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Abstract: The health care provider and the patient should be fully aware that the rationale for therapy of acute HIV infection is based on theoretical considerations, and the potential benefit should be weighed against the potential risks. ...
http://www.aegis.org/pubs/catie/2010/catie176-07_en.html
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Abstract: The present study provides empirical evidence that men with acute HIV infection are biologically hyper-infectious because of increased genital shedding of HIV. In addition, the present study has provided evidence that, during acute infection, HIV load increases and decreases in semen in approximate parallel with change ...
http://www.aegis.org/pubs/i-base/2004/ib040506-21.html
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Abstract: Surprisingly, acute HIV infection appears to reduce HBV loads in hepatitis B patients. ...
http://www.aegis.org/pubs/aidswkly/2004/aw040505.html
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Abstract: Because people with acute HIV infection contribute disproportionately to transmission of the virus, identifying these persons is a critical public health challenge. The current cross-sectional study outlines targeted approaches the authors developed for detecting HIV RNA in persons with negative serological tests. Stud ...
http://www.aegis.org/news/ads/2009/ad090848.html
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Abstract: When acute HIV and an STI are co-infections, presenting signs/symptoms are more likely due to the STI than HIV, although non-specific symptoms consistent with Acute HIV Infection Syndrome can occur. Pharyngeal gonorrhea was often symptomatic in the setting of acute HIV. All at-risk anatomical sites should be tested for ...
http://www.aegis.org/conferences/hiv-glasgow/2008/1758-2652-11-s1-p303.html
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Abstract: The stepwise pooling algorithm using RNA PCR is a feasible and potentially valuable strategy for screening for acute HIV infection in populations at high risk of HIV acquisition such as STD clinic clients. ...
http://www.aegis.org/conferences/iac/2006/mope0132.html
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Abstract: Is desquamation of palms and soles a symptom of acute HIV infection? ...
http://www.aegis.org/askdoc/askd030906.html
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Abstract: Partner counseling and referral services can be highly effective in the setting of acute HIV infection, where it can be focused on individuals with extraordinary immediate risk of transmission (>5% per coital act) and large numbers of risky contacts. Partner counseling and referral services can identify source patients ...
http://www.aegis.org/conferences/croi/2006/371.html
File Name: 371.html, Size: 7KB, Last Modified: Sunday, February 05, 2006 at 8:12:04 PM
Abstract: Screening negative samples for acute HIV infection using a pooled RNA testing approach should be considered in all settings with at least a 0.55% positive HIV test rate where urgent notification and follow-up are possible. ...
http://www.aegis.org/conferences/croi/2006/374.html
File Name: 374.html, Size: 7KB, Last Modified: Sunday, February 05, 2006 at 8:12:04 PM
Abstract: Acute HIV infection cases contributed to an 8.8% increase in the rate of HIV case identification. Incorporation of the NAAT protocol to detect acute HIV infections represents a substantial improvement over current HIV screening algorithms that solely use standard antibody testing. Enhanced case detection may be especia ...
http://www.aegis.org/conferences/croi/2006/914.html
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Abstract: This study offers unique insight into HIV testing behaviors and illnesses prior to the diagnosis of acute HIV infection. Symptoms of the acute HIV infection were extremely common, but few patients presented to their primary physician and the diagnosis of acute infection was rarely considered. There is a great need to e ...
http://www.aegis.org/conferences/croi/2005/565.html
File Name: 565.html, Size: 8KB, Last Modified: Tuesday, February 22, 2005 at 8:12:04 PM
Abstract: NAAT-based screening detected an additional 5% of HIV infections over standard HIV testing at STD clinic and community HIV testing sites—most were acute HIV infections with opportunities for secondary prevention. Acute HIV infections were detected in black males with symptomatic STD and in males who identified as MSM. ...
http://www.aegis.org/conferences/croi/2005/964.html
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Abstract: These results suggest that a substantial number of people seeking care for acute STD in Malawi have acute HIV co-infection that would be undetected by standard testing. Real-time pooled RNA testing for detection of acute HIV and quality control is feasible at centers of excellence in sub-Saharan Africa; however, parall ...
http://www.aegis.org/conferences/croi/2005/20.html
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Abstract: BACKGROUND: acute HIV infection (HIV seroconversion syndrome) is a condition that occurs 2 to 4 weeks after infection by the HIV virus and clinically is manifested in 40 - 90% of cases presented as a transient symptomatic illness resembling infectious mononucleosis or other viral flu syndromes. The only way for confirm ...
http://www.aegis.org/conferences/iac/2004/mopeb3106.html
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Abstract: BACKGROUND: Primary HIV infection (PHI) offers an opportunity to impact the earliest stages of HIV infection. Public health benefit may also accrue from reduced transmission from infectious persons. METHODS: The Duke-UNC-Emory Primary HIV Infection (PHI) Consortium has identified and enrolled patients with acute HIV in ...
http://www.aegis.org/conferences/iac/2004/tupeb4536.html
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Abstract: BACKGROUND: Analysis of the T cell repertoire can be useful to better understand the capacity of highly active antiretroviral therapy (HAART) to facilitate the reconstitution of the immune system during infection with the human immunodeficiency virus (HIV). METHODS: We have studied two groups of HIV+ patients who were ...
http://www.aegis.org/conferences/iac/2004/mopea3015.html
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Abstract: Replication-competent HIV was readily cultured at multiple time points from the resting CD4+ T cells of children treated with effective HAART from early infancy, and in the absence of seroconversion. Initiation of HAART during acute HIV infection in infants has no impact on the establishment of the resting CD4+ T cell ...
http://www.aegis.org/conferences/croi/2004/387.html
File Name: 387.html, Size: 8KB, Last Modified: Sunday, February 08, 2004 at 8:12:04 PM
Abstract: These data indicate that despite initial control of viremia, durable immune control in persons following treated acute infection occurs infrequently, and that larger trials will be needed to determine the potential clinical and virologic benefit of this approach. Loss of viremia control occurred in some individuals des ...
http://www.aegis.org/conferences/croi/2004/24.html
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Abstract: With HIV VCT enhanced by NAT, public helath programs can actively monitor HIV transmission in populations by identifying incident infections in real-time. The additional cases identified by NAT are those with maximm potential for secondary spread. The Screening and Tracing Active Transmission (STAT) program is a new mo ...
http://www.aegis.org/conferences/croi/2004/20.html
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Abstract: <p><b>BACKGROUND:</b> HLA-B57, as well as CTL responses restricted by this allele, have been strongly associated with long-term non-progressive HIV infection. However, their impact on viral replication during acute HIV infection is not understood. This study assessed clinical and immunlogical parameters during acute ...
http://www.aegis.org/conferences/iac/2002/thpea7113.html
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Abstract: <p><b>BACKGROUND:</b> Acute HIV infection is occurring in at risk populations but is predominantly undiagnosed. Acute HIV screening is not part of routine testing since direct tests for HIV such as RNA PCR are expensive and may have inadequate specificity for screening as prevalence will usually be low. </p> <p><b>M ...
http://www.aegis.org/conferences/iac/2002/thpeb7194.html
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Abstract: <p><b>BACKGROUND:</b> Non-human primate studies suggest a parallel relationship between semen and blood viral load over time during acute HIV infection. We hypothesized a similar pattern would hold in humans. </p> <p><b>METHODS:</b> We measured concurrent blood and semen HIV RNA concentrations from 32 individuals wi ...
http://www.aegis.org/conferences/iac/2002/thorc1487.html
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Abstract: <p><b>BACKGROUND:</b> We hypothesized that the overall sensitivity of p24 antigen testing in acute HIV infection might be limited by the appearance of anti-p24 antibody complexes in the last weeks prior to seroconversion. We examined whether a heat-dissociated p24 assay (HD-Ag) would improve sensitivity for acute HIV ...
http://www.aegis.org/conferences/iac/2002/tupec4893.html
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Abstract: It has long been hypothesized that semen viral load is the explanation for why there appears to be greater HIV transmission associated with acute infection. A study presented at the Ninth Conference on Retroviruses and Opportunistic Infections (Pilcher C., Tien H., Stewart P., et al. Estimating transmission probabiliti ...
http://www.aegis.org/news/ads/2002/ad021251.html
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Abstract: Susceptible partners of individuals with acute HIV infection may be at 20-fold greater risk per exposure compared to partners of individuals at virologic set point due to higher HIV shedding in semen. ...
http://www.aegis.org/conferences/croi/2002/366-m.html
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Abstract: In this antiretroviral naïve women with acute HIV infection, the detection of those mutations prior to treatment starting indicate a transmission of a multiresistant strain of HIV : zidovudine, lamivudine and PI. Selection of efavirenz associated mutations can be explained by initial resistance to lamividine (M184V) an ...
http://www.aegis.org/conferences/iashivpt/2001/357.html
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Abstract: <p><b>BACKGROUND:</b> Transmission of HIV resistant to antiretroviral agents has principally been reported in patients from urban areas in the NE and Western US. Little is known about antiretroviral resistance in patients with acute HIV infection acquired in non-urban areas in the SE. </p> <p><b>METHODS:</b> 20 patien ...
http://www.aegis.org/conferences/croi/2001/425.html
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Abstract: <p><b>BACKGROUND:</b> A rapid increase in viral load followed by a sharp fall towards a quasi-steady-state level characterises acute HIV-infection. In parallel, a sharp fall followed by an increase to relative normal counts of CD4+ T cells and to (somewhat) higher CD8+ T cells is found. Limitation of target cells and/o ...
http://www.aegis.org/conferences/croi/2001/418.html
File Name: 418.html, Size: 6KB, Last Modified: Sunday, February 04, 2001 at 8:12:04 PM
Abstract: Viral dynamics were intensively investigated in eight patients with acute HIV infection to define the earliest rates of change in plasma HIV RNA before and after the start of antiretroviral therapy. We report the first estimates of the basic reproductive number (R(0)), the number of cells infected by the progeny of an ...
http://www.aegis.org/aidsline/1999/dec/a99c0174.html
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Abstract: To date, most studies of the immunologic and virologic pararmeters during primary HIV infection have focused on symptomatic patients who present with a defined clinical syndrome. We have analyzed the primary immune response to acute HIV infection in a subset (n=9) of acute seroconvertors from ...
http://www.aegis.org/aidsline/1998/jun/m9860342.html
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