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9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV19-21 July 2007, Sydney, Australia |
LONG-TERM SUBCUTANEOUS TISSUE CHANGES AMONG ANTIRETROVIRAL NAÏVE PERSONS INITIATING THREE NUCLEOSIDE REGIMENS
Antiviral Therapy 2007; 12(Suppl. 2):L30 (abstract no. P-17)
JC Shlay1, S Sharma2, G Bartsch2, G Peng2, CL Gibert3 and C Grunfeld4 for the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA)
1Denver Community Programs for Clinical Research on AIDS, University of Colorado Health Sciences Center, Denver, CO; 2CPCRA Statistical and Data Management Center, University of Minnesota, Minneapolis, MN; 3Wide-Reaching AIDS Program, Veterans
Affairs Medical Center and George Washington University, Washington DC; 4Veterans Affairs Medical Center and University of California, San Francisco, CA, USA
AIM: Changes in adipose tissue assessed among ARV-naïve patients initiating one of three NRTI-containing regimens.
METHODS: We compared changes in 308 patients initiating stavudine+lamivudine (d4T; n=63), zidovudine+lamivudine (ZDV; n=192) or abacavir+lamivudine (ABC; n=53) with PIs, NNRTIs or both. Anthropometry performed at baseline and 4-month intervals. Rates of change (slopes) (mm/year) were compared over 36 months of follow-up.
RESULTS: Early slopes (month 4–12) were compared with late slopes (month 16–36) (Table 1). For d4T and ZDV, most early slopes showed gains, while late slopes showed loss. There was less late slope loss for ABC. Rates of change over all follow-up visits (Table 2). Losses seen for ZDV (abdomen, thigh, triceps) and d4T (abdomen, thigh) were significantly different compared with ABC. No differences seen between d4T versus ZDV.
| Table 1. (Abstract P-17) | ||||||
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| d4T Early |
d4T Late |
ZDV Early |
ZDV Late |
ABC Early |
ABC Late |
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| Subscapular | 0.22 | –0.07 | 0.75 | 0.16 | 0.37 | 0.21 |
| Suprascapular | 0.37* | –0.44* | 1.04* | –0.53* | –0.25 | –0.23 |
| Abdomen | 0.23* | –2.75* | –0.29* | –1.89* | 0.48 | 0.78 |
| Thigh | 0.03 | –1.54 | 0.50* | –1.46* | 1.61 | 0.10 |
| Triceps | –0.54 | –0.78 | –0.36* | –1.34* | 2.03* | –0.69* |
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| (*comp. P-value <0.05) | ||||||
| Table 2. (Abstract P-17) | ||||
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| d4T slope (P) |
ZDV slope (P) |
ABC slope (P) |
Comp. P-value |
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| Subscapular | 0.16 (0.7) | 0.01 (1.0) | 0.54 (0.2) | 0.5 |
| Suprascapular | –0.04 (0.9) | –0.71 (<0.01) | –0.22 (0.6) | 0.3 |
| Abdomen | –1.07 (0.03) | –1.11 (<0.01) | 1.01 (0.05) | <0.01 |
| Thigh | –1.31 (<0.01) | –1.32 (<0.01) | 0.06 (0.9) | 0.02 |
| Triceps | –0.68 (0.09) | –1.54 (<0.01) | –0.14 (0.7) | <0.01 |
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CONCLUSIONS: In this prospective evaluation, subcutaneous tissue changes varied by regimen. Similar losses demonstrated for d4T and ZDV, while ABC had gains. Differences in early versus late slopes for d4T and ZDV suggest initial recovery followed by long-term treatment effect.
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2007-07-24
P-17
Copyright © 2007 - International Medical Press Ltd. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Medical Editor, International Medical Press, 36 St Mary-at-Hill, London EC3R 8DU, United Kingdom.