIV/AIDS, Dermatology and STD (NCHADS) had to adapt the role of home-based care (HBC) services to changing needs. |
| ThPdE05 | GREATER INVOLVEMENT OF PLWHA IN TREATMENT, CARE AND SUPPORT: THE TANZANIAN EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE05 M. Kasili1, J.W. Karomba2, S. Haule3 The government should give higher priority to PLWHAs involvement in the response to the epidemic also for NGOs are advised to involve PLWHAs in service delivery. |
| ThPdE06 | IMPLEMENTING NIGERIA'S HIV/AIDS PALLIATIVE CARE POLICY FRAMEWORK Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE06 G. Asuquo A major recommendation from the process was the need for a national palliative care policy and guidelines and capacity building plan to be finalized based on this framework. Also recommended was the need to update the essential drug list, review prescribing authority, improve monitoring and evaluation, infrastructure and capacity for quality palliative care. |
| Key Challenge Area 1 | |
| ThKc1 | Addressing Obstacles to Research |
| ThKc101 | EXPERIENCE IN IDENTIFYING AND RETAINING HIV HETEROSEXUAL SERODISCORDANT COUPLES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc101 H.S. Martins, M.T.S. Tavares, A. Silva, M.C. Oliveira, F.M.A.O. Mello, G.A. Calvet, M.Q.R. Darmont, S.R. Ribeiro, J.A. Menezes, E.C. Joao Obstacles identified in that population: unwillingness to disclose HIV status, frequent partner change, lack of family and social support, lack of motivation of HIV negative partners towards clinic visits partly due to interference of working hours. In spite of continuous efforts on the part of a cooperative multidisciplinary team a hard task remains to improve the approach to such a population. |
| ThKc102 | HIGH UPTAKE OF HIV AND STI RESULTS AFTER COMMUNITY CONSULTATION IN A POPULATION-BASED SURVEY OF HIV, STI AND RISK BEHAVIOR, GEM, RURAL WESTERN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc102 T. Thomas1, H. Vandenhoudt2, A. Ogendo3, F. Otieno3, E. McLellan-Lemal4, W. Chege1, P. Bondo3, C. Zeh1, J. Vulule3, A. Buve5, L. Slutsker6, K. Decock7 Consultation with the community about recruitment approaches, sampling, and specimen collection procedures was crucial to developing successful study procedures. The cross-sectional study demonstrated that conducting study procedures of a sensitive nature are acceptable and feasible in the Gem family compounds. |
| ThKc103 | DEVELOPMENT OF AN ETHICAL COMMITTEE FOR A COMMUNITY BASED ORGANIZATION IN MUMBAI, INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc103 M. Mcguire1, V. Anand2, P. Prabhughate2, M. Sivasubramaniam2, A. Row Kavi2 Development of independent non-academic ethical committees should be considered on an individual situation bases. For successful capacity building there must be a focus on training participants of ethical committees in developing country to incorporate both multiple international ethical doctrine as well as local ethical guidelines. Additionally, it is necessary to create a framework that includes local interpretation of basic elements of western ethical guidelines like autonomy of individuals versus autonomy of communities in developing countries. Establishing ethical committees can be a tool used for building capacity that could evolve into sustainable international collaborations while simultaneously facilitating in-country accountability. With international development aiming for community responsibility and cross collaboration and train, ethical committee development is a useful tool for long term sustainability. |
| ThKc104 | HELPING RESEARCHERS TO BETTER DIALOGUE WITH PARTICIPANTS AROUND RESEARCH PROCESSES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc104 M. McKay1, S. Alicea2, T. Messam2, N. Beharie2, C.B. Bronx, NY2 The culture of research often lends to difficulty in communicating with potential research participants across various stages, ranging from recruitment to dissemination of study results. This gap in communication inhibits true collaboration between community and researchers, which in turn affects quality of outcomes. |
| Key Challenge Area 2 | |
| ThKc2 | Expanding Human Resource to Scale up Prevention and Treatment II |
| ThKc201 | CLINICAL MENTORING IS A HIGH IMPACT COMPONENT OF THE NATIONAL STRATEGY TO SCALE-UP ART IN LESOTHO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc201 J. Sun1, M. Ramatlapeng1, S. Farley2, M. Charles2, K. Mayer2 Clinical mentoring programs must be tailored to the specific needs of national ART programs. Given the scarcity of physicians in Lesotho, nurses are the primary providers of healthcare, particularly at health centers. The MOHSW is rolling out ART at health centres to expand access at the community level, using a combination of didactic training and clinical mentoring. Outcomes show that within 3 weeks, nurses in health centers with clinical mentoring can correctly initiate and monitor ART according to national guidelines. |
| ThKc202 | MODEL ART CLINIC IN A BIG AFRICAN MARKET WORKPLACE SETTING: A UNIQUE AND INNOVATIVE COLLABORATION AT THE ST. BALIKUDDEMBE MARKET CLINIC, UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc202 P. Iutung1, A. Wapakabhulo2, F. Lule3, E. Madraa4, H. Mudondo2, M. Adair5, C. Farthing5, M. Weinstein5, B. Kakeeto2, B. Kayongo6, H. Chang7, B. Okongo1 As the demand for ART and care services increase, there is a corresponding constraint on health care services. The Uganda government has partnered with NGOs to address some of these challenges. HIV/AIDS has affected all sectors and the informal sector of which the market is part of has not been spared. The epidemic has crippled many booming small scale businesses and affected the livelihoods of many people. Accessing free ART for market vendors meant taking time off and going to queue for many hours in congested clinics. For the traders, this meant lose of business hours and money. Against this background, AHF, MAVAP, DII, MSI and the MoH partnered to provide preventive, testing, treatment and care services in the market place. |
| ThKc203 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc203 Abstract not available. |
| ThKc204 | CAPACITY BUILDING FOR COMMUNITY PHARMACIES IN AFRICA: THE TECHNICAL SUPPORT NECESSARY FOR BETTER CARE AND TREATMENT OF PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc204 J. Potet, J. Langlois, C. Prunier-Duparge, E. Fleutelot This initial, concrete intervention has made local actors aware of their capacity to progress. Thus, they are motivated to face the challenges that still remain. Access to treatment and to follow-up tests, reinforcement of training for pharmaceutical staff and recognition of the benefit of community pharmacies by public authorities, are all challenges to overcome in order to achieve the objective of quality medical treatment. By continuing this technical support to community pharmacies, Sidaction hopes to reinforce the capacities of its partner-organizations. |
| ThKc205 | CLUSTER RANDOMIZED INTERVENTION TRIAL TO EVALUATE THE IMPACT OF "OPTING-OUT" VS. "OPTING-IN" STRATEGIES ON THE UPTAKE OF HIV COUNSELING AND TESTING OF TB PATIENTS IN THE PROVINCE OF THE EASTERN CAPE, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc205 D.S. Pope1, A.N. DeLuca1, P. Kali2, H. Hausler3, E. Hoosain4, M.A. Chaudhary5, R.E. Chaisson1 Use of an opt-out strategy resulted in a significant improvement in the proportion of TB cases counseled and tested for HIV, though uptake was still low. Pragmatic, cluster-randomized studies carried out in the public sector can inform policy decisions. |
| Key Challenge Area 3 | |
| ThKc3 | Intensify Involvement of Youth |
| ThKc301 | GREATER INVOLVMENT AND REPRESENTATION OF AFRICAN YOUTHS LIVING WITH HIV/AIDS IN HIV/AIDS PROGRAMMING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc301 K. Essomeonu, African Young Positives Network A core premise of HIV/AIDS programming involving youth should be that they are more effective when young people living with HIV/AIDS (YLWHA) are actively involved in their design, implementation and evaluation. Current HIV/AIDS programmes seem to regard YLWHA more as a "problem" to be solved by outside intervention, rather than a resource central to prevention, education, and amelioration. By ensuring the participation and involvement of YLWHA, HIV/AIDS programmes will have greater relevance and credibility, and will hopefully encourage VCT, self-disclosure, safe and protected sex, and healthy behaviour, rather than denial, unprotected sex, and the damaging effects of stigma. |
| ThKc302 | CAN'T WE ALL JUST GET ALONG? MULTI-SECTORAL RESPONSES AND THE CHALLENGES OF EMBARKING ON HIV/AIDS WORK BY NON-AIDS SERVICE ORGANISATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc302 J. Coultas, C. Fuss In conjunction with external experts, including established ASOs, non-governmental organisations need to identify and design programming that is reflective of their unique capacities to join the multi-sectoral response to HIV/AIDS. In turn, ASOs must also be receptive to building partnerships with NGOs in order to build their capacities to carry out sustainable HIV/AIDS programming. Suggestions on how both communities can come together to strengthen the fight against AIDS are provided in this presentation. |
| ThKc303 | ADVOCACY BY YOUTH TO YOUTH; ENHANCING THE PARTNERSHIP BETWEEN YOUTH AND GOVERNMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc303 A.Y. Laksmana As the implementation of the law, IYP strongly believe that sustain peer education network model will be the most appropriate and effective way to involved young people in HIV/ AIDS movement a well as in advocacy and policy making. |
| ThKc304 | HIV/AIDS PREVENTION AMONG VULNERABLE YOUTH IN CENTRAL AMERICA AND THE CARIBBEAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc304 M. Vergara To achieve sustained capacity building to support HIV/AIDS prevention initiatives among vulnerable youth there is a need to promote ownership of interventions by country authorities, technical staff, youth and community; built upon already existing programmes, facilities and services; document and systematize successful experiences to demonstrate results; plan intervention results in the mid and long terms; and, support demonstrative projects to provide evidence-based for policy formulation and scaling-up. |
| Key Challenge Area 4 | |
| ThKc4 | Learning to Lead: Developing Leadership Capacities |
| ThKc401 | ACHIEVIENG SUCCESS TO REDUCE STIGMA AND DISCRIMINATION THROUGH WOMEN'S FORUM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc401 D.J. Pommoanna, J. Augustine A peer-led women's forum enables empowerment of Women living with HIV. Capacity building programmes framed based on the needs of women Living with HIV will develop them as advocates and facilitate reduction in stigma and discrimination. |
| ThKc402 | NATIONAL POLICY DEVELOPMENT AND LEGISLATION IMPROVEMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc402 M. Sarybaeva Multisectoral approach, involvement of PLWHA in every exercise shall be the rule since all activities have to be vulnerable groups oriented. This approach proved its successfulness. Currently the normative acts to ensure law implementation mechanism in place are being developed. Legal services for vulnerable population need to be extended and be sustainable. |
ThKc403 | INNOVATIVE PARTNERSHIPS FOR INCREASING EFFECTIVENESS IN ADVOCACY AND MEDIA WORK Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc403 K. Elouardighi1, S. Kaboré2 National advocacy plans by grassroots organizations typically contain a significant media work component. However, there are often specific issues that advocates need to mediatize which are better suited to be processed by foreign-based, locally-consumed media than by local-based, locally-consumed media. In such circumstances, how can advocates from differing countries work together to access media resources located abroad, in order to enhance their respective national media-based advocacy plans? This paper presents a generally transposable model for international partnerships to enhance national media-based advocacy plans, based on the experience between the Access to Essential Drugs Network (RAME, Burkina Faso) and ACT UP-Paris (France). |
| ThKc404 | FRONTAIDS: DIRECT ACTION TO DEFEND THE RIGHTS OF PLWHA IN RUSSIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc404 A. Rumantsev1, A. Volgin1, A. Rylkov2, E. Schetov3 Direct Action should be considered a means of not only of protesting the unnecessary death and suffering of PLWHA, but preventing it by promoting policy change. Creation of an international network of practitioners of direct action to promote exchange of experience and support for activities. PLWHA and AIDS activists should reach out to like minded activist groups from other spheres such as human rights activists and environmentalists. |
| Key Challenge Area 5 | |
| ThKc5 | Four Aspects of Scale Up |
| ThKc501 | ACCELERATED PMTCT SERVICES IN BOTSWANA: SOME LESSONS LEARNT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc501 J. Puvimanasinghe, K. Seipone, K. Keapoletswe, T.W. Steen Adherence to national PMTCT protocols needs to be further strengthened. Issues related to nevirapine resistance and the dilemma of infant feeding should be addressed. Links should be created with child welfare and family planning services. There is a need to strengthen mechanisms for infant follow-up and early infant testing. |
| ThKc502 | TUBERCULOSIS EDUCATION FOR ALL PEOPLE LIVING WITH HIV BY PEOPLE LIVING WITH HIV: COMMUNITY AND HOSPITAL BASED APPROACH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc502 S. Pintong1, P. Kaewrakmook2, N. Puruksa2, I. Chaita3, V. Mooljoy3, S. Moolphate4, S. Luangjina5, S. Trongsakul5, D. Chaisangrit4, J. Ngamvithayapong-Yanai6 PHA-volunteers play substantial role in ensuring TB education for PHA who visit the hospital and who live in the community. Group education facilitated peer learning process which potentially produced better TB knowledge. |
| ThKc503 | MAKING LOCAL HEALTH SERVICES MORE RESPONSIVE TO THE NEEDS OF RURAL COMMUNITIES: A SOUTH AFRICAN CASE STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc503 Y. Nair, S. Maimane, C. Campbell We highlight lessons learned emphasizing the role of an 'external-change agent' in bridging the gap between rural health workers & grassroots community workers; in building skills, conceptual frameworks necessary for health workers to address community needs through their daly activities, & supporting junior health workers in convincing seniors of the need for greater collaboration in shaping their work. We also highlight key areas for building capacity to enable government employees to translate social development policy mandates into action & respond to the specific needs of the communities they serve. |
| ThKc504 | INNOVATIVE POLICIES AND STRATEGIES IN CAMBODIA FOR IMPLEMENTING TB/HIV COLLABORATIVE ACTIVITIES WITHIN A CHALLENGING ENVIRONMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc504 E. Mao Tan1, C.V. Mean2, K. Okada3, M. Ghidinelli4, N. Seguy4, P. Jayavanth5 Mechanisms for TB-HIV collaboration should focus on programme-based policies, identify areas that complement each other and develop practical operational procedures that could translate policy into action. |
| Poster Exhibitions | |
| Track A - Biology and Pathogenesis of HIV | |
| ThPE0001 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0001 Abstract not available. |
| ThPE0002 | ASSESSING ALTERNATE PATHWAYS OF VIRUS INACTIVATION BY NON-NEUTRALISING ANTIBODIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0002 S. Campbell1, A. Schoenberner1, A. Wheatley1, J. Howard1, B. Loveland2, R. Center1, D. Purcell1 Both beneficial and undesirable effects of non-NAbs, such as enhancement of infection, were identified. Our data highlights the importance of the alternate protective functions of antibodies, especially in light of the extreme difficulty in eliciting useful neutralising antibody responses with current experimental vaccines. |
| ThPE0003 | DESIGN AND IMMUNOGENICITY OF HIVCON, A NOVEL HIV-1 VACCINE CANDIDATE BASED ON CONSERVED REGIONS OF CLADES A-D Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0003 S. Letourneau, A.J. Mcmichael, T. Hanke Thus, so far, we have successfully generated DNA, adenoviral and MVA vectors carrying the immunogen gene, and HIVCON has been able to induce broad and strong CD8(+) T cell responses in mice. |
| ThPE0004 | HIV-1 VIRUS-LIKE PARTICLES (VLP) ACTIVATE DENDRITIC CELLS AND INDUCE EX VIVO T CELL RESPONSE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0004 L. Buonaguro1, M.L. Tornesello1, G.K. Lewis2, E. Aricò3, F.M. Marincola3, F.M. Buonaguro1 Our results show that baculovirus VLPs activate MDDCs and stimulate the production of cytokines involved in the Th-1 and Th-2 pathways, elucidating the mechanisms triggering the cell-mediated immunity observed in VLP-immunized animals. The intra-cellular Toll-like receptors appear to be involved in this process and additional signaling pathways induced by VLPs in the MDDCs are currently under evaluation by gene profiling analysis. These data give an insight into the mechanisms of the cellular immunity induced in vivo by VLPs, which may be extremely useful to optimize and modulate the immune response. |
| ThPE0005 | DEVELOPMENT OF VARICELLA ZOSTER VIRUS AS A PERSISTENT, REPLICATING SIV/HIV VACCINE VECTOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0005 D.O. Willer1, M.A. Luscher2, P.A. Sandstrom3, J. Brooks4, J. Fournier5, K.S. MacDonald1 This VZV-based SIV/HIV vaccine study will address the key issues of the immunogenicity and protective efficacy of this herpesvirus vector. The principal goal of this research is to develop a protective HIV vaccine, which can be tested in a nonhuman primate challenge model, and ultimately be transitioned into human clinical trials. |
| ThPE0006 | RATIONAL VACCINE DESIGN TO ELICIT HIV-SPECIFIC T HELPER CELL RESPONSES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0006 X. Huang, Y. Jia, S. Philpott, M. Behr, A. Ramsingh A gag p24 epitope expressed in a T helper cell context of a CVB4 vaccine vector is more effective at inducing gag p24-specific T helper cell responses than the same epitope expressed in a CTL context. The data suport our hypothesis that the immunological context of expression of HIV-1 peptides in a vaccine vector influences the development of specific immune responses. |
| ThPE0007 | REPLICATION-DEFICIENT VACCINIA VIRUS DIS RECOMBINANT AS AN EFFECTIVE AND SAFE MUCOSAL VACCINE FOR IMMUNODEFICIENCY VIRUS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0007 N. Yoshino1, M. Kanekiyo2, T. Okamura2, Y. Hagiwara3, K. Someya2, K. Matsuo2, Y. Ami4, N. Yamamoto2, S. Sato1, M. Honda2 We developed a replication-deficient vaccinia DIs recombinant as a safe and effective mucosal HIV/AIDS vaccine. Furthermore, intradermal immunization of the live rDIsSIVgag/pol also has a potential as mucosal vaccine vector as well as that of systemic immunization. |
| ThPE0008 | MIMOTOPES SELECTED WITH BROADLY NEUTRALIZING IGG FROM LONG-TERM NON-PROGRESSORS INDUCE HIV-1 NEUTRALIZING ANTIBODIES UPON IMMUNIZATION OF MICE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0008 S. Antoni, M. Humbert, B. Brill, U. Dietrich Higher titers of HIV-1-neutralizing antibodies in LTNP plasma as compared to non-LTNP may indicate a protective role of these antibodies in LTNPs. The mimotopes selected with the LTNP IgG are able to induce HIV-1 neutralizing antibodies upon immunization of mice. Thus, these mimotopes represent candidates for the derivation of potential vaccines. |
| ThPE0009 | PURIFICATION AND CHARACTERIZATION OF KNH1144 SOSIP GP140, A STABILIZED SUBTYPE A OLIGOMERIC HIV-1 TRIMER Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0009 S.P.N. Iyer1, M. Franti1, D.N. Fisch1, A.A. Krauchuk1, A.K. Dey2, J.P. Moore2, W.C. Olson1 Tween-treated KNH1144 SOSIP showed favorable antigenic properties and currently is being evaluated for immunogenicity in rabbits. |
| ThPE0010 | A NOVEL GP120 SPEFICITY FOR IGG1 B12 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0010 J. Waruk1, T.B. Ball1, J. Berry2, K. Cheng3, F.A. Plummer2 These results highlight a potential new significance of the gp120 amino terminus, and C1. The evidence here suggests that IgG1 b12 binds the amino terminus, and that we have identified a novel, potentially neutralizing epitope. Further studies to characterize the IgG1 b12-amino terminus interactions are underway. |
| ThPE0011 | ACTIVITY OF DIFFERENT VACCINE-ASSOCIATED PROMOTER ELEMENTS IN HUMAN DENDRITIC CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0011 T. Papagatsias1, G. Rozis1, T. Athanasopoulos2, F. Gotch1, G. Dickson2, S. Patterson1 Vaccine design approaches that target dendritic cells (DC) usually aim at achieving high levels of transgene expression. Careful selection of the promoter element driving expression of the foreign gene is therefore important. |
| ThPE0012 | HUMORAL AND CELLULAR IMMUNE-TARGETED PRIME-BOOST HIV VACCINE CONSISTED OF RECOMBINANT BCG AND REPLICATIONDEFECTIVE VACCINIA VIRUS DIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0012 K. Matsuo, T. Okamura, M. Kanekiyo, S. Hattori, S. Horibata, N. Yamamoto, M. Honda These results suggest that prime-boost BCG/DIs encoding both env and gag genes show promise as humoral and cellular immune-based vaccine against HIV-1. |
| ThPE0013 | A LOW-DOSE CODON-OPTIMIZED RECOMBINANT BCG-BASED HIV VACCINE: PRIME-BOOST VACCINATION WITH RECOMBINANT BCG AND REPLICATION-DEFECTIVE RECOMBINANT VACCINIA VIRUS DIS EVOKES SIV-SPECIFIC IMMUNITY WHICH OVERCOME THE ANAMNESTIC BCG IMMUNITY IN MACAQUES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0013 M. Kanekiyo1, Y. Ami2, K. Matsuo1, K. Someya1, T. Okamura1, Y. Suzaki2, N. Yoshino3, N. Yamamoto1, M. Honda1 A prime-boost vaccination consisting of rBCG and rDIs can overcome the anamnestic effects of BCG vaccination in macaques. Therefore, the codon-optimized rBCG-based vaccine proved to be efficient by combination with the rDIs for the clinical utility. |
| ThPE0014 | MUCOSAL HIV BINDING ANTIBODY (BAB) AND NEUTRALIZING ACTIVITY (NA) IN RESPONSE TO A BIVALENT GLYCOPROTEIN (GP) 120 PREVENTIVE VACCINE IN A HIGH-RISK HIV UNINFECTED COHORT OF WOMEN FROM CHICAGO PARTICIPATING IN THE VAXGEN VAX004 TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0014 J.A. Schneider1, B. Parekh2, M. Ackers2, H.Y. Chen3, P. Graham1, M. Gurwith4, R. Hershow3, K. Mayer5, R.M. Novak1 HIV specific BAbs following vaccination were present in this cohort. Trichomonas as an STD or CL as an indicator of an inflammatory process may increase transudation of antibodies across the vaginal mucosa. Mucosal inflammation, more commonly found in high heterosexual risk women, may lead to increased BAb in the genital tract mucosa following vaccination. |
| ThPE0015 | IDENTIFICATION OF MHC IDENTICAL MACAQUES FOR AIDS RESEARCH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0015 J. Wojcechowskyj, R. Wiseman, J. Greene, T. Gopon, K. Krebs, D. O'connor Mauritian Cynomolgus macaques offer the opportunity to evaluate SIV-specific T cell responses in MHC 'pseudotwins', animals that have completely identical MHC class I and class II allele repertoires. This is a significant advantage over existing nonhuman primate models for AIDS, such as Asian-origin Rhesus and Cynomolgus macaques, in which genetic diversity generally limits MHC matching only to single alleles. |
| ThPE0016 | FELINE IMMUNODEFICIENCY VIRUS (FIV)-CAT MODEL FOR AIDS: T CELL IMMUNITY IMPORTANT FOR PROPHYLACTIC VACCINE PROTECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0016 R. Pu, E. Sato, J. Yamamoto CD4+ and CD8+ T cell immunity was important for dual-subtype FIV vaccine protection, suggesting the importance of developing an HIV vaccine that induces strong HIV-specific multi-T cell immunity. |
| ThPE0017 | BROAD-SPECTRUM ANTI-HIV MICROBICIDE ACTIVITY OF THE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR UC781 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0017 M. Hossain, M. Parniak UC781 shows potent antiviral activity against virtually all strains of HIV-1 as well as against a variety of drugresistant virus variants. Although UC781 potency is substantially reduced against NNRTI-resistant virus variants, the "memory effect" exerted by pretreatment of cells with concentrations of UC781 well below those in current microbicide formulations of UC781 is able to completely abrogate subsequent infection by all HIV-1 strains tested, including NNRTI-resistant virus and all subtypes of HIV-1. UC781-based microbicides will likely be efficacious in different geographical regions. |
| ThPE0018 | THE SULFONATED TOPICAL MICROBICIDE PRO2000 INHIBITS DENDRITIC CELL-MEDIATED HIV TRANSMISSION TO SUSCEPTIBLE TARGET CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0018 N. Teleshova1, T. Chang1, A. Profy2, M. Klotman1 PRO2000 efficiently blocks HIV infection in MDDC-target cell co-cultures, and inhibits DC-mediated virus transmission supporting the potential value of PRO2000 as anti-HIV topical microbicide. |
| ThPE0019 | THE CANDIDATE POLYANIONIC MICROBICIDE, PRO 2000, INHIBITS ENTRY MEDIATED BY DIVERSE HIV-1 ENVELOPES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0019 D. Dhawan, B. Zerhouni-Layachi, M. Klotman PRO 2000 is active against diverse HIV-1 Env-pseudotyped viruses. Although PRO 2000 has been postulated to interact with the V3 loop in a charge dependent manner, it inhibits HIV-1 gp120 across a spectrum of V3 loop charges and gp120 N-glycosylation patterns. Given that topical microbicides are currently in clinical trials worldwide, it is critical that their preclinical evaluation includes testing against diverse viral isolates. |
| ThPE0020 | DISCOVERY OF MK-0518 A NOVEL, POTENT AND SELECTIVE HIV INTEGRASE INHIBITOR IN PHASE III CLINICAL TRIALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0020 V. Summa1, P. Pace1, A. Petrocchi1, R. Laufer2, R. Cortese2, D.J. Hazuda3, M.D. Miller3, W.A. Schleif3, J.P. Vacca4, S.D. Young4, M. Rowley2 Details of the discovery, SAR and preclinical PK properties of a series of HIV-Integrase inhibitors leading to MK- 0518, currently in phase III clinical trials for the treatment of HIV/AIDS, will be presented. |
| ThPE0021 | NEW FUSION INHIBITOR PEPTIDES, TRI-999 AND TRI-1144, ARE POTENT INHIBITORS OF ENFUVIRTIDE AND T-1249 RESISTANT ISOLATES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0021 D.K. Davison1, R.J. Medinas1, S.M. Mosier1, T.S. Bowling1, M.K. Delmedico1, J.J. Dwyer1, N. Cammack2, M.L. Greenberg1 Clinical trials of enfuvirtide (ENF) revealed primary resistance mutations occurring within gp41 positions 36 – 45. Two new investigational fusion inhibitors (FIs), TRI-999 and TRI-1144, display potent activity against ENF- and T-1249-resistant isolates selected in vitro TRI-999 and TRI-1144 were designed from a more N-terminal HR2 region than ENF. TRI-999 consists of an optimized wild-type HR2 sequence plus a linker-fatty acid attached to an internal lysine. TRI-1144 contains helix-stabilizing motifs along a similar region. |
| ThPE0022 | VALIDATION OF A NOVEL APPROACH FOR HIV-1 FUSION INHIBITOR DRUG DISCOVERY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0022 C. Finnegan, I. Burimski, T. Jackson, A. Castillo, N. Kilgore, M. Reddick, A. Yunus, M. Zuiderhoff, T. Nitz, C. Wild, G. Allaway, K. Salzwedel These results validate this approach for identifying small molecule HIV fusion inhibitors with novel mechanisms of action. The compounds identified in this study are currently being optimized for drug development and may lead to attractive therapeutic alternatives to peptide-based fusion inhibitors. |
| ThPE0023 | SURVEY OF BRECANAVIR (BCV) AND OTHER PROTEASE INHIBITOR (PI) SUSCEPTIBILITY TO HIV-1 VARIANTS CONTAINING PI RESISTANCEASSOCIATED AMINO ACID SUBSTITUTIONS (RAS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0023 C. Craig1, P. Yates1, M. StClair2, M. Ait-Khaled3 BCV shows greater potency than APV, IDV, LPV, ATV and TPV and lower FC than all PIs except TPV/r, which shows relatively low intrinsic potency and low clinical cut-off. The BCV virologic profile along with early signs of good tolerability and efficacy in subjects with PI-resistant isolates further supports its on-going development. |
| ThPE0024 | TNX-355 IS ACTIVE AGAINST ENFUVIRTIDE RESISTANT HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0024 S. Weinheimer, K. D'arigo, M. Fung, S. Lewis, T. Duensing Cross resistance within a class of antiretrovirals is common. Treatment-experienced HIV-1 infected patients require therapy with agents capable of inhibiting resistant viruses. None of the HIV-1 mutants tested in this study showed cross resistance to enfuvirtide. Coupled with the observed in vitro synergy, these data support the use of TNX-355 in combination with enfuvirtide or in patients that have decreased susceptibility to enfuvirtide. |
| ThPE0025 | FOSALVUDINE TIDOXIL, A NOVEL ALOVUDINE-DERIVED PRODRUG IS ACTIVATED AND INHIBITS THE REPLICATION OF HIV-1 IN HUMAN PBMC Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0025 F. Reuss, M. Kulke, J. Braspenning, B. Heckl-Östreicher, H.-G. Opitz Fosalvudine in vitro is activated in human PBMC and inhibits the replication of HIV-1 in PBMC. In vivo, low concentrations are found in murine fat tissue and bone marrow, suggesting a potential for low hematopoietic toxicity. |
| ThPE0026 | DESIGN OF A NOVEL PEPTIDIC HIV-1 FUSION INHIBITOR AGAINST DRUG-RESISTANT VIRUSES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0026 J. Chen1, Y. He2, M. Dong1, H. Lu2, S. Hou1, J. Li2, S. Jiang2, Q. Dai1 We developed a novel peptide that has potent anti-HIV activity against primary HIV-1 isolates with distinct genotypes and biotypes and those resistant to T20 and other anti-HIV drugs. This peptide has potential to be developed as a novel anti-HIV drug for treatment of HIV/AIDS patients who fail to respond to the currently available antiretroviral therapeutics. |
| ThPE0027 | PRECLINICAL PHARMACOKINETICS AND METABOLISM OF MK-0518, A POTENT HIV INTEGRASE INHIBITOR IN PHASE III CLINICAL TRIALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0027 O. Gonzalez-Paz, M. Taliani, A. Di Marco, E. Monteagudo, F. Bonelli, F. Fiore, M. Fonsi, F. Naimo, M. Verdirame, A. Alfieri, I. Marcucci, V. Summa, M. Rowley, R. Laufer Results from these studies indicated potentially favorable pharmacokinetic properties of MK-0518 in humans and this was confirmed in clinical studies. |
| ThPE0028 | FLUDARABINE-LOADED AUTOLOGOUS RED BLOOD CELL ADMINISTRATION INDUCES MACROPHAGES DEPLETION IN CHRONICALLY SIV INFECTED SOOTY MANGABEYS VIA A PSTAT1 DEPENDENT PATHWAY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0028 B. Cervasi1, M. Paiardini1, S. Serafini1, A. Fraternale1, S. Staprans2, G. Silvestri2, M. Magnani1 Fludarabine-loaded autologous RBC administration is able to deplete SIV-infected macrophage via a pSTAT1- dependent pathway. This suggest that, in combination with HAART, Fludarabine/RBC administrations may represent a valid therapeutic approach to reduce/or eradicate HIV infection. |
| ThPE0029 | HIV ENTRY INHIBITORS FOR NOVEL VIRAL AND CELLULAR TARGETS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0029 J. Sastry1, P. Nehete2 These gp120 and CD4 peptides targeting the host cell surface GSL and the viral envelope protein, respectively, should prove an effective combination-treatment regimen against HIV-AIDS. |
| ThPE0030 | SYNERGY AND BROAD ACTIVITY OF AN AFFORDABLE FUSION INHIBITOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0030 C. Richards, T. Wang, K. Henry, L. McHugh, D. Hamer Drugs that block the fusion step in the HIV life cycle are promising both as therapeutics and as preventative agents because they inhibit the virus prior to cell entry. Although one peptide fusion inhibitor has been clinically approved (enfuvirtide, T20), it is expensive and selects for viral resistance. We sought to create a more readily available and durable fusion inhibitor by microbial production of an extended version of T20 termed C52. |
| ThPE0031 | MECHANISM OF HIV TRANSMISSION ACROSS FEMALE GENITAL EPITHELIUM IN AN EX-VIVO MODEL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0031 S. Fernandez, A. Nazli, M. Bunce, C. Kaushic Our data indicates that R5 and X4 virus strains have differential abilities to cross the female genital mucosa to infect target cells. The presence of target cells appears to be critical for the production of infectious HIV particles under these culture conditions. These studies are providing important information regarding the ability of HIV-1 to cross the female genital mucosa. |
| ThPE0032 | GENOTYPE AND PHENOTYPE PATTERNS OF DRUG-RESISTANT HUMAN IMMUNODEFICIENCY VIRUS 1 SUBTYPE B' (THAI'B) ISOLATES FROM HAART-EXPERIENCED PATIENTS IN CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0032 L. Ma, H. Xing, J. Sun, L. Yuan, X. Si, Y. Guo, H. Chen, L. Wu, Y. Shao The genotype resistance testing can give a good guidance to clinics but phenotypic resistance testing may be helpful in finding unknown mutation and interpreting partially resistance to D4T and DDI. It is need to further study the relationship between resistance mutations and susceptibility to drug in China. |
| ThPE0033 | A COMPLEX ROLE FOR THE TETRASPANIN CD63 IN HIV REPLICATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0033 B. Friedrich, H. Chen, D. Rojo, Z. Chen, W. O'Brien In addition to its role in HIV entry of macrophages, CD63 also appears to affect late replication events, early after translation. Since CD63 is a major component of late endosomes, it is possible that CD63 is also involved in HIV maturation and budding, in various cells in addition to macrophages. Further delineation of the role of CD63 in HIV replication may lead to development of novel therapeutic compounds. |
| ThPE0034 | IMPACT OF HIV INFECTION ON HEPATITIS C VIRUS (HCV) PERSISTENCE AMONG INJECTION DRUG USERS (IDUS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0034 J. Grebely1, B. Conway1, J. Raffa2, C. Lai3, M. Krajden4, M.W. Tyndall3 In this large retrospective analysis, HIV infection and a lower CD4 nadir was associated with HCV persistence. Further prospective studies are required to determine whether decreased immune function caused by HIV leads to either a recrudescence of low-level viremia or decreased protection against HCV re-infection. |
| ThPE0035 | POST-GENOMIC UPREGULATION OF CCL3L1 EXPRESSION IN HTLV-2 INFECTED INDIVIDUALS CURTAILS HIV-1 REPLICATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0035 E. Pilotti1, L. Elviri2, M.C. Re3, G. Poli4, C. Casoli1 This study confirms a crucial protective role of CCL3L1 from either HIV infection or disease progression and highlights a previously undescribed functional upregulation of this chemokine variant in HIV positive or negative individuals infected with HTLV-2. |
| ThPE0036 | EXPRESSION OF KI-67 NUCLEAR ANTIGEN ON CD4+ T CELLS IN HIV/TB CO-INFECTED INDIVIDUALS BEFORE THE TREATMENT OF ACTIVE TUBERCULOSIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0036 B. Tegbaru1, D. Wolday1, T. Messele1, M. Westerlaken2, N. Vrisekoop2, R. Coutinho3, F. Meidema2, D. van Baarle2 Higher rate of proliferation despite lower absolute CD4+ T cell counts among HIV/TB co-infected individuals before the treatment of active tuberculosis might be related to higher immune activation that may lead to the presence of higher viral load and faster disease progression in these individuals. |
| ThPE0037 | INTERPLAY BETWEEN GONORRHEA AND HIV-1 IN THE CONTEXT OF THE CD4+ T LYMPHOCYTE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0037 W.N. Dobson1, M. Ostrowski2, A. Cochrane1, S.D. Gray-Owen1 In contrast, CD4+ T lymphocytes infected with VSV-G pseudotyped-HIV-1 or CD8+-depleted PBMCs isolated from HIV+ donors demonstrated the opposite effect. Upon exposure to gonococci, no effect on HIV expression was found in the pseudovirus system as measured by either flow cytometry or ELISA for p24 antigen. Moreover, a profound inhibition in HIV replication was apparent when CD8+-depleted PBMCs from HIV+ individuals were infected with N. gonorrhoeae, even in the presence of anti-human CD3 and CD28 antibody stimulation. Interestingly, this inhibitory effect correlated with the bacterial-dependent appearance of a CD4-/ CD8- T cell population in HIV+ CD8+-depleted PBMCs. |
| Track B - Clinical Research, Treatment and Care | |
| ThPE0038 | THE EFFECTS OF THE 76V MUTATION ON PROTEASE-INHIBITOR (PI) SUSCEPTIBILITY ARE PI- AND CONTEXT-SPECIFIC Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0038 K. Van der Borght1, H. Vermeiren1, P. Lecocq1, T. Pattery1, P. Alen1, L. Bacheler2, G. Picchio3 Mueller et al. have recently suggested that 76V decreases susceptibility to LPV and APV while increasing susceptibility to SQV and ATV. We investigated the effects of 76V on PI susceptibility using Virco's database where 76V prevalence increased from 0.17% in 1998 to 1.55% in 2005. |
| ThPE0039 | EVOLUTION OF CELERA DIAGNOSTICS VIROSEQ® HIV-1 GENOTYPIC RESISTANCE INTERPRETATION ALGORITHM (VIROSEQ) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0039 N. Marlowe1, T. Liu2, H. Leong1, R. Shafer2, M. Zoccoli1 ViroSeq update includes one new drug, nine new DRMs, and significant changes to 28 DRMs. This update has primarily affected ddI, ABC, ATV suggesting that the pace of published drug resistance data for ARVs may be slowing. |
| ThPE0040 | A DIRECT COMPARISON BETWEEN TWO HIV-1 PHENOTYPIC DRUG SUSCEPTIBILITY ASSAYS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0040 M. Van Houtte1, G. Picchio2, K. Van der Borght1, T. Pattery1, P. Lecocq1, L. Bacheler3 The LRM approach for predicting drug resistance demonstrates improved correlation with the PS assay over its preceding version while avoiding the need for rules-based calls. On most occasions, similar interpretations of resistance were observed while discordances were influenced by the use of one vs. two test cut-offs. |
| ThPE0041 | EVOLUTION OF GENOTYPING AND PHENOTYPING RESISTANCE TO ENFUVIRTIDE IN HIV-INFECTED PATIENTS WITH PERSISTENT VIRAEMIA, DURING AND AFTER TREATMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0041 M.-A. Trabaud1, L. Cotte2, J.L. Labernardière3, S. Binay3, J.C. Tardy1, C. Trepo2, P. André1 Individual variability of mutation pattern as well as persistence of strains without mutation in the region mainly targeted by ENF resistance probably reflect that mechanisms of resistance to ENF may rely on other regions of gp41 or gp120 than residues 36 – 45. Thus population sequencing of gp41 could give insufficient information for a valuable interpretation of therapy with fusion inhibitors. |
| ThPE0042 | SUSTAINED VIROLOGICAL RESPONSE DESPITE K65R ALONG WITH OTHER RESISTANCE MUTATIONS IN HEAVILY PRE-TREATED PATIENTS – A RADATA SUBANALYSIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0042 C. Hoffmann1, T. Lorenzen2, A. Mutz3, T. Seidel4, D. Berzow5, B. Buchholz6, B. Kreft7, S. Staszewski8, C. Zamani9, B. Zinngrebe10, K. Graefe1, A. Stoehr1, A. Plettenberg1, for the Radata Study Group The K65R mutation remains rare in this large cohort of heavily pre-treated patients. Despite evidence of K65R coincidental with multiple resistance mutations, sustained virological response was possible in most cases. This was particularly true in the absence of TAMs and in pts switching to a PI-based ART containing a thymidine analogue. |
| ThPE0043 | PREVALENCE OF DRUG RESISTANT HIV STRAINS IN ANTIRETROVIRAL-NAÏVE PATIENTS WITH PRIMARY HIV INFECTION IN A LOW ENDEMIC AREA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0043 K. Nagy1, B. Kemeny2, A. Ghidan1 Transmission of drug-resistant HIV revealed by genotype testing during primary infection raises serious clinical and public health consequences as development of resistance leads to viruses escaping the control of drug combination therapy and cause disease progression. Resistant mutations observed with preliminary drug resistance appear to be far more stable, presumably because there are no competing drug-sensitive strains. Resistance testing at the time of diagnosis should be the standard of care. |
| ThPE0044 | LONGITUDINAL ANALYSIS OF HIV ENVELOPE V3 SEQUENCE EVOLUTION AND CO-RECEPTOR USE IN ANTIRETROVIRAL NAĎVE INDIVIDUALS DURING THE FIRST 30 MONTHS OF HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0044 A.J. Low, C.J. Brumme, Z.L. Brumme, W. Dong, T. Mo, P.K. Cheung, R.S. Hogg, J.S.G. Montaner, P.R. Harrigan V3-loop sequence evolution and co-receptor switch were observed after initiating HAART. Poor adherence and detection of baseline X4 were predictors of development of the "11/25" genotype, and were associated with a poorer CD4 cell response to HAART. |
| ThPE0045 | TECHNICAL VALIDATION DEFINES THE PERFORMANCE OF MONOGRAM'S HIV CO-RECEPTOR TROPISM ASSAY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0045 K. Limoli, J. Whitcomb, L. Kiss, W. Huang, S. Fransen, J. Toma, C. Chappey, N.T. Parkin, C.J. Petropoulos Monogram's Co-Receptor Tropism assay is an accurate, precise, sensitive, reproducible and robust assay for the measurement of HIV-1 CRT and has become the standard assay for patient screening and monitoring in the development of coreceptor inhibitors. Clinical studies currently in progress will help define the clinical utility of this assay. |
| ThPE0046 | LIMITATIONS IN PREDICTING HIV-1 CO-RECEPTOR TROPISM FROM V3 GENOTYPE DATA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0046 E. Stawiski1, Y. Liu1, J. Toma1, W. Huang1, S. Fransen1, J. Whitcomb1, E. Coakley1, N. Parkin1, S. Eshleman2, C. Petropoulos1, C. Chappey1 V3 sequence data can be used in predicting tropism, however, there are analytical and technical limitations to this approach to make this technique a diagnostic test with clinical value. Phenotype assays that directly measure co-receptor usage provide an alternative approach to analysis. Clinical data are needed to assess the predictive value of both phenotype and genotype approaches. |
| ThPE0047 | SEVERITY AND TYPES OF CLINICAL EVENTS BY PROXIMAL CD4 CELL COUNTS IN THE SMART STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0047 D. Cohn, for the SMART Study Group The incidence of both SE and NSE was greater in the DC than VS arm. In patients with CE at proximal CD4 cells =350, the proportion of SE were similar in DC (13%) and VS (15%). |
| ThPE0048 | IMPACT OF ANTIRETROVIRAL THERAPY ON RELAPSE AND SURVIVAL OF CRYPTOCOCCOSIS IN HIV-INFECTED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0048 U. Jongwutiwes, S. Kiertiburanakul, S. Sungkanuparph In a resource-limited setting where patients present with advanced HIV diseases and cryptococcosis, ART significantly reduced relapse and mortality rate from cryptococcosis. Initiation of ART in this population is strongly recommended and should not be delayed. |
| ThPE0049 | DIFFERING LYMPHOCYTE CYTOKINE RESPONSES IN HIV AND LEISHMANIA CO-INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0049 S. Mehta1, Z. Rodrigues2, F. Grassi3, X.-Q. Zhang1, R. Badaro4, R. Schooley1 Our results suggest that after therapy for leishmaniasis, PBMCs of HIV/Leishmania co-infected patients produce lower levels of the Th1 cytokines IL-2, IFN-γ, as well as the Th2 cytokine IL-4 in response to soluble Leishmania antigens, compared to patients infected only with leishmaniasis. |
| ThPE0050 | SECOND-LINE TREATMENT OF AIDS-ASSOCIATED PNEUMOCYSTIS JIROVECII PNEUMONIA: A SYSTEMATIC REVIEW Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0050 T. Benfield1, C. Atzori2, R. Miller3, J. Helweg-Larsen 4 Clindamycin/primaquine should be used in preference to pentamidine as second-line treatment for AIDS-associated PCP in patients who fail or develop toxicity with TMP-SMX. TMP-SMX should be used as second-line treatment in those failing first-line treatment with regimens other than TMP-SMX. |
| ThPE0051 | THE NON-PEPTIDIC HIV INHIBITOR TIPRANAVIR MODULATES PNEUMOCYSTIS IN VITRO GROWTH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0051 F. Mazza, E. Tronconi, A. Valerio, A. Cargnel, C. Atzori Despite of the fact that TPV is not a peptide like other HIV PIs, for which we have already demonstrated an anti-Pneumocystis activity, it also exerted in vitro an unexpected inibitory effect on this opportunistic infections at plasmatic concentrations achivable during HAART. During clinical practice TPV/r reaches Ctrough values exceeding concentrations detected as inhibitory in vitro against Pc. Our observation suggests that it could be useful to clinically explore TPV anti-opportunistic properties in addition to its potent antiviral effect. Interestingly, in our laboratory TPV/r was detected in epithelial lining fluid at concentrations clearly exceeding EC90 in HIV patients. |
| ThPE0052 | LONG-TERM PROGNOSIS OF HIV POSITIVE PATIENTS WITH KAPOSI SARCOMA TREATED WITH PEGYLATED LIPOSOMAL DOXORUBICIN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0052 L. Martin Carbonero1, R. Palacios2, M.E. Valencia1, E. Ferrer3, P. Saballs4, G. Sirera5, I. Santos6, J. Santos2, M. Alegre7, A. Goyenechea8, J. Pedreira9, J. González del Castillo10, F. Baldobí11, A. Ocampo12, M. Alsina13, J. Martínez-Lacasa14, M. Nuñez1, D. Podzamczer3, J. González-Lahoz1 HIV patients treated with LD had low relapse rate (14%), mostly during the first year after stopping chemotherapy. In our series, mortality rate was high, and there was an unexpected prevalence of other tumors, mainly lymphomas. |
| ThPE0053 | CYTOMEGALOVIRUS (CMV) RETINITIS IS AN IMPORTANT PROBLEM THAT IS BEING MISSED IN HIV-POSITIVE INDIVIDUALS ATTENDING ROUTINE CLINICS IN CAMBODIA! IS THERE A NEED TO INTRODUCE ROUTINE CMV SCREENING? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0053 B. Janssens1, D. Heiden2, S. Sarin3, R. Zachariah4 Preliminary findings from routine clinic settings in Cambodia, show that at least "one in ten" HIV-positive individuals with a baseline CD4 count <50 cells/mm3, have CMV retinitis, and approximately half are asymptomatic. Introducing a systematic "screening" strategy of dilated retinal examination with an indirect ophthalmoscope will allow early case detection and treatment which is likely to favourably impact CMV related vision loss, blindness and mortality. There is an urgent need for access to lowcost generic formulations of available drugs (eg valgancyclovir) for the treatment of CMV retinitis in developing countries. |
| ThPE0054 | LONGITUDINAL FOLLOW UP OF SEROLOGIC RESPONSES TO 23-VALENT POLYSACCHARIDE PNEUMOCOCCAL VACCINATION AMONG HIV-INFECTED PERSONS RECEIVING HIGHLY ACTIVE ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0054 S.-Y. Chang1, M.-Y. Chen2, S.-M. Hsieh2, W.-H. Sheng2, H.-Y. Sun2, C.-C. Hung2, S.-C. Chang2 Antibody responses to 23-valent PPV are poorer in HIV-infected vaccinees with baseline CD4+ counts less than 100 cells/μl compared with those with baseline CD4+ counts higher than 100 cells/μl. The responses may last for more than 3 years in 40% of the observed responders who continue to receive HAART regardless of baseline CD4+ counts. |
| ThPE0055 | SALIVARY IGA LEVELS IN HIV-INFECTED INDIVIDUALS WITH ORAL CANDIDIASIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0055 V.L. Gorthi1, S. Nandikonda2, U.B. Pamidimukkala1, S.S. Vanaki2, R.S. Puranik2 The reduced SIgA levels associated with decreased cellular immunity in HIV probably initiates colonization and later invasion of the oral mucosa by Candida. |
| ThPE0056 | EFFECT OF COTRIMOXAZOLE PROPHYLAXIS ON MORBIDITY AND MORTALITY OF HIV POSITIVE CHILDREN IN EASTERN INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0056 S. Bhattacharyya Cotrimoxazole (CTM) prophylaxis was highly effective in decreasing morbidity in HIV+ children in resource constraint setting with little extra cost. |
| ThPE0057 | PCP PROPHYLAXIS IS NOT REQUIRED WITH A CD4+ T CELL COUNT < 200 CELLS/μL WHEN VIRAL REPLICATION IS EFFECTIVELY SUPPRESSED Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0057 G.E. D'Egidio, S. Kravcik, C.L. Cooper, D.W. Cameron, D. Fergusson, J.B. Angel PCP prophylaxis does not appear to be required with a CD4+ cell count <200 cells/μL if plasma viral replication is effectively suppressed. This illustrates a degree of immune recovery that occurs with virologic suppression that is not reflected in CD4+ T cell count and suggests that guidelines for PCP prophylaxis may need to be re-evaluated. |
| ThPE0058 | HIV/AIDS AND ORAL CANDIDIASIS - WHAT IS THE EVIDENCE? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0058 E.D. Pienaar1, T. Young1, H. Homes2 There is a need to evaluate treatment effects of gentian violet and other less expensive anti-fungal drugs in larger studies. More research is needed amongst children. Trials should be more standardised and conform more closely to CONSORT thus improving research and also clinical practice. |
| ThPE0059 | DISSEMINATED PENICILLIOSIS – AN IMPORTANT OPPORTUNISTIC INFECTION IN HIV-INFECTED PATIENTS IN NORTHERN MYANMAR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0059 V. Johnston1, K. Zharli Aye2, F. Smithius2, P. Bjorkman3 This data suggests penicilliosis is an important opportunistic infection in HIV-infected patients in Northern Myanmar. Although fluconazole can be effective treatment failure and relapse rates are unacceptably high. The high proportion of relapses following ART suggests this pathogen can cause immune reconstitution syndrome. |
| ThPE0060 | RESPONSE OF PRURITIC PAPULAR ERUPTION (PPE) TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) MAY REPRESENT A CLINICAL MARKER OF VIROLOGICAL OUTCOME Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0060 B. Castelnuovo1, H. Byakwaga1, P. Schaefer1, M. Kamya2, R. Colebunders3 These data demonstrate that PPE is responsive to HAART. PPE response may represent a valuable clinical marker to evaluate virological outcome. |
| ThPE0061 | NEUROFILAMENT PROTEIN IN HIV-1-INFECTED PATIENTS – EFFECTS OF ANTIRETROVIRAL TREATMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0061 Å. Mellgren1, R.W. Price2, L. Hagberg3, M. Gisslén3 HAART significantly decreases high levels of NFL in CSF. NFL is a marker that directly reflects brain injury and could prove useful in following treatment effects of central nervous system injury and AIDS dementia complex. |
| ThPE0062 | THE ROLE OF SUBTYPES IN HIV-1 CENTRAL NERVOUS SYSTEM INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0062 S. Abdulle1, L. Hagberg1, B. Svennerholm2, M. Gisslén1 HIV-1 exhibits a high degree of genetic diversity and is currently divided into nine subtypes (A-D, F-H, J and K) and at least 15 circulating recombinant forms (CRFs). The aim of this study was to investigate whether subtypes play any role in the pathogenesis of HIV-1 central nervous infection. |
| ThPE0063 | NEURODEVELOPMENTAL DELAY IN HIV-INFECTED CHILDREN COMMENCING HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0063 B. Marais1, E. Malan2, G. Barry2, L. Kuhn3, E. Abrams3, H. Moultrie4, G. Sherman5, A. Coovadia1 Developmental problems were common among young HIV-infected children prior to starting HAART. Gross motor delay was the most frequent. Developmental delay correlated with markers of disease progression including disease stage, CD4% and nutritional status. An easy to administer screening instrument (such as A&S-Q) provides an objective method of assessing and identifying possible developmental problems in HIV-infected children. |
| ThPE0064 | TRAINING MATERIALS FOR PHYSICIANS AND OTHER HEALTHCARE WORKERS IN THE DIAGNOSIS AND TREATMENT OF HIV-RELATED NEUROPSYCHIATRIC DISORDERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0064 F. Cournos1, M. Wainberg1, M. Forstein2, K. McKinnon1 It is essential to diagnose and treat HIV-related neuropsychiatric disorders. To do so will require adaptation and evaluation of existing tools to ensure that they meet the specific needs of the diverse populations they are intended to benefit. |
| ThPE0065 | DISEASE PROGRESSION IS ASSOCIATED WITH SLEEP DISTURBANCES, NEUROCOGNITIVE DISORDERS AND CYTOKINE DYSREGULATION IN PEDIATRIC HIV INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0065 S. Foster1, M. Paul1, D. Glaze1, J. Reuben2, L. Harris1, E. Coen2, B. Lee2, C. Kozinetz1, H. Schwarzwald1, M. Kline1, C. Jackson1, A. Loeb1, P. Frerking1, P. Brouwers1, W. Shearer1 HIV-infected children with advanced disease appear to have more sleep disturbances and may have decreased attentional processing compared to children with well-controlled HIV infection. Cytokine messenger molecules that regulate sleep and immune responses are closely associated with disease progression and may play a role in disturbances of sleep regulation, daytime alertness, and attention in children with advanced HIV disease. |
| ThPE0066 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) INFECTION AND OTHER VIRAL CAUSES OF CENTRAL NERVOUS SYSTEM INFECTIONS IN JAMAICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0066 S. Jackson, G. Dowe, M. Smikle A paucity of data exists on the viral causes of central nervous system (CNS) infections in the Caribbean where human immunodeficiency virus -type1 (HIV-1) infection is now a major entity. It is important that the viral causes of CNS infection be identified to guide appropriate management. This study investigated the viral causes of CNS infection in Jamaica. |
| ThPE0067 | POLYMERASE CHAIN REACTION IN BLOOD SAMPLES FOR DIAGNOSIS OF CEREBRAL TOXOPLASMOSIS IN AIDS PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0067 J.E. Vidal1, A.V. Hernández1, F. Colombo2, R. Focaccia1, V.L. Pereira-Chioccola2, A.C. Penalva de Oliveira3 A positive PCR for T. gondii in blood samples was independently associated to the diagnosis of cerebral toxoplasmosis and had an elevated diagnostic value. A blood PCR may help in the early diagnosis of cerebral toxoplasmosis, and should be interpreted in conjunction with clinical, serological and radiological information. |
| ThPE0068 | HIV-ASSOCIATED DISTAL SENSORY POLYNEUROPATHY IN THE ERA OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY IN BOBO-DIOULASSO HOSPITAL (BURKINA FASO) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0068 A. Millogo, D. Maré, A. Héma, B. Sessouma Introduction of HAART has modified the course and the prognosis of HIV infection. The incidence of toxic neuropathies is increasing with longer patient life expectancy and represents a major factor in treatment limitation. |
| ThPE0069 | SIGNIFICANT SURVIVAL IMPROVEMENT IN AIDS-RELATED PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA WITH COMBINED HIGH DOSE INTRAVENOUS METHOTHREXATE AND HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0069 T. Lukiana, F. Lamontagne, A. Mouligner, J.B. Guiard Schmid, P. Bonnard, G. Pialoux Combined HAART and HD MTX dramatically improved survival of our AIDS patients with PCNLS, with a relatively moderate toxicity. |
| ThPE0070 | PREDICTIVE INDICATORS OF DISEASE PROGRESSION AND ROLE OF APOPTOSIS IN HAART-TREATED PATIENTS WITH HIV-RELATED LEUKOENCEPHALOPATHIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0070 S. Delbue1, M. Saresella2, E. Marchioni3, F.R. Guerini2, G. Spoladore4, R. Maserati4, E. Tavazzi3, P. Ferrante1 CD4+ cells, CSF HIV RNA and SNRS scores differ between NDLE and PML, being indicative of better outcome of NDLE. In classic form of PML, CSF JCV load is predictive of poor survival. Decrease of CD3+ apoptotic MBP specific cells during demyelinating diseases suggests that auto-reactive phenomenon could play a role in PML, NDLE and MS. |
| ThPE0071 | EVIDENCE OF NEUROLOGIC DETERIORATION DUE TO COMPARTMENTALIZED HIV-1 WITH DISCORDANT VIRAL LOAD RESPONSE AND RESISTANCE EVOLUTION IN CEREBROSPINAL FLUID IN A TREATMENT-EXPERIENCED PATIENT WITH UNDETECTABLE PLASMA VIRAL LOAD: A CASE REPORT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0071 M. Hull1, D. Johnston2, C. Sherlock2, R. Harrigan3, J.S.G. Montaner3 We report a case of neurologic deterioration due to compartmentalized HIV-1 with discordant viral load response and resistance evolution in CSF in a treatment-experienced patient with long-term undetectable plasma viral load. As cohorts of treatment-experienced patients age, this may become a clinically significant problem. Assessment of CSF viral load is warranted in this setting. |
| ThPE0072 | PREVALENCE AND FACTORS ASSOCIATED WITH DEPRESSION IN HIV/AIDS PATIENTS AT AMINU KANO TEACHING HOSPITAL, NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0072 M. Gadanya1, S. Shehu2 Based on these findings, it is apparent that depression is prevalent co-morbid factor in the population, and hence recommended that a comprehensive treatment strategy should be initiated using a biopsychosocial to reduce morbidity and mortality in the affected patients. |
| ThPE0073 | LONG-TERM INTERMITTENT TREATMENT WITH HIGH-CONCENTRATION CAPSAICIN DERMAL PATCH (CDP) FOR PAINFUL HIV-ASSOCIATED DISTAL SENSORY POLYNEUROPATHY (DSP) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0073 D. Simpson1, S. Brown2, S. Chang3, J. Jermano4, C107 Study Group Treatment with CDP during DB resulted in prolonged response as measured by time to re-treatment. Similar to DB results, repeat OL treatments consistently reduced pain levels over 52 weeks. CDP was well tolerated and its safety profile appeared unchanged over a year. |
| ThPE0074 | NO EVIDENCE OF DIFFERENCE IN NEUROLOGICAL PERFORMANCE ASSESSED BY THE INTERNATIONAL HIV DEMENTIA SCALE BETWEEN PATIENTS WITH PRESERVED IMMUNITY WITH AND WITHOUT HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0074 G. Lopardo1, E. Bissio1, M. Ianella2, D. Garone3, A. Crespo1, I. Cassetti2 There doesn't seem to be any difference between patients with preserved immunity who are on and off treatment regarding the neurocognitive status measured by the IHDS. The apparent lack of difference might be attributed to the low sensitivity of the scale to detect mild cognitive impairment. |
| ThPE0075 | POPULATION-LEVEL IMPLICATIONS OF THE INDIVIDUAL-LEVEL BIOLOGICAL INTERACTION BETWEEN HIV-1 AND MALARIA: QUANTITATIVE EVIDENCE FROM MODEL PROJECTIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0075 L. Abu-Raddad1, P. Patnaik2, J. Kublin3 Our results highlight how transient, repeat increases in HIV viral load resulting from recurrent co-infections, such as malaria, contribute significantly to HIV spread. Therefore, we stress the need for further clinical research to study this biological interaction and to devise optimum malaria treatment protocols that can reduce the interaction between the two diseases. |
| ThPE0076 | THE EFFECT OF HIV INFECTION AND ANTIMALARIAL IMMUNITY ON THE SEVERITY OF PLASMODIUM FALCIPARUM MALARIA IN A COHORT OF CAMEROONIAN ADULTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0076 O. Kwedi Eboa1, T. Abdouraman2, S. Ake3 The findings indicate that HIV-infected nonimmune adults are at increased risk of severe falciparum malaria. This risk is associated with a low CD4+ T cell count. This interaction is of great public health importance. |
| ThPE0077 | BACILLE CALMETTE-GUERIN LYMPHADENITIS FOLLOWING ANTIRETROVIRAL THERAPY IN JAMAICAN INFANTS WITH RAPID PROGRESSOR HIV DISEASE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0077 J. Dunkley-Thompson1, R. Pierre1, J. Steel-Duncan1, P. Palmer1, D. Davis1, P. Figueroa2, C. Christie1 Lymphadenitis occurring after the initiation of HAART with clinical improvement and immune system restoration makes the theory of Immune Reconstitution plausible. The BCG vaccine still remains generally safe with few adverse reactions and the obvious benefit of protecting against disseminated tuberculosis in HIV-infected infants far outweighs this minor theoretical risk. |
| ThPE0078 | IMMUNE RECOVERY UVEITIS IN ACQUIRED IMMUNODEFICIENCY SYNDROME: INCIDENCE, SPECTRUM, CLINICAL PREDICTORS IN A DEFINED INDIAN POPULATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0078 K. Sarkar1, S. Guha2, N. Dhali1, M. Bandopadhyay1 Symptomatic IRU is not uncommon in Indian population, though in milder form and it was not related to CMV surface area. |
| ThPE0079 | MYCOBACTERIAL IMMUNE RESTORATION DISEASE MAY RESULT FROM AN IMBALANCE OF EFFECTOR AND REGULATORY CELLULAR IMMUNE RESPONSES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0079 A. Lim1, P. Price1, M.A. French2 We provide preliminary evidence that PBMC from patients with mycobacterial IRD produce relatively more IFN-γ than IL-10 when stimulated with PPD and suggest that mycobacterial IRD may result from defective regulatory cellular immune responses to mycobacterial antigens. |
| ThPE0080 | CRYPTOCOCCAL COMPLICATIONS IN THE FIRST YEAR ON HAART: EXPERIENCES OF A SOUTH AFRICAN ANTIRETROVIRAL PROGRAMME Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0080 L. Jenkin1, A. Karstaedt2 Survival of patients with cryptococcal meningitis in Soweto is significantly improved with HAART. However, in this series, we encountered more cryptococcal IRD with higher mortality rates as compared with those seen in developed countries. Clarity on the optimal management of cryptococcal IRD is needed. |
| ThPE0081 | THE EARLY UNMASKING (WITHIN 30 DAYS) OF TUBERCULOSIS (TB) IN HIV-INFECTED UGANDANS STARTING ANTIRETROVIRAL THERAPY (ART) – A REVIEW OF 16 CASES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0081 P. Kalimugogo1, S. Kaliba1, E. Nabankema1, F. Ssewankambo1, L. John1, E. Nalintya1, R. Kyeyune1, R. Colebunders2, J. Baalwa1, A. Kambugu1 In resource limited settings with limited diagnostic facilities health care providers should be aware that undiagnosed TB may be unmasked shortly after starting ART. They should appreciate the issues involved in managing such patients. These include; whether and how to stop ART, switching from nevirapine based regimens and the use of anti inflammatory agents. |
| ThPE0082 | COMPARISON OF HISTOPATHOLOGIC FINDINGS IN NON-TUBERCULOUS MYCOBACTERIAL IMMUNE RECONSTITUTION SYNDROME (NTMIRS), DISSEMINATED MAC (DMAC), AND TUBERCULOSIS (MTB) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0082 P. Phillips1, B. Walker2, R. Joy3, J. Montaner4 The histopathology of NTM-IRS resembles that of HIV-related MTb infection much more than DMAC, and is related to CD4 count. |
| ThPE0083 | IMMUNE RECONSTITUTION SYNDROME OBSERVED IN RESOURCE POOR CLINICAL SETTINGS IN SOUTH INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0083 K. Wijeyasangary, C. Arunachalam, W. Tharmasangary ART roll out has increased the complexity of care even at a secondary care level with ART related Immune reconstitution inflammatory syndrome. Despite this it is possible to provide good quality cost effective care at secondary care level using standardizesd clinical care guidelines and limited laboratory tests. |
| ThPE0084 | THYROID HORMONES ON HIV-INFECTED TEENAGERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0084 M. Arbune1, E. Zbranca2, O. Florea3 Abnormal levels of thyroid hormones (62%), enlargement of thyroid (63.3%) and lypodistrophy (40%) are frequent on HIV+ teenagers. Transitory thyroid disturbances during pubertal age, consequence of immune reconstruction and/or associated antiretrovirals events should be potential causes, but follow-up by prospective studies are required. |
| ThPE0085 | LOW FREQUENCY OF IRIS IN PATIENTS WITH OLD HBV/HIV COINFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0085 S.M. Ruta, C. Sultana, L. Manolescu, C.E. Cernescu The duration of HIV/HBV coinfection and the late initiation of HAART during the HIV infection do not influence the incidence of IRIS, irrespective of the degree of immunosuppression or the HBV replicative activity at baseline. |
| ThPE0086 | THE MECHANISM OF ENFUVIRTIDE RESISTANCE AND STRUCTURAL INSIGHTS INTO THE CORRESPONDING FITNESS DEFICITS IN RESPONSE TO THE N43D RESISTANCE MUTATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0086 X. Bai1, J. Seedorff1, K. Wilson1, D. Ahrens1, J. Green1, D. Davison2, L. Jin2, S. Stanfield-Oakley2, S. Mosier2, M. Greenberg2, J. Dwyer1 The disruptions to the stability and structure of the six-helix bundle caused by the N43D mutation provide a mechanistic basis for the effect on ENF susceptibility and identify likely contributors to viral fitness costs occurring in response to ENF resistance mutations. They may also play a role in CD4+ gains experienced by patients with ENF mutations. |
| ThPE0087 | RECOGNITION OF TWO DIFFERENT AND MUTUALLY EXCLUSIVE MUTATIONS DRIVING THE ACQUISITION OF RESISTANCE TO PROTEASE INHIBITORS IN HIV-2: IMPORTANT ROLE OF FLAP MUTATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0087 B. Rodes1, C. Toro1, V. Duque2, K. Mansinho3, F. Antunes4, V. Soriano1 The selection of V47A and I54M/L may represent two different and mutually exclusive pathways within the flap region to develop PI resistance in HIV-2. Selection of any of these mutations in a background of natural polymorphisms might be enough to produce resistance. These results suggest that flap mutations may play a more important role in the acquisition of primary resistance in HIV-2 compared to HIV-1. |
| ThPE0088 | MOLECULAR BASIS FOR PHENOTYPIC RESISTANCE AND REDUCED REPLICATION CAPACITY DUE TO MUTATIONS IN HIV-1 PROTEASE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0088 A. Konstantinidis1, H. Mo2, L.R. Solomon3, D.M. Bartley3, K.A. Walter3, R.A. Smith3, J.M. Severin3, J. Harlan3, W.M. Kati2, A. Molla2 The decreased catalytic activity of HIV-1 mutant proteases I50L, I50V and I47A may, in part, account for their reduced replication capacities. This study also provides a molecular understanding for the resistance profiles of the four mutants. At the enzyme level it appears that D30N and I50L alone were not hyper-susceptible to other PIs compared to WT. Modeling data shows how these mutations impact the inhibitor/protein contact surface. |
| ThPE0089 | THE ABILITY OF FOUR GENOTYPIC RESISTANCE ALGORITHMS FOR PREDICTING HIV-RNA RESPONSES 4-24 WEEKS AFTER INITIATING A BOOSTED PICONTAINING REGIMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0089 Z. Fox1, J. Kjaer1, A.N. Phillips2, L. Ruiz3, B. Clotet3, S. Staszewski4, C. Holkmann Olsen1, A. Horban5, B. Ledergerber6, J.D. Lundgren1, EuroSIDA All GISs predicted larger HIV-RNA reductions in individuals with PI/r sensitivity; however discordance existed on the predicted effect of NOADR. GISs still need improvement to capture HIV-RNA changes. A consensus on which GIS to use needs to be reached. |
| ThPE0090 | GENOTYPIC AND PHENOTYPIC DRUG SUSCEPTIBILITY OF HIV-2 TO PROTEASE INHIBITORS (PIS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0090 M. Ntemgwa, B. Brenner, M. Oliveira, B. Spira, D. Moisi, M.A. Wainberg This study shows that mutations in the protease gene selected by HIV-2 isolates confer resistance to PIs. Greater decreases in susceptibility were observed when I54M was selected together with either I84V or L99F. |
| ThPE0091 | CHARACTERIZATION OF HIV-2 VARIANTS IN RESPONSE TO IN VITRO PASSAGE WITH LOPINAVIR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0091 S. Masse1, X. Lu2, T. Dekhtyar1, L. Lu1, R. Mondal1, G. Koev1, B. Bernstein1, F. Gao2, A. Molla1, H. Mo1 LPV/r may provide antiviral activity in HIV-2 infected patients. However, emergence of mutations at I47A and D17N mutation may be associated with significantly reduced LPV activity in HIV-2. |
| ThPE0092 | CD4 INCREASES IN PATIENTS WITH ONGOING VIRAL REPLICATION WHILE RECEIVING ENFUVIRTIDE ARE ASSOCIATED WITH V38 AND OTHER MUTATIONS IN GP41 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0092 T. Melby1, M. DeSpirito2, R. Demasi2, G. Heilek-Snyder3, J. Thommes4, M. Greenberg1, N. Graham2 We confirm that substitutions at the V38 position were associated with sustained CD4 increases in patients failing ongoing ENF-based therapy. Other substitutions in gp41 were also associated with sustained CD4 increases and deserve further study. These data are consistent with a viral fitness cost and/or reduced pathogenicity in viruses developing resistance to ENF. |
| ThPE0093 | GENOTYPIC DRUG RESISTANCE MUTATIONS AMONG HIV-INFECTED PATIENTS FAILING A REGIMEN OF FIXED-DOSE COMBINATION OF STAVUDINE, LAMIVUDINE AND NEVIRAPINE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0093 W. Manosuthi1, S. Kiertiburanakul2, B. Piyavong2, N. Chumpathat1, S. Sungkanuparph2 After failing a fixed-dose combination of d4T/3TC/NVP, almost all patients have lamivudine and NNRTI resistance. Patients who have HIV-RNA >4 log copies/ml at the time of virologic failure detection have a higher risk for multi-NRTI resistance. Early detection of virological failure may provide more options and better treatment outcomes. |
| ThPE0094 | DRUG RESISTANT MUTATIONS IN CHILDREN FAILING ANTIRETROVIRAL THERAPY IN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0094 E.M. Songok1, R. Lwembe2, W. Ochieng2, S. Kageyama3, H. Ichimura3, KEMRI-JICA Project Our results suggest that though majority of resistant children had subtype B associated primary mutations, subtype B-associated "secondary" resistance mutations could be "primary" mutations in non-B HIV-1 infection. Similarly RT resistance mutations could persist for long (9 years) after possible vertical transmission, and that resistance mutations found as minor populations could subsequently expand to cause significant ART failure. |
| ThPE0095 | PHENOTYPIC ANALYSIS OF T74S POLYMORPHISM IN THE PROTEASE OF HIV-1 OF B AND C SUBTYPES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0095 E.A.J.M. Soares, L.M.F. Gonzalez, A.F.A. Santos, T.M. Souza, A. Tanuri, R.M. Brindeiro, M.A. Soares The subsstitution T74S does not seem to be a major drug resistant mutation, as it does not alter susceptibility to PIs per se. On the other hand, it seems to re-sensitize protease multi-resistant viruses to certain PIs. This mutation should be further studied in clinical settings and potentially considered in drug resistance interpretation algorithms. The information should also be used in rational sequential drug combination strategies. |
| ThPE0096 | FACILITATED SELECTION OF TENOFOVIR RESISTANCE IN HIV-1 SUBTYPE C Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0096 B. Brenner1, M. Oliveira1, D. Moisi1, M. Ntemgwa1, F. Doualla-Bell1, M. Essex2, M. Wainberg1 TDF-based regimens will need to be carefully monitored in subtype C infections for possible selection of K65R. |
| ThPE0097 | PRIMARY HIV DRUG RESISTANCE IN ARGENTINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0097 A. Petroni1, G. Deluchi1, M.B. Bouzas2, E. Loiza3, D. Pryluka4, D. Garone5, V. Nasiff6, D. Pugliese3, I. Cassetti7, S. Echazarreta8, vL. Morganti9, J. Benetucci1 The >5% resistance threshold found indicates a need for sentinel resistance surveillances, pointing out the need of updating the current resistance testing guidelines in Argentina. |
| ThPE0098 | CHARACTERIZATION OF PROTEASE INHIBITOR-RESISTANT HIV-1 IN THERAPY-NAÏVE INDIVIDUALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0098 S. Ibe, U. Shigemi, S. Fujisaki, S. Fujisaki, J. Hattori, N. Mamiya, M. Hamaguchi, T. Kaneda In vitro experiments indicated that several mutations in the gag gene contribute to improved replicative fitness of PI-resistant viruses in therapy-naďve individuals. Resistant viruses could thus survive and persist in drug-free conditions without reversion to wild-type. |
| ThPE0099 | RESISTANCE PROFILE AFTER TREATMENT WITH AN ATAZANAVIR-CONTAINING REGIMEN: FIRST INTERIM ANALYSIS RESULTS FROM THE IMPACT STUDY (BMS AI424 – 128) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0099 A. Zolopa1, W. Towner2, C. Zurawski3, G. Crofoot4, D. Butcher5, S. Wang5, J.F. Maa5, D. Seekins5 In this cohort, primary PI mutations, including I50L, were not seen at VF in patients on initial PI-based therapy with ATV/r. The prevalence of I50L in PI-experienced patients experiencing VF on an ATV-containing regimen was 10%. Use of PI/r prior to ATV/r appeared to reduce the prevalence of I50L. |
| ThPE0100 | GENOTYPIC MUTATIONS IN PATIENTS FAILING HAART WITH LOW-LEVEL VIREMIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0100 F. Maggiolo1, A. Callegaro2, D. Ripamonti1, M. Airoldi1, A. Acerbis2, F. Nozza2, E. Bombana1, A. Goglio2, F. Suter1 In the case of virologic failure of HAART the resistance mutation pattern influences the entity of HIV-RNA rebound. Not yet established drug-resistance mutations are strictly linked with HIV-RNA levels probably influencing viral replicative capacity. Why individual patients develop early an higher number of novel mutations has still to be explained. |
| ThPE0101 | TRUVADA-COHORT- PREVALENCE OF PRIMARY RESISTANCE IN THERAPY-NAÏVE PATIENTS IN GERMANY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0101 H. Knechten1, B. Ranneberg2, L. Gallo2, M. Kirsch1, C. Höhn1, R. Ehret1, P. Braun1 The prevalence of primary mutations in this evaluation corresponds with results found in other German studies. Contrary to these, however, we observed an almost equal distribution between the detected resistances to NRTIs, NNRTIs and PIs. These data will be verified in a larger cohort. |
| ThPE0102 | WHEN TO INITIATE HAART IN SUB-SAHARAN AFRICA? A SOUTH AFRICAN COST-EFFECTIVENESS STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0102 M.H.Y. Badri1, S. Cleary2, G. Maartens3, J. Pitt1, L.-G. Bekker1, C. Catherine1, R. Wood1 Although starting therapy at <200 was the most efficient use of resources, clinical benefits increased significantly with early therapy initiation. Countries with less severe resource constraints could consider starting therapy at higher thresholds. |
| ThPE0103 | COMPARISON OF THREE ONCE-A-DAY REGIMENS AS FIRST-LINE HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0103 F. Maggiolo1, D. Ripamonti1, G. Migliorino2, C. Martinelli3, L. Sighinolfi4, G. Quinzan1, G. Gregis1, C. Abeli2, M. Airoldi1, F. Suter1 The studied once-a-day regimens show a good virologic efficacy and are generally well tolerated. In the case of virologic failure, selected mutations are highly influenced by the NRTI choice and about one third of the patients do not present NNRTI mutations. OD therapy favors adherence. |
| ThPE0104 | EFFICACY AND SAFETY OF NEVIRAPINE VERSUS EFAVIRENZ WHEN COMBINED IN ART REGIMENS IN HIV-INFECTED ANTIRETROVIRAL-NAÏVE PERSONS (THE NNRTI SUBSTUDY OF FIRST-CPCRA 058) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0104 M. van den Berg-Wolf1, G. Peng2, Y. Xiang2, K. Huppler Hullsiek2, L. Chen3, R.D. MacArthur4, R.M. Novak5, M. Kozal6, B. Schmetter7, C. Heneley8, M. Dellinger9, Terry Beirn Community Programs for Clinical Research on AIDS 058 Study Team Virologic responses were comparable for patients randomly assigned NVP or EFV after median follow-up of 5 years; however, virologic failure on NVP was associated with more drug resistance. In the NVP arm there was a trend for lower rates of AIDS or death, however there were more adverse events. Larger, longer-term trials of initial ART regimens are needed to assess clinical outcomes with adequate power. |
| ThPE0105 | TIME TO STOPPING OR SWITCHING HAART INITIATED IN PRIMARY HIV INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0105 K. Bhaskaran, CASCADE Collaboration HAART initiation in primary infection appears to result in a high probability of switching from/stopping initial therapy in the short term. Individuals starting NNRTI-regimens were more likely to continue their first regimen, but the high proportion stopping therapy by 6 months is of concern as the long half-life of NNRTIs could increase their vulnerability to resistance compromising the whole class. |
| ThPE0106 | EXPOSURE AND RESPONSE TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) IN ART NAÏVE CHILDREN IN THE UK AND IRELAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0106 A. Judd1, K.J. Lee1, T. Duong1, A.S. Walker1, K. Butler2, S. Donaghy3, H. Lyall4, J. Masters5, E. Menson3, V. Novelli6, C. Peckham5, A. Riordan7, M. Sharland3, P. Tookey5, G. Tudor-Williams4, D. Gibb1 Attainment of VL suppression one year after first-line ART improved over time, although 'late' switching was a feature throughout. The finding of better immunologic but not virological responses in girls requires further investigation. |
| ThPE0107 | META-ANALYSIS OF EFAVIRENZ-BASED THERAPY IN ADVANCED HIV DISEASE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0107 R.M. Plank1, S. Eapen2, M.L. Pisculli3, P.E. Sax4 Efavirenz-based regimens are significantly more likely to achieve virologic suppression than comparator third-drugs in patients with high baseline viral loads. Based on these results, there are no data to support favoring PI-based over EFV-based treatment in this patient population. |
| ThPE0108 | TREATMENT INITIATION WITH ZIDOVUDINE-CONTAINING HAART LEADS TO A LOWER RISE IN THE ABSOLUTE CD4 CELL COUNT BUT DOES NOT INCREASE THE RISK OF CLINICAL PROGRESSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0108 A. Lahn1, G. Kaufmann2, M. Battegay2, M. Opravil1, and the Swiss HIV Cohort Study Over a four-year period, ZDV lead to a lower rise in absolute, but not in the % CD4 counts. The effect can be explained as a relative lymphopenia and bears no increased risk of HIV-associated clinical events. |
| ThPE0109 | CHANGES IN CD4 CELL COUNT OUT TO SIX YEARS IN PERSONS WITH SUSTAINED VIROLOGIC SUPPRESSION. IMPLICATIONS FOR WHEN TO START ARV THERAPY? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0109 R. Moore, J. Keruly Only patients with baseline CD4 > 350 returned to near normal CD4. These data suggest that waiting to start HAART at lower CD4 levels will result in the CD4 not returning to normal levels and the clinical event rate is higher. This may have implications for when to start therapy. |
| ThPE0110 | EARLY EXPERIENCE OF FREE ANTIRETROVIRAL THERAPY PROGRAMME IN MUMBAI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0110 D. Shah1, N. Borges1, A. Deshpande2, D. Vaswani1 86.5% patients are alive at 12 months with significant rise in CD4 counts. In patients who survived, recovery occurred mostly in first 6 months. This is consistently seen in all the monthly cohorts. As treatment continued number of deaths and defaulters dropped in cohort from 6 to 12 months, adherence improved. Steps are taken to find lost to follow up patients and prevent further dropouts through tracing and adherance counselling .The early results are encouraging enough to further continue & expand the programme at large scale. |
| ThPE0111 | OVERVIEW OF TIME TO LOSS OF VIROLOGIC RESPONSE (TLOVR) OUTCOMES BETWEEN EFAVIRENZ-BASED REGIMENS IN ART-NAÏVE HIV-1-INFECTED ADULTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0111 J.A. Bartlett1, S.-S. Chen2, J.B. Quinn2, M. Wulfsohn2 In studies of efavirenz-based regimens, responses range from a high of 80% (TDF/FTC) to a low of 64% (ABC/3TC ) as defined by TLOVR. |
| ThPE0112 | PREDICTIVE FACTORS OF VIROLOGICAL FAILURE IN NAÏVE PATIENTS INITIATING HAART (HIPPOCAMPE - ANRS 121 TRIAL): INTERACTION BETWEEN NRTI-SPARING REGIMEN, SUBTYPE B VIRUSES AND ADHERENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0112 C. Duvivier1, J. Ghosn1, L. Assoumou2, C. Soulié3, G. Peytavin4, V. Calvez3, J.M. Molina5, B. Jarrousse6, C. Allavena7, C. Katlama1, D. Costagliola2, and HIPPOCAMPE Team In ARV-naïve patients, a NRTI-sparing-regimen was virologically less potent than standard-NRTI-containing- HAART especially in patients harboring subtype B viruses and less "forgiving" in patients with poor adherence. |
| ThPE0113 | RESOLUTION OF ANEMIA WITH USE OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) AMONG HIV-INFECTED PATIENTS IN SOUTHERN INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0113 R. Subbaraman1, S. Singh2, A.J. Cecelia3, B. Devaleenal3, T. Yepthomi3, K.H. Mayer4, N. Kumarasamy3 HAART may resolve anemia in a large proportion of patients even in developing countries, considerably improving quality of life. |
| ThPE0114 | USING A PROBABILISTIC COMPUTER SIMULATION OF HIV PROGRESSION TO ESTIMATE THE OPTIMAL THRESHOLD FOR INITIATING ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0114 R.S. Braithwaite1, M.S. Roberts2, S. Shechter3, J.L. Goulet1, C.C. Chang4, S.L. Fultz1, M.B. Goetz5, C.L. Gibert6, M. Rodriguez-Barradas7, A. Schaefer3, A.A. Butt4, A.C. Justice1 In this preliminary attempt to account for toxicity and disutility from ART in modeling its optimal timing, we have initially found that earlier treatment initiation appears to increase survival and quality-adjusted life-years. |
| ThPE0115 | REGIMEN MODIFICATION IN SUBJECTS INITIATING HAART DURING ACUTE OR EARLY HIV INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0115 L. Apuzzo1, F. Vaida2, J. Gallant3, K. Ernstrom2, S. Little2, J.-P. Routy4, M. Kilby5, J. Levy6, F. Hecht6, E. Connick7, M. Markowitz8, B. Conway9, B. Walker10, D. Cooper11, J. Margolick1 The most common reason for treatment modification was toxicity. Triple class regimens were modified earlier than either PI or NNRTI based regimens. Toxicity management strategies should be discussed with patients prior to initiating HAART in acute/early infection. |
| ThPE0116 | HIGH-RISK GROUPS IN AFRICA: A PRIORITY TARGET FOR HAART NATIONAL PROGRAMMES? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0116 A. Ouédraogo1, N. Nagot2, I. Konaté1, L. Vergne1, H. Weiss2, M.C. Defer1, V. Foulogne3, D. Djabaré4, P. Mayaud2, P. Van de Perre5, Yerelon Study group The implementation of HAART in high risk, hard to reach populations is feasible and is likely to alter HIV-1 dynamics in West Africa. Such programmes require a comprehensive and non-stigmatising access to health care, free HAART, psychological and peer support. |
| ThPE0117 | HIV/AIDS PREVENTION AND CARE PROGRAM: THE INITIATION OF ARV IN LAO PDR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0117 P. Phimmasone The first line regimen is very useful for people living with HIV/AIDS in poor setting countries, close following up and ongoing counseling of patients are essential to maintain efficacy. More understanding and support of the authorities and all HIV/AIDS organizations are needed to improve quality of care and extend the project forever. |
| ThPE0118 | WHAT'S NEXT FOR 3-BY-5? WHO FIRST LINE REGIMEN (D4T/3TC /NVP) ON TREATMENT RESPONSE AMONG ANTIRETROVIRAL-NAÏVE INDIVIDUALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0118 L.W.Y. Tam, P.R. Harrigan, B. Yip, J.S.G. Montaner, C.J. Brumme, V.S. Gill, R.S. Hogg Our results demonstrate the urgency for second and third line approaches to the 3-by-5 Initiative. If our therapy outcomes represent those in lesser-developed countries, then the population on d4T/3TC /NVP requiring second line treatment is 30% at 12 months and 40% at 24 months; >10% would have some degree of drug resistance by 24 months. |
| ThPE0119 | PREDICTORS' THRESHOLD FOR AIDS MORTALITY IN HIV-1-INFECTED ADULT SENEGALESE PATIENTS CHANGE WITH TIME AFTER HAART INITIATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0119 P. de Beaudrap1, J.-F. Etard2, N.F. Ngom Guèye3, I. Ndiaye4, P.M. Guèye5, P.S. Sow4, R. Ecochard1, I. Ndoye6, E. Delaporte2, ANRS 1290 Categorization of covariates provides better insight into biological processes, but may expose to several pitfalls. In this Senegalese cohort, there were changes in the cut-off with time, which may lead to misinterpretation of Cox model results. |
| ThPE0120 | META-ANALYSIS OF EFFICACY AND SAFETY FOR CLINICAL STUDIES OF D4T 40MG VERSUS 30MG BID IN 1008 PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0120 A. Hill1, K. Ruxrungtham2, M. Havanich3, E. Wolf4, A. Milinkovich5, J. Gatell6, E. Ribera6 In this meta-analysis, d4T 40mg and 30mg BID showed equivalent antiviral efficacy by standard US FDA criteria. In cohort studies, the incidence of peripheral neuropathy and lipoatrophy was lower at the 30mg BID dosage. |
| ThPE0121 | EFFECTS OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON FREE TESTOSTERONE (TFREE) LEVELS AND FAT-FREE MASS (FFM ) IN MEN IN A PROSPECTIVE, RANDOMIZED TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0121 M. Dubé1, R. Parker2, K. Mulligan3, P. Tebas4, G. Robbins5, S. Grinspoon6, AIDS Clinical Trials Group A5005s and 384 Study Teams Subnormal Tfree levels occurred infrequently among these antiretroviral-naïve subjects. Tfree increased after initiating antiretrovirals, with greater increases with ZDV+3TC vs ddI+d4T, and efavirenz vs nelfinavir at 64 weeks. Increases in Tfree were weakly associated with increased FFM and thus may be responsible in part for the greater relative FFM increases with ZDV+3TC or efavirenz. |
| ThPE0122 | TRENDS IN INITIATION AND SWITCHING OF HAART BY INITIAL REGIMEN TYPE IN THE WOMEN'S INTERAGENCY HIV STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0122 E.T. Golub1, L. Benning1, A. Sharma2, M. Gandhi3, M. Cohen4, M. Young5, S.J. Gange1 In the WIHS, trends and correlates of initiation are changing over time, with PI-based regimens less likely than others, CD4+ counts no longer correlated with regimen type choice, and over half of women switching therapy within the first year on HAART. Studies of therapy response by regimen type may need to consider controlling for demographics, in addition to CD4+, in order to avoid residual confounding. |
| ThPE0123 | EFFICACY AND SAFETY OF ATAZANAVIR (ATV) BASED HAART IN VIROLOGICALLY SUPPRESSED SUBJECTS SWITCHED FROM LOPINAVIR/RITONAVIR (LPV/RTV) TREATMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0123 J.M. Gatell1, T. Branco2, L. Sasset3, F. Pulido4, A. Macor5, S. Gothelf6, C. Gruber7, L. Odeshoo8, V. Wirtz8, E. Ledesma9 Simplification to an unboosted ATV-based regimen provided comparable antiretroviral efficacy and improvements in plasma lipids, compared to subjects who continued on LPV/RTV. Both treatment arms were generally safe and well tolerated, with subjects on ATV reporting less gastrointestinal symptoms. |
| ThPE0124 | THE IMPACT OF TIMING OF REGIMEN CHANGE ON OUTCOMES DURING ART FAILURE IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0124 C. Hoffmann1, S. Charalambous2, T. Puso2, K. Fielding3, D. Martin4, C. Innes2, G. Churchyard2, R. Chaisson5, A. Grant3 While early switching provided good results, an approach of waiting 6 months before regimen switch for persistent failure also provided good suppression. 58% of patients switched >6 months after failure suppressed while 40% suppressed at 6 months even without regimen change. This suggests potential alternatives to the paradigm of rapid regimen change in settings with only one 2nd line regimen. |
| ThPE0125 | CURRENTLY MARKETED NUCLEOS(T)IDES PROVIDE ONLY MARGINAL ADDITIONAL VIRAL LOAD (VL) SUPPRESSION TO REGIMENS INCLUDING ENFUVIRTIDE (ENF) AND BOOSTED PIS (PI/R) IN TRIPLE CLASS EXPERIENCED PATIENTS (TEPS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0125 R. DeMasi1, J. Thommes2, N. Graham1 In this population of triple-class experienced patients harbouring MDR, ENF provided greater VL suppression than other currently marketed ARVs, with boosted PIs providing intermediate and nucleos(t)ides marginal or no VL suppression, respectively. These data support the concomitant use of ENF and an active boosted PI to achieve maximal virologic suppression in TEPs and also underscore the continuing need for the development of new ARVs active against drug resistant virus. |
| ThPE0126 | LONG TERM DURABILITY OF BOOSTED INDINAVIR AND EFAVIRENZ IN PATIENTS WITH COMBINATION NUCLEOSIDE ANALOGUE FAILURE IN A RESOURCE CONSTRAINED SETTING: 4- YEAR FOLLOW-UP OF HIV-NAT 009 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0126 A. Avihingsanon1, M. Boyd2, P. Pornprasit1, N. Chomchey1, P. Kaewon1, S. Ubolyam1, K. Ruxrungtham3, J. Lange4, D. Cooper5, P. Phanuphak1 IDV/r bid plus EFV qd provides a potent, durable response after combinationNRTI failure. Dosing of ritonavirboosted IDV at 800/100mg bid, even with efavirenz, proved toxic, and the majority of patients had TDM-guided IDV dose reductions without compromising virological control. |
| ThPE0127 | IMPACT OF RESISTANCE AND STRUCTURED TREATMENT INTERRUPTION (STI) ON RESPONSE TO SALVAGE ANTIRETROVIRAL (ARV) THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0127 A. Thorne1, R. Harrigan2, N. Lapierre1, S. Walmsley3, CTN 164 Study Group Reversion to wild type virus after a 12 week STI did not impact the likelihood of virologic suppression to a salvage regimen. At the time of virologic failure, only 33% had new key mutations, which were most commonly observed to the NNRTI component of the salvage regimen. |
| ThPE0128 | EFFICACY AND SAFETY OF LOPINAVIR/RITONAVIR SWITCHING TO ATAZANAVIR IN HIV-INFECTED PATIENTS WITH UNDETECTABLE PLASMA VIREMIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0128 A. Ruiz-Sancho, P. Rivas, F. Blanco, P. García-Gasco, V. Asensi, P. Labarga, V. Soriano, J. González-Lahoz Switching from LPV/r to ATV is relatively well-tolerated and associated with significant improvements in the lipid profile. However, heavily PI exposed patients could be more prove to experience virological failure. |
| ThPE0129 | HAART IN CHILDREN AND ADOLESCENTS IN LATIN AMERICA: RELATIONSHIP BETWEEN VIRAL LOAD AND CLINICAL CHARACTERISTICS FROM THE NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT INTERNATIONAL SITE DEVELOPMENT INITIATIVE (NISDI) PEDIATRIC STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0129 R. Oliveira1, J. Byrne2, R. Souza3, A. Tiraboschi4, H. H.S.Marques5, R. Succi6, L.K. Serchuck7, NISDI Pediatric Protocol Study Group In this preliminary analysis, ARV-experienced children maintained on HAART with persistently DETECT VL had a similar proportion of disease progression compared to those with UNDETECT VL. These data suggest that ARV-treated children, particularly those with limited therapeutic options, may not require immediate ARV change when they have DETECT VL. |
| ThPE0130 | LAMIVUDINE MONOTHERAPY IN FAILING HIV-1-INFECTED PATIENTS: PREDICTORS OF IMMUNOLOGICAL/CLINICAL RESPONSE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0130 A. Danise1, A. Castagna1, L. Galli1, S. Tiberi1, N. Gianotti1, G. Penco2, L. Sighinolfi3, A. Ruggieri4, T. Prestileo5, A. Lazzarin1 Lamivudine monotherapy achieves the best ICR in patients with CD4>500 and/or nadir CD4>300. This strategy could be investigated as an alternative to the immediate switching of a failing antiretroviral regimen. |
| ThPE0131 | SIMPLIFICATION TO A ONCE-DAILY EFAVIRENZ (EFV)-BASED HAART REGIMEN FROM A TWICE-DAILY OR MORE FREQUENT HAART REGIMEN MAINTAINS VIROLOGIC SUPPRESSION AT 48 WEEKS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0131 B. Boyle1, J. Morales Ramirez2, D. Brand3, J. Forish4, K. Porter4, J. Maa4, D. Seekins4, R. Khanna4 Simplification from BID or more frequent HAART to a QD EFV-based HAART regimen maintained virologic suppression and resulted in a low rate of adverse events. There was higher treatment satisfaction and preference in patients taking a QD EFV-based regimen. |
| ThPE0132 | KALETRA MONOTHERAPY - A REAL-LIFE EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0132 L. Waters, B. Gazzard, M. Bower, M. Nelson In our series of drug-experienced individuals mLPV/r was associated with improved immunological parameters regardless of virological response. 50% achieved an undetectable (less than 50 copies/ml) VL and 73% a greater than 1log10 reduction. As most subjects switched to mLPV/r for poor compliance this data supports this strategy in poorly adherent drugexperienced patients. |
| ThPE0133 | RATES OF CD4 DECLINE AND AIDS EVENTS AMONG INDIVIDUALS RECEIVING HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) WHO PERSISTENTLY FAIL TO ACHIEVE VIROLOGICAL SUPPRESSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0133 C. Sabin1, C. Smith1, A.M. Geretti2, M. Youle3, F. Lampe1, A. Phillips1, M. Johnson3 A minority of patients do not achieve an undetectable VL whilst on HAART, probably due to sub-optimal adherence. CD4 declines in these patients are modest when compared to those among untreated individuals in the pre-HAART era. The risk of AIDS is high, but does not increase until after a prolonged period with detectable viraemia. |
| ThPE0134 | SINGLE AGENT HAART WITH LOPINAVIR/R (LPV/R) IN ART-NAÏVE AND PRE-TREATED HIV-1-INFECTED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0134 J. Goelz1, E. Wolf2, A. Moll1, C. Koegl2, H. Jaeger3 Single agent HAART with LPV/r allows to maintain long-term virological control and an increase of CD4 count >100/ µl in naïve and pre-treated patients. Efficacy was comparable to standard triple therapy. Therapy was convenient; we did not see any severe side effects. Contrary to earlier studies, one PI-naďve patient developed resistance to LPV/r. |
| ThPE0135 | THE LOPSAQ STUDY: 48-WEEK ANALYSIS OF A BOOSTED DOUBLE PROTEASE INHIBITOR REGIMEN CONTAINING LOPINAVIR/RITONAVIR PLUS SAQUINAVIR WITHOUT ADDITIONAL ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0135 S. Staszewski1, E. Babacan1, C. Stephan1, M. Stuermer2, B. Dauer1 The combination of LPV/r and SQV without RTIs is a potential option as salvage therapy for patients experiencing therapy failure due to resistance or RTI-toxicity. This regimen may not be suitable for patients with very low baseline CD4 cell counts, very broad antiretroviral therapy experience or extensive PI-resistance mutations. |
| ThPE0136 | COMBINATION OF TMC114/RITONAVIR AND TMC125 IN PATIENTS WITH MULTIDRUG RESISTANT HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0136 J. Montaner1, M. Harris1, G. Larsen1, B. Woodfall2, D. Miralles2, P.R. Harrigan1 Combination therapy including TMC114/ritonavir and TMC125 could represent a viable treatment option for patients with drug-resistant HIV. |
| ThPE0137 | THE EFFECTS OF PROTEASE INHIBITORS AND NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS ON THE IMMUNE SYSTEM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0137 H. Stocker1, S. Sopper2, C. Weber1, H. Walter3, K. Arastéh4, Kompetenznetz HIV/AIDS Deutschland NRTI and PI differ in their effects on the immune system independent on their antiviral activity. Our results may help to develop treatment strategies for patients whose viral load cannot be suppressed by the currently available drugs. |
| ThPE0138 | DISCONTINUATION OF ENFUVIRTIDE AFTER LONG-TERM ADMINISTRATION IN HIV-1-INFECTED PATIENTS - THE SWISS HIV COHORT STUDY (SHCS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0138 L. Elzi1, G. Kaufmann1, R. Weber2, B. Hirschel3, M. Cavassini4, H. Furrer5, E. Bernasconi6, P. Vernazza7, T. Klimkait8, M. Rickenbach9, M. Battegay1 Our data indicate that T-20 should not be initiated too late. In most pts stopping T-20 viremia is not controlled and and CD4 tend to decrease. Discontinuation of T-20 may be associated with a poorer prognosis. |
| ThPE0139 | THE IMMUNOLOGIC AND VIROLOGIC SUCCESS OF LAMIVUDINE AND EMTRICITABINE IN TREATMENT-EXPERIENCED PATIENTS WITH THE M184V MUTATION: ARE THREE ACTIVE AGENTS REALLY NECESSARY? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0139 K. Furtek1, N. Crum-Cianflone1, M. Bavaro2, A. Truett2, H. Chun2, G. Utz2, B.R. Hale2, Tri-Service AIDS Clinical Consortium (TACC) 3TC or FTC use with two active antiretrovirals achieved good virologic and immunologic responses among treatment-experienced patients with the M184V mutation. Success of this regimen is predicted by a high initial CD4 count and fewer baseline TAMs. |
| ThPE0140 | TIPRANAVIR/RITONAVIR IS MORE EFFECTIVE AGAINST PROTEASE INHIBITOR (PI)-RESISTANT STRAINS THAN OTHER RITONAVIR-BOOSTED PI IN HEAVILY ANTIRETROVIRAL-EXPERIENCED HIV-INFECTED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0140 C. de Mendoza1, E. Ribera2, P. Barreiro1, A. Corral1, M. Garcia-Leon1, L. Valer1, J. Gonzalez-Lahoz1, V. Soriano1 PI/r-based regimens provide a significant rate of VR as salvage therapy. The main determinant of potency is the baseline protease resistance profile. While APV seems to be less potent, TPV/r demonstrated higher potency in patients with ≥5 PRM. |
| ThPE0141 | IMPACT OF RACE ON EFFICACY AND THE OCCURRENCE OF NERVOUS SYSTEM SYMPTOMS (NSS) IN HIV-INFECTED PATIENTS FOLLOWING SIMPLIFICATION FROM A TWICE-DAILY OR MORE FREQUENT HAART REGIMEN TO A ONCE-DAILY EFAVIRENZ (EFV)-BASED HAART REGIMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0141 M. Sension1, D. Jayaweera2, P. Lackey3, A. Farajallah4, J. Maa4, D. Seekins4, R. Khanna5 Following simplification to a QD EFV-based HAART regimen, the percentage of patients maintaining virologic suppression among Whites, Blacks, and Hispanics was similar. The rate of new onset NSS and discontinuation due to NSS was similar between races. |
| ThPE0142 | LONG-TERM EFFICACY OF ENFURVITIDE - THE RADATA-FUZEON COHORT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0142 C. Hoffmann1, T. Lorenzen1, K. Arasteh2, G. Fätkenheuer3, P. Gute4, H. Knechten5, J.v. Lunzen6, J. Rockstroh7, B. Salzberger8, S. Staszewski9, M. Stoll10, N. Postel11, A. Stoehr1, A. Plettenberg1 ENF showed a remarkable treatment success in this large cohort of heavily pretreated patients. Discontinuation due to side effects were low. The results of this study are comparable to those of randomized, controlled studies with ENF. |
| ThPE0143 | FACTORS ASSOCIATED WITH VIRAL SUPPRESSION IN PATIENTS WITH THREE DRUG CLASSES RESISTANCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0143 M.J. Perez-Elias, C. Gutierrez, I. Garcia-Arata, B. Hernadez, D. Lopez, A. Moreno, F. Dronda, J.L. Casado, C. Page, J.C. Galan, S. Moreno A significant number of patients may achieve virological response despite MM to the three drug classes. The resistance pattern of accumulation of MM in PR and the combination of 184+210+215 in RT preclude virological response, whereas a boosted PI based regimen was associate with higher rates of virological response. |
| ThPE0144 | PREDICTORS FOR THE INITIAL CD4 DECLINE AFTER ANTIRETROVIRAL TREATMENT INTERRUPTION IN THE SMART STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0144 B. Grund, for the SMART Study Group The CD4 decline was steepest during the first 2 months. High CD4 at discontinuation, low CD4 nadir, HIV RNA ≤400, and prior AIDS are independently associated with steeper initial CD4 decline. |
| ThPE0145 | THE EFFECT OF EPISODIC CD4-GUIDED ANTIRETROVIRAL THERAPY ON QUALITY OF LIFE: RESULTS OF THE QUALITY OF LIFE SUBSTUDY OF SMART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0145 W. Burman, for the SMART Study Group Episodic use of ART as in SMART did not improve quality of life. Physical functioning, general health perception, and energy scores worsened among patients in the DC group compared to the VS group. |
| ThPE0146 | ISS PART. FACTORS PREDICTING SUCCESS AND RESISTANCE IN THE STI ARM OF A RANDOMIZED, CONTROLLED TRIAL OF CONTINUOUS VERSUS INTERMITTENT HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0146 M. Giuliano, L. Palmisano, R. Bucciardini, V. Fragola, M. Andreotti, C. Galluzzo, M. Pirillo, R. Amici, M.G. Mancini, L. Weimer, S. Vella, and the Italian ISS PART Clinical Centers In the STI arm a lower proportion of subjects with > 500 CD4 cells/mmc was found at the end of follow up; however this had no impact on safety and rate of virologic failure. Mutations in 38/136 subjects were a major concern in STI arm and were predicted by archived mutations at baseline and use of an unboosted PI HAART. |
| ThPE0147 | MODELLING CD4 CELL COUNT DECLINE DURING TREATMENT INTERRUPTION (TI) STRATIFIED BY PRE-TREATMENT CD4 NADIR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0147 M. Hull1, R. Joy2, R. Hogg3, J.S.G. Montaner3 Our results suggest that CD4 declines during TI occurred at higher rates for those with a CD4 nadir ≤250. As a result, these patients should continue to receive monthly CD4s. In contrast, patients with CD4 nadir >250 can probably be monitored monthly during the first 12 weeks, and less frequently thereafter, once the CD4 cell count has reached a plateau. |
| ThPE0148 | RATES AND PREDICTORS OF VIROLOGIC AND IMMUNOLOGIC RESPONSE TO THERAPY RESUMPTION AFTER TREATMENT INTERRUPTION IN HIV-1 CLINICAL PRACTICE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0148 G. Touloumi1, N. Pantazis1, H.A. Stirnadel2, S.A. Walker3, K. Porter3, CASCADE The majority of subjects who re-initiated treatment after TI, achieve virologic response but some may not achieve complete immune reconstitution. For a subgroup of subjects (aged> 40 years, with CD4<350 cells/µl and without virologic response to first HAART) future TIs may not be safely affordable. These patients need careful and close monitoring if they decide, or have to, interrupt therapy. |
| ThPE0149 | CD4 GUIDED TREATMENT MANAGEMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0149 T. Dyner, V. Cafaro, L. Boly CD4 guided treatment decision making is a valid approach to long term disease management. CD4 as the benchmark for beginning treatment is critical. Studies show patients maintain clinical benefit from cART despite resistance and ongoing viremia. New studies are now evaluating whether CD4 guided treatment decision making should be added to the algorithm by which we assess if our patients should be encouraged to continue failing but tolerable regimens when immunologic benefit prevails with CD4 count >350 cells/mm3. |
| ThPE0150 | PREDICTIVE VALUE OF BASELINE IMMUNOLOGICAL PARAMETERS FOR CD4 COUNT CHANGE IN HIV-INFECTED PATIENTS WITH CHRONIC VIRAL SUPPRESSION BEFORE UNDERGOING A TREATMENT INTERRUPTION: RETROSPECTIVE STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0150 K. Huang1, S. Boulet1, C. Tsoukas1, M. Loutfy2, N. Bernard1 In the setting of successfully treated chronic HIV infection, the lack of proliferation to CMV viral lysate at baseline was associated with a smaller drop in CD4 count during TI. Pre-TI immune parameters may have predictive value for CD4 count decline during TI. |
| ThPE0151 | FACTORS ASSOCIATED WITH ADHERENCE AND TREATMENT FAILURE IN DIRECTLY ADMINISTERED ANTIRETROVIRAL THERAPY (DAART): AN ANALYSIS OF OVER 16,000 OBSERVED DOSES IN METHADONE CLINICS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0151 G.M. Lucas, B.A. Mullen, R.D. Moore Ongoing drug use was associated with both non-adherence and treatment failure in a methadone-based DAART program. An increased risk of treatment failure was not observed until supervised dosing adherence rates fell below 70%. |
| ThPE0152 | FACTORS ASSOCIATED WITH NON-STRUCTURED TREATMENT INTERRUPTIONS (NTIS) AMONG INJECTION DRUG USERS (IDUS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0152 S.H. Mehta1, D. Vlahov2, J. Astemborski1, D.D. Celentano1, G.M. Lucas3, G.D. Kirk1, N. Galai1 NTIs were very common in this cohort of IDUs and occurred most frequently in the setting of active drug use and disruption of health care continuity. Effective linkages between primary care for HIV and substance abuse treatment may increase HAART sustainability and improve outcomes in this population. |
| ThPE0153 | A MOTIVATIONAL INTERVENTION FOR IMPROVING TREATMENT ENROLLMENT IN SYRINGE EXCHANGE PARTICIPANTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0153 M. Kidorf, R. Brooner The combination of motivational interviewing and behavioral incentives with a treatment readiness group appears to be an effective way to enhance enrollment in opioid agonist treatment in this important subset of untreated intravenous drug usrs, and improve the public health contributions made by community syringe exchanges. |
| ThPE0154 | DIRECTLY OBSERVED THERAPY (DOT) FOR THE TREATMENT OF HIV-INFECTION IN INJECTION DRUG USERS (IDUS): 2000-2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0154 H. Tossonian1, J. Raffa2, J. Grebely1, M. Viljoen3, M. Khara3, A. Mead3, M. McLean3, F. Duncan3, S. DeVlaming3, B. Conway1 Not only can DOT programs be developed for the administration of HAART in IDUs, but their success can be maintained for 6 years or more, paralleling the success of HAART in other patient groups. |
| ThPE0155 | ANTIRETROVIRAL THERAPY IN INTRAVENOUS DRUG USERS: RESULTS FROM A COMPREHENSIVE ROUTINE HIV CARE PROJECT IN NANNING, SOUTHERN CHINA GUANGXI ZHUANG AUTONOMOUS REGION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0155 N. Durier1, C. Loke2, Y.N. Yang1, Z.R. Tang3, D. Sauvageot4 Very good short to mid-term outcomes were seen among IDU starting routine care ART in our program, and despite more advanced HIV disease at baseline, outcomes were comparable for IDU and non-IDU. Provision of ART for this population should not be denied. |
| ThPE0156 | INJECTION DRUG USE (IDU), NON-IDU SUBSTANCE USE, AND RECEIPT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0156 D. Weinstein1, G. Barkanic1, C. McGowan1, S. Raffanti1, R. Moore2, T. Sterling1, T. Hulgan1 IDUs had more outpatient clinic visits per year, but less time on HAART than those with other substance use disorders and those without a substance use history. These results suggest that factors besides access to outpatient care limit HAART utilization in the IDUs. Future studies should better characterize these additional factors. |
| ThPE0157 | INTEGRATING VOLUNTARY COUNSELING AND TESTING AND PRIMARY CARE FOR INJECTION DRUG USERS IN NEPAL: AN ALTERNATIVE APPROACH FOR A HARD-TO-REACH POPULATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0157 J. Andrews1, D. Gurubacharya2, M. Adhikari3 The integration of VCT into PHC, which has been successful in other countries, is an appropriate alternative to stand-alone services in Nepal, particularly for engaging hard-to-reach populations. This model should be implemented for other populations such as commercial sex workers and labor migrants, for whom specialized NGOs are providing health care (such as STI services) but not VCT, and in rural areas, where few can travel for multiple days to visit stand-alone VCT sites but may be more likely to do so to access PHC. |
| ThPE0158 | SUCCESS STORY IN DOTS PROVISION FOR HIV POSITIVE INJECTING DRUG USERS IN CHENNAI, INDIA - A MODEL FOR REPLICATION IN DEVELOPING COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0158 P. Mahalingam1, K. Kalai Arasi2, K. Jacob2 Nurses in developing countries must acquire more knowledge on managing common opportunistic infections and put their learning into practice. Commitment from the community health nurses will surely improve the health seeking behaviour of the HIV-infected IDUs. |
| ThPE0159 | TREATMENT OF HIV+ DRUG USERS IN THE UKRAINE: IMPACT OF BUPRENORPHINE MAINTENANCE THERAPY (BMT) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0159 S. Dvoryak1, R.D. Bruce2, L. Sylla2, F. Altice2 More HIV+ drug users urgently need BMT to improve HIV and health outcomes. Legislative changes to existing drug policy are urgently needed, including less stringent laws for buprenorphine prescription and allowance of methadone to the existing national formulary. Moreover, the cost of buprenorphine from the current supplier is prohibitively expensive (US $0.71/mg) for sustainability of the scale up process. Buprenorphine requires lower negotiated prices and/or the addition of methadone to the existing formulary for HIV+ drug users. |
| ThPE0160 | HAZARDOUS ALCOHOL USE: A RISK FACTOR FOR NON-ADHERENCE AND LACK OF SUPPRESSION IN HIV INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0160 G. Chander, B. Lau, R. Moore Hazardous alcohol use alone and combined with IDU was associated with decreased ART uptake, adherence, and viral suppression. Interventions targeted at alcohol use may improve HIV outcomes. |
| ThPE0161 | INTEGRATING BUPRENORPHINE TREATMENT INTO HIV CARE: EXAMPLES FROM THE BUPRENORPHINE AND HIV CARE EVALUATION AND SUPPORT (BHIVES) COLLABORATIVE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0161 L. Weiss1, R. Finkelstein1, J. Netherland1, L. Eldred2, D. Fiellin3, P. Lum4, K. McElroy2, M. Gourevitch5 HIV treatment programs should consider providing integrated buprenorphine treatment. BHIVES outcomes will provide guidance regarding approaches to integrated service delivery that match clinical and patient characteristics and optimize HIV-related and opioid dependence outcomes. |
| ThPE0162 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0162 Abstract unavailable. |
| ThPE0163 | RELATIONSHIPS AMONG AT-RISK ALCOHOL USE, CRACK COCAINE, HAART, AND ADHERENCE OVER 10 YEARS IN A COHORT OF U.S. WOMEN WITH HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0163 D. Grey1, J. Cook1, J. Burke-Miller1, M. Cohen2, D. Vlahov3, F. Kapadia3, R. Cook4, R. Schwartz5, T. Wilson5, C. Ponath6, K. Anastos7, E. Golub8, J. Richardson9, L. Goparaju10 Women with HIV/AIDS in the U.S. who are at-risk for an alcohol problem, who use crack cocaine, or both are less likely to use HAART or to adhere to HAART regimens independent of psychological or socioeconomic status. Women may be selfmedicating, may be avoiding care, or may be may be less likely to be offered HAART by caregivers because of their use of drugs or alcohol. These issues should be addressed in this difficult to treat population. |
| ThPE0164 | LESSONS LEARNED IN THE BORDERLANDS: CASE NARRATIVES OF MEDICATION ADHERENCE BARRIERS AND FACILITATORS FOR PERSONS SURVIVING WITH A SERIOUS MENTAL ILLNESS AND HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0164 J. Roman1, N. Hanrahan2, D. Rolin1, L.H. Aiken3, M.B. Blank4 Stable housing, interpersonal relationship techniques and cognitive behavior therapy provide a base from which to build self agency and improve medication adherence. |
| ThPE0165 | THE PREVALENCE OF MENTAL ILLNESS AMONG HOMELESS AND MARGINALLY HOUSED HIV-POSITIVE INDIVIDUALS IN SAN FRANCISCO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0165 S. Weiser1, D. Bangsberg2, S. Dilworth1, J. Cohen2, E. Riley2 The majority of HIV-infected urban poor participants in this study screened positive for more than one lifetime psychiatric disorder, and had co-occurring substance abuse. The overwhelming burden of mental illness in this population requires critical attention both to decrease mental illness morbidity, and to improve HIV clinical outcomes and health care utilization. |
| ThPE0166 | NURSES PRESENT NARRATIVES OF LESSONS LEARNED ABOUT MEDICATION ADHERENCE OF PERSONS LIVING WITH HIV AND SERIOUS MENTAL ILLNESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0166 D. Rolin1, N. Hanrahan2, J. Roman1, L.H. Aiken3, M.B. Blank4 We recommend a consistent relationship over time with a psychiatric nurse who meets these clients in the community; coordinates the care among multiple providers and vendors, and intervenes with increasingly intense psychoeducation and memory aides to improve medication adherence. |
| ThPE0167 | ANTIRETROVIRAL TREATMENT CAN BE SUCCESSFUL WITHIN A PRISON SETTING. THE EXPERIENCE FROM BANGKWANG CENTRAL PRISON THAILAND! Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0167 M. Srisuphanthavorn1, B. Chayatub1, A. Chua2, V. Ngammee2, P. Cavailler2, R. Zachariah3, D. Wilson2 Our preliminary experience shows that it is possible to offer ART in a prison setting and satisfactory outcomes can be achieved under program conditions. Efforts should be made to ensure that prisoners too, have access to basic HIV/AIDS prevention and care interventions including ART. |
| ThPE0168 | ANTIRETROVIRAL THERAPY OF HIV-INFECTED INJECTION DRUG USERS, PERSONS IN A DRUG ADDICTION TREATMENT PROGRAM, AND FORMER DRUG USERS: THE SWISS HIV COHORT STUDY (SHCS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0168 M. Huber1, B. Ledergerber1, M. Rickenbach2, H. Furrer3, L. Elzi4, B. Hirschel5, M. Cavassini6, E. Bernasconi7, P. Vernazza8, R. Weber1, Swiss HIV Cohort Study Compared with non-IDU, "IDU" who had ceased injecting drugs had a similar likelihood of being on ART and of having a suppressed viral load. In contrast, persons with continued IDU (i.e., injecting while in a DTP, current IDU) were less likely to have a suppressed viral replication, and the rate of AIDS was higher. |
| ThPE0169 | FIELD TESTING OF WORLD HEALTH ORGANIZATION (WHO) RECOMMENDATIONS FOR INITIATING ANTIRETROVIRAL THERAPY (ART) WHERE CD4 IS NOT AVAILABLE REVEALED DISAPPOINTING SENSITIVITY AND SPECIFICITY AMONG STAGE I AND II PATIENTS; A TOTAL LYMPHOCYTE COUNT (TLC) CUT-OFF OF <2500 CELLS/ML COULD HELP RATION THE REFERRAL FOR CD4 TESTING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0169 K. Chan1, D. Tu2, C. Mills3, R. Elema3, M. Verputen4, R. Bedell5, M. Olaiya6, K. Braker7, L. Shanks8, R. Adlington9, B. Hogg1 A large number of patients in stage I or II are eligible for ART but are missed by WHO criteria. This study highlights the need for improved access to CD4 for these patients. A clinical algorithm, using a TLC cut-off of 2500cells/ml, will be presented as a tool for rationing the use of CD4 testing in this population. |
| ThPE0170 | THE ROLE OF ACCOMPAGNATEURS IN DELIVERY OF ANTIRETROVIRAL THERAPY IN RURAL RWANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0170 K.C. Walker1, J.M. Harerimana2, J.J. Furin3, H.M. Epino1, S.N. Stulac1, F. Chelot4, M.L. Rich3 By training and employing community members to accompany patients receiving ART, it is possible to scaleup rapidly and achieve high rates of patient retention. The training and compensation of accompagnateurs improves their own quality of life and allows them to educate others in the community at large. |
| ThPE0171 | WE STOP AIDS: A SIMPLE CHECKLIST FOR HEALTH CARE WORKERS TO IDENTIFY CONDITIONS POSSIBLY RELATED TO HIV WITH THE AIM OF INCREASING REFERRALS TO VOLUNTARY COUNSELLING AND TESTING (VCT) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0171 F. Breitenecker1, H. Kamwetsa2, J. Mwale2, L. Gonzalez2, C. Breitenecker1, M. Joshua3, M. Ngwira3, L. Linje4, D. Chimutu4 The WE STOP AIDS checklist should be widely introduced to health care providing facilities in resource limited settings with high HIV prevalence. The checklist has shown to be a simple and well accepted tool for identification of patients possibly infected with HIV and improving referral rates to VCT. |
| ThPE0172 | INCREASE IN UPTAKE OF VOLUNTARY HIV TESTING IN THE SETTING OF COMPREHENSIVE FREE HEALTH CARE IN RURAL HAITI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0172 L.C. Ivers1, R. Cruff2, J.G. Jerome2, P. Paul2, M. Raymonville2, J.S. Mukherjee3 Rates of uptake of HIV testing increased dramatically in the context of providing quality general medical and HIV care free of charge. By integrating HIV testing with routine medical care and encouraging consulting clinicians to offer tests, a high rate of acceptability and uptake of HIV testing can be achieved. |
| ThPE0173 | EXPERIENCE WITH TENOFOVIR DF (TDF) + EMTRICITABINE (FTC) IN ANTIRETROVIRAL-NAĎVE PATIENTS AT UGANDA CARES, A RURAL AFRICAN HIV TREATMENT PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0173 B. Okongo1, P. Iutung1, H. Katete1, E. Namagala2, E. Madraa2, M. Ssonko1, C. Simmons3, M. Adair4, C. Farthing4, M. Weinstein4, D. Namusoke5, N. Kenya-Mugisha6, H. Chang7 This experience demonstrates a first-line TDF-based ARV backbone results in less morbidity compared to regimens containing either AZT or d4T. The improved tolerability and safety outcomes observed in the TDF/FTC regimen may be more striking in resource limited settings, than in resource rich settings - probably because patients begin ART at much lower CD4 counts. |
| ThPE0174 | FROM PMTCT TO COMPREHENSIVE MOTHER AND CHILD HIV CARE SERVICES, EXPERIENCE OF MARAGWA DISTRICT IN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0174 L. Marani1, J. Kauki2, M. Kamande1, D. Odera3, V. Torres4 Integration of comprehensive care services within the MCH in rural settings by changing testing strategy including group counseling, use of the opt out approach, increase in manpower allows for better access by a majority of future mothers who then exhibit a lower drop out rate as well as optimizing the resources available. |
| ThPE0175 | CARE - AN OPEN-LABEL COHORT PROGRAM TO EVALUATE THE IMPACT OF PROVIDING FREE COMPREHENSIVE CLINICAL CARE TO HIV-1-INFECTED INDIVIDUALS IN RESOURCE-LIMITED SETTINGS IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0175 E. Bissagnene1, C.F. Otieno2, P.S. Sow3, C.F. Kityo4, E. Waalberg5, T. Rinke de Wit6, F. Wit7, E. Hassink7, R. Bennink7, J. Lange6 Although CARE was envisaged as an access program, it was executed as a clinical study. Regulatory and logistic problems emerged (such as adhering to ICH-GCP guidelines and time to gain ethical approvals). Source documents had to be adjusted, instructions for correct drug-handling and drug-accountability were necessary, and laboratory procedures had to be adjusted in line with Western standards. Data monitoring frequency was intensified and site managers were appointed to improve communication because of language problems, cultural differences and long-distance management. Additional funding was provided for treatment of adverse events and co-morbidities. Despite the operational lessons, CARE shows that the impact of providing free comprehensive clinical care in resource-limited settings can be comparable to a Western setting. To mitigate start-up problems in the future, it is recommended to perform a pilot program with a few patients before the actual program starts. |
| ThPE0176 | IMPROVING THE ODDS: CONSIDERING THE OPERATIONAL BARRIERS TO EFFECTIVE HIV ARV DELIVERY IN LOW RESOURCE SETTINGS - LESSONS FROM SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0176 J. McGuire1, N. Makwedini2 Formative evaluation of ARV delivery site development should take place throughout the planning and implementation processes; monitoring and evaluation efforts need to focus on specific site-based challenges; strategies for facilitating donor effort integration into sustainable system responses are needed. |
| ThPE0177 | MORBIDITY AND MORTALITY AMONG HIV-INFECTED WOMEN AND THEIR INFANTS WHILE PARTICIPATING IN A CLINICAL TRIAL IN MALAWI: THE BAN STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0177 B. Bramson1, L. Hyde2, C. Chasela2, C. Chavula2, M. Majawa2, N. Mumba2, M. Hosseinipour3, Y. Ahmed4, A. Kourtis4, R. Jafali2, G. Tegha2, G. Joaki2, R. Knight5, F. Martinson2, D. Chilongozi2, P. Kazembe6, D. Jamieson4, C. van der Horst1, the BAN Study Despite the inclusion within clinical trials of high quality care and laboratory support, morbidity and mortality in resource-poor settings can remain high. This may result from factors difficult to remediate within the context of a research trial. |
| ThPE0178 | PEDIATRIC HAART IN RESOURCE-LIMITED SETTINGS: THE DREAM MODEL OF CARE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0178 G. Liotta1, P. Germano2, L. Palombi1, E. Buonomo1, P. Scarcella1, M. Magnano San Lio3, P. Narciso4, C.F. Perno5, N. Abdul Magid6, M.C. Marazzi7, DREAM program The impact of HAART on the survival and quality of life of children appears to be extremely relevant. The necessity of guaranteeing good adherence to treatment calls for the implementation of ad hoc treatment models. Home care is a very effective tool to encourage and support parents/relatives of children. |
| ThPE0179 | USING LAY PROVIDERS AS HIV MEDICS TO BRIDGE THE HUMAN RESOURCE GAP IN ART SERVICE DELIVERY: EXPERIENCES FROM UGANDA AND ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0179 G. Musoke1, G. Akampumuza1, M. Adair2, P. Iutung1, R. Burrows3, R. Nsakanya4, M. Weinstein2, C. Farthing2, H. Chang5, B. Okongo1 There is a need to get HIV Medics recognized, certified then entered into the health system. There is further need to train more of them considering the short time it takes to complete, good quality of work they do and urgent need to fill HR gaps. |
| ThPE0180 | IS OBSTETRIC SURGICAL INTERVENTION SAFE IN HIV-INFECTED WOMEN IN A RESOURCE LIMITED SETTING? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0180 R. Bhosale1, M. Bhide2, S. Dabak3, P. Naphade3, N. Gupte2, J. Sastry2, R. Bollinger4, B.J.Medical College-Johns Hopkins University MTCT Study group With adequate peripartum care, obstetric surgical interventions are safe in HIV-infected women in resource-limited settings. Some rise in cesarean wound discharge and risk of episiotomy gaping observed in HIV-infected women is not significant. |
| ThPE0181 | EARLY IMMUNOLOGIC AND VIROLOGIC RESPONSES TO ART IN RURAL RAKAI, UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0181 S.J. Reynolds1, J. Kagaayi2, G. Nakigozi2, F. Makumbi2, P. Opendi2, P. Nakamya2, R. Gray3, M. Wawer3, T.C. Quinn4, T. Lutalo2, D. Serwadda2 The majority of participants achieved full viral load suppression at 6 months. Very few participants would have been identified as being at risk for early virologic failure by immunologic monitoring alone emphasizing the need for low cost methods for viral load monitoring. |
| ThPE0182 | ASSESSMENTS AND CERTIFICATION OF HOSPITALS AS CATALYSTS TO IMPROVE THE QUALITY OF SERVICES IN THE NATIONAL HIV/AIDS CARE AND TREATMENT PROGRAM OF TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0182 R.O. Swai1, B. Bwijo1, D. Kihwele1, E. Straatsma2, G. Haverkamp2 This process has been a catalyst to improve the quality of C&T services. After the assessment visit ART providers had a complete picture, usually for the first time, of the weaknesses and costs to provide C&T at their facility. Certification of sites serves as an incentive for further improvement. The centrally collected assessment data are useful for program planning purposes by the Ministry of Health/NACP. |
| ThPE0183 | FREEWARE DATABASE FOR FOLLOW-UP OF HIV-PATIENTS AND PROGRAMS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0183 S. Thai1, A. Len1, P. De Munter2, O. Koole2, W. Schrooten3, L. Lynen2 Scaling up of clinical HIV care and treatment services in resource poor settings gives rise to large cohorts of patients in chronic care. This requires monitoring of individual patients, cohorts and programs; a complex task which can only be successfully performed by using an electronic database. |
| ThPE0184 | FACTORS ASSOCIATED WITH VERTICAL TRANSMISSION OF HIV IN A COHORT WITH LOW RATES OF PERINATAL TRANSMISSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0184 E.S. Machado1, C.B. Hofer1, S.A. Nogueira2, T.P. Costa3, I.F.A. Farias3, R.T.C. Mercadante3, M.d.F.L. Garcia3, A.C.S. Loureiro3, V.M. Costa3, V.H.A. Ximenes3, R.H. Oliveira3, T.F. Abreu3, J.S. Lambert4 A low rate of VT was possible through a multi-disciplinary team approach to pregnant women, distribution of ARV and formula free of charge and avoiding breastfeeding. In this ideal situation, prolonged ruptured of membranes and irregular use of ARV during prenatal or labor were the main factors associated with perinatal transmission of HIV. |
| ThPE0185 | NUTRITIONAL SUPPORT FOR INFANTS OF NON-BREASTFEEDING, HIV-POSITIVE MOTHERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0185 R. Ternier1, A. Beckett2, F. Dieudonne3, F. Chelot3, J.S. Mukherjee4, L.C. Ivers5 PMTCT programs continue to debate the merits of breastmilk versus formula in the developing world; however, in both cases, infants are vulnerable to malnutrition after weaning. This program demonstrates that in the context of comprehensive HIV care, a simple, relatively inexpensive nutritional support program has a high rate of acceptability and high level of success in preventing morbidity and mortality among infants of non-breastfeeding HIV-infected women during the weaning period. |
| ThPE0186 | PRIVATE SECTOR INVOLVEMENT IN NATIONAL SCALE UP OF ANTIRETROVIRAL THERAPY (ART) IN MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0186 E.J. Schouten1, S. Chuka2, E. Libamba3, S. Makombe3, A.D. Harries3, R. Kumwenda2, D. Lungu4 The private sector should be considered in the national scale up plans for ART. |
| ThPE0187 | ANTIRETROVIRAL ADHERENCE: INDICATIONS OF A POTENTIAL PROBLEM IN KZN, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0187 I. Corless1, D. Wantland2, P. Nicholas1, P. McInerney3, B. Bhengu3, B. Ncama3, C. McGibbon4, S. Davis5 These findings indicate that those with longer time on ARVs were less adherent than those newly starting ARV regimens. This indicates the need for strengthening interventions to maintain the 95% or better adherence required to prevent subsequent resistance to the available ARV regimens. These interventions should focus on providing food supplements to persons receiving antiretroviral medications, and strengthening an individual's knowledge of self-care symptom management as a component of improving an individual's sense of well-being. |
| ThPE0188 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0188 Abstract not available. |
| ThPE0189 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0189 Abstract not available |
| ThPE0190 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0190 Abstract not available |
| ThPE0191 | EVALUATION OF MORTALITY AND OTHER PROGRAMME LOSSES IN A COMMUNITY-BASED ANTIRETROVIRAL PROGRAMME IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0191 S. Lawn1, L. Myer2, G. Harling1, C. Orrell1, L.-G. Bekker1, R. Wood1 Loss to follow-up and late mortality rates were low, reflecting good cohort retention and treatment response. However, the extremely high pre-treatment and early mortality rates indicate that patients are enrolling with far too advanced immunodeficiency. Causes of late access to the ART programme such as delays in health care access, health system delays, or inappropriate treatment criteria need to be addressed. |
| ThPE0192 | DECENTRALIZED INTEGRATED TB/HIV PROGRAM IN AN UNSTABLE ENVIRONMENT (NIMBA COUNTY, LIBERIA) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0192 D. Eibach1, M. Zar2, C.P. Nyantee3, A. Runge2 At present MSF is the only NGO who provides VCT and HIV services in upper Nimba. Our future plans include expanding HIV awareness campaigns, especially in the field of ANC, to offer daily VCT in all the PHCs, to introduce ARVs for HIV-2 and 2nd line. |
| ThPE0193 | VISUAL INSPECTION WITH ACETIC ACID (VIA) FOR CERVICAL CANCER SCREENING IN HIV-INFECTED ZAMBIAN WOMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0193 V. Sahasrabuddhe1, G. Parham2, M. Mwanahamuntu3, V. Mudenda3, S. Vermund4 Although it had a lower sensitivity than cytology in our study, the comparable specificity makes VIA a useful adjunct test to cytology for reducing the number of false positive results. Reduced loss to follow-up may improve overall program effectiveness of programs incorporating VIA. "See-and-treat" protocols involving VIA-based screening need evaluation in clinical trials for HIV-infected women in resource limited settings. |
| ThPE0194 | ADHERENCE TO ANTIRETROVIRAL THERAPY AMONG INDIAN HIV-INFECTED PERSONS SEEKING CARE IN THE PRIVATE SECTOR IN MUMBAI, INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0194 B. Shah1, L. Walshe2, D.G. Saple3, S. Mehta4, J.P. Kharkar5, J.P. Ramnani5, R. Bollinger2, A. Gupta2 Adherence among persons seeking care in private clinics in Mumbai appears to be similar to that reported in the West, despite high monthly out-of-pocket ARV costs. |
| ThPE0195 | VILLAGE OUTREACH VCT AND HIV TREATMENT PROGRAM IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0195 M. Adair1, P. Iutung2, S. Volz3, D. Ahairwe2, T. Grimes4, M. Weinstein1, B. Okongos2, H. Chang5 Most Ugandans live in rural areas and are extremely poor. They cannot afford to travel long distances to access HIV testing and care. Without out reach interventions hundreds of people would not know their HIV status nor access life saving medications. Endeavors are ongoing to expand this program to other rural areas in Uganda. |
| ThPE0196 | HIV/AIDS UNIVERSITY DEGREE FOR FRENCH SPEAKING HEALTHCARE PROFESSIONALS OF SUB-SAHARAN AFRICA: THE INTERNATIONAL TRAINING COURSE OF OUAGADOUGOU (BURKINA FASO) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0196 J.-B. Guiard-Schmid1, J. Drabo2, A.B. Sawadogo3, P. Guissou4, A. Ouédraogo5, M. Sawadogo6, G. Pialoux1, W. Rozenbaum7 However, it should be integrated in a Master degree and follow-up of students after the training should be added to the next session (2006, May 29 to June 24). Trainers will follow the students one year after the training and short recycling training sessions will be created next year for the past students. |
| ThPE0197 | SUPPORTING ART ADHERENCE IN A PREDOMINANTLY IDU DRIVEN EPIDEMIC: THE VIETNAM EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0197 R. Burdon1, V.N. Phinh2, D.D. Cuong3 Adherence to ART is an essential part of any ART program. Strategies for successful adherence in a predominantly IDU driven epidemic provide significant challenges to many countries scaling up ART programs. |
| ThPE0198 | DO HEALTH CARE WORKERS WITH HIV/AIDS HAVE DELAYED INITIATION OF ANTIRETROVIRAL THERAPY AND HIGHER MORTALITY WHEN COMPARED WITH OTHER PATIENTS IN MALAWI? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0198 K. Bezanson1, K. Pouteau1, A. Mnthambala2, P. Stephany2, D. Chiwewe2, R. Kumumbala2, J. Orbinski3, R. Upshur4, M. Schull4, K. Rouleau4 HCWs may be less likely than non-HCWs to initiate ARV at an earlier stage of HIV/AIDS, and their mortality rate may be higher. The largest proportion of HCWs initiated ARV in Stage IV. These results are not explained by distance from home to clinic or differences in education. Our results suggest the need to better understand HCW attitudes toward their risk of HIV/ AIDS and barriers to treatment access. |
| ThPE0199 | COMMUNITY BASED TREATMENT AND CARE TO CHILDREN LIVING WITH AIDS: EXPERIENCES FROM AN AREA WITH HIGH HIV PREVALENCE AND LOW RESOURCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0199 C. To1, R. Song2, H. Ding3 Within the next few years, Chi Heng would like to continue working with the Clinton Foundation and the Chinese government to expand the program to cover at least the whole county, where over two hundred children need to take pediatric antiretroviral drug. |
| ThPE0200 | DELAYED RECOGNITION OF HIV INFECTION IN MALNOURISHED CHILDREN IS ASSOCIATED WITH POOR CLINICAL OUTCOME IN LOW HIV PREVALENCE SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0200 C.V. Nweneka This study suggests that delayed diagnosis of HIV infection in severely malnourished children is associated with poor clinical outcome. In low prevalence resource-poor settings where such diagnosis is likely to be missed, clinical guidelines outlining the indications for HIV screening in malnourished children might improve clinical outcome. |
| ThPE0201 | INTEGRATED TB AND HIV SERVICES: AN APPROACH FOR QUALITY IMPROVEMENT OF CARE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0201 P. Wannasorn Expansion the model with emphasized in quality, suggestive, and repeated HIV counseling for TB patients. Explore for high TB mortality rates are needed. |
| ThPE0202 | COMMUNITY DRIVEN HIV/AIDS CARE AND TREATEMENT IN RESOURCE LIMITED SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0202 S. Kassaye1, F. Ndayishimiye2, I. Tiendrebeogo3, A. Herman4, L. Francis5, D. Onyango6, R. Machekano7, A. Sall2, D. Israelski8 This model is effective in delivering ART to people who need them the most. Immunological and clinical monitoring occurred at regular intervals. People enrolled in community based ART programs are experiencing immunological benefit despite the absence of intense virologic monitoring. We recommend the CDD model as part of the global strategy to scale up ART in resource limited settings. |
| ThPE0203 | SPECIMEN REFERRAL SYSTEM: QUALITY LABORATORY SERVICES FOR ART DELIVERY AT ALL LEVELS OF CARE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0203 K. Torpey1, F. Mwale2, L. Stuart3, G. Bryan2, N. Lamson1, C. Thompson1, Y.D. Mukadi4 To optimize resources in the purchase and use of laboratory equipment, especially CD4 machines, a specimen referral system can be employed to provide quality laboratory service at all ART sites. |
| ThPE0204 | MISSING THE TARGET: 3×5, THE GLOBAL FUND, AND TREATMENT ACCESS IN THE DOMINICAN REPUBLIC - LESSONS FROM THE INTERNATIONAL TREATMENT PREPAREDNESS COALITION REPORT CARD Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0204 E. Schiff1, R. Stern2, M. Galeas3, P. Pina4, C. Collins5 Long term resource commitments for universal treatment access are needed by the Dominican government and international donors. Civil society advocacy and research must be strengthened, and encouraged. The widespread and corrosive influence of political patronage related to public health policy must be avoided or minimized to ensure resource allocation and treatment scale up occurs efficiently and medicines and care are available where and to those who need them most. HIV/AIDS outpatient treatment sites must provide improved care to people living with both HIV and TB. |
| ThPE0205 | RAPID SCALE UP AND SUCCESSFUL TRANSITION FROM FEE-PAYING TO FREE OF CHARGE ANTIRETROVIRAL THERAPY (ART) IN QUEEN ELIZABETH CENTRAL HOSPITAL, BLANTYRE, MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0205 J.J.G. van Oosterhout, J.J. Kumwenda, G. Mateyu, T.K. Hartung, P.N.A. Harris, E.E. Zijlstra Identification of ART failure, combined HIV - tuberculosis treatment, the long waiting list for ART and an expanding administration are challenges in the ART clinic of QECH that await innovative solutions. |
| ThPE0206 | SUCCESSFUL COMMUNITY STRATEGIES TO PREVENT POST PARTUM HIV TRANSMISSION IN THE DOMINICAN REPUBLIC Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0206 E. Perez-Then1, R. Espinal2, L. Rivera3, R. Carvajal2, V. Sanchez4, R. Rodriguez4, B. Meteluz4, M. Algarroba4, L. Santos5, B. Fernandez5, C. Wilfert6, A. Ammann7, G. Shor-Posner8 These results demonstrate the importance of developing specific community strategies to prevent post partum HIV transmission and to establish links to soccial support. Increased emphasis by the community component supervisors and counselors on the benefits of cup, instead of bottle feeding, would likely establish an even greater increase in preventing diarrhea episodes. |
| ThPE0207 | LINKAGE TO CARE AND MORTALITY AT 18 MONTH FOLLOW-UP IN A COHORT OF NEWLY DIAGNOSED HIV-POSITIVE MEDICAL INPATIENTS IN MULAGO HOSPITAL, UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0207 R. Wanyenze1, D. Bangasberg2, C.A. Liechty3, J. Nansubuga1, H. Kasakye1, A. Gasasira1, H. Mayanja-Kizza1, M.R. Kamya1 Majority of the patients were receiving HIV/AIDS care and treatment at 18 months. However, the delay in accessing care coupled with high mortality highlights the need for earlier diagnosis and linkage to care. The high disclosure rate to spouses promotes prevention and support of infected individuals but limited disclosure to other sexual partners needs to be addressed during follow-up counseling. Although, positive outcomes of testing were predominant, the negative outcomes warrant attention during follow-up support, care and treatment. |
| ThPE0208 | USE OF AN EXISTING TUBERCULOSIS PROGRAM TO IMPLEMENT ANTIRETROVIRAL TREATMENT IN AN URBAN SLUM, NAIROBI KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0208 L. Wanjiku Nganga1, E. Phillips2, A. Njoroge2, J. Odhiambo3, O. Muhenje3, B. Marston3, L. Marum3, K. DeCock3 Using preexisting TB program infrastructure is an effective strategy to increase access to HIV care and treatment in resource limited settings and can be used to identify ART eligible patients by screening all TB suspects irrespective of the TB outcome. |
| ThPE0209 | HEALTH SYSTEM AND NGO ALLIANCE FOR EFFECTIVE PREVENTION OF MOTHER TO CHILD TRANSMISSION OF HIV IN A WEST AFRICAN COUNTRY: A FEASIBLE CHALLENGE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0209 M. Kande1, S. Rashed2, S. Diakite3, L.Y. Toure4, S. Charron5, O. Laplante5 Extension of this experiment should take the same attention to reinforcement of the health system in synergy with NGOs who carry out mobilisation activities to ensure adhesion to programm activities and support the organisation of people infected and affected by HIV. |
| ThPE0210 | SECURE THE FUTURE COMMUNITY-BASED TREATMENT SUPPORT PROGRAMMES DELIVER QUALITY CARE FOR HIV PATIENTS IN RESOURCE-LIMITED SETTINGS IN SOUTHERN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0210 R. Wanless1, H. Sattie2, Z. Chirwa3, S. Khan4, J. Kabengele5, P. Mahaliyana6, R. Sayed7 Delivering quality, comprehensive care for HIV/AIDS patients in resource-limited settings is challenged by inadequate personnel and infrastructure, high levels of stigma and poor education. The Bristol-Myers Squibb Secure the Future project launched four community-based treatment programmes for patients with HIV/AIDS in resource-limited settings in southern Africa in 2004. The programmes were partnerships between a hospital clinic and community-based organizations and aimed to provide holistic care comprising community and clinical services. |
| ThPE0211 | NEW APPROACH FOR PROVIDING AN ESSENTIAL PACKAGE OF CARE FOR PLHA IN NEPAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0211 K. Moktan1, L. Stevens1, A. Basnyat1, P. Miller2 Basic HIV care and treatment (health assessment, OI prophylaxis and treatment and palliative care) should be made available to PLHA and services strengthened even in resource-poor settings where ART is not yet available. |
| ThPE0212 | TRAINING DOCTORS IN DEVELOPING COUNTRIES – A TWINING PROJECT BETWEEN AIDS HEALTHCARE FOUNDATION (AHF), LOS ANGELES, AND THE SHANGHAI PUBLIC HEALTH CENTER (SPHC), YIELDS RESULTS AND PROVIDES A MODEL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0212 C. Farthing1, H. Lu2, W. Xu2, D. Lui3, Y. Cao4, AIDS Healthcare Foundation, Shanghai Public Health Center We hope that this bilateral/twinning arrangement will serve as a model for other institutions to emulate, and we would hope that every major HIV treating institution in the developed world will make similar linkages. |
| ThPE0213 | PRELIMINARY OUTCOMES OF PROVIDING ANTIRETROVIRAL THERAPY TO CHILDREN AT A PUBLIC SECTOR HIV CLINIC IN LESOTHO, SOUTHERN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0213 J. White1, R. Armstrong1, L. Lekena2, M. Mitchel1, P. Berger3, B. Cornelson3, J. Young1, J. Redelinghyus1, T.-t. Sepetla2 The first group of children to receive care at Tšepong Clinic were in advanced stages of their HIV infection. Initiating and supporting children on ARVs before they reach advanced illness remain significant challenges. |
| ThPE0214 | ASSESSMENT OF PHARMACEUTICAL MANAGEMENT SYSTEMS IN SUPPORT OF THE KENYA NATIONAL ANTIRETROVIRAL PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0214 N. Kusu, C. Njuguna, J. Mukoko, J. Maundu, J. Wachira, M. Thuo, M. Wangai A survey using a rapid, targeted approach quickly identifies key problem areas and generates site-based recommendations. Programs should use assessment results immediately for both strategic planning and implementing interventions. Using ART staff to perform other site assessments builds skills in monitoring, designing interventions, and training, which they can apply in their own facilities. |
| ThPE0215 | NURSE CENTERED CLINIC ORGANIZATION IN LOW RESOURCE SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0215 C. Lyons, T. Clark, J. Friend, M.-L. Hicks, C. Ramstead, G. Vandenberg Minimal training is required to provide tools to expand the role of nursing, and can be implemented at clinic sites. Full utilization of health care professional´s skills is essential to quality care, and meeting the need. |
| ThPE0216 | PERCEIVED BARRIERS AND PROPOSED SOLUTIONS TO IMPLEMENT COMBINED TB/HIV ACTIVITIES IN ZAMBIA AND SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0216 K. Shanaube1, H. Ayles1, N. Beyers2, P.-G. Faussett3, ZAMSTAR Study Team Delivery of combined TB/HIV activities in resource poor health systems and communities is a major challenge. Some of the barriers identified require additional investment. However, others may be overcome by re-orienting existing services. |
| ThPE0217 | PREVALENCE AND PREDICTORS OF DEPRESSIVE SYMPTOMS AMONG YOUTH-HEADED HOUSEHOLDS IN GIKONGORO, RWANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0217 L. Brown1, N. Boris2, J. Rice3, T. Thurman1, J. Ntaganira4, L. Snider5 YHH should be targeted for psychosocial interventions in AIDS-affected areas. Programs which focus on food security and also target social inclusion and grief are indicated. Meeting the needs of the large number of children cared for by youth who report high levels of depressive symptoms is critical. |
| ThPE0218 | COMMUNITY BASED, MULTI-PARTNERSHIP CARE MODEL IMPROVES ADHERENCE IN RESOURCE-LIMITED SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0218 Y. Abebe1, D. Selassie2, S. Ejigu2, R. Lekasse2, C. Harris3, D. Siraj4, A. Getachew5, I. Asfaw6, H. Getu7, T. Sinclair8, D. Stevens8, T. Nolan9, A. Getaneh10 The care model must be refined and strengthened to address more patients requiring care. Replication of the care model in other hospitals within the country will markedly improve the effectiveness of national ART program. |
| ThPE0219 | SCALING UP ANTIRETROVIRAL THERAPY FOR IMPOVERISHED HIV-1-INFECTED PATIENTS IN RURAL CAMBODIA: FEASIBILITY, EFFICACY AND SAFETY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0219 D. Laurillard1, K.K. Lak2, S. Peo3, S. Yim4, W. Taing5, S. Sun4, T. Phe6, K. Khen1, T. Sok1, A. Goldfeld7 Provision of HAART to adults and children in a rural resource-poor setting by a local NGO upon a TB treatment platform is effective. Access to HAART in rural areas will decrease the number of patients who must relocate to urban centers to obtain treatment, resulting in severing critical economic and emotional support networks leading to further destitution and poor outcomes. |
| ThPE0220 | THE IMPACT OF DIRECT NUTRITIONAL INTERVENTION ON IMMUNE AND ANAEMIC STATUS OF HIV POSITIVE PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0220 B. Sackey1, F. A Yeboah2, S.J. Anie3, P. Oti-Boateng4, J. Dontwi5 Our study clearly shows the benefit of good and early nutrition intervention on the quality of life of PLWHAs and perhaps the progression of HIV infection. |
| ThPE0221 | THOROUGH TRAINING, SUPPLIES, SUPERVISION AND SUPPORT IMPROVES MOTIVATION AND RETENTION OF CRITICALLY NEEDED COMMUNITY HOME-BASED CARE (CHBC) VOLUNTEERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0221 A. Chinguwo, S. Namakhwa, N. Bamusi The impact of HIV/AIDS in Malawi, like in many Sub Saharan countries, far exceeds the health system's capacity. Thus, motivated volunteer home-based carers are a critical part of the response for chronically ill people and their families. |
| ThPE0222 | EXPERIENCES AFTER HANDOVER OF A COMPREHENSIVE CARE PROJECT TO THE MINISTRY OF HEALTH (MOH) OF GUATEMALA AND THE GLOBAL FUND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0222 M.J. Valverde, F. Doerner The sustainable handover was only possible due to the price reduction for HAART and reliable supply lines with needed drugs. National and regional procurement systems have to be developed and emergency supply plans in place. |
| ThPE0223 | TREATMENT OUTCOMES AMONG PATIENTS TREATED WITH STANDARD HAART REGIMENS IN BUSIA, WESTERN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0223 E. Carillo de Casas, H. Cox, C. Ferreyra, P. Isaakidis, C. Mansilla, M.J. San Miguel, S. Moore, F. Mitjavilla, A. Revuelta, M. Rodriguez This program demonstrates the feasibility and efficacy of providing HAART routinely in a resource constrained setting. Survival at 12 months after treatment initiation remains high. To reduce mortality further, there is a need to start patients on treatment before CD4 levels fall to below 50. |
| ThPE0224 | ENSURING QUALITY PATIENT CARE DURING RAPID SCALE UP OF ANTIRETROVIRAL (ARV) THERAPY IN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0224 M. Morris, C. Bolton, J. Mwanza, H. Manda, M. Gillespie, M. Kabeta, S. Reid Quality care can be achieved, even in large ART programs, with adequate allocation of resources and innovative approaches to continuous quality control, feedback, task shifting and supportive supervision. |
| ThPE0225 | E-MEDICINE HEALTHCARE INFORMATION DELIVERY TO OPTIMIZE THE CARE OF HIV/AIDS PATIENTS IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0225 S.P. Sood1, V.W.A. Mbarika2 There is a dire need to aggressively combat the HIV/AIDS pandemic through healthcare information delivery to both patients and healthcare workers, especially African physicians who may not have easy access to such information while based in Africa. E-medicine is a modality of healthcare information and service delivery where consumers seek support from distant locations, using information technologies (IT). E-medicine has the potential to improve the delivery of HIV/AIDS information by providing increased access for underserved communities to a range of valuable services. In several African countries, E-medicine healthcare information delivery is beginning to improve the care of PWAs and is an increasingly important component of HIV/AIDS care and support, particularly for such resource-limited settings. |
| ThPE0226 | SUSTAINING A YOUTH CAREGIVING PROGRAM: LESSONS AFTER A FIVE-YEAR PROGRAM IN RURAL NORTHERN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0226 E. Williams1, C. Searle1, S. Geibel2, K. Schenk3, A. Zulu4 To help sustain youth caregiving activities, program managers should plan ahead to build capacity, including increasing ability to mobilize local resources, transfer roles and responsibilities to community actors, and generate greater community support to meet the needs of PLHA, OVC, and families. |
| ThPE0227 | TRAINING CLINICAL OFFICERS AND REGISTERED NURSES IN UGANDA AND ZAMBIA: TOWARDS HUMAN CAPACITY BUILDING FOR DELIVERY OF ART IN CLINICS AND HOSPITAL SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0227 M. Adair1, G. Musoke2, P. Iutung2, G. Akampumuza2, R. Burrows3, R. Nsakanya4, M. Weinstein1, C. Farthing1, B. Okongo2, H. Chang5 AHF's training program has succeeded in expanding the pool of specialized HIV care providers in these countries and, by complementing the Medical Officers' ability to care for more patients, has greatly aided ARV scale-up efforts. Plans are now under way to provide similar trainings in Rwanda and Swaziland. |
| ThPE0228 | ALTERNATIVE DELIVERY OF CARE TO PLWA: LESSONS AND CHALLENGES FROM UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0228 M. Kyakuwa Need to build more coalitions and partnerships for care delivery if ART programs are to be sustained. |
| ThPE0229 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0229 Abstract not available. |
| ThPE0230 | IMPLEMENTING ROUTINE DIAGNOSTIC HIV COUNSELING AND TESTING IN TB CLINICAL SETTINGS IN TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0230 S. Egwaga1, Z. Msumi2, N. Bock3, P. Nadol3, E. Mmari4, J. Moore3, B. Miller3 Linkages between TB and HIV programs need strengthening to establish reliable mechanisms for referrals between programs. DCT roll out should continue and be coordinated with ART scale up. |
| ThPE0231 | THE SOCIAL HEALTH CLINIC: AN INTERNATIONAL PARTNERSHIP IN PHNOM PENH, CAMBODIA: FIRST 15 MONTHS OF OPERATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0231 S. Chel1, S. Huffam2, J. Elliott2, S. Pouv1, C. Hun1, V. Saphonn1, J. Kaldor2, D. Cooper2, C.V. Mean1 Rapid enrolment and commencement of ART were achieved during the initial period of operation of SHC whilst maintaining adequate follow up and treatment outcomes. Substitution of single agents for toxicity and drug interactions were common. |
| ThPE0232 | WHO STAGING, CD4 AND TOTAL LYMPHOCYTE COUNT THRESHOLD'S PROGNOSIS OF HIV/AIDS PATIENTS IN RESOURCE LIMITTED SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0232 F. Mitjavila1, A. Cirera Viladot2, L. Villa2, F. Ibańez2, S. Morote2, C. Mansilla2 Mortality risk was substantially higher at CD4 thresholds and clinical staging recommended by WHO to initate ART but there was not much correlation with TLC, although recording was very poor. Main differences between SSA and LA were detected in WHO clinical classification. |
| ThPE0233 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0233 Abstract not available. |
| ThPE0234 | THE CONTINUUM OF CARE STRENGTHENED FOR CHILDREN THROUGH ARK'S COMMUNITY ARV PROGRAMME IMPLEMENTATION IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0234 A. Grimwood, S. Giese, M. Malahlela, N. Schaay, A. Jason In the delivery of effective, community-based ARV treatment consideration needs to be given to how the needs of children affected by HIV/AIDS can be considered within the framework of ARV-related service delivery. The review of the ARK model in an area like Nkandla will provide practitioners with an example of such delivery. |
| ThPE0235 | INTEREST OF A FREE OF CHARGE ACCESS TO ART FOR PLWA IN BENIN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0235 D.M. Zannou1, C. Courpotin2, M. Lougbégnon1, B. Sèmègan1, B. Affédjou1 Even a small financial charge might be a break for access to treatment of the poorest PLWA. Our results show the positive influence of a free of charge access to treatment which helps us to improve access to treatment for all PLWA needing ART. |
| ThPE0236 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0236 Abstract not available. |
| ThPE0237 | INTEGRATING HIV CARE INTO A REPRODUCTIVE HEALTH CLINIC IN SANTO DOMINGO, DOMINICAN REPUBLIC Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0237 G. Mir Mesejo1, C. Vaughan2, V. Brache1, F.A. Benitez1, A.G. Garcia1, K. Brudney2 It is possible to integrate HIV/AIDS services successfully into a reproductive health clinic in a limited resource setting. A strong adherence program with interdisciplinary participation positively influences patient outcome. |
| ThPE0238 | LESSONS LEARNED FROM IMPLEMENTING THE HIV CONTINUUM OF CARE IN VIETNAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0238 V.N. Phinh1, V.N. Son2, K. Green3, R. Burdon4 The Continuum of Care model should be considered as an effective model for the scale up of HIV care and treatment services in Vietnam. |
| ThPE0239 | MAKING THE TARGET. AIDS TREATMENT ACCESS ON THE FRONTLINES: LEARNING FROM 3 BY 5 TO REALIZE THE UNIVERSAL ACCESS PLEDGE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0239 O. Akanni1, F. Hassan2, J. Thomas3, J. Kamau4, International Treatment Preparedness Coalition (ITPC) Specific recommendations were made for each of the six target countries; better collaboration among multilateral agencies and more work by these agencies to address specific challenges in countries; an international strategic plan that includes country-specific strategies, with timelines and clear assignments of responsibility for specific tasks for multilateral agencies and others; increased funding from both rich and less developed countries; anti-stigma programs; and more supportive policies from the IMF and World Bank. |
| ThPE0240 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0240 Abstract not available. |
| ThPE0241 | PREVENTION OF MOTHER TO CHILD TRANSMISSION (PMTCT PLUS) PROGRAMME AT THE CENTRE MEDICAL ST CAMILLE, OUAGADOUGOU, BURKINA FASO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0241 G. De Iaco1, V. Pietra2, S. Capone1, S. Pignatelli2, F. Castelli1 Since 2003 the Centre Medicale St Camille in Ouagadougou (CMCS) is providing antiretroviral therapy (HAART) given from the Ministry of Health of Burkina Faso for pregnant women, infants and partners screened by the programme of PMTCT. |
| ThPE0242 | MORBIDITY AND MORTALITY CHARACTERISTICS IN PATIENTS ACCESSING HAART IN A RURAL PRIMARY CARE SETTING IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0242 V. Naranbhai1, R. Manchanda2, K. Naidoo1, T. Moodley1, S. Sayana3, M. Mashego1, S. Ntsele1, Q. Abdool Karim1, CAT Team Observed mortality proportions are similar to other HAART-inititation settings. More aggressive identification and treatment of these, potentially manageable, opportunistic infections and predictors of poor therapeutic outcomes may help in ameliorating the observed mortality rates and enhance the numbers benefiting from urgent HAART provision in resource constrained settings. |
| ThPE0243 | INNOVATIVE DEVELOPMENT IN THE MANAGEMENT OF PLWHA WITHIN A RESOURCE CONSTRAINED REGIONAL CDC INFECTIOUS DISEASES HOSPITAL IN URUMQI, XINJIANG NW CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0243 S. Moore1, C. Yang2 Further development of treatment protocols are needed to reduce the cost of care. Expansion of the RCC to include more comprehensive counselling and improve referrals (and follow-up) between treating hospitals and promotion of this model to other parts of China in similarly resource constrained environments. |
| ThPE0244 | REACHING SEX WORKERS WITH VOLUNTARY COUNSELLING, TESTING AND CARE SERVICES: THE MAMATA CARE AND TREATMENT CENTRE EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0244 A. Saha1, T. Jana2, D. Banerjee3, S. Das4 It is possible to identify and overcome the barriers of testing and care for FSWs through provider-initiated interventions designed, run and managed by FSWs themselves. The MCTC experience is an example of "out of the box" approach to increasing acceptability of VCT and care and support among marginalised communities that needs further research to develop a strong evidence-base for "good practices" with other key populations. |
| ThPE0245 | PAEDIATRIC HIV IN A TERTIARY HEALTH FACILITY IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0245 A. Eneh, R. Ugwu, A. Nte, R. Oruamabo, F. Adesina PMTCT is still at the rudimentary level. Introduction of ART has greatly improved the outcome of the HIV-infected children; however lots of children are lost to follow up. |
| ThPE0246 | TELEMEDICINE TO IMPROVE HIV CARE IN RESOURCE-LIMITED SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0246 M. Zolfo1, L. Lynen1, M. Bateganya2, S. An3, V. Renggli1, R. Colebunders1 Telemedicine is a cheap and effective method of providing clinical support and continuing education to healthcare workers treating HIV-positive patients in resource-poor countries. By giving to clinicians the opportunity to access continuous support through a discussion forum and to access policy documents, we intend to lower the threshold for launching and maintaining ART projects in resource-limited settings. |
| Track C – Epidemiology, Prevention and Prevention Research | |
| ThPE0247 | HIGH RISK SETTINGS STRATEGY: AN 'EMERGENCY' RESPONSE TO HIV IN PAPUA NEW GUINEA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0247 P.R. Proto de Souza1, R. Pakure2, C. Kelly3, L. Bola4, F. Bundu4, M. Toole5 In order to further promote sustainability of the HRSS, local partnerships with private sector and NGOs should be continued, together with strengthening of managerial and monitoring skills, followed by decentralisation of funds and decision-making on future steps. |
| ThPE0248 | AS LITTLE AS ONE PEER EDUCATOR CAN INCREASE ACCEPTANCE OF HIV TESTING IN A PMTCT PROGRAMME Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0248 J. Penner1, R. Marima2, C. Olubwayo2, S. Onunga3, E. Bukusi2, C. Cohen4 Peer educators should be incorporated into PMTCT programs. Given that many HIV positive women are not employed, the stipend offered can be an important source of income for the peer educator and remains affordable at the programme level. More attention to involving the male partner in PMTCT is needed. |
| ThPE0249 | OUTCOMES OF A MULTILEVEL RCT FOR HIV PREVENTION AMONG INJECTION DRUG USERS AND THEIR SEXUAL PARTNERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0249 C. Latkin1, K. Tobin2 The results of this study suggest that active injection drug users can be trained to teach others methods of HIV risk reduction and that these activities may lead to a reduction in the HIV risk behaviors among the drug using peer educators and among their network members. |
| ThPE0250 | LONG-TERM CHANGES IN HIGH-RISK SEXUAL BEHAVIORS BETWEEN COMMUNITY AND COURT RECRUITED FEMALE COCAINE-USERS IN ST. LOUIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0250 C. Callahan, S. Bradford, A. Ben Abdallah, L. Cottler These findings suggest that even the highest risk drug-using women are able to initiate healthier behaviors to reduce the risk of contracting HIV. Further analyses regarding the reduction of changes in drug use behaviors are forthcoming. |
| ThPE0251 | SEXUAL RISK REDUCTION INTERVENTIONS DO NOT INADVERTENTLY INCREASE THE OVERALL FREQUENCY OF SEXUAL BEHAVIOR: A METAANALYSIS OF 174 STUDIES WITH 116,735 PARTICIPANTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0251 N.D. Smoak1, L.A.J. Scott-Sheldon1, B.T. Johnson1, M.P. Carey2, SHARP Research Team HIV-risk reduction interventions do not increase the overall frequency of sexual activity. To the contrary, for some "at risk" sub-groups, interventions reduce the frequency of sexual events and partners, especially when interventions include behavioral science theory-related components. |
| ThPE0252 | EFFECTS OF A STRUCTURAL INTERVENTION FOR THE PREVENTION OF INTIMATE PARTNER VIOLENCE AND HIV IN SOUTH AFRICA: A CLUSTER RANDOMIZED TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0252 P. Pronyk1, J. Hargreaves2, J. Kim1, L. Morison2, C. Watts2, G. Phetla1, J. Busza2, J. Porter2 Integrated development strategies using MF may play an important role in reducing structural vulnerabilities to HIV and IPV in southern Africa. Effects on levels of IPV, even in the short term, have the potential to be pronounced. |
| ThPE0253 | FEMALE CONDOM SKILLS TRAINING IS EFFICACIOUS IN INCREASING FEMALE CONDOM USE AND PROTECTED SEX AMONG ETHNICALLY-DIVERSE WOMEN ATTENDING FAMILY PLANNING CLINICS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0253 K. Choi, C. Hoff, W. Hussey, O. Grinstead, C. Gomez We demonstrated the efficacy of skills training in increasing female condom use and protected vaginal intercourse among ethnically-diverse women attending family planning clinics. |
| ThPE0254 | STOP AFGHAN AIDS (SAA) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0254 W. Niazi1, R. Gordon2 Funding of US$30 million is needed for 5 years to keep the HIV/AIDS epidemic from exploding, and US$5 million/year to treat existing cases. Our unique approach to the epidemic, combining math and imams, i.e., quantitation to reduce the epidemic below the threshold, driving the number of cases eventually down to zero, and adherence to scholarly Sharia law accepted by this 98% Muslim country, with leadership by the Ministry of Public Health, may set an example of how to stop the epidemics in the 85% of countries that still have small epidemics. |
| ThPE0255 | CONDITIONAL CASH TRANSFER TO COMMUNITY-LED HIV/AIDS INITIATIVES (CCT/CHAI) AND ITS EFFECTIVENESS IN ADDRESSING BASIC SOCIAL NEEDS OF ORPHANS IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0255 S. Kiirya CCT to CHAIs is an effective strategy for ensuring access to basic psychosocial services by needy orphans. It also enhances community competency to identify, own and act upon problems caused by HIV/AIDS. This approach should be adopted throughout Uganda, and replicated in countries with similar social, cultural and economic conditions. |
| ThPE0256 | PRIDE IN THE CITY, AN INNOVATIVE COMMUNITY LEVEL INTERVENTION FOR BLACK MEN WHO HAVE SEX WITH MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0256 K. Washington1, M. Roberson2, G. English2 Culturally competent interventions that build and affirm the Black MSM community, while disseminating HIV/ STI prevention messages can result in the "hard-to-reach" Black MSM community accessing HIV testing and STI screening services. |
| ThPE0257 | EDUCATING RURAL COMMUNITY THROUGH PWE - TRADITIONAL THEATRICAL PERFORMANCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0257 D.Y.Y. Cho, D.K.A. Myint In the future, attempts are to be made to access the effectiveness of the pwe and to incorporate more messages on stigma and discrimination and care and support. |
| ThPE0258 | INCREASING SYRINGE ACCESS AND HIV PREVENTION IN CALIFORNIA: PRELIMINARY FINDINGS FROM A DUAL OPT-IN PHARMACY ACCESS INITIATIVE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0258 T. Stopka1, R. Garfein2, A. Ross1, S. Truax1 While authorization of SB1159 has occurred in some California LHJs, the dual opt-in process has been slow to make non-prescription syringes available through registered pharmacies. Further research is needed to identify barriers to adopting SB1159 and to identify areas for improving technical assistance among the various stakeholders. |
| ThPE0259 | INTEGRATING HIV PREVENTION & RAPID HIV TESTING INTO TREATMENT FOR INCARCERATED WOMEN WITH CO-OCCURRING DISORDERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0259 D. Salina1, L. Lesondak2, L. Razzano3, A. Weilbaecher1 To facilitate HIV risk reduction in substance using women, co-morbid factors must be addressed within a comprehensive framework. Incarcerated women with co-occurring disorders require integrated programming that address multiple facets of their high-risk lives. |
| ThPE0260 | SEXUAL RISK REDUCTION FOR AFRICAN-AMERICANS: A RESEARCH SYNTHESIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0260 L.A.J. Scott-Sheldon1, J.M. La Croix1, N.D. Smoak1, J.R. Anderson2, B.T. Johnson1, M.P. Carey3 Condom use improved when interventions occurred in 2 to 5 sessions and included skills training and motivational enhancement. The necessity of multiple sessions may be particularly important information for community-based organizations that often have only brief periods in which to intervene. |
| ThPE0261 | SUCCESSES AND CHALLENGES IN RECRUITING PARTICIPANTS INTO A STUDY OF A BEHAVIORAL INTERVENTION FOR HIV PREVENTION IN MUMBAI, INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0261 A. Hernandez1, M. Yu1, U. Khan1, S. Kundu2, M. Mcguire1, M. Ekstrand1, H.R. Jerajani2, C.P. Lindan1 Strategies for recruiting persons into prevention programs in India may benefit by using connections and outreach within communities particularly when public health clinics are not well viewed. Well-trained and caring staff can create a positive and respectful experience for clients, and increased likelihood other clients seeking services. Any recruitment strategy should always undergo careful ethical review. |
| ThPE0262 | COMMUNITY INVOLVEMENT THE BEDROCK OF SUCCESS: CASE STUDIES FROM THE AFRICAN YOUTH ALLIANCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0262 U. Daniels1, J. Senderowitz2 Several segments of the community - parents, teachers, religious leaders - are especially important in shaping young people while others seem more distant but have significant impact on young people's access to HIV information and services. More recently, young people are influencing community attitudes to sexuality and reproductive health concerns. Community involvement emphasizes community ownership and is gaining prominence in programme design. |
| ThPE0263 | RETENTION OF PEER EDUCATORS IN A BEERHALL-BASED HIV PREVENTION INTERVENTION IN HARARE, ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0263 C. Chasakara1, K. Makumbe1, C. Mashoko1, D. Mukote1, I. Chivayo1, W. Munetsi1, S. Shoniwa1, R. Tigere1, G. Woelk1, W. McFarland2, K. Fritz2 High retention of peer educators in a bar-based intervention is achievable. Strategies for successful retention include a clearly articulated and transparent incentive plan focused on non-monetary gifts, a well-structured support plan with specific curricula for continued skill development, strong relationships between intervention facilitators and peer educators to ensure adequate social support, and a data management system for tracking peer educator participation and outreach needs. |
| ThPE0264 | ADAPTATION OF EFFECTIVE BEHAVIORAL INTERVENTIONS FOR USE WITH HIGH RISK POPULATIONS IN HONDURAS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0264 L. Bautista de Mejia1, D. Darrow de Mora2, M. Hamdallah2 COMCAVI sees great potential in diffusing the adapted interventions throughout high risk communities and adapting and disseminating additional effective interventions throughout Honduras and in other countries world-wide. |
| ThPE0265 | REDUCTION IN INJECTION RISK BEHAVIORS AMONG YOUNG INJECTION DRUG USERS USING A PEER-EDUCATION INTERVENTION: THE CIDUS III/DUIT STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0265 R.S. Garfein1, S. Bailey2, E.T. Golub3, A. Greenberg4, H. Hagan5, D.L. Hanson6, S. Hudson7, F. Kapadia8, P. Kerndt9, M. Latka8, L. Ouellet2, D.W. Purcell10, S.A. Strathdee11, H. Thiede12, I.T. Williams13, for the DUIT Study Team Interventions providing information, enhancing risk reduction skills, and motivating behavior change through peer education training can decrease injection risk behaviors among young IDUs who are at high risk for HIV and HCV infections. |
| ThPE0266 | CONSISTENT CONDOM USE AMONG UNIVERSITY STUDENTS IN SOUTH AFRICA: A LONGITUDINAL STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0266 G.A. Heeren1, J.B. Jemmott1, A. Mandeya2, J.C. Tyler2 University students in South Africa are at high risk of STI, including HIV. Risk reduction interventions should focus on their hedonistic beliefs, normative beliefs regarding partners and peers, and control beliefs regarding condom-use technical skills and impulse control. |
| ThPE0267 | ALTERNATIVE LEADERSHIP OF YOUNG WOMEN; A LOW COST MODEL OF HIV/AIDS INTERVENTIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0267 M. Agarwal1, A. Narang2, S. Goyal3, A. Chaudhuri4, V. Srivastava5 Nurturing alternative leadership amongst rural women on "HIV and development" and peer led family approach were the key success factors in CHARCA project. This low cost model is both sustainable and replicable for expansion in developing countries. |
| ThPE0268 | PSYCHOSOCIAL ISSUES AMONG THE HIV-INFECTED URBAN POOR: RESULTS OF UNIVERSAL SCREENING IN AN HIV PRIMARY CARE SETTING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0268 C. Nollen1, H. Wolfe1, A. Nugent2, V. Sharp1 Almost one in six patients in our HIV center have co-occurring MH, SA, and IPV issues, and are less likely to take antiretrovirals when faced with at least two psychosocial issues, despite no preliminary indication of better health than patients with one or none of these issues. Rates may be similar in other urban HIV centers, highlighting the need for universal screening and intensive tailored treatment for these vulnerable patients. |
| ThPE0269 | A PERSPECTIVE ON COMMUNITY BASED NGOS' INVOLVEMENT IN HIV/AIDS ISSUE IN CHINA FROM SICHUAN PROVINCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0269 L. Dan1, T. Manchester2, Y. Jie1, P. Xiao You3, Z. Shi1 Several barriers currently hinder NGOs' involvement. These can be addressed by: Harmonizing the policy and legal environment; Ensuring provincial level NGOs are aware of and access to both domestic and international funds; Building more capacity for community-based NGOs; Ensuring the sustainability of community-based NGOs by allowing domestic NGOs to collect organization fees. |
| ThPE0270 | DESIGN, IMPLEMENTATION, AND EVALUATION OF HIV/AIDS PREVENTION MASS MEDIA CAMPAIGNS: HOW ARE WE DOING? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0270 S. Noar, P. Palmgreen, A. Clark, S. Cavendish, R. Zimmerman Future HIV/AIDS media campaigns would benefit greatly from harnessing the potential of more elements that have been identified as being associated with effective campaigns, as well as a strengthening of both process and outcome evaluation components. Suggestions for how this can be accomplished, including recommendations for specific outcome evaluation designs (e.g., interrupted time series designs), will be discussed. |
| ThPE0271 | HIV POSITIVE WOMEN GIVING BIRTH: DIFFERENCES IN WOMEN WITH AND WITHOUT PRENATAL CARE, ST. PETERSBURG, RUSSIA, 2004-2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0271 N. Akatova1, D. Kissin2, A. Rakhmanova3, E. Vinogradova4, A. Yakovlev5, D. Jamieson2, J. Robinson6, W. Miller7, K. Glynn2, S. Hillis2 Among HIV-infected mothers giving birth over a 1 year period, those without PNC had lower rates of ARV prophylaxis and ceasarian-section, higher rates of low birth weight, infant abandonment, and perinatal transmission. Therefore, every effort must be made to improve PNC utilization and to strengthen prevention of perinatal transmission among HIV-infected women without PNC. |
| ThPE0272 | EVIDENCE BASED RAPID SCALING UP OF INTERVENTIONS WITH MEN WHO HAVE EX WITH MEN (MSM) AND TRANS-GENDER (TG) PERSONS IN ANDHRA PRADESH: LESSONS LEARNT FROM THE INTERNATIONAL HIV/AIDS ALLIANCE'S PROGRAM IN ANDHRA PRADESH, INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0272 S. Sengupta, C. De Zoysa, S. Das It is estimated that around 31% of the sexual encounters between MSM in Andhra Pradesh include anal sex, out of which only 44 % are protected We present a model for rapid scaling up of interventions among MSM and TG populations. |
| ThPE0273 | DOUBLE STIGMA: DISCRIMINATION AND VIOLENCE AMONGST FEMALE SEX WORKERS AND MEN-WHO-HAVE-SEX-WITH-MEN IN ANDHRA PRADESH, INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0273 F. Samuels1, R. Verma2, C. George3 Empowerment processes are key in promoting self-confidence and self-esteem amongst FSWs and MSM. A supportive enabling environment is also central in assisting key populations cope with stigma, discrimination and violence. |
| ThPE0274 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0274 Abstract not available. |
| ThPE0275 | LONGITUDINAL RESULTS FROM A SCHOOL-BASED HIV AND ALCOHOL PREVENTION CURRICULUM IN SOUTH AFRICAN PERI-URBAN SCHOOLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0275 R. Zimmerman1, A. Bhana2, P. Cupp1, S. Feist-Price3 We have demonstrated that a curriculum developed in the West can be successfully adapted after careful formative research to be effective in changing both sexual attitudes and behavior of adolescents over a 15 month period in KwaZulu-Natal, South Africa. |
| ThPE0276 | HIV/AIDS IN SOUTH AFRICAN DOCUMENTARY FILM, C. 1990 - 2000 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0276 R. Hodes This article concludes with some general observations about the positive and negative aspects of the documentaries and their impact on public perceptions of HIV/AIDS in South Africa. |
| ThPE0277 | INFLUENCE OF A PEER MENTORING INTERVENTION ON HCV-RELATED HEALTHCARE UTILIZATION AMONG YOUNG HCV-INFECTED IDUS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0277 R.S. Garfein1, H. Hagan2, M. Latka3, E.T. Golub4, F. Kapadia3, J. Campbell5, D.L. Thomas6, M. Pu1, S. Bonner3, R.A. Pollini1, T. King Thiel7, S.A. Strathdee1, for the STRIVE Team Our peer mentoring intervention was significantly associated with making and attending appointments with a liver specialist for HCV infection among young, HCV-infected IDUs by the 3-month follow-up visit. This intervention holds significant promise for increasing medical monitoring of HCV infection among young IDUs. |
| ThPE0278 | COMMUNITY-DRIVEN ORPHAN CARE IN ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0278 G. Mukaratirwa1, F. Chihota1, B. Mupambo1, L. Mandimutsira1, M. McKenzie2, A. Jenkins3 Participatory community action can provide beneficial orphan care as long as there are sustainable income generation projects and mutual support groups for orphan caregivers. |
| ThPE0279 | RANDOMIZED CLINICAL TRIAL OF AN INTERVENTION TO PREVENT HIV AMONG WOMEN AT HIGH RISK Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0279 C. Mallory1, M. Hesson-McInnis2 Women engaged in high risk activities such as drug use and sex trading are more likely to become infected with HIV. This pilot study is designed to test an intervention based on the concepts of self-efficacy, gender and power, and awakening. |
| ThPE0280 | BRIEF COUNSELING TO PROMOTE PATIENT-BASED STD PARTNER NOTIFICATION REDUCES MEN'S SEXUAL RISK BEHAVIOR AND SUBSEQUENT RISK FOR HIV/STD INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0280 T. Wilson1, N. Liddon2, M. Hogben2, S. Rubin2, J. Williams3, A. Cintron3, R. Curney3, W. McCormack3, M. Augenbraun3 Clinic-based approaches to promote patient referral for STI assessment and treatment are effective for men, but did not reduce women's risk for HIV/STI. |
| ThPE0281 | UNDIAGNOSED HIV INFECTION AND COUPLE HIV DISCORDANCE AMONG HOUSEHOLD MEMBERS OF HIV-INFECTED PEOPLE RECEIVING ANTIRETROVIRAL THERAPY IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0281 W. Were1, J. Mermin1, N. Wamai1, A. Awor1, S. Bechange1, S. Moss1, P. Solberg2, R. Downing1, A. Coutinho3, R. Bunnell1 Provision of home-based VCT to household members of people initiating ART was well-accepted and resulted in detection of a large number of previously undiagnosed HIV infections and HIV-discordant relationships. |
| ThPE0282 | IT HAS BROUGHT QUIETNESS IN OUR RELATIONSHIP: YOUNG SOUTH AFRICANS' EXPERIENCES OF THE HIV BEHAVIOURAL INTERVENTION STEPPING STONES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0282 K. Wood1, K. Bakam2, R. Jewkes2, N. Duvvury3, Y. Skweyiya2 Stepping Stones had an impact on both men and women, but men were better able to effect change in their sexual practices, particularly condom use. Stepping Stones sought to promote gender equity and reduce gender-based violence, and there is some suggestion of effectiveness in this regard, yet our findings raise questions about how feasible it is to achieve this with one behavioural intervention. |
| ThPE0283 | HIV & PUBLIC HEALTH INTERVENTIONS: TESTING A MODEL THAT ENHANCES QUALITY OF LIFE IN INNER CITY JOHANNESBURG Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0283 J. Vearey, M. Oliff Societal and structural change is required for effective HIV prevention and treatment efforts. With the absence of the required political led change, communities need to initiate change themselves. Viewing quality of life as a longterm investment, and designed as sustainable, community-led structures, QLCs assist this process and can be implemented in other communities where self-efficacy and control over daily life is currently limited. |
| ThPE0284 | SCALING UP HIV PREVENTION PROGRAMS FOR IDUS IN FOUR CITIES OF PUNJAB - PAKISTAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0284 S. Qureshi There has been a rapid increase of injecting drug use in Pakistan over the last few years. According to recent studies, it is no more confined to major urban areas and there is an increased HIV prevalence among IDUs. Scaled-up response is inevitable to confine HIV/AIDS epidemic among IDUs. |
| ThPE0285 | EFFICACY OF A WOMEN-FOCUSED INTERVENTION AT REDUCING ALCOHOL USE AMONG SEX WORKERS IN SOUTH AFRICA: DIFFERENTIAL EFFECTS BY HIV TESTING AND STATUS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0285 W. Wechsberg1, R. Karg1, K. Riehman1, W. Luseno1, C. Parry2 These findings underscore the efficacy of reducing alcohol use for women who are HIV negative and the need for interventions to include motivation enhancement to reduce alcohol use among women who are HIV positive. |
| ThPE0286 | TARGETED MOBILE STI SERVICES REDUCED HIV AND STI PREVALENCE AMONG FEMALE SEX WORKERS IN 16 DISTRICTS OF NEPAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0286 C. Chaudhary1, G. Bhatta2 The targeted STI services delivered to FSWs through mobile clinics in the sites close to the potential users were found to be an effective strategy. Collaboration with STI and local BCI partners is effective for accessing FSWs and probably contributed to reducing the prevalence of HIV and STI in them. |
| ThPE0287 | A SUCCESSFUL ONLINE BEHAVIORAL INTERVENTION FOR MEN WHO HAVE SEX WITH MEN (MSM) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0287 M.A. Chiasson1, F. Shuchat Shaw2, M. Humberstone3, S. Hirshfield1 Recent increases in HIV infection among MSM highlight the urgent need for additional behavioral interventions. We wrote, filmed and evaluated an 8 minute, dramatic video designed to promote critical thinking about HIV disclosure, risky sexual behaviors and the complex beliefs and attitudes underlying these behaviors from multiple perspectives. |
| ThPE0288 | SERIOUS MENTAL ILLNESS AND HIV: A SYNDEMIC APPROACH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0288 N. Hanrahan1, L.H. Aiken2, M.B. Blank3, R. Stall4 Additive effects of a cluster of epidemics require examining the connections between bio-psycho-social problems rather than the usual approach which is an emphasis on a single isolated health problem. |
| ThPE0289 | WOMAN AND PRISON: WORKING PREVENTION OF THE HIV/STD/AIDS IN THE JAIL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0289 M. Lima We found the invisibility of the feminine universe, few studies and actions that promote the rights of women prisioners, lack of access for accomplishment of examinations and difficulties in the treatment of the AIDS making possible the vertical transmission of the HIV and, thus making it difficult the reduction of the vulnerabilities of these women. |
| ThPE0290 | CREATING AND TESTING MECHANISMS FOR MEANINGFUL COLLABORATION BETWEEN MEMBERS OF URBAN COMMUNITIES AND HIV PREVENTION RESEARCHERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0290 M. McKay1, S. Alicea2, B. Bannon2, J. Watson2 Findings suggest that researchers seeking to involve urban minority community residents in HIV prevention projects should consider salience, personal meanings, beliefs and expectations, and constraints that residents perceive in order to encourage community participation. Additionally, The Theory of Unified Behavior Change may act as a tool in understanding community members' participation in HIV prevention efforts. Lastly, the quantitative instrument created may be useful to researchers seeking to recruit community residents to participate in community based HIV prevention projects. |
| ThPE0291 | THE IMPACT OF HIV ON FERTILITY IN COMMUNITIES WITH HIGH HIV PREVALENCE: EVIDENCE FROM POPULATION BASED SURVEYS IN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0291 R. Banda1, K. Fylkesnes2 There were indications of substantial impacts of HIV on fertility among middle-aged women (25-49 years) being mostly biological. Behavioural changes in young urban women contributed strongly to reduced fertility, but to what extent they were attributed to the HIV epidemic merits further study. |
| ThPE0292 | EFFECTS OF A BEHAVIORAL INTERVENTION ON HEPATITIS C KNOWLEDGE AMONG YOUNG HCV-INFECTED INJECTION DRUG USERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0292 R.A. Pollini1, T.K. Thiel2, E.T. Golub3, M. Latka4, H. Hagan5, R.S. Garfein1, F. Kapadia4, J.V. Campbell6, D.L. Thomas7, S.A. Strathdee1, for the STRIVE Project Team Consistent with other studies, HCV knowledge was low among HCV-infected young IDUs. Our behavioral intervention based on peer mentoring shows potential for improving HCV knowledge. |
| ThPE0293 | THE PLIGHT OF TRANSGENDER IN PHNOM PENH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0293 M. Chanthan Continue to improve knowledge of HIV and STIs and to encourage more srey sros to take on the role of peer leaders and educators to widen the impact. Continue to strengthen the collaboration amongst other NGOs and government agencies in order to provide greater access to services. Propose to the government to include srey sros in statistics such as the HIV/AIDs Sentinel Surveillance surveys. |
| ThPE0294 | LISTENING, RESPONDING AND EVOLVING: KEEPING UP THE MOMENTUM TO CHANGE YOUR HIV EDUCATION PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0294 D. Kreznarich, K.B.K. Chan Public health units in developed countries need to continually conduct timely and critical assessments of their HIV/AIDS programs. Public health workers must work together with community members and management to continuously improve their connections with grassroots HIV efforts. |
| ThPE0295 | PARTNER DISCLOSURE OF HIV STATUS AMONG HIV POSITIVE PREGNANT WOMEN IN NORTHERN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0295 A.S. Sagay1, J. Musa1, C.C. Ekwempu1, G.E. Imade1, A. Babalola1, G. Daniyan1, N. Malu1, J. Idoko1, P. Kanki2 The reactions of partners of HIV positive mothers to disclosure of their wives' HIV status are predominantly supportive. This should strengthen strategies to promote partner disclosure. Interventions to promote safer sex practices among sero-discordant couples should be strengthened. |
| ThPE0296 | THEORY-BASED PREDICTORS OF CONDOM USE AMONG UNIVERSITY STUDENTS IN THE UNITED STATES AND SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0296 G.A. Heeren1, J.B. Jemmott1, A. Mandeya2, J.C. Tyler2 University students in SA are at high risk of STI, including HIV. The TPB may provide a useful framework for interventions to reduce their risk. Such interventions should especially focus on building self-efficacy to use condoms. |
| ThPE0297 | INTERVENTION STUDIES ON DRUG ABUSE AND HIV/AIDS IN CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0297 W. Liu1, M. Wen2 More evidences and well-designed intervention studies are urgetnly needed to evaluate effectiveness of harm reducatiction in China. |
| ThPE0298 | BODY EMPOWERMENT INTERVENTION FOR CRACK-USING WOMEN LEADS TO SIGNIFICANT REDUCTIONS IN SEXUAL RISK BEHAVIOR WITH PRIMARY PARTNER Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0298 E. Gollub1, K. Armstrong2, T. Boney3, S. Chattre4, A. Lavalanet5, K. Mackey4 Participatory multi-session interventions stressing body knowledge and demystification, women's solidarity, and female barriers like the FC, can help reduce sexual HIV risk in crack-using women. Both FC and MC contribute to risk reduction; both should be included in standard HIV-CT. |
| ThPE0299 | EXPERIENCES WITH COMMUNITY MOBILISATION & SUPPORT OF AIDS ORPHANS AND VULNERABLE CHILDREN IN YAOUNDE, CAMEROON Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0299 M. Penn Richard It is recommended that community members be empowered to be fully involved in identifying OVC problems, taking decisions and actions that would help them to be self-reliant. Talk of teaching to fish rather than providing fish! |
| ThPE0300 | MAMEKHAYA: ENHANCING SOUTH AFRICAN PMTCT PROGRAMS WITH CULTURALLY-ADAPTED EVIDENCED-BASED INTERVENTIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0300 D. Futterman1, J. Shea2, M. Besser2, L. Klosinski3, S. Stafford1, M.J. Rotheram-Borus3 Qualitative work confirmed that the interventions developed for US populations contain relevant and universal themes as well as engaging techniques for its successful adaptation in South Africa. A pilot of the intervention will demonstrate if it is efficacious for the women involved and feasible for implementation by mentor mothers and scale up by TMP. |
| ThPE0301 | A PROJECT INNOVATES MARITAL HIV PRIMARY PREVENTION AMONG BRAZILIAN HOMOSEXUALS, BY DEVELOPING SPECIFIC TECHNOLOGY AND RAISING POLICY-MAKERS' AWARENESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0301 T. Besozzi Policy-makers should include marital prevention among their priorities, for interventions to become widespread. Statistical research is needed to gauge the prevalence of marital HIV transmission, with specific data on same-sex couples. Homofobia (including internalized homofobia) remains a hindrance to prevention work, and must be addressed appropriately. |
| ThPE0302 | FAMILY MATTERS: THE NEXT GENERATION OF HIV INTERVENTIONS IN THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0302 S.-J. Lee1, C. Jiraphongsa2, S. Khumtong2, S. Iamsirithaworn2, C. Pittayawongannon2, P. Thammawijaya2, M.J. Rotheram1, L. Li1, R. Detels3 Mounting an effective family-based intervention needs to be performed in a systematic, collaborative manner that involves all parties, to ensure the success, relevance, and sustainability. Building on the existing programs in Thailand, we are currently mounting a collaborative initiative to involve families living with HIV, focusing on family well-being, in a non-stigmatizing setting. |
| ThPE0303 | SELECTION BIAS IN AIDS PREVENTION TRIALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0303 S. Marcus, M. McKay, J. Weaver, W. Bannon We recommend a propensity score approach for assessing who attends AIDS prevention interventions. This methodology can be useful for interpreting efficacy results and provides important information that can be used to improve interventions, recruiting or engagement policies. |
| ThPE0304 | TEACHING CONDOM USE SKILLS: HANDS ON PRACTICE IS SUPERIOR TO OBSERVATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0304 D. Calsyn1, M. Hatch-Maillette2, S. Doyle2, S. Cousins3, T. Chen4 A "hands on" practice of condom use was superior in teaching condom use skills than a condom use demonstration, which was superior to no intervention. |
| ThPE0305 | RAPID SITUATIONAL ASSESSMENTS ON HIV PREVALENCE AND RISK FACTORS AMONG PEOPLE INJECTING DRUGS IN PUNJAB, PAKISTAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0305 A. Shams, Injecting Drug Users In order to minimize damage and to curb the pandemic we need to decide at a policy level to immediately initiate and/or scale up street based comprehensive harm reduction interventions to prevent HIV among IDUs and those closely associated. Interventions to prevent HIV/AIDS among IDUs need to be mainstreamed within the health care system of the Government in partnership with civil society organizations and networks affiliated with affected communities. |
| ThPE0306 | SEXUALLY ACTIVE HIV+ PATIENTS FREQUENTLY REPORT NEVER USING CONDOMS IN AUDIO COMPUTER-ASSISTED SELF-INTERVIEWS CONDUCTED AT ROUTINE CLINICAL VISITS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0306 B.R. Schackman1, Z. Dastur1, Q. Ni1, M.A. Callahan1, J. Berger2, D.S. Rubin3 Inconsistent condom use is frequent in sexually active HIV+ patients and 19% report never using condoms, many with detectable HIV RNA. Never using condoms is associated with depression and ART non-adherence. ACASI is an effective tool for eliciting sensitive information in order to identify patients for counseling about condom use during clinical encounters. |
| ThPE0307 | THE NEED FOR MOTHER TO CHILD HIV TRANSMISSION CONTROL IN CHINA: A NECESSITY, NOT A LUXURY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0307 A.S. Abdullah1, G.F. Quan2, Z.X. Shia3, S.H. Ebrahim4 General and targeted efforts to increase awareness about HIV transmission including mother to child transmission (MTCT) are still needed in China. The marriage and pre-pregnancy certification - related health visits that are unique to china offers an unprecedented opportunity to provide targeted counseling and encourage HIV testing of couples. |
| ThPE0308 | A RANDOMIZED CONTROLLED TRIAL (RCT) TO REDUCE HIV SEX-RISK BEHAVIORS AMONG HOSPITALIZED RUSSIAN SUBSTANCE DEPENDENT PATIENTS: THE RUSSIAN PARTNERSHIP TO REDUCE THE EPIDEMIC VIA ENGAGEMENT IN NARCOLOGY TREATMENT (RUSSIAN PREVENT) STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0308 J.H. Samet1, E. Krupitsky2, D.M. Cheng3, A. Raj4, V. Egorova2, S. Levenson5, S. Meli6, C. Bridden6, E. Verbitskaya2, M.L. Kamb7, E. Zvartau2 A marked reduction in sex-risk behaviors was noted at 3-month follow-up; however, the decrease did not vary significantly by treatment group. Understanding the relative impact of the intervention, condom distribution, and subject assessment on reducing risky sexual behaviors will be important to effectively design behavioral RCTs for reducing HIV risk in Russia. |
| ThPE0309 | INVOLVING TRADITIONAL HEALTH PRACTITIONERS (THPS) TO SCALE UP UPTAKE OF A PREVENTION OF MOTHER-TO-CHILD TRANSMISSION OF HIV PROGRAM IN RURAL UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0309 R. Achola1, D. Balaba2, H. Ramadhan2, J. Kalamya Namonyo3, J. Homsy4, C.D. Okumu5 Prevention of mother-to-child transmission (PMTCT) of HIV remains a major public health challenge worldwide. Although PMTCT interventions have been established throughout Uganda, uptake remains low with most mothers not delivering in formal health facilities. |
| ThPE0310 | BEHAVIOR CHANGE AND HEALTH-RELATED INTERVENTIONS FOR HETEROSEXUAL RISK REDUCTION OF HIV AMONG DRUG USERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0310 S. Semaan1, D. Des Jarlais2, R. Malow3 Because no single intervention component is sufficient, a comprehensive strategy is needed to control the heterosexual transmission of HIV to and from drug users. It is important to adapt effective interventions to the specifics of local settings and to address relevant contextual factors. Creating an international depository of data on HIV sexual transmission rates among drug users will be helpful in adapting and evaluating effective interventions. |
| ThPE0311 | ETHNOGRAPHY AS A CRITICAL STEP TO INFORM CULTURAL ADAPTATIONS OF HIV PREVENTION INTERVENTIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0311 M. Wainberg1, D. Pinto2, A. Gonzalez3, K. Elkington1, P. Mattos4, V. Terto5, PRISSMA - Projeto Interdisciplinar do Sexualidade, Saúde Mental e Aids - Interdisciplinary Project in Sexuality, Mental Health and AIDS People with severe mental illness (SMI) are at elevated risk for HIV infection in Brazil. Brazilian psychiatric facilities do not offer tested HIV prevention interventions targeted to this population. This study conducted formative research using ethnographic methods in two psychiatric settings in Rio de Janeiro to determine HIV prevention intervention elements needed (e.g., content, delivery strategies, etc.) to adapt existing efficacious U.S. HIV prevention interventions. |
| ThPE0312 | EXPANDING HIV/AIDS/STD PREVENTION AND CARE INTEGRATED TO PRIMARY CARE IN SÃO PAULO, BRAZIL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0312 M.E.L. Fernandes, S.P. Barbosa Jr., R. Resegue, I.G.C. Gouvea, A.D. Jatene The present strategy is a unique model for implementation of large scale HIV/AIDS/STD prevention and care in Brazil and should be expanded to other geographic areas. |
| ThPE0313 | PROMOTING PLEASURE FOR SAFER SEX - A GLOBAL MAPPING EXERCISE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0313 W. Knerr Safer sex and pleasurable sex are not mutually exclusive, yet most programmes give this impression by using fear of disease to motivate people to practice safer sex. The safer sex/HIV sector (with notable exceptions) avoids discussion of sexual pleasure, while the sex media avoids safer sex, with few films and materials featuring condom use or non-penetrative pleasurable sex as legitimate options. |
| ThPE0314 | CLIENTS AND FAMILIES OF FEMALE SEX WORKERS AND MEN-WHO-HAVE-SEX-WITH-MEN: THEIR POTENTIAL ROLE IN PREVENTION EFFORTS IN INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0314 F. Samuels1, R. Verma2, C. George3 HIV prevention programs in India have focused on sex workers to the neglect of clients - they are perpetrators of violence, stigma and discrimination and are a bridge between sex workers and the general population. This hidden population of clients could make a significant difference to prevention and care programs in future. Family focused programs are also key, since a supportive family environment can act as a springboard into the community. |
| ThPE0315 | FEMALE CONDOM AMONG VULNERABLE POPULATIONS IN BRAZIL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0315 P. Telles Dias1, K. Page-Shafer2 This assessment identified practical factors that can guide the development of female condom promotion/distribution messages. A key factor in the effective long-term adoption of female condoms identified by clients was the provision of sustained and explicit support. These results will help guide efforts for continued promotion and adoption of the female condom among women and their male partners. |
| ThPE0316 | CUSTOMIZING EVIDENCE-BASED PRACTICES INTO CULTURALLY SPECIFIC AREAS: NEW COMMUNICATION APPROACH IN A PILOT PROJECT IN MOUNTAINOUS DISTRICTS OF VIETNAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0316 H. Pham1, P. Walton2 HIV has spread significantly to rural areas, especially along transportation routes and where ethnic minorities reside. In Hoa Binh very little work on HIV prevention has been conducted. Changed values, few entertainment options, widespread gambling, drinking and drug use inter alia, all make HIV an ever-present threat. Considered as taboo topics, HIV/AIDS/sexual health are left to the under-resourced health sector. Limited budget, geographic barriers and cultural differences are all contribute to make HIV/AIDS in this region a unique challenge. |
| ThPE0317 | ATTITUDINAL IMPEDIMENTS AND FACILITATORS ASSOCIATED WITH USING EVIDENCE-BASED MODELS FOR HIV PREVENTION AT AFRICAN AMERICAN COMMUNITY - BASED ORGANIZATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0317 M. Foster, S. Kegeles, G. Rebchook US CBOs are being strongly encouraged to use evidence-based interventions, and although AACBOs were enthusiastic about this, there is dissatisfaction with most existing interventions because of perceptions of cultural insensitivity. Involving CBO staff and the BMSM community in the development process are important approaches to correct this situation. |
| ThPE0318 | CASUAL PARTNERS AMONG SOUTH AFRICAN MEN IN STEADY RELATIONSHIPS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0318 J.B. Jemmott III1, G.A. Heeren1, Z. Ngwane2 A large percentage of South African men in steady relationships may still have sexual intercourse with other partners, and often without using a condom. Interventions should target reducing multiple concurrent partnerships and increasing condom use among South African men, including married men and those in other steady relationships. |
| ThPE0319 | FARMING WITH YOUR HOE IN A SACK: CONDOM ATTITUDES, ACCESS AND USE IN RURAL MWANZA, TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0319 M. Plummer1, T. Ingall1, J. Wamoyi2, G. Mshana2, K. Nyalali2, A. Obasi3, M. Makokha4, R. Hayes1, D. Ross1, D. Wight5 The MkV intervention was introduced into a population that was confused and hostile towards condoms, and for which condom access was very limited. The intervention increased awareness of the potential value of condoms, which may be an important step towards long-term behaviour change, particularly if reinforced by intensive, community-wide condom promotion. Future intervention efforts should focus on improving men's personal risk perception; condom access also needs to be improved. |
| ThPE0320 | BRINGING ALL PARTIES TO THE TABLE: AN INNOVATIVE STIGMA-REDUCTION INTERVENTION FOR HEALTHCARE PROVIDERS IN CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0320 S. Wu1, L. Li1, Z. Wu2, Z. Yan2, M. Jia3, Y. Zhang3 Bringing intervention facilitators from diverse backgrounds is an innovative approach. Delivering intervention training in a more engaging way is novel in China and Chinese culture. It appeared that the new approach this intervention pilot had was appropriate, feasible and effective. |
| ThPE0321 | BROADENING ACCESS TO VCT: COMMUNITY-BASED COUNSELING CENTERS IN RURAL AREAS OF NANGABO - WAKISO DISTRICT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0321 V. Gumisiriza1, A. Kaddu2 Use of similar centers with lay counselors could broaden access to VCT in resource-poor settings. Centres should be well-advertised within communities so that their location is known. Provision of other services does not require trained healthcare staff but reduces stigma and improves the popularity of facilities at minimal cost. |
| ThPE0322 | DEVELOPMENT AND IMPACT OF LOCAL COMMUNITY MOBILIZATION ACTIVITIES FOR PMTCT SERVICES IN ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0322 T. Mukotekwa1, C. Marangwanda2, E. Chirapa3 Community mobilization is an ongoing process and should continue to form an integral part of any PMTCT service provision. A comprehensive community mobilization strategy should include a mixture of different activities with a focus on the integration and participation of programme graduates. |
| ThPE0323 | USING SPORT TO PROMOTE AIDS EDUCATION FOR AT RISK YOUTHS. AN INTERVENTION USING PEER COACHES IN FOOTBALL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0323 C. Maro, G. Roberts, M. Sørensen The findings show first, AIDS education is effective, and secondly AIDS education through peer coaches in sport is more effective than conventional. Results suggest that current context in Tanzania require multicultural approach in particular community based sport interventions. |
| ThPE0324 | ACCEPTABILITY OF AN INTERVENTION TO PREVENT HIV AMONG WOMEN AT HIGH RISK Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0324 C. Mallory, M. Neely The Women First! intervention is very well received by participants, but will require revisions to the educational sessions to reduce redundancy and equally distribute the content of the educational sessions so that there is a consistent level of intensity. |
| ThPE0325 | COUNSELING BARGIRLS ON SEXUAL HEALTH PROBLEMS; INTERVENTION TECHNIQUES AND OTHER EMERGING ISSUES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0325 N. Kandoi1, J. Abraham2 Counseling services for vulnerable populations like bargirls besides addressing risk of STI and HIV needs to address their other personal issues that may impact their sexual behaviors through counseling techniques based on client needs. |
| ThPE0326 | DEVELOPING A NATIONAL PROGRAM TO STRENGTHEN TRADITIONAL HEALTH PRACTITIONERS HIV/AIDS PREVENTION, CARE AND SUPPORT SKILLS IN BOTSWANA - A CRITICAL ANALYSIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0326 R. Rogerson As Botswana currently has the highest prevalence rate of HIV/AIDS in the world: 38.5%, the role of THP's is becoming increasingly fundamental. Traditional African medicine continues to contribute to complimentary and integrative research, practices and methodologies. Botswana's steps in implementing a national traditional health program, traditional healer policy and fostering biomedical and ethnomedical dialogue through a multisectoral approach; provides strong indicators for integrative healthcare models internationally. |
| ThPE0327 | EDUCATING NURSES IN THE CARE OF HIV-INFECTED INMATES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0327 M. Hubbard1, S. Walker1, A. Gallucci1, G. Clifford1, C. Moehs2, L. Wright3, D. Fish1 Printed self-study materials are an innovative way to reach correctional nurses with up-to-date HIV treatment information. Due to the time constraints of nurses in correctional institutions, these self-study guides offer flexibility in achieving continuing education. Because of nurses' satisfaction with this type of education, designing independent studies for other types of HIV practitioners warrants consideration. |
| ThPE0328 | A USABLE MODEL OF ADAPTATION FOR DEVELOPING EVIDENCE-BASED HIV PREVENTION INTERVENTIONS IN A NEW CULTURE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0328 M. Wainberg1, P. Mattos2, K. McKinnon1, V. Terto3, PRISSMA - Projeto Interdisciplinar do Sexualidade, Saúde Mental e Aids - Interdisciplinary Project in Sexuality, Mental Health and AIDS Although our target population was Brazilian psychiatric patients, our approach has relevance to adapting HIV prevention interventions to other populations and other cultures. Adaptations of evidence-based HIV prevention interventions from one culture to another that are acceptable to both the recipients and the providers are needed together with continued effort toward disseminating a usable model of adaptation. |
| ThPE0329 | FIRST LET'S TALK: A COMPREHENSIVE COMMUNICATION APPROACH TO HIV/AIDS PREVENTION FOR AFRICAN YOUTH AND THEIR COMMUNITIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0329 A. Murphy1, A. Muthigani2, M. Bruening2, L. Neubauer1, G. Harper1, J. Ruto2, A. Bangi1 A comprehensive communication approach to HIV/AIDS in Africa should focus on more than mass media information dissemination and include opportunities for interpersonal communication. |
| ThPE0330 | COMMUNITY POST INTERVENTION STUDY ON KAP Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0330 U.R. Chilezi Despite almost universal awareness of HIV/AIDS, significant personal behaviour change remains elusive. It is however encouraging that some improvement is being made in the areas of condom use, HIV testing and HIV/AIDS related discrimination. |
| ThPE0331 | INFECTION CONTROL PRACTICES AT HEALTH CARE FACILITIES IN KARACHI, PAKISTAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0331 A.M. Kazi1, S.A. Shah2, R. Khanani3, N. Rafique4, N. Baloch5 The results of the study show poor infection control practices at this tertiary care facility in Karachi. With no functioning infection control program, including ongoing training of health care workers, improper infectious waste disposal and negligible incineration facilities. |
| ThPE0332 | PROGRAMME SUSTAINABILITY: AN OPERATION RESEARCH TRIALING TWO COMMUNITY LEVEL HIV PREVENTION EXIT STRATEGIES IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0332 A. Ankomah1, J. Anyanti1, Z. Akinyemi2, O. Oluigbo2, O. Idogho3, E. Arogundade2 Behaviour was maintained among groups where CBOs emerged late compared with where CBOs emerged early. Early formation of CBOs may result in lack of focus and loss of interest in the programme, as the CBOs may also want to "move on". Again the CBOs may have unrealistic expectations in the programme which may not materialize. |
| ThPE0333 | WORKING TO BUILD SUSTAINABLE AIDS-MANAGEMENT STRUCTURES IN RESOURCE LIMITED SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0333 Y. Nair1, S. Maimane1, C. Campbell2 We outline how the community-led project is currently working to 'institutionalise' itself through building broad-based grassroots structures and permanent links with four external partnership structures (municipality, health and welfare departments and a regional NGO). Working closely with local residents, the municipality will eventually take long-term responsibility for the formal administrative side of project co-ordination. The municipality is working to establish this project as a 'best practice model' throughout the region in the interests of effective and sustainable HIV/AIDS work. |
| ThPE0334 | SUSTAINABLE VOLUNTARY COUNSELING AND TESTING (VCT) SERVICES IN CAMBODIA, MYANMAR AND VIET NAM: WHO IS WILLING TO PAY? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0334 C. Om, D. Shaw, T. Roes, K.T. Tar, K.M. Wai, N.B. Hang, N.D. Anh Fees for HIV testing need to balance concerns about sustainability with increasing access to services for vulnerable population groups. Promotion of VCT services through outreach and SRH clinics should promote the benefits of testing and provide a transparent and equitable fee structure. |
| ThPE0335 | PROVIDING HIV POST-EXPOSURE PROPHYLAXIS FOR NON-OCCUPATIONAL EXPOSURE FOR LONG-TERM OVERSEAS WORKERS FROM GERMANY - LESSONS LEARNED Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0335 J. Schaefer1, S. Weinreich2, G. Schneider3 Agencies and organisations sending personnel to countries with high HIV prevalence should equip them with NONO-PEP advice and with the appropriate drugs. |
| ThPE0336 | THE EFFECT OF VCT ON PRIMARY AND SECONDARY PREVENTION OF HIV/AIDS: PRESENTATION OF DATA FROM RWANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0336 T. Mukabarasi1, C. Kamenga2, D. Murray1, E. Micomyiza1, M. Ngabonziza1, J. Price1, P. Ndabamenye1 |
| ThPE0337 | NATIONAL VOLUNTARY COUNSELING AND TESTING (VCT) PROGRAMME IN INDIA: SCALING-UP QUALITY VCT SERVICES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0337 A. Khera1, S. Mehrotra2, B. Mahanty3 The government of India is successful in rapidly scaling-up of quality VCT as part of a comprehensive HIV prevention, care and treatment programme. A significant expansion of VCT services to sub-district level is planned. |
| ThPE0338 | REACHING TRUCKERS WITH HIV/STI PREVENTION SERVICES ON THE SOUTHERN BORDER OF BRAZIL: A FEASIBLE AND WELL-ACCEPTED INTERVENTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0338 J. Diaz1, J. Pulerwitz2, S. Lippman3, M. Chinaglia1, C. Ogura4 This mobile clinic at the customs station was inexpensive, well received, and should be replicated. Truckers asked program staff and customs station managers to maintain the services, and in the end, funding was found from a local university, which will continue offering the services for free; and will use the trailer as a teaching site. |
| ThPE0339 | KNOWLEDGE BEHAVIOUR MODIFICATION (KBM) AND COST BENEFIT ANALYSIS (CBA) IN CHANGE COMMUNICATION INTERVENTION AMONGST YOUNG PEOPLE IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0339 U. Omo - Obi1, P. Okoh1, S. Amade2, A. Obioma3, B. Mbakwem4 For the multiplication of current efforts, there is a need to sustain and increase current funding, institutional capacity building, strategic cost effective programming and development of culturally sensitive behaviour modification tools through community driven participatory methods and ownership systems. |
| ThPE0340 | ENSURING SUSTAINABILITY OF HIV PREVENTION PROGRAMMES FOR YOUNG PEOPLE: APPROACHES OF THE AFRICAN YOUTH ALLIANCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0340 U. Daniels1, J. Senderowitz2, C. Boyce3, G. Hainsworth3, H. Shariff4 Plan for the end. A strategy for sustainability is essential, as is the early ability to make plans operational. Build on what exists. Sustainable activities must be part of the normal operating structure. Capacity-building undergirds sustainable activities and requires adequate resources to help implementers become professional and accountable and able to diversify income sources. |
| ThPE0341 | COMPARATIVE STUDY OF HIV/AIDS AND STI PREVENTION METHODS AMONG YOUTHS IN SLUM COMMUNITIES IN BANGKOK Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0341 R. Jommaroeng1, S. Chaitiamras2, S. Techapalokul3, T. Sutthikiri1, K. Kanggarnrua4, P. Phanuphak2 It is proved that life skill-based approach was more effective than traditional didactic approach even it took longer time. It worked well even among low-educated youth while didactic approach did not work for them. Life skill approach includes participatory approach, which can entertain youths while doing activities and increasing their knowledge at the same time. |
| ThPE0342 | EXTENDING ACCESS TO HIV/AIDS PREVENTION AND CARE TO RURAL POPULATIONS IN CÔTE D'IVOIRE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0342 A. Agneroh1, K. Badou1, N. Konan Bogui1, C. Kouassi1, C. Longuet2, L. Laplace2, J. Fattoh3, S. d'Aurelle de Paladines2, D. de Korte2 Implementation of access to HIV counseling & testing, care, and referral to treatment will require evaluation. HIV programs concentrating on rural populations in other countries in conflict can benefit from lessons learned. |
| ThPE0343 | SCREENING CAMPAIGN FOR THE GENERAL PUBLIC Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0343 A. Bonnineau1, R.S. Bucknall2 In the Paris region the general public especially the poor continue to discover late, a HIV and/or a Hepatitis infection. This means that the treatment starts late, with less chances to be successful, as well people unaware of thier HIV status risk to contaminate others. Our NGO AIDES, work hand in hand with the medical screening teams. Together we work in the street, like outside a busy subway or train station. |
| ThPE0344 | ADULT SEX VENUES: GETTING IN THE DOORWAY A COST EFFECTIVE INTERVENTION PLAN FOR COMBATING HIV/STDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0344 H. Ramsey1, K. Dreiss2 In January 2005, four primary syphilis cases reported the same adult video arcade as the point of sexual contact. In response, Austin/Travis County Health Department began an aggressive outreach intervention program to prevent additional STD cases. The target was men who frequent adult sex venues (bookstores, adult video arcades and massage parlors) for sex with anonymous partners. |
| ThPE0345 | AN EFFECTIVE WAY OF BEHAVIOR CHANGE INTERVENTION ON CLIENTS: A SUCCESS STORY OF PEER BASED APPROACH IN NEPAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0345 A. Shrestha, R. Shrawan Base on experience, conducting peer base DIC and peer base approach in Nepal is very much effective and successfully approach to means for BCI component for clients. |
| ThPE0346 | METHODS AND INNOVATION IN HARM REDUCTION: THE LATE NIGHT BREAKFAST BUFFET (LNBB) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0346 V. Rose1, H. Raymond2, T. Kellogg2, A. Bachrach3, W. McFarland2 Late night harm reduction services, especially needle exchange, are feasible and acceptable; however, adequate time is needed to establish field presence. Field-based results and anonymous testing may have increased testing uptake. Needle exchange hours should be extended beyond existing hours to reach a late night population of MSM. |
| ThPE0347 | RESPONSE DRIVEN SAMPLING: REACHING SEX WORKERS POST DEMOLITION OF GOA'S RED-LIGHT AREA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0347 M. Shahmanesh1, S. Wayal2, S. Mendoza2, V. Patel3, D. Mabey4, F. Cowan5 RDS identified widely disseminated networks of SWs, 1/3 of whom had not been reached by the thirteen organizations. High prevalence of infections, and misconceptions about HIV, suggest an urgent need to utilize these networks to deliver HIV prevention. That over 90% were free to leave SW suggests that RDS may not reach SWs denied freedom of movement. |
| ThPE0348 | ENHANCING DISSEMINATION OF EVIDENCED-BASED HIV INTERVENTIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0348 J. Fitzpatrick1, S. Truax2, B. Aoki1, K. Sitter2, G. Lemp1 Capacity building through Web-based programs for HIV/AIDS prevention providers is central to maintaining high-quality prevention. Lessons from California may provide an expedient example for others with diverse at-risk populations across large population areas. |
| ThPE0349 | BARBERS AND THEIR HAIR CUTTING SALOONS IS EFFECTIVE TOOL FOR BEHAVIOR CHANGE COMMUNICATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0349 A. Gupta1, D. Singh1, P. Sharma1, V. Deepak2, D.A. Haag3 Distribution of 8620 condoms in one year indirectly indicates the impact of these services. Adding incentives i.e. supply of disinfectants, prize winning quiz for customers, etc., may increase interest of barbers and results could be further improved. Low literacy could be neutralized by supplementary training. |
| ThPE0350 | EFFECTIVENESS OF THE APPRECIATION-INFLUENCE-CONTROL (AIC) APPROACH TO COMMUNITY MOBILIZATION FOR HIV/AIDS IN BANGKOK, THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0350 O. Rhucharoenpornpanich1, B. Limanonda2, C. Sirinak1, K. Fox3, N. Boonyabuddhi3, W. Liewluck1, W. Levine4, W. Subhachaturas5 The AIC approach can effectively mobilize communities to improve awareness and attitudes about HIV/AIDS, and may more broadly increase community problem-solving capacity. Based on this experience, this approach is being expanded to 260 additional Bangkok communities. |
| ThPE0351 | EFFECTIVENESS AND FEASIBILITY OF A 100% CONDOM USE PROGRAM IN REDUCING TRANSMISSION OF HIV/STDS IN FEMALE SEX WORKERS IN CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0351 S.B. Wei1, Z.D. Chen2, W. Zhou2, J.G. Shan2, W.D. Shi3, H.F. Wang2, Y.H. Xu3, C.Y. Cai4 Consistent condom use can significantly reduce STDs incidence, and reduce the sexual transmission of HIV. Therefore, our results suggest that 100% CUP in entertainment establishments is an effective and feasible strategy for AIDS/STDs control in China. |
| ThPE0352 | BUILDING AND MAINTAINING QUALITY HIV COUNSELING AND TESTING AND INJECTION SAFETY PRACTICES. WHAT DOES IT TAKE IN A POOR RESOURCE SETTING? EXPERIENCES FROM 5 NGO CT SITES AND 3 NGOS' HOSPITALS IN INJECTION SAFETY PRACTICES IN MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0352 E.S. Gumbo Constant monitoring for PQI, counselors' networking meetings, management support and peer observations of counselors performances are very important in building and maintaining quality of counseling and testing and also improving injection safety and infection prevention practices. Constant and sustained mentorship is key to building quality of care in poor resource countries. |
| ThPE0353 | TARGETED INTERVENTIONS (TI) - ENSURING BETTER PERFORMANCE THROUGH PARTICIPATORY NGO MANAGEMENT SYSTEM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0353 A. Ezhilpari, P. Rangasami, K. Pramod, S. Vijayakumar Participatory NGO Management system evolved by TANSACS has proved to be efficient; the same could be replicated at national level for strengthening of NGO program management. |
| ThPE0354 | NUTRITIONAL CARE AND SUPPORT OF PEOPLE LIVING WITH HIV/AIDS UNDER ANTI RETROVIRAL THERAPY: MANAGEMENT OF NUTRITION-RELATED SYMPTOMS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0354 D. Adama1, N. Adama2, N. Malick3, C. Djibril4 Management of nutrition-related symptoms such as diarrhoea and anorexia must be strengthened in these patients and for health workers. Nutrition intervention programs should provide appropriate nutrition support for patients under ARV. |
| ThPE0355 | EFFECT OF EMPLOYEE SENSE OF EFFICACY ON COMMUNITY INTERVENTIONS FOR HIV PREVENTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0355 M. Montaño1, K. Cowling1, M. Dorres2, S. Goldenkranz1 All staff should receive training regarding all components of the HIV intervention to emphasize the importance of their roles, irregardless of direct contact with target communities. If staff of a community-based intervention have a high sense of efficacy, their optimism will filter through to the target community, facilitating change. Contact with target communities and between teams fosters a high sense of efficacy. |
| ThPE0356 | TRAINING AND SUSTAINING PEER PARENT LEADERS FOR HIV PREVENTION WORK - RAISING SEXUALLY HEALTHY CHILDREN PROGRAM FOR IMMIGRANT FAMILIES IN TORONTO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0356 H. Co The Raising Sexually Healthy Children model is a cost-effective practice model that has been effective in promoting discussions of sexual health education in populations where the discussions of sex, sexuality, and STI/HIV are stigmatised and taboo. |
| ThPE0357 | LESSONS LEARNED IN THE DEVELOPMENT OF AN HIV RESOURCE FOR ADOLESCENTS THAT EXPLAINS CLINICAL ASPECTS OF HIV IN EASY TO READ LANGUAGE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0357 S. Lambert1, M. Tesch2 Lessons learnt from the attempt to present HIV in easy to read language be utilised in the development of similar resources. This resource be distributed widely in areas of need. |
| ThPE0358 | SEX FROM A TO Z: A GAY & BISEXUAL MALE YOUTH-TARGETED HIV/STI PREVENTION CAMPAIGN FRAMED IN HUMOUR AND SEXPOSITIVITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0358 B. Houghton It is important for AIDS Service Organizations to be edgy and creative with youth-focused campaigns. Campaigns are competing with countless other marketing materials aimed at youth and therefore must stand out boldly. Once attention is earned, messages must not talk down to, preach to, or judge youth. Instead, messages should affirm the positive aspects of sex and sexuality and include safety as one of those aspects. |
| ThPE0359 | PROMOTING HIV PREVENTION THROUGH THE MEDIUM OF FOOTBALL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0359 M.J. McGilvray, T. Genders If HIV prevention is to impact on adolescents then it must be delivered in an appealing way. The 2010 World Cup in South Africa provides the perfect impetus to address a critical need. Selling courses as a product to corporate businesses allows us to "roll out" HIV prevention. |
| ThPE0360 | THE INFLUENCE OF EXTERNAL NGOS ON THE OUTCOME OF PEER EDUCATION: CASE STUDY OF A YOUTH PREVENTION PROGRAMME IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0360 S. Maimane, Y. Nair, C. Campbell External organisations implementing AIDS programs often assume its others (usually poor community members) that must change their behaviour. As members of external organisations we need to look at how our own actions and practices unintentionally reinforce the disempowering dynamics that drive the epidemic, rather than resulting in the sustained behavour change we hope for. We discuss the implications of our findings for northern NGOs delivering peer education to youth in southern countries. |
| ThPE0361 | A MULTI-SECTORAL APPROACH TO SRH AND HIV PREVENTION AMONGST YOUNG PEOPLE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0361 U. Daniels1, J. Senderowitz2, C. Boyce3, G. Hainsworth3, L. Mueller4, H. Shariff5 Programmes seeking to improve adolescent sexual and reproductive health (ASRH) are typically based on health promotion, social and behavior change. Delivering an integrated, comprehensive range of interventions through multiple implementing partners, at a scale capable of halting and reversing current HIV trends - remains a challenge. |
| ThPE0362 | IS IT WORKING? YOUTH HIV PEER EDUCATION IN POST-CONFLICT SIERRA LEONE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0362 A. Woolnough Icely1, K. Bah2, R. Baggaley3, T. Makanjuola4 Kenema's youth sexual behaviour is conducive to HIV transmission, frequently having multiple sexual partners, often concurrent, and with low condom use. Key influencing factors include peer pressure, poverty pressures, cultural and religious beliefs, and gender imbalances in sexual decision-making. Denial of HIV by youth is a major barrier in HIV prevention, and an area where peer educators have an impact. The project demonstrated some increased knowledge and contributed to changes in condom use amongst targeted youths, especially out-of-school youth. However, knowledge levels and condom use remain low, facilitating HIV transmission. Effective prevention interventions are urgently required in Sierra Leone. This study suggests youth HIV peer education is one intervention helping to combat denial and increase knowledge and condom use. |
| ThPE0363 | THE PARENTS MATTER! PROGRAM (PMP): EFFECTIVENESS OF A FAMILY-BASED SEXUAL RISK PREVENTION PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0363 L. Armistead1, R. Forehand2, N. Long3, S. Wyckoff4, K. Miller4 Family-based prevention programs can help promote sexual communication between parents and pre-adolescent children and is associated with reduced sexual intentions, the primary predictor of initiation of sexual intercourse. |
| ThPE0364 | YOUTHS BRING RELIGIOUS LEADERS TOGETHER FOR AN EFFECTIVE FIGHT FOR THE PREVENTION OF STIS AND HIV/AIDS IN BENIN, WEST AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0364 L. Abdel Aziz Tidjani Sexual and reproductive health related issues including HIV/AIDS for adolescents and youths are a taboo subject in most of Africa countries. Peer education activities that are undertaken at various levels on sexual and reproductive health issues, prevention of HIV transmission through condom using are frequently criticized by youths themselves. This is because the discussion of sexuality issues seems to be in contradiction with held religious and cultural values. When the youths try to discuss these issues, they are asked to talk with the religious leaders who are enforces of religious values. Considering the role that religion plays in our communities and society, as well as its role in decision-making about social issues especially on sexual issues, the youths decided to network directly with religious leaders. They decided to build partnerships with religious leaders in sexual and reproductive health and STI/HIV issues programs. They also focused on programs that were aimed at providing moral support to the people living with HIV/AIDS. This approach gave birth to Benin session of NAYA; Network for the Adolescent and Youth of Africa. |
| ThPE0365 | THE CHALLENGE OF REACHING FEMALE OUT-OF-SCHOOL YOUTHS WITH HIV/AIDS BEHAVIOUR CHANGE INTERVENTION IN HIGH-RISK COMMERCIAL ENVIRONMENT: A CASE STUDY OF OBOLLO-AFOR, ENUGU STATE NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0365 I. Osaigbovo, C. Udonsi Creative approaches are required to arrest the attention of this sort of target. A useful strategy will be to use skill acquisition or any activity that will add economic value to their life as entry point. Besides, the intervention activity should be of short-duration not lasting more than one hour per session as anything above with need to high attrition among the target population. |
| ThPE0366 | THE WINDOW OF OPPORTUNITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0366 S. Roylance Creative approaches are required to arrest the attention of this sort of target. A useful strategy will be to use skill acquisition or any activity that will add economic value to their life as entry point. Besides, the intervention activity should be of short-duration not lasting more than one hour per session as anything above with need to high attrition among the target population. |
| ThPE0367 | SCALING UP PEER EDUCATION IN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0367 D. Kitavi Peer education in Kenya is a popular approach to HIV prevention and reproductive health promotion among youth. |
| ThPE0368 | LESSONS LEARNT FROM 2-YEARS PROJECT IMPLEMENTATION - HIV/AIDS PREVENTION FOR CHILDREN WITH DISABILITIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0368 L. Nguyen Thi Thu Children with disabilities should be supported to receive especially appropriate care and support, which contributes to the proper fulfillment of their rights and reintegration in the community. |
| ThPE0369 | PEER BASED LIFE SKILLS EDUCATION: AN EFFECTIVE APPROACH FOR HIV PREVENTION IN THE GEOGRAPHICALLY CHALLENGED AND RESOURCE LIMITED SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0369 V.P. Nepal, J. Nirpa Peer education has been found to be an influential tool in eliciting individual behavior change among the peer groups, which is the best suitable approach for HIV prevention in the resource limited settings as this is a low cost approach. This approach is also found effective for the countries with difficult geographic settings. |
| ThPE0370 | IMPLEMENTATION AND EVALUATION OF A PARTICIPATORY HIV/AIDS PREVENTION PROGRAMME FOR YOUNG WOMEN IN KARNATAKA, INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0370 B. Majumdar1, C. Byrne2, G. Browne3, J. Roberts3, T. Chambers4, Y. Lawlor4, J. Mitton5, A. George Jain6, J. D ' Sa7, C. Sudahker7, A. Bhaduri7, D. Acharya8 The findings from the present study revealed that participatory HIV/AIDS prevention training is an effective method of delivering education to empower Anganwadi workers to train young village young women and thereby prepare them to train others in their community. Participatory training empowers trainees by fostering facilitation and decision-making skills, and offers a means to provide greater access to information about HIV/AIDS in rural communities where it is lacking. |
| ThPE0371 | EFFORTS TO MOTIVATE BEHAVIOR CHANGE THROUGH PRODUCTION AND USE OF A MUSIC VIDEO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0371 A. Biru1, F. Stuer2 An Assessment conducted by Family Health International/Ethiopia in Addis Ababa, Ethiopia, identified stigma and discrimination as a major barrier to any kind of change in behavior for HIV prevention and AIDS care, treatment and support. Interventions targeting stigma on a community level were needed to support a meaningful change in attitudes and behavior. |
| ThPE0372 | YOUTH FRIENDLY SEXUAL AND REPRODUCTIVE HEALTH (SRH) SERVICES: THE "TOP RESEAU" CLINIC FRANCHISE IN MADAGASCAR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0372 V. Rajoela1, M. Mensah2, A. Randriantsalama2 In order to achieve behavior change among at risk youth and other vulnerable groups in Madagascar, exposure to communication activities along with improved service delivery is needed. Where youth friendly services are combined with targeted communication, health impact is maximized. |
| ThPE0373 | INTEGRATION OF PARTICIPATORY ACTION RESEARCH WITH YOUTH PEER EDUCATION FOR HIV/AIDS PREVENTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0373 K. Goto1, J.S. Tiffany2, G. Pelto3 Our research suggests that participatory action research among youth may provide peer educators with the opportunity to re-conceptualize peer education and explore new, less didactic educational approaches for the prevention of HIV/ AIDS. |
| ThPE0374 | KIJANA PROJECT: YOUTH HELPING YOUTH IN THE AGE OF HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0374 S.M. Richards-Govere1, A. Govere2, W. Majoni3 It is hoped that by being invited to IAC 2006 to share our project that adults will take us seriously and act as our allies and advocates. We hope to raise funds this year through a fashion show at Stanford University and to develop a new website that will attract more people to Kijana. We also want to provide more incentives for youth to participate in the project. |
| ThPE0375 | THE IMPORTANCE OF FAMILY: HOW ZAMBIAN ADOLESCENTS MAKE DECISIONS ABOUT HIV COUNSELING AND TESTING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0375 J.A. Denison1, N. Lungu2, W. Dunnett-Dagg2, A.P. McCauley3, M.D. Sweat1 Relational-level factors, particularly family-related constructs, were significantly associated with adolescents having tested for HIV and their demand for the service. These findings highlight the need to examine relational and family-level factors when developing, implementing, and evaluating VCT strategies to reach adolescents. |
| ThPE0376 | PEER-TO-PEER APPROACH FOR ADOLESCENTS AND YOUTH STIS AND HIV/AIDS EDUCATION AND PREVENTION 2004-2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0376 V. Espinoza, E. Acevedo, J. Trujillo, M. Dinev Achieve political commitment and support; Coordinate with health services; Create networks of capacity-builders, with peer educators, teachers, health professionals, and youth with HIV/AIDS; and Establish a follow-up plan that includes capacity-building and technical assistance. |
| ThPE0377 | STRENGTHENING THE PREVENTIVE CAPACITY OF GRASSROOTS YOUTHS FOR IMPROVED COMMUNITY RESPONSE TO HIV INFECTION IN LAGOS STATE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0377 K. Oyelohunnu1, U. Udofia2 Young people still present the only hope of reversing the HIV infection profile in Nigeria. Equipping them with skills, support and reproductive health services remains the most suitable option to address HIV AIDS burden affecting this populous country. |
| ThPE0378 | ARTS-BASED PARTICIPATORY METHODOLOGIES IN HIV AND AIDS PREVENTION AND EDUCATION: TOOLS FOR EVALUATING KNOWLEDGE PRODUCTION IN SOCIAL CHANGE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0378 S. Walsh1, C. Mitchell1, F. Islam2, R. Tao1 The arts in the fight against HIV and AIDS are often marginalized. Even though there are thousands of projects and a general enthusiasm for this kind of work, few researchers are studying why (or how) it is effective. There is need for more attention to this type of programming. |
| ThPE0379 | J SPOT: YOUTH PORTAL FOR EDUCATION ON SEXUALITY AND HIV/AIDS PREVENTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0379 A. Anglas Carpena PUNTO J (J SPOT) responds to the need for information and guidance on sexuality and HIV/AIDS among young people ages 15 to 24 who, by using the Internet, empower themselves by participating in finding the answers to their questions and sharing ideas about sexuality. The project has a region-wide impact in Latin America and the Caribbean. In its first year on line, the portal aims to reach 15,000 young people, with an emphasis on dissemination of information so that other countries can create and implement their own portals. |
| ThPE0380 | BEYOND VICTIMS AND VILLAINS: EVIDENCE-BASED LIFE SKILLS EDUCATION DESIGNED FOR SOUTH AFRICAN SCHOOLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0380 N. Andersson1, A. Ho-Foster2, H. Sonnekus2 The current stage of implementation appears well-suited for programmatic evaluation, to occur together with a robust, staggered cluster randomised controlled trial to assess programme effectiveness. |
| ThPE0381 | HIV AND POPULAR CULTURE: A WEB-BASED EDUCATIONAL RESOURCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0381 D. Wessner, L. Marcil This website on HIV and pop culture is an effective educational tool. We found that it improves knowledge about and attitudes toward HIV among Southeastern US college students as well as minority youth, both at-risk populations. HIV information presented through the Internet and involving popular culture may appeal more to young people than information presented in traditional academic formats, thus making this information more accessible. This site could be useful both in informal settings and as part of structured educational curricula. Because of the Internet's broad reach, this type of educational website may have great potential to disseminate important information to hard to reach populations. |
| ThPE0382 | SYSTEMATIC REVIEW OF ABSTINENCE-ONLY AND ABSTINENCE-PLUS PROGRAMS FOR THE PREVENTION OF HIV INFECTION IN HIGH-INCOME COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0382 K. Underhill, P. Montgomery, D. Operario Rigorous evaluations of abstinence-only programs have not demonstrated any long-term effects on behavior. Abstinence-plus programs may have significantly protective effects on a number of risk behaviors at long-term follow-up, but results were inconsistent across studies. Several programs appear especially effective, meriting further investigation. Findings were limited by poor reporting, underutilization of biological outcomes, lack of intention-to-treat analyses, and lack of evaluations comparing abstinence-only to abstinence-plus designs. |
| ThPE0383 | ENGAGING CHILDREN AS ADVOCATES OF HIV/AIDS PREVENTION IN REMOTE AREAS: SUCCESS AND CHALLENGES IN MASBATE CITY, PHILIPPINES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0383 M.F. Nora Local, national and international health campaigns should involve "touch, feel and be involved strategies," led by children, supported by all stakeholders and institutionalized in schools and communities. |
| ThPE0384 | EVALUATION OF THE HEALTH COMPONENT WITHIN THE SCALING UP OF AN INNOVATIVE SEXUAL AND REPRODUCTIVE HEALTH PROGRAMME FOR YOUNG PEOPLE, IN MWANZA TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0384 L. Medard1, M. Rwakatare2, J. Komrower1, C. Kishamawe1, M. Makokoha2, J. Changalucha1, F. Mohammed2, A. Obasi3 Large-Scale MoH-led training can significantly increase health worker knowledge and attitudes on ASRH and improve their abilities to provide YFS. However, there are various inhibitory factors that need to be addressed so as to ensure the initial positive benefits of these trainings are sustained over time. |
| ThPE0385 | SCALE UP OF HIV PREVENTION PROGRAMS AND SERVICES FOR YOUTH IN EL SALVADOR AND THE DOMINICAN REPUBLIC: LINKING SEXUAL AND REPRODUCTIVE AND HIV/AIDS SERVICES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0385 S. Canfield, J. Galvao, J. Halverson, R. Sanghvi, R. Finlay, V. Ward Results highlight important advances in linking young people with quality, integrated HIV/AIDS/STI and sexual and reproductive health services. |
| ThPE0386 | SCENES OF PREVENTION: NATIONAL CONTEST DISCOVERING DUAL MESSAGES IN MOZAMBIQUE CONTEXT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0386 L. Giurao1, C. Silveira1, A. Tivane2, R. Albasini3, R. Cossa4, M. Bazima5 Taking into account that in many places of Mozambique theatre is the only means to communicate messages to the community, it is important to regularly monitor the quality of messages presented through theatre to make theatre a successful information and health education tool. The national contest offered an opportunity to improve the young people's theatrical and technical skills and encouraged community-level, effective health promotion efforts. |
| ThPE0387 | SAFER SEX CAMPAIGNS IN RUSSIA: NEW MOVE TOWARDS BEHAVIOR CHANGE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0387 O. Barkalova Mass media remains the most effective means to inform youth about HIV/AIDS and to prepare ground for behaviour change however campaign approach has to be adjusted to changing situation. |
| ThPE0388 | KAPB STUDY IN FIRST YEAR STUDENTS OF SARATOV UNIVERSITY, RUSSIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0388 C. Marimoutou1, L. Potemina2, J.-L. Mattei1, P. Toubiana3, M. Frappas3, R. Andrei1, J.-A. Gastaut1 A large work has to be done for information and prevention as well in regards of contamination route and their prevention as for tolerance towards HIV-infected people. |
| ThPE0389 | YOUTH TO YOUTH INITIATIVE IN HIV PREVENTION - AN INDIAN EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0389 T. Mathew, A. Sobha, S. Philip, R.S. Nisha In developing countries where cultural barriers still prevail in discussing personal sexual behaviours and issues related to HIV / AIDS, using trained youth to motivate other youth could be a cost effective strategy to initiate behavioural changes at a young age. |
| ThPE0390 | "SAFE FROM HARM" - PILOT TEST RESULTS FROM A DELAYED DEBUT INTERPERSONAL COMMUNCIATION PROGRAM DESIGNED TO IMPACT PARENT-ADOLESCENT COMMUNICATION ABOUT HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0390 J.L. Greene, J. Berman Despite taboos regarding parent/child communication about sex in Africa, it is possible to overcome these barriers by enhancing communication skills and technical knowledge. Study limitations include small sample size. Scale-up of Safe from Harm should continue as a means to promote delayed sexual debut among African youth. |
| ThPE0391 | COMMUNITY - BASED CARE AND SUPPORT PROGRAM FOR AIDS ORPHANS AND VULNERABLE CHILDREN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0391 M.O. Taiwo, E. Ejalonibu, O. Olatunji Organizations and institutions should provide more support that will empower affected communities to facilitate quality of life for the orphans and vulnerable children. Similarly, design of such efforts should facilitate community ownership for sustainability. |
| ThPE0392 | IMPLEMENTING PREVENTION PROGRAMS THROUGH PEER EDUCATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0392 C. Sereyvoath Project staff working with youth and adolescents must understand their role as facilitators of change and providers of support. The role of youth as service providers to their peers is fundamental to successful peer based interventions; this must be consistently supported by staff working in an advisory and supporting capacity. |
| ThPE0393 | PEER-EDUCATION BASED ON SECONDARY SCHOOLS CLUB AS AN EFFECTIVE COMMUNICATION STRATEGY FOR HIV PREVENTION IN CAMEROON Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0393 E. Kanjo1, J.P. Tchupo2 Club-based peer education structures more around cultural activities than other strategies of the like and would attract more followers. Promotional materials would attract more targeted youths. Model-based demonstrations or message delivery would increase acquisition of knowledge and change of behaviours. Among other factors, the clubs would last long because outgoing students (members)are constantly replaced by others. |
| ThPE0394 | COMMUNITY DRIVEN HIV/AIDS INTERVENTION PROJECTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0394 S.B.L. Setumo Many HIV interventions have failed because they are externally conceptualized and influenced. The community driven HIV/AIDS intervention project focuses on putting commuity members in the drivers seat thereby promoting community ownership, participation and involvement in conceptualizing, creating, planning and implementation of HIV/AIDS interventions at community level. |
| ThPE0395 | DESIGNING A SECONDARY SCHOOL HIV PREVENTION PROGRAM: KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0395 E. Maticka-Tyndale1, M. Gichuru2 |
| ThPE0396 | FOSTERING YOUTH RESILIENCY IN EGYPT: POTENTIALS AND CHALLENGES IN A LOW PREVALENCE BUT NOT LOW HIV/AIDS RISK COUNTRY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0396 E. ElKharrat We recommend further studies on the generic, cross-cultural and multi-dimensional nature of HIV prevention programmes. Wider experimentation and implementation is required, so that benefits go beyond the HIV/AIDS challenge to meet various developmental challenges. |
| ThPE0397 | BREAKING THE CULTURE OF SILENCE ON SEXUAL AND REPRODUCTIVE HEALTH ISSUES AMONG ADOLESCENTS IN NORTHEASTERN NIGERIA THROUGH PEER EDUCATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0397 A. Olaleye1, O. Faromoju2, O. Afachung2, O. Ladipo3, A. Ajuwon4, F. Oronsaye1, G. Delano3 Peer education is an effective approach in promotion of SRH information in culturally sensitive communities. |
| ThPE0398 | SEXUALITY FAIR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0398 L.M. Umbasía, L. Mendieta, C. Serrano, A. Mejía A sensitization strategy through ludic and focalized experiences for young people was developed. It allowed the promotion of attitude changes, to develop HIV/STI prevention and to promote sexual and reproductive health in young people (settlers and indigenous population) of three towns in the Colombian Amazonia and Orinoquia. An area characterised by poverty, geographical isolation and the risks associated with frontiers zones populations. |
| ThPE0399 | PILOT STUDY OF KNOWLEDGE, ATTITUDES AND WILLINGNESS OF SOWETO ADULTS TO ALLOW ADOLESCENTS TO PARTICIPATE IN HIV VACCINE TRIALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0399 N. Skhosana, G. De Bruyn, J. McIntyre, G. Gray Despite some misconceptions, parents and teachers indicated confidence in medical research. Studies exploring willingness to participate in trials may not reflect willingness to participate in actual trials but may sensitize communities to the need to participate in these trials. Parents/guardians in Soweto indicated high degrees of willingness to allow their children to participate in HIV vaccine trials. This was qualified with the need to be involved in the research. |
| ThPE0400 | SOMOS DIFERENTES, SOMOS IGUALES - SDSI (WE'RE DIFFERENT, WE'RE EQUAL): A COMMUNICATION FOR SOCIAL CHANGE STRATEGY FOR HIV-AIDS PREVENTION IN NICARAGUA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0400 I. Solorzano The ongoing evaluation and lessons learned during implementation provide an opportunity to: explore and reflect about methodologies used to evaluate communication for social change; improve design and implementation of prevention programs; analyze issues and concerns related social and individual changes and the relevance of integrating edutainment and social mobilization around HIV-AIDS prevention. |
| ThPE0401 | THE IMPACT OF THE HISPANIC FAMILY INTERVENTION PROGRAM (HFIP) FOR PREVENTION OF HIV/AIDS IN HIGH-RISK ADOLESCENTS AND THEIR PARENTS: AN EVALUATION STUDY OF A LOS ANGELES HISPANIC SAMPLE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0401 R. Cervantes1, C. Kaplan1, A. Melena2 The HFIP is a successful model for HIV prevention in Hispanic families. Future evaluation studies with Hispanic immigrant families need to budget sufficient resources to relocate families for follow-up to improve the validity of results. |
| ThPE0402 | THE EXPERIENCE OF THE RUSSIAN RED CROSS (RRC) IN IMPLEMENTING COMMUNITY-BASED HIV/AIDS PROGRAMMING IN RUSSIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0402 E. Vyalba As one of the largest community-based organizations in Russia, RRC has the potential to become a leader in the fight against HIV/AIDS. With Government efforts in HIV/AIDS intensifying in recent months, RRC is well positioned to scale up, expand its community and volunteer-based programs, and become an active leader in the fight against HIV/AIDS in Russia. |
| ThPE0403 | 100% CONDOM USE PROGRAM IN BANTEAY MEANCHEY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPE0403 K. Pisey, C. Vannarith, C. Chansophoan Camb |