9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 19-21 July 2007, Sydney, Australia

HEPATIC LIPID AND ADIPOSE TISSUE DISTRIBUTION IN HIV-INFECTED MEN

Antiviral Therapy 2007; 12(Suppl. 2):L28 (abstract no. P-13)

Q He¹, G Ionescu¹, MJ Glesby², DP Kotler¹ and ES Engelson^1
1Division of Gastroenterology, Department of Medicine, St. Luke’s-Roosevelt Hospital Center, Columbia University, New York, NY, USA; ²Division of International Medicine & Infectious Disease, Department of Medicine, New York Presbyterian Hospital, Cornell University, New York, NY, USA

OBJECTIVE: Many studies have demonstrated associations between visceral adipose tissue (VAT) and hepatic lipid in non-HIV populations. However, a single study in HIV lipodystrophy patients, using proton magnetic resonance spectroscopy (MRS) for hepatic lipid and a single slice MRI for VAT, failed to find a correlation. This study further investigates the relationship between hepatic lipid and whole body adipose tissue content and distribution in HIV-infected men.

METHODS: Data from 18 HIV-infected men were retrospectively analysed for this study. Eleven men with HIV- related fat redistribution and insulin resistance were studied prior to initiating a clinical study of growth hormone therapy and seven men taking zidovudine were studied prior to participating in a treatment-switch study. MRS was applied to quantify hepatic lipid volume, expressed as methylene/(methylene+water)×100%, using jMRUI spectrum analysis software, with water as an internal standard. Whole body adipose tissue volumes, that is, subcutaneous adipose tissue (SAT) and VAT, were measured by MRI. A simple correlation analysis was performed.

RESULTS: Total VAT volume was 5.8±2.6 l (mean ±SD, range 1.5–10.6). Whole body SAT volume was 19.3±9.2 l (range 8.6–41.5). Hepatic lipid content was 3.7±2.5% (range 0.5%–9%) which is consistent with the previous report of hepatic fat in HIV-infected men (2.9–8.1%). Hepatic lipid correlated significantly with total VAT (r=0.52, P=0.028) but not with SAT (r=0.12, P=0.62).

CONCLUSION: Hepatic lipid content is associated with VAT volume in HIV-infected men.

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2007-07-24
P-13

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