[33] MORTALITY AND MORBIDITY IN HIV-INFECTED INFANTS TREATED BEFORE 6 MONTHS OF AGE

2nd International AIDS Society Conference on HIV Pathogenesis and Treatment

Paris, France - July 13 - 16, 2003

[TITLE:] MORTALITY AND MORBIDITY IN HIV-INFECTED INFANTS TREATED BEFORE 6 MONTHS OF AGE

[AUTHOR(S):] A Faye
French Prospective Cohort, Paris, France

IAS Conf HIV Pathog Treat 2003 Jul 13-16;2nd: Abstract No. 33
Antiviral Therapy 2003; 8(Suppl. 1):S192

[ABSTRACT:] Background: The clinical impact of early treatment of infected newborns on the risk of the early-onset, severe form of HIV infection with encephalopathy has not been evaluated on a large scale.

Methods: We evaluated the risks of death, opportunistic infection and encephalopathy for children of the French Prospective Cohort (EPF), treated with HAART before the age of 6 months.

Results: Among the 85 infected newborns since 1997, when HAART became available, 35 infants were treated before the age of 6 months. The birth characteristics of this group of children did not differ significantly from those of the 403 infected children of the cohort born before that date. Only one child developed an opportunistic infection during the first 18 months of life and none of the children presented encephalopathy. None of the children died. In the group of control children born before 1997, 6% suffered opportunistic infections, 12% presented encephalopathy and 12% died before the age of 18 months (P<10³ for all parameters).

Conclusions: Children given early multitherapy do not suffer the early-onset, severe form of childhood HIV infection.

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