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Abstract: Dyslipidaemia is a common problem affecting HIV-infected patients receiving antiretroviral therapy. Since publication of preliminary guidelines in 2000, numerous studies have addressed the risk of cardiovascular disease, the mechanisms of dyslipidaemia, drug interactions, and the treatment of lipid disorders in HIV-inf ...
http://www.aegis.org/pubs/i-base/2003/ib030408-18.html
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Abstract: PURPOSE: To prospectively validate the AIDS Clinical Trials Group ACTG) staging classification for AIDS-associated Kaposi s sarcoma (KS). PATIENTS AND METHODS: Two hundred ninety-four consecutive patients enrolled in eight ACTG therapeutic trials for AIDS-associated KS were staged prospectively according to tumor exte ...
http://www.aegis.org/aidsline/1997/dec/m97c0071.html
File Name: m97c0071.html, Size: 9KB, Last Modified: Sunday, December 28, 1997 at 8:12:04 PM
Abstract: An independent quality assurance program has been established by the Virology Committee of the AIDS Clinical Trials Group in the Division of AIDS, National Institute of Allergy and Infectious Diseases, for monitoring polymerase chain reaction (PCR) assays for human immunodeficiency virus type 1 (HIV-1) DNA that are pe ...
http://www.aegis.org/aidsline/1994/may/m9450448.html
File Name: m9450448.html, Size: 11KB, Last Modified: Saturday, May 28, 1994 at 8:12:04 PM
Abstract: OBJECTIVE--The purpose of this study was to determine whether the beneficial effects of zidovudine seen overall in two recently completed placebo-controlled clinical trials are also apparent in blacks, Hispanics, women, and intravenous drug users. DESIGN--Two double-blind placebo-controlled randomized clinical trials, ...
http://www.aegis.org/aidsline/1992/feb/m9220503.html
File Name: m9220503.html, Size: 10KB, Last Modified: Friday, February 28, 1992 at 8:12:04 PM
Abstract: <p><b>BACKGROUND:</b> A breakdown of toxicity events in ACTG Study 5025, closed for toxicity, suggested an increased incidence of potentially fatal pancreatitis. </p> <p><b>METHODS:</b> Incidence rates of pancreatitis were estimated in 20 adult ACTG studies which included didansosine ( ddI ...
http://www.aegis.org/conferences/iac/2000/wepeb4255.html
File Name: wepeb4255.html, Size: 7KB, Last Modified: Sunday, July 09, 2000 at 8:12:04 PM
Abstract: The results of the AIDS Clinical Trials Group (ACTG) 076 protocol have proved that antiviral medications, specifically zidovudine (ZDV; AZT ), can reduce HIV transmission from mother to fetus. However, AZT therapy is not a viable option for many women- ...
http://www.aegis.org/aidsline/1996/jun/m9660522.html
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Abstract: During 1987, a new era in the approach to treatment of severe human immunodeficiency virus (HIV)-I infections was entered. The increased availability of zidovudine and its licensure in many countries have resulted in its widespread use. With these developments have come a multitude of new questions. How long will clin ...
http://www.aegis.org/aidsline/1988/nov/m88b0237.html
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Abstract: One of the nations leading AIDS caretakers is gone. Recognized as an outstanding physician during his life, John Carey of Case Western Reserve University, Cleveland, Ohio, posthumously received the Young Investigator Award of the AIDS Clinical Trials Group. ...
http://www.aegis.org/pubs/aidswkly/1995/aw951208.html
File Name: aw951208.html, Size: 6KB, Last Modified: Monday, January 05, 2009 at 10:05:32 PM
Abstract: Women treated with nevirapine to prevent vertical HIV transmission may be at risk of developing viral drug resistance, researchers warn. ...
http://www.aegis.org/pubs/aidswkly/2002/aw020807.html
File Name: aw020807.html, Size: 9KB, Last Modified: Monday, January 05, 2009 at 9:58:41 PM
Abstract: AEGIS, AIDS Daily Summary, HIV, AIDS, HIV infection, opportunistic infections. var gaJsHost = (https: = document.location.protocol) ? "https:ssl. : "http:www. document.write(unescape(3Cscript src= + gaJsHost + "google-analytics.com/ga.js' type=text/javascript'3E%3C/script%3E"ion" CONTENT=Young childr ...
http://www.aegis.org/news/ads/1994/ad941992.html
File Name: ad941992.html, Size: 10KB, Last Modified: Sunday, January 04, 2009 at 6:49:12 PM
Abstract: AEGIS, AIDS Daily Summary, HIV, AIDS, HIV infection, opportunistic infections. var gaJsHost = (https: = document.location.protocol) ? "https:ssl. : "http:www. document.write(unescape(3Cscript src= + gaJsHost + "google-analytics.com/ga.js' type=text/javascript'3E%3C/script%3E"ion" CONTENT=The AIDS Cli ...
http://www.aegis.org/news/ads/1988/ad881649.html
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Abstract: Expected elevations of TC and TGC due to pregnancy were observed in both groups and declined after delivery. Fasting TC and TGC were higher in protease inhibitor treated patients in pregnancy. Increased LPD levels did not affect pregnancy outcome, but long term significance is unclear. LAC levels, even the few that wer ...
http://www.aegis.org/conferences/lipo/2006/64.html
File Name: 64.html, Size: 8KB, Last Modified: Monday, September 25, 2006 at 6:29:23 AM
Abstract: The use of HAART is highly effective in reducing mortality among children and adolescents infected with HIV. Effects of HAART on survival, appropriately controlling for confounding by severity, are consistent with those observed in adult trials. ...
http://www.aegis.org/conferences/iac/2006/weab0303.html
File Name: weab0303.html, Size: 8KB, Last Modified: Sunday, August 13, 2006 at 7:00:01 AM
Abstract: The Stanford AIDS Clinical Trials Group (ACTG) is actively recruiting patients for the following studies. ...
http://www.aegis.org/pubs/beta/1989/beta0302.html
File Name: beta0302.html, Size: 4KB, Last Modified: Sunday, June 30, 2002 at 2:45:58 PM
Abstract: 1989 Issue No. 4 - November. ddI (dideoxyinosine). Etienne Hafs ddI (dideoxyinosine) is one of a group of promising anti-HIV drugs called nucleoside analogues. Like AZT and other analogues, it works by inhibiting replication of HIV and reducing the rate atx which cells become infected with the virus. ...
http://www.aegis.org/pubs/beta/1989/default.asp
File Name: default.asp, Size: 7KB, Last Modified: Saturday, March 31, 2001 at 4:39:13 AM
Abstract: Trimethoprim-sulfamethoxazole (TMP/SMX) is recognized as the superior agent for Pneumocystis carinii pneumonia (PCP) prophylaxis but a high incidence of adverse drug reactions, which may be due to toxic drug metabolites, limits its use. AIDS Clinical Trials Group protocol 268 was a randomized, double-blind, controlled ...
http://www.aegis.org/aidsline/2000/dec/a00c0231.html
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Abstract: Use of human immunodeficiency virus (HIV) drug-resistance testing in therapeutic decision making may be aided by understanding the relationship between results of genotypic and drug-susceptibility phenotypic assays. We investigated this relationship by applying 3 different statistical methods-cluster analysis, recursi ...
http://www.aegis.org/aidsline/2000/nov/a00b1056.html
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Abstract: This paper describes the AACTG Adherence Instruments, which are comprised of two self-report questionnaires for use in clinical trials conducted by the Adult AIDS Clinical Trials Group (AACTG). The questionnaires were administered to 75 patients at ten AACTG sites in the USA. All patients were taking combination antir ...
http://www.aegis.org/aidsline/2000/nov/a00b0936.html
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Abstract: OBJECTIVE: To determine the efficacy and safety of amphotericin B oral suspension (ABOS) for the treatment of fluconazole refractory oral candidiasis in persons with HIV infection. DESIGN AND SETTING: A prospective, multicenter, open label trial at 25 study centers within the AIDS Clinical Trials Group. PATIENTS AND M ...
http://www.aegis.org/aidsline/2000/oct/a00a0378.html
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Abstract: To evaluate HIV-1 RNA and CD4+ cell responses to therapy as predictors of clinical progression and to evaluate levels and trends of these markers prior to clinical failure, HIV-1 RNA measurements were retrospectively obtained on subjects who progressed to AIDS or death and a random sample of subjects who did not. Samp ...
http://www.aegis.org/aidsline/2000/oct/a00a0615.html
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Abstract: The effect of food on didanosine bioavailability and interpatient pharmacokinetic variability was examined in children infected with human immunodeficiency virus type 1 (HIV-1). Didanosine pharmacokinetics were determined during fasting and fed conditions in HIV-infected children enrolled in the Pediatric AIDS Clinica ...
http://www.aegis.org/aidsline/2000/aug/a0080887.html
File Name: a0080887.html, Size: 8KB, Last Modified: Monday, August 28, 2000 at 8:12:04 PM
Abstract: OBJECTIVES: To compare the impact of three different nucleoside reverse transcriptase inhibitor regimens, zidovudine (ZDV) monotherapy, didanosine (ddI) monotherapy, and ZDV plus ddI combination therapy , on central nervous system (CNS) outcomes in symptomatic human imm ...
http://www.aegis.org/aidsline/1999/nov/a99b0177.html
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Abstract: OBJECTIVE: To describe the effect of zidovudine on human immunodeficiency virus type 1 (HIV-1) and on the course of disease in infants who became infected while they and their mothers received zidovudine preventive therapy or placebo in Pediatric AIDS Clinical Trials Group Protocol 076. STUDY DESIGN: Observational sub ...
http://www.aegis.org/aidsline/1999/sep/a9991117.html
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Abstract: OBJECTIVE: To evaluate initial changes in CD4 cell count as a surrogate endpoint for clinical outcome in HIV-infected patients. DESIGN: Meta-analysis of all relevant Phase II and III randomized clinical trials undertaken by the Adult AIDS Clinical Trials Group. METHODS: Individual patient data were obtained from each ...
http://www.aegis.org/aidsline/1999/mar/a9930973.html
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Abstract: OBJECTIVE: The Pediatric AIDS Clinical Trials Group (PACTG) Protocol 300 assessed the clinical efficacy and safety of combination zidovudine/lamivudine (ZDV/ 3TC ) compared with either didanosine (ddI) alone or combination ZDV/ddI. STUDY DESIGN: Childre ...
http://www.aegis.org/aidsline/1999/jan/a9910495.html
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Abstract: Mechanisms underlying the delay in dominance of syncytium-inducing (SI) phenotype HIV-1 (human immunodeficiency virus type 1) in vivo are unknown. Both random mutational events and selective pressures operative only late in the disease process have been suggested to underlie the shift from CCR5 to alternative corecept ...
http://www.aegis.org/aidsline/1998/aug/m9880566.html
File Name: m9880566.html, Size: 9KB, Last Modified: Saturday, August 29, 1998 at 6:29:23 AM
Abstract: ACTG 116B/117: High Levels of AZT Resistance May Predict HIV Disease Progression. News from NIAID - June 8, 1993 National Institute of Allergy and Infectious Diseases, National Institutes of HealthPatients carrying strains of HIV highly resistant to the drug zidovudine (. AZT. may be more likely than t ...
http://www.aegis.org/news/niaid/1993/cdc93054.html
File Name: cdc93054.html, Size: 7KB, Last Modified: Tuesday, July 21, 1998 at 3:03:51 PM
Abstract: The objective of this study was to identify prognostic factors for survival in patients with pretreatment CD4 ...
http://www.aegis.org/aidsline/1998/jan/m9810791.html
File Name: m9810791.html, Size: 9KB, Last Modified: Thursday, January 29, 1998 at 6:29:23 AM
Abstract: This paper reviews the rationale for the AIDS Clinical Trials Group (ACTG) protocol 076 design, the study results and the implications of these results, including discussion of the US Public Health Service Task Force recommendations on the use of zidovudine to reduce perinatal transmission and for prenatal human immun ...
http://www.aegis.org/aidsline/1997/dec/m97c0963.html
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Abstract: The National Institute of Allergy and Infectious Diseases (NIAID) has awarded 23 4-year grant programs to the Pediatric AIDS Clinical Trials Group, a national network that coordinates research projects. The money will support 21 trials, a data management center, and a new Coordinating and Operating Center. The restruc ...
http://www.aegis.org/aidsline/1997/aug/m9781263.html
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