Your Search for adaptive immune response matched 44 Documents (Page 1 of 2).
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Abstract: During acute HIV-1 infection, NK cell numbers and activity dominate at a time when the adaptive immune response is still developing, and then decline with the appearance of HIV-1-specific CD8+ T cell responses. These data reflect a dynamic interplay between the innate and adaptive immune response during acute HIV-1 inf ...
http://www.aegis.org/conferences/croi/2006/376.html
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Abstract: Increased levels of soluble forms of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) and E-selectin have been found in the sera of HIV-infected patients and have been associated with disease progression. The aim of the present study was to investigate whether this phenomenon reflects activation o ...
http://www.aegis.org/aidsline/1998/feb/m9820407.html
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Abstract: Cop-1 regulates both innate and adaptive immune responses in experimental models of HIVE and shows promise for treatment of human disease. ...
http://www.aegis.org/conferences/croi/2006/335.html
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Abstract: The disrupted NK-DC interactions occurring in HIV-1 infected viremic individuals is a possible explanation for the impaired adaptive immune response to HIV and may lead to a defective clearance of HIV-infected cells. ...
http://www.aegis.org/conferences/iashivpt/2005/mooa0306.html
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Abstract: In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis. Severe combined immunodeficient mice, which lack B and T lymphocytes, exhibited considerably less bone loss ...
http://www.aegis.org/aidsline/1999/sep/a9991178.html
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Abstract: Only two HIV vaccines have been taken through efficacy trials so far. In the first HIV vaccine efficacy trial started ten years ago, recombinant gp120 protein, the CD4-binding subunit of the HIV envelope, was used as vaccine antigen. The vaccine neither prevented HIV acquisition nor reduced the viral load in those acqu ...
http://www.aegis.org/pubs/plos/pathogens/2008/journal.ppat.1000114.html
File Name: journal.ppat.1000114.html, Size: 7KB, Last Modified: Wednesday, September 24, 2008 at 6:29:25 PM
Abstract: IRF-1 is a host immune regulator and a potential transcriptional activator of HIV-1 replication. We conclude that IRF-1 is an important determinant of host susceptibility to HIV-1 infection. Lowered IRF-1 expression or response at early stage may be crucial in disrupting the establishment of HIV-1 infection and allow f ...
http://www.aegis.org/conferences/iac/2006/moax0103.html
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Abstract: Resistant women have significantly altered innate responses to some TLR ligands compared to uninfected controls, which may reflect their ability to mount a protective adaptive response to HIV-1. Interestingly cytokines known to induce cellular immunity were depressed while these women had elevated immunosuppressive cyt ...
http://www.aegis.org/conferences/iac/2006/weaa0301.html
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Abstract: Because Th17 cells play a central role in innate and adaptive immune response to extracellular bacteria, these data provide a rational explanation for the chronic enteropathy in HIV infection. Thus, therapeutic approaches to reconstitute Th17 numbers and/or function may be of benefit in HIV infection. ...
http://www.aegis.org/conferences/croi/2008/116.html
File Name: 116.html, Size: 7KB, Last Modified: Sunday, February 03, 2008 at 7:12:04 PM
Abstract: The most striking finding was a reduced expression of CCR7 in TLR-stimulated pDC of HIV-infected children who have poor immunologic response or ongoing, active viral replication while on ART. A defect in homing of the pDC to lymph nodes could break the link between innate and adaptive immune response to HIV. ...
http://www.aegis.org/conferences/croi/2006/20.html
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Abstract: Taken together, these data demonstrate significant perturbations in the NK cell compartment as early as acute HIV-1 infection, with an impairment of the overall NK cell response to mitogenic stimulation early in acute infection, while the NK cell response to MHC-devoid target, which is increased initially, but wanes ov ...
http://www.aegis.org/conferences/croi/2006/375.html
File Name: 375.html, Size: 7KB, Last Modified: Sunday, February 05, 2006 at 8:12:04 PM
Abstract: This study presents the first evidence that NKT cell function is impaired during early HIV infection, but significantly improves with effective treatment with ART. NKT cells are also shown to display anti-HIV-1 activity in vitro, mediated by IFN-gamma secretion. Preservation of NKT cell function may therefore be import ...
http://www.aegis.org/conferences/croi/2006/409.html
File Name: 409.html, Size: 7KB, Last Modified: Sunday, February 05, 2006 at 8:12:04 PM
Abstract: Background Natural Killer (NK) cells are the most potent effectors of natural immunity. Their ability to lyse virus infected cells as well as produce cytokines and chemokines without prior activation may be important in supporting adaptive immune response in HIV infection. Cellular immune response by NK cells may play ...
http://www.aegis.org/conferences/iac/2004/a10455.html
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Abstract: BACKGROUND: NK cells play a pivital role in the first line of defense against virally infected cells prior to the development of the adaptive immune response. Given the association between the expression of a particular NK cell KIR and slower disease progression, NK cells may be critical in HIV infection. OBJECTIVE: We ...
http://www.aegis.org/conferences/iac/2004/moppa2002.html
File Name: moppa2002.html, Size: 6KB, Last Modified: Monday, July 12, 2004 at 6:29:23 AM
Abstract: These studies investigate a potential role that (gd cells may be playing in keeping mangabeys free of disease progression in SIV infection. The high levels of CD8<sup>+</sup> Vd1 gdT cells in mangabeys and their ability to express Th1 and Th2 cytokines indicate this population in particular may be important. ...
http://www.aegis.org/conferences/croi/2004/244.html
File Name: 244.html, Size: 7KB, Last Modified: Sunday, February 08, 2004 at 8:12:04 PM
Abstract: Previous results have described a reduction in NKT cells within the first year of HIV infection due to a selective depletion of CD4+ NKT cells. Our data show that both NKT cells and the CD4+ NKT cell subset decline rapidly, within the first 2 to 3 months after infection. While previous results have found that this decl ...
http://www.aegis.org/conferences/croi/2004/245.html
File Name: 245.html, Size: 8KB, Last Modified: Sunday, February 08, 2004 at 8:12:04 PM
Abstract: This is the first time immune responses are studied starting 24 hours pi in primates. The selective changes in circulating DC subsets and CD56+/CD3– lymphocytes strongly suggest a specific role for these cells in setting the balance between the innate and adaptive immune responses and viral replication. ...
http://www.aegis.org/conferences/iashivpt/2003/176.html
File Name: 176.html, Size: 7KB, Last Modified: Monday, July 14, 2003 at 6:29:23 AM
Abstract: The first edition of this book was published in 1994 and reviewed in this journal as number 412, September, 1995. At that time it was highly recommended. It is still highly recommended. The field of immunobiology is moving at a rapid pace, resulting in much new material in this second edition. Every chapter has been up ...
http://www.aegis.org/pubs/books/1997/bk970631.html
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Abstract: Tumor necrosis factor (TNF) and the type I TNF receptor (TNFRI), p55, are critical for resistance against primary infections with the intracellular bacterial pathogen Listeria monocytogenes. Importantly, however, susceptibility to primary listeriosis in cytokine-deficient mice does not preclude the development or expr ...
http://www.aegis.org/aidsline/2000/oct/a00a0252.html
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Abstract: Infections can influence concurrent and subsequent Th1 vs Th2 immune responses to Ags. Through pattern recognition of foreign unmethylated CpG dinucleotides, the vertebrate innate immune system can sense infectious danger and typically replies with a Th1-polarized adaptive immune response. We examined whether CpG-DNA ...
http://www.aegis.org/aidsline/2000/oct/a00a0234.html
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Abstract: The CD40-CD40 ligand (CD40L) interaction is a key event in the initiation of an adaptive immune response, and as such the therapeutic value of CD40L blockade has been studied in many experimental models of tissue transplantation and autoimmune disease. In rodents, transplantation of allogeneic tissues under the cover ...
http://www.aegis.org/aidsline/2000/jan/a0010656.html
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Abstract: CD4+ T cells are considered to be the major controlling element of the adaptive immune response. They recognize foreign peptides by interaction of the T cell receptor (TCR) with peptide complexed to major histocompatibility complex (MHC) class II molecules on the surface of antigen presenting cells (APC). Once activat ...
http://www.aegis.org/aidsline/1999/nov/a99b0139.html
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Abstract: Pattern recognition receptors of the innate and adaptive immune systems apparently recognize unmethylated CpG motifs of bacterial DNA. Cells of the innate immune system are activated directly by CpG motifs, and the resulting response dictates a Th1 bias to the developing adaptive immune response. Interestingly, antige ...
http://www.aegis.org/aidsline/1999/jul/a9970147.html
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Abstract: The diversity of naive CD4 T cells plays an important role in the adaptive immune response by ensuring the capability of responding to novel pathogens. In the past, it has been generally accepted that naive CD4 T cells are intrinsically long-lived; however, there have been studies suggesting some CD4 T cells are short ...
http://www.aegis.org/aidsline/1999/jul/a9970644.html
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Abstract: For more than thirty years it has been apparent that serious injury in humans and experimental animals is associated with a decrease in immune functions dependent upon T cells, the principal cells involved in initiating adaptive immune responses. This review focuses on more recent evidence that T helper cell function ...
http://www.aegis.org/aidsline/1999/jul/a9970501.html
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Abstract: The human embryo and subsequent fetus is a semi-allograft and immunologically foreign to the mother. Successful embryonic implantation and maintenance of normal pregnancy depends on intricate interactions between the invading embryo, maternal endometrium and maternal immune response. Cytokines are pivotal in determini ...
http://www.aegis.org/aidsline/1998/jun/m9861390.html
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Abstract: In the adaptive immune response to most viruses, both the cellular and humoral arms of the immune system play complementary roles in eliminating virus and virus-infected cells and in promoting recovery. To evaluate the relative contribution of CD4+ and CD8+ effector T lymphocytes in virus clearance and recovery, we ha ...
http://www.aegis.org/aidsline/1998/mar/m9830724.html
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Abstract: Despite many years of study, relatively little is known about the effector mechanisms that operate against intestine-dwelling nematodes. Most of the current understanding comes from studies of laboratory model systems in rodents. It is clear that when an intestinal helminth infection takes place the immune system geneC ...
http://www.aegis.org/aidsline/1998/feb/m9820157.html
File Name: m9820157.html, Size: 10KB, Last Modified: Sunday, March 01, 1998 at 6:29:23 AM
Abstract: Interleukin 12 (IL-12) is produced by phagocytic cells, antigen-presenting cells and B lymphocytes in response to bacteria or intracellular parasites. IL-12 acts on T and natural killer (NK) cells inducing: production of cytokines, particularly gamma-interferon (IFN-gamma); proliferation; and enhancement of cell-media ...
http://www.aegis.org/aidsline/1996/nov/m96b1250.html
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Abstract: Cytokine patterns elicited by infection are critical in the regulation of the adaptive immune response and in the resolution of infection. Using a murine model of pneumonia induced by intranasal inoculation with the Chlamydia trachomatis mouse pneumonitis (MoPn) biovar, we found that the patterns of immune responses a ...
http://www.aegis.org/aidsline/1996/oct/m96a1063.html
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