Prognostic index for risk of progression of Kaposi’s Sarcoma

HIV Treat Bull - Vol. 7, No. 7/8, September 2006

Mark Bower and colleagues from the Chelsea and Westminster Hospital London, presented a prognostic score for patients diagnosed with Kaposi’s Sarcoma (KS), derived from analysing covariates predictive of overall survival in a cohort of 326 HIV+ patients who developed KS since 1996.

The score in these patients, ranged from 0 to 15 and was calculated starting at the number 10. It incorporated:

Table 1: PSS (phenotypic sensitivity score)

Individuals with a prognostic score of 0, 5, 10 and 15, had 1 year survivals of 99.4%, 96.7%, 83.4% and 37.8% and 5 year survivals of 98.4%, 91.8%, 63.1% and 8.4% respectively. Increasing the prognostic score by 1 increased the risk of death by 40% (HR 1.4, 95% CI 1.28-1.53, bootstrapped HR 1.39, 95% CI 1.25-1.51) and the index has a concordance of 76.8% (95% CI 71.7-82.3%). The prognostic index, validated internally using a bootstrap procedure with resampled data, applied to individuals on and off HAART at KS diagnosis.

The study concluded that this score can be used to guide therapeutic options.

Ref: Bower M, Sanitt A, Mazhar D et al. A prognostic index for AIDS-associated Kaposi Sarcoma in the era of highly active antiretroviral therapy. Poster abstract TUPE0046.

2006-09-10
IB060709-21

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