9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 19-21 July 2007, Sydney, Australia

IMPACT OF LIPOATROPHY ON QUALITY OF LIFE IN HIV- INFECTED INDIVIDUALS RECEIVING ANTIRETROVIRAL THERAPY (ART)

Antiviral Therapy 2007; 12(Suppl. 2):L32 (abstract no. P-21)

R Rajagopalan¹, D Laitinen¹ and B Dietz^2
1Abbott Laboratories, Abbott Park, IL, USA; ²Abbott Laboratories, Ludwigshafen, Germany

OBJECTIVE: Metabolic and morphological side effects occur in HIV-infected individuals receiving antiretroviral treatment (ART). Peripheral fat loss, particularly in the face, limbs and/or buttocks, is referred to as lipoatrophy and has been found to be highly stigmatizing and to adversely impact quality of life. Consumer Health Sciences Survey data collected in 2006 were analysed to evaluate the impact of lipoatrophy on quality of life in HIV-infected individuals receiving ART.

METHODS: The impact of lipoatrophy was evaluated using multiple regression with item scores and mental component summary (MCS) and physical component summary (PCS) scores from the Medical Outcomes Trust questionnaire, SF-8 as dependent variables and lipoatrophy as independent variable controlling for baseline age, sex and ethnicity as covariates. Clinical meaningfulness (mean difference divided by population standard deviation, d/s) of differences between the group with lipoatrophy and the one without was also evaluated.

RESULTS: A cohort of 1,022 subjects with at least 6 months of ART was selected based on data availability on lipoatrophy (yes/no). There were 80% male, 90% between the ages of 30 and 60 years, and 37% Hispanic, and 27% each of African American and White. Overall, prevalence of lipoatrophy was 18.6%. Statistically significant (P<0.001) differences in quality of life (as measured by SF8 individual item scores and MCS and PCS scores) were observed between the two groups. The differences between the groups in item and summary scores were clinically meaningful in small to medium range (0.28 to 0.43).

CONCLUSION: Lipoatrophy has a significant negative impact on quality of life in HIV-infected patients who already suffer considerable deficiency in quality of life.

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2007-07-24
P-21

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