AIDSWEEKLY Plus; Monday, June 22, 2009
Staff Medical Writers

NewsRx -- Investigators publish new data in the report 'Haplotype analysis of HLA-A, -B antigens and -DRB1 alleles in south Indian HIV-1-infected patients with and without pulmonary tuberculosis.' "We have shown earlier the association of human leucocyte antigen (HLA)-A11 with resistance and HLA-B40 and -DR2 with susceptibility to HIV and HIV-TB. In the present study, we have attempted to find out the HLA-DR2 subtypes and the possible HLA-A/-B/-DRB1 haplotype combinations that are associated with susceptibility or resistance to HIV and HIV with pulmonary tuberculosis (HIV+PTB+)," scientists in Chennai, India report (see also HIV/AIDS Co-Infection).

"HLA-DR2 subtyping was carried out by polymerase chain reaction-based sequence-specific oligonucleotide probe method. Overrepresentation of HLA-DRB1*1501 in HIV-positive PTB-negative (HIV+PTB-) patients (p=0.004, P(c)=0.06) and -DRB1*1502 in HIV-positive PTB-positive (HIV+PTB+) patients (p=0.019) was observed as compared to healthy controls. Haplotype analysis revealed an increased frequency of HLA-A2-DRB1*1501 haplotype in HIV+PTB-patients (p=0.008) and HLA-A2-DRB1*1502 among HIV+PTB+ patients (p=0.01) compared to healthy controls. The haplotypes B40-DRB1*1501 and B40-DRB1*04 were found to be moderately increased in HIV+PTB(-) and HIV+PTB+ patients (p <0.05). The study suggests that HLA-A2-DRB1*1501 haplotype may be associated with HIV infection while HLA-A2-DRB1*1502 haplotype might be associated with susceptibility to PTB in HIV patients," wrote S. Raghavan and colleagues, Indian Council of Medical Research.

The researchers concluded: "Moreover, HLA-B40-DRB1*1501 and HLA-B40-DRB1*04 haplotypes may be associated with susceptibility to HIV infection and to PTB in HIV patients."

Raghavan and colleagues published their study in International Journal of Immunogenetics (Haplotype analysis of HLA-A, -B antigens and -DRB1 alleles in south Indian HIV-1-infected patients with and without pulmonary tuberculosis. Int J Immunogenet. 2009 Jun;36(3):129-33.

For additional information, contact S. Raghavan, Tuberculosis Research Centre, Indian Council of Medical Research, Mayor V R Ramanathan Road, Chetput, Chennai 600031, India.

The publisher's contact information for the International Journal of Immunogenetics is: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA.

Keywords: India, Chennai, HIV/AIDS Co-Infection, AIDS, Acquired Immunodeficiency Syndrome, Cutaneous Tuberculosis, Diagnosis, Diagnostics, Enzyme Research, HIV, Human Immunodeficiency Virus Bacterial Infection, Immunogenetics, Mycobacteria, Mycobacterium Tuberculosis, Polymerase, Virology.

This article was prepared by AIDS Weekly editors from staff and other reports.

2009-06-22
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