AIDSWEEKLY Plus; Monday, December 21, 2009
Staff Medical Writers

2009 DEC 21 - (NewsRx.com) -- "This paper reports the synthesis of novel 4'-hydrophobic pocket deoxythreosyl C-nucleosides," scientists in Seoul, South Korea report (see also Antivirals).

"The key threose-like intermediates 9 and 14 were constructed from acyclic ketone derivatives, respectively. The antiviral activities of the synthesized compounds against the HIV-1, HSV-1, HSV-2, and HCMV viruses were evaluated," wrote J.H. Hong and colleagues.

The researchers concluded: "The 9-deaza-adenine derivatives 10 and 20 showed good anti-HIV activity without exhibiting significant cytotoxicity."

Hong and colleagues published their study in Archiv der Pharmazie (Synthesis and In-vitro Activity of 4'-Modified Analogues of ddA as Potent Anti-HIV Agents. Arch Pharm (Weinheim). 2009 Oct;342(10):600-4).

For additional information, contact C.H. Oh, Korea Institute Science & Technology, Biomaterials Chemical Research Center, Seoul 136791, South Korea.

The publisher's contact information for the journal Archiv der Pharmazie is: Wiley-V C H Verlag GmbH, PO Box 10 11 61, D-69451 Weinheim, Germany.

Keywords: City:Seoul, Country:South Korea, AIDS/HIV, Antiviral, Antivirals, Pharmaceuticals, Treatment, Viral Inhibition, Viral Therapy, Virology

This article was prepared by AIDS Weekly editors from staff and other reports.

2009-12-21
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