AIDSWEEKLY Plus; Monday, June 21, 2004
Staff Medical Writers

According to published research from Italy, "CD95(APO-1/Fas)-mediated apoptosis of bystander uninfected T cells exerts a major role in the HIV-1-mediated CD4+ T-cell depletion. HIV-1 gp120 has a key role in the induction of sensitivity of human lymphocytes to CD95-mediated apoptosis through its interaction with the CD4 receptor. Recently, we have shown the importance of CD95/ezrin/actin association in CD95-mediated apoptosis."

"In this study," reported F. Luciani and colleagues, "we explored the hypothesis that the gp120-mediated CD4 engagement could be involved in the induction of susceptibility of primary human T lymphocytes to CD95-mediated apoptosis through ezrin phosphorylation and ezrin-to-CD95 association."

Results demonstrate "that gp120/IL-2 combined stimuli, as well as the direct CD4 triggering, on human primary CD4+ T lymphocytes induced an early and stable ezrin activation through phosphorylation, consistent with the induction of ezrin/CD95 association and susceptibility to CD95- mediated apoptosis."

Luciani concluded, "Our results provide a new mechanism through which HIV-1-gp120 may predispose resting CD4+ T cell to bystander CD95-mediated apoptosis and support the key role of ezrin/CD95 linkage in regulating susceptibility to CD95-mediated apoptosis."

Luciani and colleagues published their findings in Cell Death and Differentiation (CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4+ T lymphocytes. Cell Death Differ. 2004 May;11(5):574-82.

Additional information can be obtained by contacting S. Fais, Ist Super Sanita, Immunology Laboratory, Viale Regina Elena 299, I-00161 Rome, Italy.

The publisher of the journal Cell Death and Differentiation can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St., London N1 9XW, England.

The information in this article comes under the major subject areas of AIDS & HIV, Apoptosis, Immunology and Receptor Studies.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Luciani F, Matarrese P, Giammarioli AM, et al. "CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4(+)T lymphocytes", Cell Death Differ. 2004 May;11(5):574-82

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