Your Search for Adult AIDS Clinical Trials Group or AACTG matched 168 Documents (Page 1 of 6).
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Abstract: MMAS may be superior to AACTG, due to less internal attrition. Association between MMAS and viral load was found, but not for AACTG, possibly due to lack of power. AACTG may be too complicated for this unselected HIV-infected population, and the item wording may have encouraged social desirability explaining the higher ...
http://www.aegis.org/conferences/hiv-glasgow/2006/p174.html
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Abstract: Introduction: Inadequate adherence is the most important factor predicting failure to HAART in HIV-infected subjects. With the recently implemented government-funded antiretroviral program in Mexico , use of HAART is now widespread in this country, however the prevalence of non-adherence and the optimal instruments hav ...
http://www.aegis.org/conferences/iac/2004/b12476.html
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Abstract: Dyslipidaemia is a common problem affecting HIV-infected patients receiving antiretroviral therapy. Since publication of preliminary guidelines in 2000, numerous studies have addressed the risk of cardiovascular disease, the mechanisms of dyslipidaemia, drug interactions, and the treatment of lipid disorders in HIV-inf ...
http://www.aegis.org/pubs/i-base/2003/ib030408-18.html
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Abstract: This paper describes the AACTG Adherence Instruments, which are comprised of two self-report questionnaires for use in clinical trials conducted by the Adult AIDS Clinical Trials Group (AACTG). The questionnaires were administered to 75 patients at ten AACTG sites in the USA. All patients were taking combination antir ...
http://www.aegis.org/aidsline/2000/nov/a00b0936.html
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Abstract: The AACTG NeuroScreen is a brief, simple and low-cost global screening tool that provides acceptable diagnostic efficiency in HIV neurological disease. Serial NeuroScreen assessments in A5001 and A362 will permit estimation of the prevalence and course of neurocognitive impairment and DSPN in over 3000 individuals. Bec ...
http://www.aegis.org/conferences/croi/2004/493.html
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Abstract: Genetic variants may predict virologic failure and/or emergence of drug-resistant HIV. "Efavirenz and nelfinavir are metabolized by cytochrome P-450 (CYP) 2B6 and CYP2C19, respectively, with some involvement by CYP3A. Nelfinavir is a substrate for P-glycoprotein, which is encoded by MDR1. The present study examined ass ...
http://www.aegis.org/pubs/aidswkly/2006/aw060104.html
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Abstract: <p><b>BACKGROUND:</b> Defining immunologic, virologic, and host factors that influence response to Antiretroviral Therapy (ART), and their impact on long-term outcomes is key to individualizing therapy for HIV + pts. </p> <p><b>METHODS:</b> We analyzed baseline (BL) factors associated with ART response in HIV + , ART- ...
http://www.aegis.org/conferences/croi/2003/572.html
File Name: 572.html, Size: 7KB, Last Modified: Monday, February 10, 2003 at 8:12:04 PM
Abstract: AIDS TREATMENT NEWS compiled this list and checked the Web sites as we went to press in early March. Please let us know of other meetings that should be on this list. We can run updates if necessary. * 2002 National STD Prevention Conference, March 4-7, San Diego http://www.stdconference.org/ * The Presidential Advisor ...
http://www.aegis.org/pubs/atn/2002/atn37807.html
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Abstract: La question de la résistance médicamenteuse préoccupe les gens concernés par les traitements du VIH/sida depuis de nombreuses années. Au fil du temps, le VIH est capable de modifier sa structure de sorte qu'il puisse résister aux effets des médicaments antirétroviraux. Lorsqu'une résistance se développe, l'effet des mé ...
http://www.aegis.org/news/catie/2000/catf-n20000603.html
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Abstract: Blood lipid (fat) abnormalities have become a significant concern for many people taking antiretroviral therapy and for the people who treat them. High cholesterol and triglyceride levels are commonly observed in people on HAART, a fact that raises concerns about increased risk for heart disease in these patients. ...
http://www.aegis.org/news/catie/2000/cate-n20000603.html
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Abstract: Expected elevations of TC and TGC due to pregnancy were observed in both groups and declined after delivery. Fasting TC and TGC were higher in protease inhibitor treated patients in pregnancy. Increased LPD levels did not affect pregnancy outcome, but long term significance is unclear. LAC levels, even the few that wer ...
http://www.aegis.org/conferences/lipo/2006/64.html
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Abstract: These results show that with a large enough dataset and adequate distribution of resistance levels, the performance of interpretation systems for identifying abacavir and ddI resistance can be evaluated and that several of these systems performed well. ...
http://www.aegis.org/conferences/hivdrw/2006/84.html
File Name: 84.html, Size: 6KB, Last Modified: Wednesday, June 14, 2006 at 6:29:23 AM
Abstract: Multilocus interactions involving genes important for T-cell expansion and survival may predict CD4 increases during ART. Further studies are warranted to validate these associations and define underlying mechanisms. ...
http://www.aegis.org/conferences/croi/2006/443.html
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Abstract: DAPD and MMF were safe and well tolerated. DAPD monotherapy had modest antiretroviral activity (–0.35 log10) in heavily pre-treated subjects with extensive NRTI resistance. In contrast to synergy observed in vitro, DAPD activity over 2 weeks was not increased by MMF (500 mg twice daily) in this study. Assays of DAPD an ...
http://www.aegis.org/conferences/croi/2006/517.html
File Name: 517.html, Size: 8KB, Last Modified: Sunday, February 05, 2006 at 8:12:04 PM
Abstract: These results raise the question of external validation of existing interpretation systems and emphasize the need for collaborative work to improve existing systems both by increasing the sample size and by developing innovative statistical approaches. ...
http://www.aegis.org/conferences/hivdrw/2005/9.html
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Abstract: Mitochondrial haplogroup T was more frequent in Caucasians who developed subjective peripheral neuropathy while on ddI/d4T during Study 384. The polymorphism that defines this haplogroup is located in the ND5 region of the mitochondrial gene encoding Complex I respiratory transport chain subunits and may point to varia ...
http://www.aegis.org/conferences/croi/2005/43.html
File Name: 43.html, Size: 8KB, Last Modified: Tuesday, February 22, 2005 at 8:12:04 PM
Abstract: AEGiS, 12th Conference on Retroviruses and Opportunistic Infections, San Francisco, HIV, AIDS,. 12th Conference on Retroviruses and Opportunistic Infections Boston, Massachusetts - February 22-25, 2005FACTORS ASSOCIATED WITH TIME TO CD4 COUNT < 350/mm3 AFTER A TREATMENT INTERRUPTION FOLLOWING EFFECTI ...
http://www.aegis.org/conferences/croi/2005/582.html
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Abstract: Plasma F2-IsoP levels were unexpectedly high at baseline in cryopreserved specimens from these study subjects compared to levels from a previous study that included HIV-infected adults not receiving ART. This may reflect ex vivo auto-oxidation of some plasma specimens. Although F2-IsoP increases tended to be somewhat g ...
http://www.aegis.org/conferences/croi/2005/399.html
File Name: 399.html, Size: 9KB, Last Modified: Tuesday, February 22, 2005 at 8:12:04 PM
Abstract: Subjects with a variant T allele at CYP2B6 position 516 may be at increased risk for developing NNRTI-resistant HIV-1 when simultaneously stopping all drugs in EFV-containing regimens, although variability within genotypes is considerable. Risk is greatest in T/T homozygotes with prolonged medication discontinuation. T ...
http://www.aegis.org/conferences/croi/2005/651.html
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Abstract: Among subjects initiating NVP in South Africa, MDR1 3435C > T was associated with decreased hepatotoxicity, whereas a CYP2B6 SNP known to be associated with delayed EFV clearance did not predict risk of hepatotoxicity on NVP. These findings, if confirmed in other populations, may ultimately foster more rational prescri ...
http://www.aegis.org/conferences/croi/2005/833.html
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Abstract: The comparison between double and single PI groups was limited by early termination of enrollment and the resulting small sample size. RNA and CD4+ cell responses did not differ significantly between groups in the ITT analyses and trends favored the double PI group in the AT analyses, although this should be interpret ...
http://www.aegis.org/conferences/croi/2005/577.html
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Abstract: Treatment with EFV+2 NRTI led to lower rates of regimen failure than treatment with LPV/r+EFV, due to decreased toxicity and a trend toward reduced virologic failure. ...
http://www.aegis.org/conferences/croi/2005/162.html
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Abstract: The switch to a non-NRTI containing combination of LPV/r+EFV was associated with significant improvement in appendicular fat, increases in serum lipids, and stable glucose metabolism and regional bone mineral density. These findings support the observations that LPV/r has minimal effects on glucose metabolism, but is a ...
http://www.aegis.org/conferences/croi/2005/40.html
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Abstract: BACKGROUND: As HIV-related therapies and supportive services are provided in resource limited settings, it is crucial to have reliable evaluation methods. Aside from mortality, little data is collected on the human impact of HIV. Patient questionnaires can be used to assess therapies, care and services, and policies. W ...
http://www.aegis.org/conferences/iac/2004/e11602.html
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Abstract: BACKGROUND: As South Africa implements its Operational Plan for Comprehensive HIV and AIDS Care, an accurate method of measuring antiretroviral adherence will be crucial for optimizing outcomes. We examined whether an instrument designed to measure adherence in the developed world is applicable in a resource-limited se ...
http://www.aegis.org/conferences/iac/2004/wepeb5829.html
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Abstract: A CYP2B6 allelic variant that may occur more commonly in blacks than whites is associated with approximately 3-fold higher plasma EFV levels between homozygote genotypes during HIV treatment initiation. Interindividual differences in metabolism may in part explain susceptibility to EFV CNS side effects. ...
http://www.aegis.org/conferences/croi/2004/133.html
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Abstract: Overall, the PI NFV and the NNRTI EFV appear to have comparable effects on fasting lipids, with a better total:HDL-C ratio with EFV. Lipids tended to be slightly more favorable with ZDV+3TC than ddI+d4T. HDL-C changes correlated with entry HIV disease status. Insulin resistance worsened in the group as a whole, but did ...
http://www.aegis.org/conferences/croi/2004/74.html
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Abstract: In this ZDV-experienced population suppressed to <500 copies/mL on IDV + 2 NRTI, ABC intensification did not reduce the rate of treatment failure, virologic failure, frequency of intermittent viremia, or the level of residual viremia below 50 copies/mL. CD4 responses and resistance profiles at virologic failure were al ...
http://www.aegis.org/conferences/croi/2004/56.html
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Abstract: No significant differences in ART adherence were observed between male and female patients.Medical evaluation of adherence to ARV based on patients' responses is influenced by the patients' need of social acceptance, and is therefore subject to patient lying. This can explain the discrepancy between estimated adherence ...
http://www.aegis.org/conferences/eacs/2003/293.html
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Abstract: <p><b>BACKGROUND:</b> Published reports of the prevalence of asymptomatic hyperlactatemia among HIV-infected individuals have ranged from 4%-36%. The significance of these elevations in lactate in the absence of symptoms remains uncertain. In addition, the variability in the reported AH prevalence may reflect cohort di ...
http://www.aegis.org/conferences/croi/2003/761.html
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