|
16th International AIDS ConferenceToronto, Canada — August 13-18, 2006 |
Cite as: Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. xx
| Table of Contents Main Monday Tuesday Wednesday Thursday Late-Breakers |
| Thursday | Oral Abstracts |
| ThAa01 | Preclinical Vaccine Development |
| ThAa0101 | ENHANCED HIV/SIV SPECIFIC CELLULAR IMMUNITY IN MACAQUES FOLLOWING A NOVEL PEPTIDE IMMUNOTHERAPY (OPAL) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0101 Kent S., Chea S., De Rose R., Batten C.J. CTL responses can be monitored in vivo by infusing peptide-pulsed autologous cells. The infusion of Overlapping Peptide-pulsed Autologous cells (OPAL) sharply enhances broad SHIV-specific CD4+ and CD8+ T cell responses. This simple technique holds promise for the immunotherapy of HIV. |
| ThAa0102 | NON-INFECTIOUS PAPILLOMA VIRUS - LIKE PARTICLES (VLPS) INHIBIT HIV REPLICATION: IMPLICATIONS FOR IMMUNE CONTROL OF HIV REPLICATION BY IL-27 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0102 Fakruddin J.M.1, Lempicki R.2, Yang J.2, Adelsberger J.3, Pineres A.4, Pinto L.4, Lane H.C.5, Imamichi T.1 The identification of IL-27 as a novel anti-HIV-1 cytokine along with a better understanding of the molecular mechanism of action of IL-27 may lead to the rational design of a new immune-based therapy against HIV-1 infection. |
| ThAa0103 | PRIME-BOOST VACCINATION WITH PLASMID DNA AND A CHIMERIC ADENOVIRUS TYPE 5 VECTOR WITH TYPE 35 FIBER INDUCES PROTECTIVE IMMUNITY AGAINST HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0103 Xin K.-Q.1, Someya K.2, Yoshida A.1, Honda M.2, Okuda K.1 These findings indicate that an Ad5/35 vector-based HIV vaccine may be of considerable value for clinical use. |
| ThAa0104 | COMPARATIVE EVALUATION OF CD70, LIGHT AND 4-1BBL, AS COSTIMULATORS OF HUMAN ANTI-VIRAL MEMORY CD8 T CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0104 Wang C., Wen T., Watts T. Thus, three costimulatory molecules from the same gene cluster have different impact on anti-viral memory CD8 response in human and CD70 and 4-1BBL represent a promising adjuvant combination for expanding CD8 effector cells. This work was funded by the Canadian Institutes of Health Research and by CANVAC, the Canadian Network for Vaccines and Immunotherapeutics. |
| ThAa0105 | CHIMERIC CD40L/SHIV VIRUS-LIKE PARTICLES ENHANCED DENDRITIC CELLS ACTIVATION AND BOOSTED IMMUNE RESPONSES AGAINST HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0105 Zhang R., Li M., Chen C., Yao Q. These data demonstrate that chimeric CD40L/SHIV VLPs are able to potently induce DC maturation and activation, mainly through CD40 and CD40L interaction. CD40L/VLPs can enhance both humoral and cellular immune responses to the SIV Gag and HIV Env protein in a mouse model. The results indicate that incorporation of CD40L into VLPs may be highly effective in enhancing immunogenicity of HIV vaccines. |
| ThAa02 | HIV-1 Mediated Pathogenesis |
| ThAa0201 | CXCR4-SPECIFIC VIRAL LOAD PREDICTS CLINICAL HIV-1 DISEASE PROGRESSION DURING HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0201 Philpott S.1, Ledergerber B.2, Klimkait T.3, Burger H.1, Kitchen C.4, Bürgisser P.5, Gorgievski M.6, Joller H.7, Perrin L.8, Piffaretti J.-C.9, Schmid P.10, Gormley A.1, Schroeder T.1, Weiser B.1, Swiss HIV Cohort Study QXR and X4-specific viral loads were strong predictors of disease progression during HAART, independent of and in addition to CD4 count or total viral load. They promise to be useful for clinical management of HIV-1 infection. |
| ThAa0202 | HIV-1 VPR EXERTS NEUROPATHOGENIC EFFECTS CAUSING NEURONAL APOPTOSIS AND GLIAL CELL TYPE-DEPENDENT NEUROINFLAMMATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0202 Barsby N.1, Jones G.2, Jhamandas J.3, Dickie P.3, Cohen E.4, Power C.5 Vpr-induced neuronal apoptosis occurs by both direct and indirect mechanisms. Direct application of soluble Vpr causes apoptosis involving Akt suppression and caspase-9 activation while the indirect effects may be mediated by excitation of glial cells. |
| ThAa0203 | HIV-1 TAT PROTEIN INDUCES COX-2 THROUGH A NFAT/AP-1 MEDIATED MECHANISM IN ASTROCYTOMA CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0203 Blanco A.1, Alvarez S.1, Suñé C.2, Fresno M.3, Muñoz-Fernández M.A.1 COX-2 regulation by extracellular Tat in human U-87 astrocytoma cells is highly induced in a NFAT/AP-1 dependent way. |
| ThAa0204 | MICROARRAY BASED STUDY OF EARLY INTERACTIONS BETWEEN HIV-1 AND A PBMC POPULATION HIGHLY ENRICHED IN CD4+ T CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0204 Imbeault M., Tremblay M.J. We conclude that HIV-1 rapidly influences the transcriptional profile of primary CD4+ T lymphocytes and sensitizes bystanders CD4+ T lymphocytes to apoptosis, primarily via p53 upregulation. |
| ThAa0205 | THE NEF-TCR INTERACTION: POTENTIAL ROLE IN AUGMENTATION OF T-CELL SIGNALING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0205 Kim W.M., Sigalov A.B., Stern L.J. By binding specifically to the cytoplasmic domain of TCRζ, Nef may function as a biological crosslinker capable of clustering multiple TCR complexes from within the intracellular compartment. The potential for Nef to augment T cell activation through the formation of TCR clusters presents a novel mechanism of Nef function and T cell signaling. |
| ThAa03 | HIV Drug Development |
| ThAa0301 | THE LEDGF-INTEGRASE INTERACTION AS A NEW TARGET FOR ART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0301 Vandekerckhove L., De Rijck J., Gijsbers R., Christ F. Witvrouw M., Debyser Z., Molecular Medicine The highly potent inhibition of HIV-1 replication by the IBD of LEDGF/p75 provides a proof-of-principle for a novel antiviral therapeutic strategy targeting the interaction of LEDGF/p75 with HIV-1 IN. By binding to HIV-1 IN, the IBD likely competes with the binding of native LEDGF/p75 that is required to dock the preintegration complex to the chromosomes. DKA resistant strains remain susceptible to inhibition by IBD. Peptides and small molecules targeting LEDGF/IN interaction offer great potential as future antiviral agents. |
| ThAa0302 | BIOCHEMICAL AND ANTIVIRAL ACTIVITY OF MK-0518, A POTENT HIV INTEGRASE INHIBITOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0302 Miller M.1, Witmer M.1, Stillmock K.1, Felock P.1, Ecto L.2, Flynn J.2, Schleif W.2, Dornadula G.1, Danovich R.1, Hazuda D.1 MK-0518 is a potent HIV integrase inhibitor that displays broad antiviral activity against HIV isolates, including isolates resistant to other classes of HIV drugs. The virological profile of MK-0518 support its use in combination with all other classes of antiretroviral agent. |
| ThAa0303 | NEXT GENERATION FUSION INHIBITOR CANDIDATES TRI-1144 AND TRI-999 HAVE IMPROVED PHARMACOKINETICS: PROGRESS TOWARDS ONCE/WEEK DOSING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0303 Delmedico M.1, Bray B.1, Cammack N.2, Di J.1, Heilman D.1, Silinski P.1, Webb S.1, Wring S.1, Greenberg M.1 Enfuvirtide (ENF, Fuzeon™), the first approved HIV entry inhibitor, is administered by SC injection twice/day and is an important therapeutic option for treatment-experienced patients. The Next Generation Fusion Inhibitor (NGFI) goal is to improve upon ENF efficacy while decreasing injection frequency to once/week. Two NGFI peptide candidates, TRI-1144 and TRI-999, demonstrate substantial improvements in potency, genetic barrier to resistance and pharmacokinetics. These peptides have been evaluated in sustained-release formulations. |
| ThAa0304 | PL-100, A NOVEL PROTEASE INHIBITOR WITH A HIGH GENETIC BARRIER Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0304 Dandache S.1, Wainberg M.A.2, Panchal C.1, Wu J.J.1 PL-100 is a promising new PI that forces HIV into a unique mutational pathway that conferred only a mild resistance to our drug and that proved detrimental to its replication capacity. No cross-resistance to other PIs was observed. The mutational pathway made the virus more sensitive to a few other PIs that could potentially be applied in combination with PPL-100, a phosphorylated form of PL-100 currently in Clinical Phase I trials in Canada, in a more potent HAART regime. |
| ThAa0305 | COOPERATIVE INTERACTION BETWEEN A CCR5 ANTAGONIST, APLAVIROC(873140/ONO-4128), AND HUMAN CCR5 WITH ALLOSTERIC MECHANISM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAa0305 Shibayama S.1, Tanihiro T.1, Takeda K.1, Watanabe N.1, Hayashi T.1, Sagawa K.1, Demarest J.2, Mcdanal C.2, Sparks S.2, Takaoka Y.3, Fukushima D.1 [3H]aplaviroc showed persistent binding to human CCR5 both in vivo and in vitro, but was dissociated 10-times faster from the huCCR5 (Ile198Met) mutant despite a similar kon value in both CCR5s. Ile198 in transmembrane region-5 is a key residue to confer the property. The binding of aplaviroc does not appear to follow the law of mass-action simply according to the analysis of Scatchard plot and Hill plot. The results imply that involvement of positive co-operativity and CCR5 dimerization in the binding mechanism of aplaviroc is associated to persistent RO. |
| ThAb01 | HIV-1 Mediated Pathogenesis |
| ThAb0101 | LONG-TERM CHANGES IN LIPIDS AND GLUCOSE/INSULIN LEVELS AMONG HIV-INFECTED ANTIRETROVIRAL NAÏVE PERSONS RANDOMIZED TO PI VS. NNRTI VS. PI + NNRTI-BASED ANTIRETROVIRAL REGIMENS: RESULTS OF THE CPCRA 061 METABOLIC STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0101 Shlay J.1, Bartsch G.2, Peng G.2, Wang J.3, Gibert C.4, Visnegarwala F.5, Raghavan S.S.6, Xiang Y.2, Farrough M.7, Perry H.8, Kotler D.3, Grunfeld C.9, El-Sadr W.6 In this prospective trial, all ART strategies had impact on lipid and glucose metabolism. Highest increase in TG and LDL was noted in PI+NNRTI containing regimens. HDL increased the least on PI. Significant increases in insulin were seen with all strategies. These findings necessitate close monitoring of patients. |
| ThAb0102 | NUMBER AND MIGRATORY ACTIVITY OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN HIV-INFECTED PATIENTS RECEIVING HIGHLY ACTIVE ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0102 O. Korzh, S. Krasnokutskiy, G. Kotchuev EPC biology, which is critical for neovascularization and the maintenance of vascular function, is altered in HIVinfected patients receiving HAART. Our data strongly suggest that dysfunction of circulating EPC has a role in the progression of cardiovascular disease in these patients. |
| ThAb0103 | IN UTERO NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR EXPOSURE AND SIGNS OF POSSIBLE MITOCHONDRIAL DYSFUNCTION IN HIV-UNINFECTED CHILDREN IN THE PEDIATRIC AIDS CLINICAL TRIALS GROUP PROTOCOLS 219 & 219C Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0103 Brogly S.1, Ylitalo N.2, Mofenson L.3, Oleske J.4, Van Dyke R.5, Crain M.6, Abzug M.7, Brady M.8, Patrick J.-P.9, Hughes M.10, Seage III G.R.2 There was no association between overall in utero NRTI exposure and possible MD. The association with first in utero exposure to 3TC and to ZDV/3TC in the 3rd trimester warrants investigation in studies that rigorously assess MD and achieve better control of confounding. |
| ThAb0104 | RISK OF DISCONTINUATION OF NEVIRAPINE DUE TO TOXCITIES IN ANTIRETROVIRAL NAIVE AND EXPERIENCED PATIENTS WITH HIGH AND LOW CD4 COUNTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0104 Mocroft A.1, Lacombe K.2, Rockstroh J.3, Gasiorowski J.4, Antunes F.5, Panos G.6, d'Arminio Monforte A.7, Rakhmanova A.8, Phillips A.N.1, Lundgren J.D.9, for the EuroSIDA study group Patients in the HE group had a reduced risk of discontinuation due to TOXPC compared to patients from the HN group. Patients in this study were not randomised to treatment, and the results should be interpreted with caution. While NVPc is not recommended for antiretroviral-naïve patients with high CD4 counts due to the risk of TOXPC, results from this analysis suggest it may be safer for use in antiretroviral experienced-patients starting NVPc. |
| ThAb0105 | GLOMERULAR DYSFUNCTION AND ASSOCIATED RISK FACTORS FOLLOWING INITIATION OF ART IN ADULTS WITH HIV INFECTION IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0105 Reid A.1, Stöhr W.2, Walker S.2, Ssali F.3, Munderi P.4, Gilks C.5, on behalf of the DART Trial Severe GFR impairments were infrequent on all regimens, and patients with baseline renal impairment showed greatest improvements, suggesting that renal benefits outweigh risks over the short-to-mid-term. Differences between regimens in changes from baseline were small, statistically significant but clinically insignificant. Investigating the potential for longer-term nephrotoxicity requires further follow-up. |
| ThAb0106 | CHANGES IN ADIPOSE TISSUE MITOCHONDRIAL DNA QUALITY AND QUANTITY - RELATION TO HIV DISEASE, LIPOATROPHY AND EXPOSURE TO STAVUDINE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0106 P. Mallon1, R. Sedwell1, N. Duarte2, A. Kelleher1, D. Cooper1, A. Carr3 Decreases in SAT mtDNA quantity and quality occur with HIV-infection. Greater mtDNA depletion in lipoatrophic patients (especially those on d4t), with no changes in mtDNA quality, regardless of ongoing d4t exposure, suggests that this further mtDNA depletion may arise through mechanisms other than inhibition of DNA pol-γ. |
| ThAb02 | Scaling Up ART: Time to Deliver |
| ThAb0201 | PROJECT HEART: INITIATING CARE AND ARV TREATMENT FOR OVER 45,000 PEOPLE IN 22 MONTHS IN FOUR AFRICAN COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0201 Marlink R.1, Adjorlolo-Johnson G.1, Anglaret X.2, Bolton C.3, Boni-Ouattara E.4, Bulterys M.5, Buono N.6, Dabis F.2, Ellerbrock T.7, Essombo J.4, Fullem A.8, Gavitt C.9, Giddy J.10, Ginsburg A.1, Giphart A.9, Grundmann C.11, Havlir D.12, Hawkins S.11, Hirschhorn L.8, Holst H.10, Hurkchand H.6, Kline M.13, Lyons C.12, Maharaj S.6, McCullough R.11, Neluheni T.6, Nolan M.14, Nwanyanwu O.15, Oguda L.11, Reid S.3, Schimana W.9, Seyler C.16, Sinkala M.17, Spensley A.11, Stringer E.18, Stringer J.18, Swai M.19, Tanoh A.4, Tindyebwa D.9, Toure S.20, Wahl A.1, Wiktor S.21, Wilfert C.1, Project HEART Implementation Teams The number on treatment is high, despite many challenges across settings, including uptake of pediatric patients; patient follow-up; management of toxicities/OIs and providing basic HIV care to the large number of patients either on treatment or not yet eligible for treatment. The number of children on ART needs to increase to meet existing needs. Many treatment sites have reached capacity, emphasizing the need to train both primary care facilities and non-physicians for management of HIV/AIDS C&T. |
| ThAb0202 | REACHING THE WHO/UNAIDS 3×5 INITIATIVE TARGET IN NAMIBIA – WHAT DID IT TAKE? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0202 Katjitae I.1, Mugala-Mukungu F.1, Goraseb M.2, Damesyn M.3, Matroos E.4, Hamineme N.2, Kaura H.5, Gaeseb J.6, Stevens L.7, Shihepo E.2, Forster N.8, Kenyon T.3 Next steps include decentralizing ART from hospitals to health centers and transferring more tasks from doctors to nurses; increasing emphasis on quality; and development of a human resource plan to meet Namibia's needs for sustaining ART in the future. |
| ThAb0203 | OUTCOMES OF HAART IN HIV-1 INFECTED INDIVIDUALS IN BUENOS AIRES, ARGENTINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0203 Zala C.1, Hogg R.2, Salomon H.3, Chan K.2, Ceriotto M.4, Beltran M.5, Burgos M.6, Montaner J.S.2, Cahn P.1, and the PUMA study team We report data on the effect of HAART within a population-based cohort in Argentina. Initiation of HAART was associated with an advanced HIV disease. Urgent efforts are needed to optimize timing of initiation of antiretroviral therapy in our setting. |
| ThAb0204 | KNOWLEDGE, ATTITUDES, AND PRACTICES OF HIV CARE AND ANTIRETROVIRAL THERAPY AMONG HIV-INFECTED ADULTS ATTENDING PRIVATE AND PUBLIC CLINICS IN INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0204 Vaidya S.B.1, Ramchandani S.R.2, Saple D.G.3, Mehta S.H.4, Pandey V.P.5, Vadrevu R.6, Rajasekaran S.7, Bhatia V.P.8, Chowdhary A.8, Bollinger R.C.9, Gupta A.9 Knowledge and access to ART were greater for patients attending private clinics, but overall levels were low in both private and public settings. Further educational and programmatic efforts are needed to improve treatment awareness and access for HIV-infected persons in both public and private settings in India. |
| ThAb0205 | INSTITUTIONAL CHALLENGES IN ACCESS TO DRUGS IN DEVELOPING COUNTRIES: AN ANALYSIS OF DRUG FORECASTING AND DRUG CONSUMPTION CAPACITY IN AFRICAN HEALTH CARE INSTITUTIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAb0205 Arnold C.1, K¨rzinger M.L.1, Besson M.-H.1, Sembatya Y.2, Ladner J.3, Saba J.1 Forecasting challenges are frequent. Adequate forecasts should be projected on drug demand consistent with capacity limitations and not on epidemiological indicators. Uptake of VDP and DPP programs appears to be limited by institutional capacity. Analytical data on institutional capacity will be presented. |
| ThAc01 | PMTCT: Meeting the Needs of Moms and Babies |
| ThAc0101 | 18-MONTH EFFECTIVENESS OF SHORT-COURSE PERINATAL ANTIRETROVIRAL REGIMENS COMBINED TO INFANT-FEEDING INTERVENTIONS FOR PMTCT IN ABIDJAN, CÔTE D'IVOIRE. DITRAME PLUS ANRS 1201/1202 2001 – 2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0101 Leroy V.1, Ekouévi D.K.2, Dequae-Merchadou L.1, Viho I.2, Becquet R.1, Tonwe-Gold B.2, Rouet F.3, Horo A.4, Sakarovitch C.1, Timité-Konan M.5, Dabis F.1, Toni T.3, DITRAME PLUS ANRS 1201/1202 Study Group A combination of perinatal ZDV+3TC+sdNVP associated to infant-feeding interventions reduces significantly MTCT of HIV with long-term benefit until age 18 months. |
| ThAc0102 | ILLNESS DURING PREGNANCY IS ASSOCIATED WITH IN UTERO HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) TRANSMISSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0102 Farquhar C.1, Mbori-Ngacha D.2, Harris J.3, Wamalwa D.2, Bosire R.4, Redman M.5, Gichuhi C.2, Obimbo E.2, Overbaugh J.5, John-Stewart G.1 Illness during pregnancy was an independent risk factor for in utero HIV-1 transmission in this cohort. Prevention and treatment of co-infections should be considered as potential interventions to reduce HIV-1 transmission during the antenatal period. |
| ThAc0103 | VIRAL SAFETY OF FLASH-HEATED BREASTMILK AS AN INFANT FEEDING OPTION FOR HIV POSITIVE MOTHERS IN DEVELOPING COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0103 Israel-Ballard K.1, Donovan R.2, Chantry C.3, Coutsoudis A.4, Sheppard H.2, Sibeko L.5, Abrams B.1 Breastmilk viral loads were relatively low in this population of women without advanced disease. FH is capable of inactivating HIV in naturally infected breast milk from HIV positive mothers. FH may be a practical infant feeding method for mothers in developing countries who need safe alternatives. |
| ThAc0104 | HIV PREVALENCE RATES AMONGST 6 WEEK OLD INFANTS IN SOUTH AFRICA: THE CASE FOR UNIVERSAL SCREENING AT IMMUNIZATION CLINICS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0104 Rollins N.1, Mzolo S.1, Little K.2, Horwood C.3, Newell M.-L.4 Screening of all infants at immunisation clinics using this method is an effective and feasible method to monitor the overall impact of PMTCT programmes. In settings where longitudinal follow-up of HIV-infected mother and their children has proven to be difficult universal informed screening of infants at 6 week immunisation visits could serve as an additional opportunity for women to learn their HIV status, identify exposed and infected children early and to increase referrals to the HIV care programmes including ART programmes. |
| ThAc0105 | HOW WELL DO PMTCT PROGRAMS IN INDIA FACILITATE ACCESS TO HIV CARE AND SEXUAL AND REPRODUCTIVE HEALTH (SRH) SERVICES FOR HIV-POSITIVE WOMEN? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0105 Sharma Mahendra V.1, Sarna A.1, Rutenberg N.2, Rau A.3, Singh L.B.4, Mudoi R.3, Oinam A.4, Pakkela V.5, Panda S.6 Interim analysis indicates that linkages between PMTCT programs and HIV care and SRH services are weak. Failure to address the SRH needs of women and to connect them to HIV care is a shortcoming of the PMTCT program. Study results will be used to strengthen linkages between PMTCT and other services vital to meeting the needs of HIV-positive women. |
| ThAc02 | Are We Living Longer, Better Lives? Trends in Morbidity and Mortality |
| ThAc0201 | PERSISTENT CONTRIBUTION OF SUBSTANCE ABUSE TO EXCESS MORTALITY AMONG PERSONS WITH AIDS IN NEW YORK CITY, 1999 – 2003 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0201 Pfeiffer M.R., Hanna D.B., Begier E.M., Sepkowitz K.A., Torian L.V., Sackoff J.E. IDU constitute a disproportionate share of deaths among persons with AIDS in NYC. Excess deaths were mainly due to substance abuse-related causes including overdose, HCV and other liver diseases. Mortality could be cut substantially by addressing these causes through substance abuse treatment, HCV treatment, and promotion of harm reduction strategies such as syringe exchange programs and naloxone distribution to treat accidental overdose. |
| ThAc0202 | TRENDS IN MORTALITY AND CAUSES OF DEATH AMONG HIV-INFECTED INDIVIDUALS DIAGNOSED IN THE UK: 1993 – 2004 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0202 Ciancio B.C.1, Forde J.2, Dougan S.2, Chadborn T.2, Delpech V.2 Early diagnosis and treatment could prevent some AIDS-related deaths, particularly among black African heterosexuals. For MSM public health intervention should also consider the prevention of deaths due to cardiovascular and hepatic disease. |
| ThAc0203 | CHILD MORTALITY ACCORDING TO MATERNAL AND INFANT HIV STATUS IN ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0203 Marinda E.1, Humphrey J.H.2, Iliff P.J.3, Mutasa K.3, Piwoz E.G.4, Moulton L.H.2, Nathoo K.J.5, Ward B.J.6, Salama P.7, ZVITAMBO Study Group Mortality is exceedingly high among HIV-infected children. The earlier children are infected, the faster they die. Respiratory infection is by far the major cause of their deaths. These data highlight the need for timely antiretroviral treatment and cotrimoxazole prophylaxis for HIV-infected children. |
| ThAc0204 | RETROSPECTIVE COHORT STUDY OF SURVIVAL RATES IN A SEROCONVERTER COHORT OF NEARLY 2000 SOUTH AFRICAN GOLD-MINERS OVER 10 YEARS OF FOLLOW-UP Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0204 Glynn J.1, Sonnenberg P.2, Nelson G.3, Bester A.4, Shearer S.4, Murray J.5 This study is much the largest cohort of individuals with known dates of seroconversion available in Africa, HIV infection sharply increased mortality rates to high levels. Mortality rates in the HIV positive men were slightly higher than those in the West before ARVs, but the median survival is slightly longer than that reported in Uganda. |
| ThAc0205 | ANEMIA IN EARLY STAGES OF HIV-1 INFECTION IN ADULTS IN BOTSWANA, AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAc0205 Sales S.1, Campa A.1, Essex M.2, Wester W.3, Redd A.2, Burns P.2, Duan R.1, Xue L.1, Bussman H.3, Arimi P.3, Widenfelt E.3, Thior I.3, Makhema J.3, Marlink R.2, Baum M.K.1, Micronutrient Study Team Anemia was prevalent in this African cohort in early stages of HIV-1C disease. Since anemia has been found independently related to HIV mortality, efforts to better monitor, diagnose and treat are needed in the region. Additional studies on types of anemia among patients with early HIV-1C infection and its association to viral characteristics are needed. |
| ThAd01 | Strategies for equity and efficiency in HIV/AIDS assistance |
| ThAd0101 | MODELING THE POTENTIAL IMPACT OF HIV CHEMOPROPHYLAXIS STRATEGIES AMONG MEN WHO HAVE SEX WITH MEN IN THE UNITED STATES: HIV INFECTIONS PREVENTED AND COST-EFFECTIVENESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0101 Desai K.1, McGreevey W.P.2, Ackers M.L.3, Hall H.I.3, Hu D.J.3, Sanders R.2, Sansom S.L.3, Scotton C.R.3, Soorapanth S.3, Stewart S.R.4, Boily M.C.1, Garnett G.P.1, McElroy P.D.3 Even with modest levels of efficacy, HIV chemoprophylaxis among high-risk MSM in a major US city could prevent a significant number of HIV infections and be cost effective. |
| ThAd0102 | PRIVATE-PUBLIC PARTNERSHIP TO SCALE UP RESPONSE IN THE TRANSPORT SECTOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0102 Jenkin J.1, Landis R.2, Matthew P.3 In southern Africa, where humanitarian crises result in huge quantities of food being transported by road, saving lives and risking lives oddly intertwine. Sexual networks flourish along transport routes placing long distance truck drivers, including those moving food aid for the World Food Programme (WFP), at the heart of the action. TNT, the global transport/logistics company, recognized that industry practices can endanger drivers and fuel the epidemic. With core business of each linked to both problem and solution, WFP and TNT overcame different corporate cultures and objectives to work together to increase industry accountability and protect the lives of drivers and their sexual partners. |
| ThAd0103 | MONITORING HIV/AIDS FINANCIAL FLOWS FROM GLOBAL INITIATIVES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0103 Dmytraczenko T., De S. As HIV/AIDS funds increasingly flow from external sources to NGOs, the ability of government to exercise stewardship over prevention and care is challenged. As demonstrated by the experiences of the governments of Kenya, Malawi, Rwanda, Ukraine, Vietnam, Zambia and Zimbabwe, developing systems to track the flow of resources against program objectives can be a powerful tool in guiding HIV/AIDS policy. |
| ThAd0104 | PROTECTING AFRICA'S WILDLIFE AND PARKS: THE IMPACT OF AIDS ON THE ZAMBIA WILDLIFE AUTHORITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0104 Rosen S.1, Hamazakaza P.2, Long L.3 AIDS is constraining ZAWA's ability to protect Zambia's wildlife and parks. Despite the logistical challenges of treating patients in remote locations, even at a cost of $1,000/patient/year, antiretroviral therapy would result in net budgetary savings to the organization and greatly increase its patrol capacity. |
| ThAd0105 | LINKING MDGS AND HIV PREVENTION: UTILIZING POSITIVE EXTERNALITIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0105 Stillwaggon E. Transmission models for HIV and other diseases must incorporate multiple factors that increase risk. Achievement of MDGs requires concerted effort to recognize and exploit the numerous interactions among the goals. Overall costs of achieving MDGs are reduced by integrating programs for interrelated diseases. |
| ThAd02 | Strategies for equity and efficiency in HIV/AIDS assistanceMethodological and Conceptual advances in social research |
| ThAd0201 | METHODOLOGICAL ISSUES AND CHALLENGES IN RESEARCHING WITH CHILD-HEADED HOUSEHOLDS IN RURAL ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0201 Francis-Chizororo M. The fact that children are heading households calls for a need to develop sensitive and appropriate research approaches and methods that place children's voices at the centre of research. |
| ThAd0202 | IMPACT OF LEVEL OF RESEARCHER SUPPORT ON COITAL DIARY RESULTS AND ACCEPTABILITY AMONG WOMEN AT HIGH RISK OF HIV IN THE MICROBICIDES DEVELOPMENT PROGRAMME FEASIBILITY STUDY IN MWANZA, TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0202 Allen C.F.1, Lees S.S.2, Desmond N.1, Der G.1, Chiduo B.3, Vallely A.2, Hayes R.2, Ross D.A.2 CDs result in higher reporting of socially stigmatised activities than FFIs, and are less sensitive to level of support. Convergence with interview results at higher levels of support also shows the relative validity of diaries. Intensive support improved the acceptability of the research process. |
| ThAd0203 | HIV/AIDS RISK RESEARCH AMONG YOUNG PEOPLE: A METHODOLOGICAL STUDY OF THE REPORTING OF SENSITIVE ISSUES AMONG ADOLESCENTS IN THE BIRTH TO TWENTY STUDY, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0203 Norris S.A.1, Richter L.M.2 Interviewer-based questioning is not recommended for collecting sensitive data from adolescents. Even though ACASI was appealing to these urban adolescents, intensive tutorial-based and supportive procedures need to be in place to overcome the technical difficulties associated with the technique. |
| ThAd0204 | RETHINKING THE COMPLEXITIES OF AIDS IMPACT: A CALL FOR INTERDISCIPLINARITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0204 Chazan M.1, Brklacich M.1, Whiteside A.2 Social vulnerability provides valuable new ways of thinking about generalized epidemics. It facilitates a reframing of AIDS as a long-wave societal stressor, which interacts with a myriad of other processes to augment differential vulnerabilities. This study illustrates that it is time to move AIDS research beyond the crisis-oriented "impact model" to a comprehensive vulnerability framework, probing the complex socio-political processes underpinning the epidemic's tragic and uneven effects. |
| ThAd0205 | MEASUREMENT AIDS: IMPROVING MEASUREMENT OF CULTURE IN HIV/AIDS RESEARCH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0205 McDonnell T.E., Gazley J.L. Drawing from advances in social science research, we offer alternative measures of culture, attitudes and practices for use in assessing prevention interventions and analyzing drivers of the HIV epidemic. |
| ThAd03 | Understanding and reaching marginalised groups |
| ThAd0301 | BUILDING REFERRAL NETWORKS BETWEEN TRADITIONAL HEALTH PRACTITIONERS AND BIOMEDICAL HEALTH SYSTEM - A STRATEGY TO REACH THE UNDERSERVED COMMUNITIES WITH COMPREHENSIVE HIV SERVICES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0301 Balaba D.1, Kyeyune P.1, Lutalo I.2, Semafumu E.3 If universal access to comprehensive HIV/AIDS care in sub-Saharan Africa is to be achieved, there is an urgent need to build functional community referral networks. |
| ThAd0302 | HOW THE OBJECT OF RESEARCH TRANSFORMED INTO RESEARCHER: A DURBAR EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0302 Pal S.1, Jana S.2, Roy G.1, Saha A.1 Given the opportunity, even illiterate or less literate sexworkers can prove their worth as researcher and can guide in helping articulating research question and framework for research. Replication of this experience is recommended to provide sexworkers a voice in setting research agendas that are "aimed at them." |
| ThAd0303 | THE DIAGNOSIS AND CARE OF HIV INFECTION IN CANADIAN ABORIGINAL YOUTH: ENGAGING THE COMMUNITY IN RESEARCH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0303 Wong T.1, Prentice T.2, Mill J.3, Jackson R.2, Sommerfeldt S.3, Worthington C.4, Archibald C.1, Myers T.5 To prevent the spread of HIV in Aboriginal communities, Aboriginal peoples must play key roles in all aspects of HIV research, including study design, implementation, result dissemination and knowledge translation. Actions taken have to address the health disparities and needs of the Aboriginal people. |
| ThAd0304 | INTENSIVE ETHNOGRAPHIC TRAINING PROGRAM FOR JUNIOR HIV/AIDS RESEARCHERS IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0304 Sember R.1, Preston-Whyte E.2, Parker R.1 The curriculum for the course be made available to social science educators across the continent and elsewhere in the world. Proficiency in ethnographic research be greatly expanded in order to foster a deeper historical and contextual understanding of the how the epdidemic is shaped and interpreted locally. With adequate supervision, junior researchers are able to undertake longitudinal ethnograph research that provides data of significant value to researchers and providers alike. |
| ThAd0305 | ABORIGINAL PERSPECTIVES ON KNOWLEDGE TRANSLATION IN COMMUNITY-BASED HIV/AIDS RESEARCH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAd0305 R. Masching1, Y. Allard2, T. Prentice1, R. Jackson1, J. Mill3, K. Barlow4 Identifying effective KT strategies that meet community need is an exciting and challenging process. This presentation seeks to continue a dialogue with Indigenous researchers from around the world regarding the application of KT strategies that effectively support research uptake at the grassroots level and beyond. |
| ThAe01 | Money Makes a Difference: Monitoring and Accountability of Global AIDS Funding |
| ThAe0101 | AN ETHICAL ANALYSIS CONTRASTING INTERNATIONAL HIV/AIDS RELIEF EFFORTS WITH RELIEF EFFORTS FOR OTHER DISEASES AND DISASTERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0101 T. Christie1, G. Asrat1, F. Koning2, J. Montaner3 The international response to disasters is fundamentally irrational. The consequences are the resultant funding disparities that violate the principle of justice with no conceivable ethical justification. |
| ThAe0102 | PEPFAR: PROMISES AND PITFALLS AND THE NEED FOR CHANGE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0102 S.A. Lynch1, D.R. Palmer2, T.R. Corcoran3 Community review is needed of PEPFAR´s policies and impact. A new paradigm for international assistance for HIV/AIDS is long overdue as are local and global programs that revolutionize the public health sector and the way aid is delivered, that ensures equity and empowers local groups by addressing the underlying socioeconomic issues that intensify the HIV/AIDS pandemic. |
| ThAe0103 | FROM POLICIES TO PEOPLE: AN ANALYSIS OF THE MECHANISMS IN PLACE TO RESOURCE COMMUNITY RESPONSES TO HIV AND AIDS IN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0103 E. Wachira1, B. Kanina2, P. Niuguna3, S. Nyokabi4, r. Weaver5, L. Webster5, P. Okaalet6 International donors have rapidly increased aid for Kenya's response to HIV and AIDS in recent years. The plans and strategies being put into place at a national level use convincing language. Yet there is concern that they are not making a real difference to the people most affected. |
| ThAe0104 | GETTING RESOURCES TO THE BASE: A COMMUNITY BASED M&E OF GOVERNMENT UTILIZATION OF FUNDS FOR HIV/AIDS AFFECTED AND INFECTED CHILDREN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0104 R. Okoh Fraud and impropriety in the use of funds provided by international donor organization for HIV/AIDS related programmes and projects are rife in Africa and many developing countries including Nigeria. HIV/AIDS Affected and Infected Children(HAIC) are in particular vulnerable to budgetary cuts and diversions during periods of lean resources because they are voiceless and lack political power. A community based Participatory Monitoring and Evaluation(PM&E) process for government spending on HIV/AIDS with special focus on budgetary allocations for HAIC programmes is absolutely imperative. |
| ThAe02 | Time to Deliver: Influencing Policy and Law |
 ThAe0200 |
INTRODUCTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0200 Jonathan Cohen, United States This is a Power Point presentation. There is no abstract available. |
| ThAe0201 | THE LIBERIAN SIGNATORY CAMPAIGN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0201 A. Attah1, D. Wallace1, J. Cooper2, M. Sheriff1 That organizations begin to advocate for stringent laws that ensure good health. |
| ThAe0202 | A POLICY ANALYSIS FOR INTERVENTIONS TO BRIDGE THE GAP BETWEEN TRADITIONAL HEALERS AND THE PUBLIC SECTOR FOR HIV/AIDS CONTROL IN UGANDA AND ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0202 R. Brugha1, M. Oliff2, R. Vongo3, D. Balaba Byansi4, P. Ndubani5, F. Ssengooba6, B.B. Kaboru7, R. King4, B.G. Team8, Bridging Gaps Implementation of a policy tracking component, in parallel to designing, implementing and evaluating a new HIV intervention, is comparatively simple and should be routine in major intervention research. Findings from the Bridging Gaps intervention will encounter greatly changed global and national policy environments, since its 2002 inception, with opportunities from new global funds but also residual policy-level obstacles to overcome. |
| ThAe0203 | FROM SCIENCE TO POLICY TO LAW IN CHINESE RESPONSE TO AIDS MOVING FROM PILOT TO SCALE-UP Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0203 Z. Wu1, S. Sullivan1, Y. Wang1, M.J. Rotheram2, R. Detels3 The China experience provides a model of positive action that should be shared with the international community, and in particular with other developing nations. |
| ThAe0204 | IT'S NOT THAT IT'S A BOTTOM, IT'S WHAT THE BOTTOM HAS BEEN DOING THAT WILL CAUSE THE PROBLEM - POLICY CONFLICTS IN HIV PREVENTION CAMPAIGN APPROVALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0204 M. Kennedy1, C. Batrouney2 Policy conflicts in this area are predictable and approval guidelines for HIV prevention resources should establish mechanisms for early identification and resolution. Approval processes should provide for input from external health promotion experts. |
| ThAe0205 | REMOVING REQUIREMENT FOR SELF-DISCLOSURE OF HIV STATUS FROM CANADA'S TEMPORARY RESIDENT VISA APPLICATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0205 L. Stoltz1, J. Anderson2, G. Flintoft2, R. Elliott3, L. Samson4, L. Binder5, M. Battista6, R. Shahin7 Candidate countries for the Conference should continue to be evaluated on the basis of their ability to assure freedom of entry for people living with HIV/AIDS, consistent with a minimally intrusive approach to the infringement of human rights. |
| ThAe03 | Law, Human Rights and HIV: Broadening the Agenda |
| ThAe0300 |
INTRODUCTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0300 Richard Elliott, Canada This is a Power Point presentation. There is no abstract available. |
| ThAe0301 | PUBLIC SERVICE FOR HUMAN RIGHTS OF PLWHA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0301 N. Panchenko Improving Russian legislation with the goal to provide access to information about HIV/AIDS, to prevention and treatment; raising public awareness about HIV/AIDS by disseminating truthful information about HIV/AIDS; inclusion people living with HIV/AIDS related policymaking process at both the regional and federal levels. |
| ThAe0302 | RHETORIC AND RISK: HUMAN RIGHTS ABUSES IMPEDING UKRAINE'S FIGHT AGAINST HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0302 R. Schleifer1, P. Skala2, K. Lezhentsev3, J. Amon1 Ukraine's obligation to ensure the human right to health require it to take urgent action to stop abuses impeding access to HIV/AIDS information and services. Drug users, people living with HIV/AIDS, and nongovernmental organizations working with them, whose efforts have been instrumental in providing HIV/AIDS information and services to marginalized groups, should be an integral part of government efforts. |
| ThAe0303 | EXAGGERATED CONTAGIOUSNESS: DELINEATING THE BOUNDARIES IN THE EVERYDAY LIVES OF CHINESE PEOPLE WITH HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0303 Y.R. Zhou The findings of this study illustrate the conflicts existing between people's mastery of HIV/AIDS knowledge and their over-carefulness towards HIV-infected bodies in practice. It suggests that AIDS education should not be limited to the dissemination of knowledge per se, and that the interactive or interpersonal dimensions of discrimination/anti-discrimination must also be taken into account. |
| ThAe0304 | ACCESSING MORPHINE FOR HIV/AIDS PAIN MANAGEMENT IN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0304 S. Nkhoma, M. Reynolds, N. Khan, P. Bhatt, G. Kombe Simplified legislation is needed to address the legal constraints to access, and medical education and training on morphine prescription and implications must be implemented. Civil society should recognize the importance of pain relief in the broader scope of palliative care and integrate it into other HIV/AIDS interventions to address comprehensive treatment and care needs of PLWHA. |
| ThAe0305 | HIV/AIDS AND HUMAN RIGHTS IN THE CARIBBEAN - THE CASE OF THE DOMINICAN REPUBLIC AND GUYANA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0305 J. Hanefeld1, J. Welsh2, G. Ducos1 For the response to HIV/AIDS to be successful human rights need to be at the centre of all policy and programming. The research shows the need for states to fulfil, protect and guarantee the human rights of their citizens in order to successfully address the challenge of HIV/AIDS. Amnesty International will campaign around the recommendations that have emerged from the research. The findings add to an evidence base highlighting the importance of a rights-based approach to HIV/AIDS. |
| ThAe0306 |
CONCLUSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0306 Richard Elliott, Canada This is a Power Point presentation. There is no abstract available. |
| ThAe04 | GIPA: Participate, Engage, Empower |
| ThAe0401 | EMPOWERMENT: WHAT DOES THIS CONCEPT MEAN FOR PLWAS? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0401 C.R. Murguía Pardo Training for PLWAs has focused on antiretrovirals, HIV/AIDS and emotional support, but not focused on issues that they consider priorities, such as human rights and advocacy. Empowerment involves providing them with information about the epidemic and support for dealing with being HIV-positive, but ignores systematic, sustained enhancement of skills to enable them taking an active, leading role in the national response to the epidemic. Few organizations are interested in empowering PLWAs because they do not understand their needs or how to meet their high expectations. PLWAs don't want a complementary role in HIV/AIDS response, they want to play a main role in the same condiitons as other civil sociaty actors. |
| ThAe0402 | CONSUMER INVOLVEMENT IN A GOVERNMENT-SPONSORED HIV QUALITY IMPROVEMENT (QI) PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0402 V. Johnson1, M. Lopez2, C. Steinbock3, D. Tietz3, J. Perou3, B. Agins3 Consumer advisory groups should be included in QI programs of governmental HIV agencies which should lead to improved consumer satisfaction with care, thereby facilitating adherence with care and treatment. Consumers should have the opportunity to participate in the selection and development of indicators to measure the quality of care and contribute to the continuous improvement activities in HIV care in the United States. |
| ThAe0403 | TOWARDS MEANINGFUL INVOLVEMENT: BUILDING FUNCTIONAL COMMUNITIES OF PEOPLE LIVING WITH HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0403 D. Walker1, E. Kamunvi2, J. Ntale Nkurunziza3 The greater involvement of PLWHA should not stop at integration into the healthcare system, but must aim at equipping PLWHA with the skills for mobiling and organizing themselves into strong action groups. It has been our experience that mature networks of PLWHA are most effective at reaching marginalized populations, both for the delivery of care-services and the introduction of prevention modalities that are culturally-appropriate. |
| ThAe0404 | LIVING AGAIN: SUPPORTING PLHA TO LEAD THE RESPONSE TO HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0404 B. Nheok1, S. Bou2, M. Dunbar3, C. Francis4, C. Natpratan4 Full participation of people living with HIV (both men and women) in the production of the video is key to ensuring the video addresses their priority information needs. PLHA have strong and motivational experiences of coping and adapting to living with HIV. It is builds their knowledge and skills and promotes ownership of the educational tool. Monitoring and follow-up support is important to provide feedback and on-the-job skills building support. |
| ThAe05 | Treatment Access, TRIPS and Trip-ups |
| ThAe0501 | HIV/AIDS AND SOUTH AFRICA'S WAR ON SCIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0501 J. Berger AIDS denialism and the associated attack on evidence-based medicine in South Africa provide a unique "opportunity" for civil society to transform the way in which lay people relate to health care services and systems. The study indicates the need for a broad civil society-lead public education campaign on evidence-based medicine that builds on - and helps to expand - HIV treatment literacy programmes. |
| ThAe0502 | MEASURING PUBLIC HEALTH - SENSITIVE DEGREE OF IPR LEGISLATION IN THE CONTEXT OF THE WTO TRIPS AGREEMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0502 G.C. Chaves, M.A. Oliveira The instrument was accurate in measuring the health-sensitive degree of IPR legislation of the countries studied. It was also possible to propose a new concept for health-sensitive IPR legislation, which includes all TRIPS flexibilities and do not includes TRIPS-Plus provisions. |
| ThAe0503 | TAKING THE FIGHT TO THEIR REALM: THE ROLE OF PATENT OPPOSITIONS IN THE STRUGGLE FOR ACCESS TO MEDICINES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0503 P. Radhakrishnan, C. Park Educate and empower civil society throughout the Global South on TRIPs-related issues; build capacity in patent law and basic pharmaceutical science. Build network for sharing of information and resources. |
| ThAe0504 | IMPROVING THE AVAILABILITY OF ARVS IN NAMIBIA BY USING POLICY CHANGE TO STREAMLINE THE DRUG REGISTRATION PROCESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0504 D. Pereko, J. Nwokike Barriers to accessing ARVs can come at different levels in the pharmaceutical system. In Namibia, an administrative backlog was keeping ARVs and other medicines off the market; a combination of policy and managerial interventions streamlined the drug registration process and made way for vital additions to HIV/AIDS treatment. Countries should monitor and evaluate all aspects their pharmaceutical policies and procedures to find "hidden" obstacles to access. |
| ThAe0505 | BENCHMARKING RESEARCH-BASED PHARMACEUTICAL COMPANY RESPONSES TO AIDS, TB, & MALARIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAe0505 D. Rosan1, B. Aires2, C. Rowan3, L. Compere4, J. Byron5, K. Hartsough6, S. Finn7 Companies should institute internal benchmarking programs to evaluate social performance versus their peers. Advocates can be more effective by taking an industry-wide approach and using competitive dynamics between companies to improve performance. |
| ThAx01 | Resistance - Before you Start HAART |
| ThAx0101 | PRIMARY HIV-1 DRUG RESISTANCE IN CANADA: UPDATED RESULTS FROM THE CANADIAN HIV STRAIN AND DRUG RESISTANCE SURVEILLANCE PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0101 N. Goedhuis, G.C. Jayaraman, J. Brooks, R. Pilon, P. Sandstrom, C.P. Archibald, Canadian HIV Strain and Drug Resistance Surveillance Program Mutations associated with antiretroviral drug resistance were found in both male and female cases, across all reported ethnic categories, and within all risk groups. Drug resistance has also been consistently noted in both recently infected and prevalent cases. These results support the need for continued surveillance of HIV diversity to inform our understanding of the changing nature of the HIV epidemic in Canada, in order to guide treatment and care strategies across the country. |
| ThAx0102 | ANALYSIS OF DRUG RESISTANCE TRANSMISSION OF ACUTELY NON-B INFECTED HIV PATIENTS IN CAMEROON Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0102 N. Ndembi1, D. Mbanya1, A. Abraha2, L. Kaptue1, R. Salata2, E.J. Arts2 The emergence of ARV resistance, particularly to nevirapine (NVP) may have a grave consequence to the success of future treatment strategies (Triomune) as well as most perinatal prevention programs utilizing NVP. |
| ThAx0103 | HIV-1 DRUG RESISTANCE GENOTYPING IN TREATMENT NAÏVE SUBJECTS USING DRIED WHOLE BLOOD SPOTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0103 S. Bertagnolio1, L. Soto-Ramirez2, R. Pilon3, R. Harrigan4, R. Rodriguez2, M. Viveros2, L. Fuentes2, T. Mo4, D. Sutherland1, P. Sandstrom3 The results suggest that DBS are a promising public health tool for HIVDR surveillance of treatment-naïve subjects, especially in regions where specimens are likely to be subjected to severe environmental conditions and where logistical difficulties for specimens handling could prevent timely blood processing. Additional investigations are needed to validate DBS as an alternative to plasma for patient monitoring. |
| ThAx0104 | A SOUTH-SOUTH COLLABORATIVE NETWORK FOR HAART RESISTANCE SURVEILLANCE AND MONITORING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0104 C. De Schacht1, M. van Vugt1, T.F. Rinke de Wit1, K. Frost2, P. van Rooijen3, R. Hamers1 Timely building of capacity for measuring HIVDR in Asia and Africa is of importance, in light of the massive scale-up of HAART in those continents. The coordination of Asian and African efforts will provide unique and complementary insights in the development of HIVDR. |
| ThAx0105 | ANTIRETROVIRAL RESISTANCE IS NOT AN IMPORTANT RISK OF THE ORAL TENOFOVIR PROPHYLAXIS TRIAL IN BOTSWANA: A SIMPLE MATHEMATICAL MODELLING APPROACH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0105 D. Smith1, P. Kebaabetswe1, K. Disasi2, D. Fleming3, L. Paxton4, M. Davis3 The oral tenofovir trial will likely result in less than 1/500th of the persons in Botswana with the K65R mutation. Most resistance will be generated within the treatment program. Patients with K65R may still be phenotypically sensitive, so TDF treatment regimens are likely to continue remain effective in Botswana despite genotypic resistance mutations among those in the treatment program and the very few who seroconvert in the trial. |
| ThAx02 | Vaccine Research |
| ThAx0201 | KNOWLEDGE AND ATTITUDES ABOUT HIV VACCINE RESEARCH AMONG HEALTH WORKERS IN TWO PROVINCES IN KENYA: BASELINE SURVEY CONDUCTED FEB-APR 2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0201 S. Kalibala1, F. Manguyu1, J. Ndinya-Achola2, S. Wakasiaka2, J.Bwayo2, W. Jaoko2, O. Anzala2 While the majority was knowledgeable in some aspects significant knowledge gaps remained and there were serious misconceptions regarding what candidate HIV vaccines were made of with some suggesting live attenuated HIV. This seems to have resulted in a lack of confidence in the safety of AIDS vaccines as shown in the lack of clear supportive attitudes on this issue. |
| ThAx0202 | USE OF CONJOINT ANALYSIS METHODS TO ASSESS HIV VACCINE ACCEPTABILITY IN THREE POPULATIONS: AN INNOVATION IN THE ASSESSMENT OF CONSUMER HEALTHCARE PREFERENCES (PROJECT VIBE) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0202 S.-J. Lee1, P. Newman2, W. Cunningham3, D. Seiden1, N. Duan1 CA methods enabled direct assessment of HIV vaccine preferences. Acceptability varied widely depending on hypothetical HIV vaccine characteristics. CA methods identified efficacy as the most important attribute across groups; preferences for other attributes varied across demographic subgroups. CA methodology may support empirically-based, population-specific interventions to increase HIV vaccine acceptability. |
| ThAx0203 | SEVEN POINTS OF ENTRY FOR ACTION - MICROBICIDES, VACCINES AND TREATMENT (MTV) ADVOCATES AGENDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0203 S. Mellors, D. Cavanagh Developing collaborative agendas requires commitment - financial and human, as well as clear action plans that can be followed up, implemented and sustained |
| ThAx0204 | SAFE ADMINISTRATION OF DNA (PTHR.HIVA) AND MVA.HIVA TO 169 HIV-1 UNINFECTED VOLUNTEERS ENROLLED IN PHASE I/II TRIALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0204 A. Guimaraes-Walker1, I. Cebere1, N. Mackie2, T. Hanke1, P. Fast3, L. Dally4, J. Weber2, A. McMichael1 Both DNA and MVA.HIVA were safe and well tolerated. The most common event post vaccination was mild local reaction at the injection site. Escalation of dose did not correlate with increased severity of reactions. There were no SAEs caused by the vaccines. When evaluating a candidate vaccine, it is vital to ensure consistency in the grading criteria within a programme consisting of overlapping trials. |
| ThAx0205 | DIFFERENCES IN WILLINGNESS TO PAY FOR SELF AND FAMILY MEMBERS AN AIDS VACCINE IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0205 P. Patil1, D. Bishai2 In a high prevalence developing country where clinical trials of experimental vaccines have been conducted, adults are willing to undertake significant expense to purchase a vaccine against HIV/AIDS particularly for themselves. Some evidence suggests that women are also more likely to spend on spouses than men. |
| ThAx03 | ABC in Africa - What is the Evidence? |
| ThAx0301 | SYSTEMATIC REVIEW OF THE IMPACT OF ABSTINENCE-ONLY PROGRAMMES ON RISK BEHAVIOR IN DEVELOPING COUNTRIES (1990 – 2005) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0301 K. O'Reilly1, A. Medley2, J. Dennison2, M. Sweat2 Even with the inclusion of new studies since our last synthesis, little evidence of the effectiveness of abstinence-only programmes in developing countries was found, either because of weak study designs or the difficulty in measuring outcomes of interest. Most evidence of effectiveness related to changes in beliefs. However encouraging changes in beliefs may be, they cannot be assumed to result in complete abstinence or other safer sexual behaviour. |
| ThAx0302 | A COW DIES WITH GRASS IN IT'S MOUTH" – FISHERMEN'S RESPONSE TO "ZERO GRAZING" IN KISUMU, KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0302 A. Sharma1, E. Bukusi1, Z. Kwena1, A. Buffardi2, B. Agot1, C. Muga1, K. Holmes2 Resources are needed for STI/HIV risk reduction through changes in the structures that influence highly localized sexual behavior. Changes in how business is transacted and provision of livelihood programmes and basic health and social services, particularly for widows and single mothers, could prevent new infections and may eventually, save on funds required for treatment and comprehensive care. |
| ThAx0303 | LIKE MOTHER LIKE DAUGHTER: THE INFLUENCE OF PERCEIVED MOTHERS' VALUES ON DAUGHTERS' ATTITUDES TOWARDS SEXUAL ABSTINENCE IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0303 O. Adeleke, A. Ankomah Mothers play an enormous role in shaping the attitudes of their daughters towards sexual abstinence. Values and belief orientation are easily imbibed through effective mother-daughter communication. Prevention of HIV/AIDS, STIs, and unintended pregnancies can be achieved through effective intra-family communication. Daughters who are properly mentored by their mothers are likely to pass across such values on to their daughters. |
| ThAx0304 | ABC - ABSTAIN, BE FAITHFUL, CONDOMISE - AFRICA'S NON-SOLUTIONS. SO WHAT WILL WORK? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThAx0304 B.A. Kenyon HIV/AIDS prevalence is increasing among children. Current prevention programs, whose core theme is "ABC", are making no difference. This presentation will explore the need for "DEFs" that are more effective and relevant in preventing sexual assault and HIV/AIDS transmission among children and youth. |
| Poster Discussions | |
| Track A | |
| ThPdA | HIV Molecular Pathogenesis |
| ThPdA01 | HIV-1 ENVELOPE GLYCOPROTEIN 120 INDUCES CYCLOOXYGENASE-2 EXPRESSION IN ASTROCYTOMA CELLS THROUGH A NUCLEAR FACTOR-κB DEPENDENT MECHANISM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA01 S. Álvarez1, M.J. Serramía1, M. Fresno2, M.A. Muñoz-Fernández1 HIV-1 gp120 alters astroglial function which compromises the function of the nearby of neuronal cells contributing to the cognitive impairment in HIV-1 infection. Cyclooxygenase-2 (COX-2) has been involved in this process, although the intracellular pathways and second messengers involved are yet unknown. |
| ThPdA02 | PERIPHERAL T CELL POPULATION OF HIV-INFECTED PATIENTS SHOWS DIFFUSED BIOCHEMICAL AND ULTRA-STRUCTURAL LESIONS TYPICAL OF THE LATE STAGES OF APOPTOSIS: CONSEQUENCES FOR CLINICAL BIOCHEMISTRY AND PATHOLOGY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA02 M. Paiardini1, B. Cervasi1, A. Favaloro2, G. Pellicanò3, C. Chirico2, G. Visalli2, I. Picerno2, G.P. Anastasi2, G. Piedimonte2 Peripheral T cells from HIV-infected patients show biochemical and ultra-structural anomalies typical of the late stages of apoptosis. These anomalies are found in a high percentage of lymphocytes in naïve or both immunological responders and non-responders treated patients. These data suggest that peripheral T cell population represents only the apoptotic fraction continuously released from lymph nodes, and may give misleading information on immune reconstitution after ART. |
| ThPdA03 | GENETIC CHARACTERISTICS OF GP160 IN ACUTE HIV-1 SUBTYPE C INFECTION: IMPACT ON DISEASE PROGRESSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA03 G.P. Bandawe1, F. Treurnicht1, Z. Woodman1, K. Mlisana2, F. van Loggerenberg2, S.S. Abdool Karim2, C. Williamson1, CAPRISA Acute Infection Study Team Early control of the infection determines viral set point and disease progression. Preliminary data suggests that individuals with rapid disease progression had higher viral diversity following transmission. Furthermore, our results suggest that in HIV-1 subtype C acute infection, transmitted viruses with longer, more glycosylated V1/V2 loops, may be associated with rapid disease progression. |
| ThPdA04 | LOCALIZATION AND CONFIGURATION OF NUCLEIC ACID IN VIRUS PARTICLE BY ELECTRON MICROSCOPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA04 T. Goto1, T. Kido1, T. Fukui2, K. Sano2 We established a method to reveal the nucleic acids in the core and to clarify their configuration in the particles. This method may play an important roles in the elucidation of viral packaging. After isolation and dissection of core from the whole virions, the relationship between nucleic acids and RT and/or NC proteins will be resolved in more detail. |
| ThPdA05 | CELL LINES HARBORING REVERSE TRANSCRIPTASE MUTATIONS IN DEFECTIVE PROVIRAL HIV-1 CAN PRODUCE INFECTIOUS VIRUSES AFTER INFECTION OF A SECOND DEFECTIVE VARIANT OF HIV-1 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA05 Y. Quan, C. Liang, M. Wainberg RNA viruses including HIV-1 generate swarms of similar but genetically distinct variants, called quasispecies. A large proportion of HIV-1 infection is defective. However, the significance of defective infection has not been well explored. We asked whether defective viruses can play any role in HIV drug resistance or HIV-1 persistent infection. |
| ThPdA06 | EVALUATING CIS- AND TRANS-MODULATORS OF HIV-1 RNA PROCESSING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdA06 C. Platt1, J. Nemet2, A. Cochrane2 Control of HIV-1 RNA processing plays an important role in regulating viral protein production. Upon synthesis, the 9 kb viral transcript is converted into over 30 mRNAs by alternative splicing, regulated by both cis- and trans-acting factors. Evaluating how these factors interact and how their modulation alters HIV-1 gene expression may identify new means of disrupting viral RNA processing and of controlling the infection. |
| Track B | |
| ThPdB | Can We Deliver? HIV and Hard to Reach Populations |
| ThPdB01 | PROGRESS OF CHINA'S METHADONE MAINTENANCE TREATMENT PROGRAMME Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB01 L. Pang, G. Mi, W. Luo, Z. Wu, National MMT Working Group The principle source of HIV transmission in China is through injecting drug use (IDU). In 2004, China opened it's first eight methadone maintenance treatment (MMT) clinics. By the end of 2005, 128 clinics had been approved and 58 were operational. This paper provides an update on the progress of those first eight clinics and their impact on controlling drug use and HIV transmission in China. |
| ThPdB02 | ACCESSING HIV/AIDS CARE AND SUPPORT SERVICES IN INTERNALLY DISPLACED PEOPLE CAMPS [IDP CAMPS] Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB02 I. Omagor, Persons living with HIV/AIDS in Internally Displaced People Camps AIDS service agencies in war affected areas should design and implement outreach clinics to enable PLWHAs access care and support services for better quality of life. Strengthening collaboration and networking is very important when applying such a model becuase various services will be offered to economically poor PLWHAs. |
| ThPdB03 | RISK FACTORS FOR FAILURE TO INITIATE PRIMARY CARE AFTER DIAGNOSIS OF HIV, NEW YORK CITY: IMPACT OF TRANSMISSION RISK AND SITE OF INITIAL DIAGNOSIS ON SUCCESSFUL TRANSITION TO CARE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB03 L. Torian, E. Wiewel, D. Hanna, J. Sackoff The majority (83%) of patients who initiate care do so within 3 months of diagnosis, suggesting that there is a window of opportunity during which the transition can most effectively be facilitated. IDU, blacks, and persons of non-US origin are at risk for delayed presentation; persons diagnosed at public and community-based testing sites are at risk for failure to present. New strategies are needed to facilitate linkage and to ensure timely presentation for care. Non-medical settings should develop more effective referral procedures so that patients transition successfully from diagnosis to care. |
| ThPdB04 | THE IMPACT OF INCARCERATION ON HIV INFECTION AMONG INJECTION DRUG USERS (IDUS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB04 K.A. Phillips1, N. Galai2, J. Astemborski2, D. Vlahov3, G.D. Kirk2, S.H. Mehta2 Correctional settings need to improve HIV care and treatment within detention/jail settings where persons stay for brief periods and further maintain continuity of care after longer periods of time spent in prison. |
| ThPdB05 | CULTURAL DIFFERENCES IN PREDICTORS OF DEPRESSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB05 L. Sanzero Eller1, Y.-F. Tsai2, M. Rivero3, G. Canaval4, C. Valencia4, E.H. Bunch5, J. Kemppainen6, F.Y. Chou7, P.J. Dole8, I. Corless9, M.J. Hamilton10, C. Coleman11, D.J. Wantland12, K.M. Kirksey13, E. Sefcik10, P. Nicholas9, K.M. Nokes14, W.L. Holzemer12, N.R. Reynolds15, C.J. Portillo12 The prevalence of depression was high in each country sampled. Predictors suggest the need for culturally-based interventions. Predictors of depression can inform interventions that vary by country. Targeted interventions may improve treatment adherence, reduce risky behaviors and improve health outcomes in people living with HIV. |
| ThPdB06 | RECRUITING THE UNREACHABLE AND THE SLIPPERY: CRACK USING WOMEN AND STREET SEX WORKERS AS SUBJECTS FOR A VACCINE PREPAREDNESS STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdB06 C. Zorrilla1, L. Santiago2, G. Estronza3, J. Perez3, G. Djomand4, S. Buchbinder5, C. Beyrer6, HVTN 903 PR Site Reported risk behaviors decreased among the women during the first year of the study. Retention rates were low and characteristic of the population: homelessness, drug use, violent neighborhoods and chaotic lifestyles. The observation time (12 months) may have been insufficient to capture HIV seroconversions or the eventual return to the original high risk behaviors. |
| Track C | |
| ThPdC | HIV Prevention in Cyberspace |
| ThPdC01 | FUN & GAMES': REACHING CANADIAN HIV-POSITIVE YOUTH ONLINE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC01 S. Flicker1, A. Buchan2, E. Goldberg3, A. McClelland4, H. Skinner5, T. Smith6, D. Taylor7, T. Veinot8, S. Read9 Health and social service providers may benefit from using www.livepositive.ca as an adjunct to their work with HIV-positive youth. This project also showed the benefits of youth involvement in creating audience-appropriate resources. Finally, it demonstrates the viability of using the Internet to reach HIV-positive youth. |
| ThPdC02 | ACCEPTABILITY AND UTILITY OF A PARTNER NOTIFICATION SYSTEM FOR SEXUALLY TRANSMITTED INFECTION EXPOSURE USING AN INTERNET-BASED, PARTNER-SEEKING WEBSITE FOR MEN WHO HAVE SEX WITH MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC02 M.J. Mimiaga1, A. Tetu2, D. Novak3, S. Adelson4, R. Vanderwarker2, K.H. Mayer5 High-risk and HIV-infected MSM reported high-levels of willingness to use electronic-media in conjunction with public-health specialists for PN if they were infected-with/exposed-to an STI. |
| ThPdC03 | THE DEVELOPMENT OF CYBER-BASED EDUCATION AND REFERRAL/MEN FOR MEN (CYBER/M4M): A CHAT ROOM-BASED INTERVENTION TO PREVENT HIV INFECTION AMONG GAY MEN AND MSM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC03 S. Rhodes1, K. Hergenrather2, B. Ramsey3, L. Yee4, A. Wilkin5 Further research on the efficacy of CyBER/M4M and similar interventions is needed. CBPR is feasible within this population, which is often considered to be "harder-to-reach," and should be considered when planning future interventions. |
| ThPdC04 | MYSEXYCITY.COM: A WEB BASED HIV PREVENTION INTERVENTION FOR MSM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC04 G. Ayala1, L. Templeton Horwitz2 This presentation will highlight the importance of community engagement in projects at their genesis. It will also model one way of tapping into the Internet as a tool for HIV prevention with young MSM. |
| ThPdC05 | NEXT GENERATION HIV PREVENTION: BUILDING HIGHLY INTERACTIVE WEB-BASED HIV INTERVENTIONS FOR MEN WHO USE THE INTERNET TO SEEK SEX WITH OTHER MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC05 B.R.S. Rosser1, S. Hooper2, C. Naumann1, J. Konstan3, T. Manning4, D. Bratland4, M. Allen4, Men's INTernet Sex II (MINTS-II) Team Entirely new approaches to HIV prevention are being developed based on technological advances and developments in the fields of computer science, virtual reality, and e-learning. This presentation will showcase what HIV prevention in the future may well look like while addressing the strengths and limitations of online interventions. |
| ThPdC06 | COMPULSIVE SEXUAL BEHAVIOR AND RISK FOR UNSAFE SEX IN ONLINE LIAISONS FOR MEN WHO USE THE INTERNET TO SEEK SEX WITH MEN: RESULTS OF THE MEN'S INTERNET SEX (MINTS-II) STUDY II Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdC06 E. Coleman1, K.J. Horvath2, M. Miner1, M. Ross3, M. Oakes4, B.R.S. Rosser1, Men's INTernet Sex II (MINTS-II) Team MISM who are sexually compulsive appear to be at greater risk for transmitting HIV to other men. HIV+ individuals may be at more risk for spreading the infection as a function of their compulsive sexual behavior and unsafe sex. Addressing CSB as part of Internet based HIV prevention efforts is a critical strategy to address safer sex behavior. |
| Track D | |
| ThPdD | Choices and Challenges of Living with ART |
| ThPdD01 | THE SOCIAL CONSEQUENCES OF ANTIRETROVIRALS: PREPARING FOR THE UNEXPECTED FUTURES OF HIV-POSITIVE CHILDREN IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD01 G. Domek In conclusion, the provision of antiretrovirals must be accompanied by a number of medical, psychological, educational, and social services that help prepare HIV-positive children for futures they only recently have been able to expect. |
| ThPdD02 | LIVING AND WORKING WITH HIV IN FRANCE IN 2003: RESULTS OF THE ANRS-EN12-VESPA STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD02 R. Dray-Spira, F. Lert, VESPA Study Group Employment status of PLWHA is associated with HIV characteristics additionally to sociodemographic/occupational situation. Management of HIV infection at work is still a challenge in 2003. |
| ThPdD03 | QUALITY OF LIFE ASSOCIATED WITH CHANGES IN WEIGHT AND BODY APPEARANCE AMONG PEOPLE LIVING WITH HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD03 A. Bayoumi Weight and body changes are common and bothersome symptoms among people with HIV and have significant and measurable quality of life effects. TTO scores indicate that participants are willing to forego 10 to 15% of future life expectancy to alleviate these symptoms. |
| ThPdD04 | CULTURAL FACTORS INFLUENCING ACCESS TO AND ADHERENCE WITH ANTIRETROVIRAL THERAPY (ART) IN AN URBAN ZAMBIAN COMMUNITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD04 E. Grant1, A. Patching2, D. Gorman3, D. Logie4, J. Mulwanda5, S. Murray6, Lothian Zambia Partnership Powerful cultural and economic factors hinder ART treatment and adherence, despite its local availability. Community based interventions aimed at deconstructing male sexual roles and behaviour, empowering women and promoting early testing are needed. Training of "treatment support workers" to help explain the role of ART and support and encourage people on ART might change poor adherence to better concordance with therapy. |
| ThPdD05 | ADVERSE CONSEQUENCES OF USER FEES FOR PATIENTS STARTED ON ANTIRETROVIRAL THERAPY (ART) IN THE GOVERNMENTAL HIV-PROGRAMS IN NIGERIA. ANALYZED IN THE INTEGRATED FREE OF CHARGE ART-PROGRAM OF MÉDECINS SANS FRONTIÈRES (MSF) IN LAGOS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD05 J. Wenkel1, W. van den Boogaard2, D. O'brien3, E. Botha Standaert4, K. Braker5, M.A. Olaiya6, B.A. Olomo4, P. Orji1, C. Mills7 The user fees charged in the Nigerian ART programs are not affordable for the vast majority of patients. Consequences can be treatment interruptions and sharing ARVs, potentially causing antiretroviral resistance and ART failure. User fees are detrimental to the long term outcome of patients and may expedite the need to provide more expensive second line ARVs. |
| ThPdD06 | IMPROVED SOCIO-ECONOMIC STATUS AND QUALITY OF LIFE AND DECREASED HOSPITALIZATION RATES AMONG PATIENTS IN THAILAND ONE YEAR AFTER INITIATING HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdD06 S. Chariyalertsak1, P. Oberdopher2, D. Thapinta3, J. Suwanteerangkul2, A. Sarna4, P. Guest5, A. Wu6 HAART dramatically improves quality of life of people living with AIDS. Increases in incomes and employment and a decrease in hospitalization suggest that HAART programs also contribute to reducing health care costs and increasing economic productivity. A national policy of providing free access to HAART for HIV-infected patients provides benefits to both the patients and society and may be a sound investment for other developing countries. |
| Track E | |
| ThPdE | Care Counts: Investing in Quality of Life |
| ThPdE01 | FUNDING CIVIL SOCIETY ORGANIZATIONS TO SCALE-UP HIV/AIDS SERVICES IN LOW RESOURCE SETTINGS; THE AIM-JSI UGANDA EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE01 D. Mabirizi The bulk of the burden against HIV/AIDS is carried by the household. It's from this unit that many community initiatives have emerged in an attempt to share the burden. Uganda is facing high demand for care and treatment services. Civil Society Organisations (CSOs) access to resourcess is below expectation yet they are vital actors in the fight against HIV/AIDS. In an effort to increase service delivery, a grants programme was designed within the national guidelines. |
| ThPdE02 | DEVELOPING MINIMUM STANDARDS FOR HOME BASED CARE IN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE02 N. Drost1, S. Glyde1, A. Munalula2, M. Mubanga1, G. Mwale3, M. Sepiso4, W. Wakunuma5 Once a set of draft standards have been developed, a country-wide process for reviewing minimum standards will take place through consultations at community, district and national levels. Standards will be redrafted according to the input received from these different stakeholders and subsequently taken to an expert review panel for further refining. A national consensus building workshop will be held towards the end of the year to advocate for the adoption of CHBC standards by the Ministry of Health and the National AIDS Council. |
| ThPdE03 | ASSESSING PALLIATIVE CARE NEEDS IN VIET NAM: A RAPID SITUATION ANALYSIS IN 5 PROVINCES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE03 K. Luong Ngoc1, K. Green2, K. Le Van1, V.N. Son2, N. Nguyen Thi Minh3, E. Krakauer4, T. Nguyen Minh5, M. Coughlan6 The prevalence of pain among PLHA and people with cancer is high while access to opiate analgesics is extremely limited. Health care workers are not adequately trained in palliative care. National palliative care guidelines, training in palliative care for healthcare workers, and palliative care services are badly needed. |
| ThPdE04 | THE CHANGING ROLE OF HOME-BASED CARE IN CAMBODIA IN THE ERA OF ART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE04 S. Samreth1, C.V. Mean1, C. Kaoeun1, B. Gnov1, N. Seguy2 With the increasing availability of health facility-based care providing antiretroviral treatment (ART) to more than half of the people in need in 2005, the National Center for HIV/AIDS, Dermatology and STD (NCHADS) had to adapt the role of home-based care (HBC) services to changing needs. |
| ThPdE05 | GREATER INVOLVEMENT OF PLWHA IN TREATMENT, CARE AND SUPPORT: THE TANZANIAN EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE05 M. Kasili1, J.W. Karomba2, S. Haule3 The government should give higher priority to PLWHAs involvement in the response to the epidemic also for NGOs are advised to involve PLWHAs in service delivery. |
| ThPdE06 | IMPLEMENTING NIGERIA'S HIV/AIDS PALLIATIVE CARE POLICY FRAMEWORK Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThPdE06 G. Asuquo A major recommendation from the process was the need for a national palliative care policy and guidelines and capacity building plan to be finalized based on this framework. Also recommended was the need to update the essential drug list, review prescribing authority, improve monitoring and evaluation, infrastructure and capacity for quality palliative care. |
| Key Challenge Area 1 | |
| ThKc1 | Addressing Obstacles to Research |
| ThKc101 | EXPERIENCE IN IDENTIFYING AND RETAINING HIV HETEROSEXUAL SERODISCORDANT COUPLES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc101 H.S. Martins, M.T.S. Tavares, A. Silva, M.C. Oliveira, F.M.A.O. Mello, G.A. Calvet, M.Q.R. Darmont, S.R. Ribeiro, J.A. Menezes, E.C. Joao Obstacles identified in that population: unwillingness to disclose HIV status, frequent partner change, lack of family and social support, lack of motivation of HIV negative partners towards clinic visits partly due to interference of working hours. In spite of continuous efforts on the part of a cooperative multidisciplinary team a hard task remains to improve the approach to such a population. |
| ThKc102 | HIGH UPTAKE OF HIV AND STI RESULTS AFTER COMMUNITY CONSULTATION IN A POPULATION-BASED SURVEY OF HIV, STI AND RISK BEHAVIOR, GEM, RURAL WESTERN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc102 T. Thomas1, H. Vandenhoudt2, A. Ogendo3, F. Otieno3, E. McLellan-Lemal4, W. Chege1, P. Bondo3, C. Zeh1, J. Vulule3, A. Buve5, L. Slutsker6, K. Decock7 Consultation with the community about recruitment approaches, sampling, and specimen collection procedures was crucial to developing successful study procedures. The cross-sectional study demonstrated that conducting study procedures of a sensitive nature are acceptable and feasible in the Gem family compounds. |
| ThKc103 | DEVELOPMENT OF AN ETHICAL COMMITTEE FOR A COMMUNITY BASED ORGANIZATION IN MUMBAI, INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. ThKc103 M. Mcguire1, V. Anand2, P. Prabhughate2, M. Sivasubramaniam2, A. Row Kavi2 Development of independent non-academic ethical committees should be considered on an individual situation bases. For successful capacity building there must be a focus on training participants of ethical committees in developing country to incorporate both multiple international ethical doctrine as well as local ethical guidelines. Additionally, it is necessary to create a framework that includes local interpretation of basic elements of western ethical guidelines like autonomy of individuals versus autonomy of communities in developing countries. Establishing ethical committees can be a tool used for building capacity t |